303 Works

PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar & Melanie Boerries
Abstract Background Current therapeutic management of advanced melanoma patients largely depends on their BRAF mutation status. However, the vast heterogeneity of the tumors hampers the success of therapies targeting the MAPK/ERK pathway alone. Dissecting this heterogeneity will contribute to identifying key players in the oncogenic progression to tailor more effective therapies. Methods We performed a comprehensive molecular and phenotypic characterization of a panel of patient-derived BRAFV600E-positive melanoma cell lines. Transcriptional profiling was used to identify...

Additional file 10 of PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar & Melanie Boerries
Additional file 9. Table S9A–D. Over-represented KEGG pathway among gene clusters in MaMe21, MaMel63a, HEM, and HDF.

Additional file 4 of PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar & Melanie Boerries
Additional file 3. Table S3A–F. Over-represented biological processes (GO-bp) among over-expressed genes in MaMel cell lines.

Temporal regulation of notch activation improves arteriovenous fistula maturation

Qunying Guo, Guang Chen, Hunter Cheng, Ying Qing, Luan Truong, Quan Ma, Yun Wang & Jizhong Cheng
Abstract Background Arteriovenous fistula (AVF) maturation is a process involving remodeling of venous arm of the AVFs. It is a challenge to balance adaptive AVF remodeling and neointima formation. In this study we temporally controlled Notch activation to promote AVF maturation while avoiding neointima formation. Methods Temporal Notch activation was controlled by regulating the expression of Notch transcription factor, RBP-Jκ, or dnMAML1 (dominant negative MAML2) in vascular smooth muscle cells (VSMCs). AVF mouse model was...

Additional file 1 of Water extract from artichoke ameliorates high-fat diet-induced non-alcoholic fatty liver disease in rats

Aihua Deng, Fengying Liu, Xuchong Tang, Yun Wang, Peng Xie, Qifu Yang & Bing Xiao
Additional file 1.

Data from: Pollination mitigates cucumber yield gaps more than pesticide and fertilizer use in tropical smallholder gardens

Iris Motzke, Teja Tscharntke, Thomas C. Wanger & Alexandra-Maria Klein
1. Pollination can be an essential but often neglected ecosystem service to mitigate crop yield gaps. Pollination services are usually studied in isolation and their relative role and possible interactions with other factors, such as major management practices, is little understood. 2. We tested how pollination (insect versus wind- and self-pollination) interacts with weed control, fertilization, and insect herbivore control and how these factors as well as flower-visiting bees influence fruit set and yield of...

Gridded drought indices based on remote sensing data for Europe (2000-2015)

M. Tanguy, S. Bachmair, K. Stahl & J. Hannaford
This dataset comprises three gridded drought indicators based on remote sensing data for Europe. The data has a spatial resolution of 0.05 degree and a temporal resolution of 1 month for the period going from 2000 to 2015. The three drought indicators are: the Vegetation Condition Index (VCI) based on satellite product NDVI (Normalised Difference Vegetation Index); the Temperature Condition Index (TCI) based on remotely sensed LST (Land Surface Temperature); the Vegetation Health Index (VHI)...

Data from: Striking cuticular hydrocarbon dimorphism in the mason wasp Odynerus spinipes and its possible evolutionary cause (Hymenoptera: Chrysididae, Vespidae)

Mareike Wurdack, Sina Herbertz, Daniel Dowling, Johannes Kroiss, Erhard Strohm, Hannes Baur, Oliver Niehuis & Thomas Schmitt
Cleptoparasitic wasps and bees smuggle their eggs into the nest of a host organism. Here the larvae of the cleptoparasite feed upon the food provision intended for the offspring of the host. As cleptoparasitism incurs a loss of fitness for the host organism (offspring of the host fail to develop), hosts of cleptoparasites are expected to exploit cues that alert them to potential cleptoparasite infestation. Cuticular hydrocarbons (CHCs) could serve as such cues, as insects...

Drought indicator time series for European NUTS regions based on remote sensing data (2000-2015)

M. Tanguy, S. Bachmair, K. Stahl & J. Hannaford
This dataset consists in a collection of remotely sensed drought indicators time series. The data was extracted from CEH's gridded remotely sensed drought indicators product (Tanguy et al., 2016; http://doi.org/10.5285/4e0d0e50-2f9c-4647-864d-5c3b30bb5f4b), which has gridded data for Europe for three drought indicators: - the Vegetation Condition Index (VCI) based on satellite product NDVI (Normalised Difference Vegetation Index); - the Temperature Condition Index (TCI) based on remotely sensed LST (Land Surface Temperature); - the Vegetation Health Index (VHI)...

Queering the competitive cooking show: performance on/of Netflix’s Nailed It! English

Alkım Kutlu
This paper will look at Netflix’s Nailed It!, a competitive cooking show that introduces humor to the traditional format. In my analysis, I will look at the genre conventions of both food television and competitive cooking shows to situate Nailed It! within both these genres to understand its particular position. In comparing the show to the conventional narrative structures and performances within genre conventions, I will come to the conclusion that Nailed It! is a...

Data from: Migration in geographic and ecological space by a large herbivore

Wibke Peters, Mark Hebblewhite, Atle Mysterud, Derek Spitz, Stefano Focardi, Ferdinando Urbano, Nicolas Morellet, Marco Heurich, Petter Kjellander, John D.C. Linnell, Francesca Cagnacci & John D. C. Linnell
Partial migration, when only part of the population migrates seasonally while the other part remains resident on the shared range, is the most common form of migration in ungulates. Migration is often defined by spatial separation of seasonal ranges and consequently, classification of individuals as migrants or residents is usually only based on geographic criteria. However, the underlying mechanism for migration is hypothesized to be movement in response to spatiotemporal resource variability and thus, migrants...

Data from: Isotopic evidence for oligotrophication of terrestrial ecosystems

Joseph M. Craine, Andrew J. Elmore, Lixin Wang, Julieta Aranibar, Marijn Bauters, Pascal Boeckx, Brooke E. Crowley, Melissa A. Dawes, Sylvain Delzon, Alex Fajardo, Yunting Fang, Lei Fujiyoshi, Alan Gray, Rossella Guerrieri, Michael J. Gundale, David J. Hawke, Peter Hietz, Mathieu Jonard, Elizabeth Kearsley, Tanaka Kenzo, Mikhail Makarov, Sara Marañón-Jiménez, Terrence P. McGlynn, Brenden E. McNeil, Stella G. Mosher … & Katarzyna Zmudczyńska-Skarbek
Human societies depend on an Earth System that operates within a constrained range of nutrient availability, yet the recent trajectory of terrestrial nitrogen (N) availability is uncertain. Examining patterns of foliar N concentrations ([N]) and isotope ratios (15N) from more than 42,000 samples acquired over 37 years, here we show that foliar [N] declined by 8% and foliar 15N declined by 0.8 – 1.9 ‰. Examining patterns across different climate spaces, foliar 15N declined across...

Data from: Biotic predictors complement models of bat and bird responses to climate and tree diversity in European forests

Luc Barbaro, Eric Allan, Evy Ampoorter, Bastien Castagneyrol, Yohan Charbonnier, Hans De Wandeler, Christian Kerbiriou, Harriet Milligan, Aude Vialatte, Monique Carnol, Marc Deconchat, Pallieter De Smedt, Herve Jactel, Julia Koricheva, Isabelle Le Viol, Bart Muys, Michael Scherer-Lorenzen, Kris Verheyen & Fons Van Der Plas
Bats and birds are key providers of ecosystem services in forests. How climate and habitat jointly shape their communities is well studied, but whether biotic predictors from other trophic levels may improve bird and bat diversity models is less known, especially across large bioclimatic gradients. Here, we achieved multi-taxa surveys in 209 mature forests replicated in six European countries from Spain to Finland, to investigate the importance of biotic predictors (i.e., the abundance or activity...

4.4. Kommunikation im medizinischen Team

Mirjam Körner, Julia Haller & Sonja Becker
Kapitel des Online Lehrbuch der Medizinischen Psychologie und Medizinischen Soziologie

Data from: Rapid evolution in native plants cultivated for ecological restoration: not a general pattern

Rouven Nagel, Walter Durka, Oliver Bossdorf & Anna Bucharova
The growing number of restoration projects worldwide increases the demand for seed material of native species. To meet this demand, seeds are often produced through large‐scale cultivation on specialized farms, using wild‐collected seeds as the original sources. However, during cultivation plants experience novel environmental conditions compared to those in natural populations, and there is a danger that the plants in cultivation are subject to unintended selection and lose their adaptation to natural habitats. Although the...

Data from: Below-ground resource partitioning alone cannot explain the biodiversity–ecosystem function relationship: a field test using multiple tracers

Annette Jesch, Kathryn E. Barry, Janneke M. Ravenek, Dörte Bachmann, Tanja Strecker, Alexandra Weigelt, Nina Buchmann, Hans De Kroon, Arthur Gessler, Liesje Mommer, Christiane Roscher & Michael Scherer-Lorenzen
1. Belowground resource partitioning is among the most prominent hypotheses for driving the positive biodiversity-ecosystem function relationship. However, experimental tests of this hypothesis in biodiversity experiments are scarce, and the available evidence is not consistent. 2. We tested the hypothesis that resource partitioning in space, in time, or in both space and time combined drives the positive effect of diversity on both plant productivity and community resource uptake. At the community level, we predicted that...

Data from: Longevity and transposon defense, the case of termite reproductives

Daniel Elsner, Karen Meusemann & Judith Korb
Social insects are promising new models in aging research. Within single colonies, longevity differences of several magnitudes exist that can be found elsewhere only between different species. Reproducing queens (and, in termites, also kings) can live for several decades, whereas sterile workers often have a lifespan of a few weeks only. We studied aging in the wild in a highly social insect, the termite Macrotermes bellicosus, which has one of the most pronounced longevity differences...

Data from: Reanalyzing the Palaeoptera problem - the origin of insect flight remains obscure

Sabrina Simon, Alexander Blanke & Karen Meusemann
The phylogenetic relationships of the winged insect lineages – mayflies (Ephemeroptera), damselflies and dragonflies (Odonata), and all other winged insects (Neoptera) – are still controversial with three hypotheses supported by different datasets: Palaeoptera, Metapterygota and Chiastomyaria. Here, we reanalyze available phylogenomic data with a focus on detecting confounding and alternative signal. In this context, we provide a framework to quantitatively evaluate and assess incongruent molecular phylogenetic signal inherent in phylogenomic datasets. Despite overall support for...

Data from: Release from prey preservation behavior via prey switch allowed diversification of cuticular hydrocarbon profiles in digger wasps

Mareike Wurdack, Carlo Polidori, Alexander Keller, Heike Feldhaar & Thomas Schmitt
The cuticle of insects is covered by a layer of hydrocarbons (CHCs), whose original function is the protection from desiccation and pathogens. However, in most insects CHC profiles are species-specific. While this variability among species was largely linked to communication and recognition functions, additional selective forces may shape insect CHC profiles. Here we show that in Philanthinae digger wasps (Crabronidae) the CHC profile co-evolved with a peculiar brood-care strategy. In particular, we found that the...

Data from: Detection of somatic epigenetic variation in Norway spruce via targeted bisulfite sequencing

Katrin Heer, Kristian K. Ullrich, Manuel Hiss, Sascha Liepelt, Ralf Schulze Brüning, Jiabin Zou, Lars Opgenoorth, Stefan A. Rensing & Jiabin Zhou
Epigenetic mechanisms represent a possible mechanism for achieving a rapid response of long‐lived trees to changing environmental conditions. However, our knowledge on plant epigenetics is largely limited to a few model species. With increasing availability of genomic resources for many tree species, it is now possible to adopt approaches from model species that permit to obtain single‐base pair resolution data on methylation at a reasonable cost. Here, we used targeted bisulfite sequencing (TBS) to study...

Data from: The functional roles of species in metacommunities, as revealed by metanetwork analyses of bird-plant frugivory networks

Hai-Dong Li, Linfang Tang, Chenxi Jia, Marcel Holyoak, Jochen Fründ, Xiaoqun Huang & Zhihsu Xiao
Understanding how biodiversity and interaction networks change across environmental gradients is a major challenge in ecology. We integrated metacommunity and metanetwork perspectives to test species’ functional roles in bird-plant frugivory interactions in a fragmented forest landscape in Southwest China, with consequences for seed dispersal. Availability of fruit resources both on and under trees created vertical feeding stratification for frugivorous birds. Bird-plant interactions involving birds feeding only on the tree or both on and under the...

16S rRNA sequencing data: Altered microbiota, impaired quality of life, malabsorption, infection, and inflammation in CVID patients with diarrhoea

Cornelia Van Schewick, Christina Nöltner, Svenja Abel, Siobhan Burns, Sarita Workman, Andrew Symes, David Guzman, Michele Proietti, Alla Bulashevska, Fernando Moreira, Veronika Soetedjo, David Lowe & Bodo Grimbacher
Background: Diarrhoea is the commonest gastrointestinal symptom in patients with common variable immunodeficiency (CVID). Objective: The aim of this study was to describe the prevalence and clinical presentation of chronic and recurrent diarrhoea in the Royal-Free-Hospital (RFH) London CVID cohort, including symptoms, infections, level of inflammation, and microbial diversity. Methods: A cross-sectional study of adult CVID patients (139 out of 172 diagnosed with CVID completed the screening questionnaire). Those with diarrhoea ≥6 days/month had stool...

Simulated dataset from 'Quantifying the causal pathways contributing to natural selection'

Jonathan Henshaw
This dataset (Antechinus.csv) relates to the worked example in the appendix of the paper: Henshaw JM, Morrissey MB, Jones AG (2020). Quantifying the causal pathways contributing to natural selection. Evolution (doi:​10.1111/evo.14091) The worked example concerns a hypothetical study of female antechinus. These are small carnivorous marsupials that use torpor to reduce energy consumption from late summer to early winter. They reproduce once per year in late winter or early spring, following which most individuals die....

Data from: Four myriapod relatives – but who are sisters? No end to debates on relationships among the four major myriapod subgroups

Nikolaus U. Szucsich, Daniela Bartel, Alexander Blanke, Alexander Böhm, Alexander Donath, Makiko Fukui, Simon Grove, Shanlin Liu, Oliver Macek, Ryuichiro Machida, Bernhard Misof, Yasutaka Nakagaki, Lars Podsiadlowski, Kaoru Sekiya, Shigekazu Tomizuka, Björn M. Von Reumont, Robert M. Waterhouse, Manfred Walzl, Guanliang Meng, Xin Zhou, Günther Pass & Karen Meusemann
Background: Phylogenetic relationships among the myriapod subgroups Chilopoda, Diplopoda, Symphyla and Pauropoda are still not robustly resolved. The first phylogenomic study covering all subgroups resolved phylogenetic relationships congruently to morphological evidence but is in conflict with most previously published phylogenetic trees based on diverse molecular data. Outgroup choice and long-branch attraction effects were stated as possible explanations for these incongruencies. In this study, we addressed these issues by extending the myriapod and outgroup taxon sampling...

Contrasting patterns of sexually selected traits in Mediterranean and continental populations of European mouflon

Kresimir Kavcic, Luca Corlatti, Toni Safner, Nikola Budak & Nikica Šprem
The expression of sexually selected traits in highly dimorphic ungulates may be influenced by environmental quality. Variations in habitat conditions can impose different constraints on the allocation of energy resources to male life-history traits, and possibly alter the female preferences for specific features. Here, we compared the horn growth patterns in male European mouflon Ovis aries musimon living in different habitats (Mediterranean vs. continental) but sharing a common genetic origin. We hypothesized that the expression...

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  • University of Freiburg
  • University Medical Center Freiburg
  • German Cancer Research Center
  • Cluster of Excellence livMatS, Freiburg Center for Interactive Materials and Bioinspired Technologies, University of Freiburg, Georges-Köhler-Allee 105, 79110 Freiburg, Germany
  • Department of Microsystems Engineering, University of Freiburg, Georges-Köhler-Allee 103, 79110 Freiburg, Germany
  • Shanghai Jiao Tong University
  • First Affiliated Hospital of Zhengzhou University
  • Harvard University
  • Department of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, PA 15261, USA
  • Material, Physical and Chemical Sciences Center, Sandia National Laboratories, Albuquerque, NM 87123, USA