164 Works

Open forest successional stages and landscape heterogeneity promote wild bee diversity in temperate forests

Tristan Eckerter, Veronika Braunisch, Jörn Buse & Alexandra-Maria Klein
Recent studies have emphasized forests as crucial habitat for wild bees. In Europe, most forests are managed following the principles of close‐to‐nature silviculture, which combine timber production and nature conservation. However, open late and early successional stages within these forests are largely missing, which could be important for wild bees. This highlights that close‐to‐nature silviculture alone might not be sufficient to conserve bees within temperate forests. Open structures such as canopy gaps and road verges...

Additional file 1 of Association of sex steroid hormones and new bone formation rate after iliac onlay grafting: a prospective clinical pilot study

Victoria Constanze Landwehr, Tobias Fretwurst, Julia Heinen, Kirstin Vach, Katja Nelson, Susanne Nahles & Gerhard Iglhaut
Additional file 1. Supplement 1. Body mass index (BMI), 17β-estradiol, testosterone, sex hormone binding globulin and meannew bone formation (NBF) in female and male patients. Supplement 2. Reference ranges (a) of the body mass index (BMI), according to the World HealthOrganization (WHO, 2000), regardless of gender and (b) of the sex steroid hormone serumconcentrations according to the criteria of the Labor Berlin - Charité Vivantes GmbH.

Additional file 1 of Prognostic value of tumor-infiltrating immune cells and immune checkpoints in elderly head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiotherapy

Alexander Rühle, Jovan Todorovic, Simon S. K. Spohn, Eleni Gkika, Christoph Becker, Andreas Knopf, Constantinos Zamboglou, Tanja Sprave, Martin Werner, Anca-Ligia Grosu, Gian Kayser & Nils H. Nicolay
Additional file 1: Table S1: Details about the antibodies used in the study.

CuZr biaxial compression 20% engineering strain

Wolfram G. Nöhring, Adam R. Hinkle & Lars Pastewka
This surface is the result of a Molecular Dynamics simulation of bi-axial compression of a CuZr (50% Cu, 50% Zr) metallic glass. The initial configuration was a CuZr cube with side length 100 nm. The glass had been produced by quenching from the melt at a rate of 1e11 K/s under fully periodic boundary conditions. In the compression simulation, the x- and y-directions were periodic, but the z-direction was free, hence the glass had free...

Polished Ultrananocrystalline Diamond

Abhijeet Gujrati, Subarna R. Khanal, Lars Pastewka & Tevis D. B. Jacobs
Polished UNCD surface topography measured using TEM, AFM, and Stylus Profilometry

Additional file 1 of Required displacement factors for evaluating and comparing climate impacts of intensive and extensive forestry in Germany

Buschbeck Christian & Pauliuk Stefan
Additional file 1: Table S1. Wood and carbon stocks in living trees in BL.Table S2. Wood and carbon stocks in living trees in WPS. Table S3. Wood and carbon stocks in living trees in NPS. Table S4. Deadwood stocks with the corresponding carbon masses for WPS and NPS. Table S5. Total carbon stocks in the forest. Table S6. Conversion factors for carbon in different tree species groups. Table S7. Wood and carbon volumes extracted in...

sj-docx-1-cpa-10.1177_07067437221128477 - Supplemental material for Trends in Involuntary Psychiatric Hospitalization in British Columbia: Descriptive Analysis of Population-Based Linked Administrative Data from 2008 to 2018

Jackson P. Loyal, M. Ruth Lavergne, Mehdi Shirmaleki, Benedikt Fischer, Ridhwana Kaoser, Jack Makolewksi & Will Small
Supplemental material, sj-docx-1-cpa-10.1177_07067437221128477 for Trends in Involuntary Psychiatric Hospitalization in British Columbia: Descriptive Analysis of Population-Based Linked Administrative Data from 2008 to 2018 by Jackson P. Loyal, M. Ruth Lavergne, Mehdi Shirmaleki, Benedikt Fischer, Ridhwana Kaoser, Jack Makolewksi and Will Small in The Canadian Journal of Psychiatry

An empirical evaluation of the impact scenario of pooling bodies of evidence from randomized controlled trials and cohort studies in medical research

Nils Bröckelmann, Julia Stadelmaier, Louisa Harms, Charlotte Kubiak, Jessica Beyerbach, Martin Wolkewitz, Jörg J. Meerpohl & Lukas Schwingshackl
Abstract Background Randomized controlled trials (RCTs) and cohort studies are the most common study design types used to assess treatment effects of medical interventions. We aimed to hypothetically pool bodies of evidence (BoE) from RCTs with matched BoE from cohort studies included in the same systematic review. Methods BoE derived from systematic reviews of RCTs and cohort studies published in the 13 medical journals with the highest impact factor were considered. We re-analyzed effect estimates...

sj-docx-1-tag-10.1177_17562848221100106 – Supplemental material for Impact of NAFLD on clinical outcomes in hepatocellular carcinoma treated with sorafenib: an international cohort study

Jessica Howell, Amit Samani, Binish Mannan, Saur Hajiev, Leila Motedayen Aval, Rebecca Abdelmalak, Vincent C. Tam, Dominik Bettinger, Robert Thimme, Tamar H. Taddei, David E. Kaplan, Max Seidensticker & Rohini Sharma
Supplemental material, sj-docx-1-tag-10.1177_17562848221100106 for Impact of NAFLD on clinical outcomes in hepatocellular carcinoma treated with sorafenib: an international cohort study by Jessica Howell, Amit Samani, Binish Mannan, Saur Hajiev, Leila Motedayen Aval, Rebecca Abdelmalak, Vincent C. Tam, Dominik Bettinger, Robert Thimme, Tamar H. Taddei, David E. Kaplan, Max Seidensticker and Rohini Sharma in Therapeutic Advances in Gastroenterology

Additional file 3 of Krüppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer

Anne-Marie Lüchtenborg, Patrick Metzger, Miguel Cosenza Contreras, Victor Oria, Martin L. Biniossek, Franziska Lindner, Klemens Fröhlich, Ambrus Malyi, Thalia Erbes, Nicole Gensch, Jochen Maurer, Andreas Thomsen, Melanie Boerries, Oliver Schilling, Martin Werner & Peter Bronsert
Additional file 3: Figure S3. Analysis of processes involved in ribosomal biogenesis in MCF7 cells. A) KLF7OE does not lead to significant changes in mRNA expression of the indicated genes in export, pseudouridylation, rRNA cleavage. B) No changes in POP1 and RMRP mRNA level by KLF7OE in MCF7 cells.

Additional file 3 of Krüppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer

Anne-Marie Lüchtenborg, Patrick Metzger, Miguel Cosenza Contreras, Victor Oria, Martin L. Biniossek, Franziska Lindner, Klemens Fröhlich, Ambrus Malyi, Thalia Erbes, Nicole Gensch, Jochen Maurer, Andreas Thomsen, Melanie Boerries, Oliver Schilling, Martin Werner & Peter Bronsert
Additional file 3: Figure S3. Analysis of processes involved in ribosomal biogenesis in MCF7 cells. A) KLF7OE does not lead to significant changes in mRNA expression of the indicated genes in export, pseudouridylation, rRNA cleavage. B) No changes in POP1 and RMRP mRNA level by KLF7OE in MCF7 cells.

Krüppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer

Anne-Marie Lüchtenborg, Patrick Metzger, Miguel Cosenza Contreras, Victor Oria, Martin L. Biniossek, Franziska Lindner, Klemens Fröhlich, Ambrus Malyi, Thalia Erbes, Nicole Gensch, Jochen Maurer, Andreas Thomsen, Melanie Boerries, Oliver Schilling, Martin Werner & Peter Bronsert
Abstract Background Ribosomal biogenesis and ribosomal proteins have attracted attention in the context of tumor biology in recent years. Instead of being mere translational machineries, ribosomes might play an active role in tumor initiation and progression. Despite its importance, regulation of ribosomal biogenesis is still not completely understood. Methods Using Gene Set Enrichment Analysis of RNA sequencing and proteomical mass spectrometry data in breast cancer cells expressing Krüppel-like factor 7 (KLF7), we identified processes altered...

Early clinical course of biopsy-proven IgA vasculitis nephritis

Sarina Butzer, Imke Hennies, Charlotte Gimpel, Jutta Gellermann, Gesa Schalk, Sabine König, Anja K. Büscher, Anja Lemke & Martin Pohl
Abstract Background IgA vasculitis (IgAV) is the most common form of systemic vasculitis in childhood and frequently involves the kidney. A minority of patients with IgA vasculitis nephritis (IgAVN), especially those presenting with heavy proteinuria and/or kidney failure at onset, are at risk of chronic end-stage kidney disease. For deciding upon treatment intensity, knowledge of the short-term clinical course of IgAVN is needed to improve treatment algorithms. Methods For this retrospective multicenter study, the medical...

Additional file 2 of Empirical evidence of study design biases in nutrition randomised controlled trials: a meta-epidemiological study

Julia Stadelmaier, Isabelle Roux, Maria Petropoulou & Lukas Schwingshackl
Additional file 2: Fig. S1. Example of calculating effect estimates. Fig. S2. Forest plot, random sequence (binary outcomes), main analysis. Fig. S3. Forest plot, random sequence (binary outcomes), sensitivity analysis: excluding highly correlated outcomes. Fig. S4. Forest plot, random sequence (binary outcomes), sensitivity analysis: including only one outcome per comparison. Fig. S5. Forest plot, random sequence (binary outcomes), subgroup analysis: clusters of interventions. Fig. S6. Forest plot, random sequence (binary outcomes), subgroup analysis: clusters of...

Sequential learning of regression models by penalized estimation

Wessel N. van Wieringen & Harald Binder
When data arrive in a sequence of two or more data sets, modeling on the most recent data set should take previous data sets into account. We specifically investigate a strategy for regression modeling when parameter estimates from previous data can be used as anchoring points, yet may not be available for all parameters, thus covariance information cannot be reused. A procedure that updates through targeted penalized estimation, which shrinks the estimator towards a nonzero...

‘We just did it as a team’: Learning and working on a paediatric interprofessional training ward improves interprofessional competencies in the short- and in the long-term

Sebastian F. N. Bode, Sebastian Friedrich & Christine Straub
Interprofessional (IP) education is essential for healthcare professionals to prepare them for future IP collaboration. IP training wards (ITWs) have been established for work-based IP education. Short-term effects of ITW placements have been published but long-term results are scarce. There are no reports on ITWs in paediatrics. We established the Interprofessional Training Ward in Paediatrics (IPAPAED) for paediatric nursing trainees and medical students. The aim of the study is to evaluate both short- and long-term...

Simulated data for: The evolution of mating preferences for genetic attractiveness and quality in the presence of sensory bias

Jonathan Henshaw
This repository contains simulated datasets relating to the publication: Henshaw JM, Fromhage L, Jones AG (2022) The evolution of mating preferences for genetic attractiveness and quality in the presence of sensory bias. Proc. Natl. Acad. Sci. USA (doi:10.1073/pnas.2206262119) In this paper, we simulate the evolution of female preferences for multiple male ornament types (e.g., ‘Fisherian’, ‘handicap’ and ‘indicator’ ornaments) that differ in their associations with genes for attractiveness and for general ‘quality’ (operationalized as the...

Additional file 1 of COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection

Wei-Yu Chi, Yen-Der Li, Hsin-Che Huang, Timothy En Haw Chan, Sih-Yao Chow, Jun-Han Su, Louise Ferrall, Chien-Fu Hung & T.-C. Wu
Additional file 1: Table S1. Vaccine effectiveness against viral variants. Studies of vaccine effectiveness against viral variants. Related to Table 2.

Additional file 3 of COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection

Wei-Yu Chi, Yen-Der Li, Hsin-Che Huang, Timothy En Haw Chan, Sih-Yao Chow, Jun-Han Su, Louise Ferrall, Chien-Fu Hung & T.-C. Wu
Additional file 3: Table S3. Vaccine booster effectiveness against viral variants. Studies of vaccine booster effectiveness against viral variants. Related to Table 2.

Additional file 1 of Borrelia multiplex: a bead-based multiplex assay for the simultaneous detection of Borrelia specific IgG/IgM class antibodies

Julia Häring, Max J. Hassenstein, Matthias Becker, Julia Ortmann, Daniel Junker, André Karch, Klaus Berger, Tatia Tchitchagua, Olaf Leschnik, Manuela Harries, Daniela Gornyk, Pilar Hernández, Berit Lange, Stefanie Castell, Gérard Krause, Alex Dulovic, Monika Strengert & Nicole Schneiderhan-Marra
Additional file 1: Table S1: Borrelia Antigens used in the Borrelia multiplex. Table S2: Assay precision and LOD of the Borrelia multiplex on different Luminex platforms. . Table S3: Cohen’s kappa coefficients for the comparison of the Borrelia multiplex with commercial Borrelia test. Table S4: Serostatus of 1,555 serum samples from a German serological survey (MuSPAD study). Figure S1: Dilution linearity of Borrelia multiplex on different Luminex platforms.. Figure S2: ROC analysis for Borrelia specific...

Additional file 1 of Borrelia multiplex: a bead-based multiplex assay for the simultaneous detection of Borrelia specific IgG/IgM class antibodies

Julia Häring, Max J. Hassenstein, Matthias Becker, Julia Ortmann, Daniel Junker, André Karch, Klaus Berger, Tatia Tchitchagua, Olaf Leschnik, Manuela Harries, Daniela Gornyk, Pilar Hernández, Berit Lange, Stefanie Castell, Gérard Krause, Alex Dulovic, Monika Strengert & Nicole Schneiderhan-Marra
Additional file 1: Table S1: Borrelia Antigens used in the Borrelia multiplex. Table S2: Assay precision and LOD of the Borrelia multiplex on different Luminex platforms. . Table S3: Cohen’s kappa coefficients for the comparison of the Borrelia multiplex with commercial Borrelia test. Table S4: Serostatus of 1,555 serum samples from a German serological survey (MuSPAD study). Figure S1: Dilution linearity of Borrelia multiplex on different Luminex platforms.. Figure S2: ROC analysis for Borrelia specific...

Borrelia multiplex: a bead-based multiplex assay for the simultaneous detection of Borrelia specific IgG/IgM class antibodies

Julia Häring, Max J. Hassenstein, Matthias Becker, Julia Ortmann, Daniel Junker, André Karch, Klaus Berger, Tatia Tchitchagua, Olaf Leschnik, Manuela Harries, Daniela Gornyk, Pilar Hernández, Berit Lange, Stefanie Castell, Gérard Krause, Alex Dulovic, Monika Strengert & Nicole Schneiderhan-Marra
Abstract Background Lyme borreliosis (LB) is the most common tick-borne infectious disease in the northern hemisphere. The diagnosis of LB is usually made by clinical symptoms and subsequently supported by serology. In Europe, a two-step testing consisting of an enzyme-linked immunosorbent assay (ELISA) and an immunoblot is recommended. However, due to the low sensitivity of the currently available tests, antibody detection is sometimes inaccurate, especially in the early phase of infection, leading to underdiagnoses. Methods...

PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar & Melanie Boerries
Abstract Background Current therapeutic management of advanced melanoma patients largely depends on their BRAF mutation status. However, the vast heterogeneity of the tumors hampers the success of therapies targeting the MAPK/ERK pathway alone. Dissecting this heterogeneity will contribute to identifying key players in the oncogenic progression to tailor more effective therapies. Methods We performed a comprehensive molecular and phenotypic characterization of a panel of patient-derived BRAFV600E-positive melanoma cell lines. Transcriptional profiling was used to identify...

Additional file 10 of PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar & Melanie Boerries
Additional file 9. Table S9A–D. Over-represented KEGG pathway among gene clusters in MaMe21, MaMel63a, HEM, and HDF.

Additional file 4 of PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar & Melanie Boerries
Additional file 3. Table S3A–F. Over-represented biological processes (GO-bp) among over-expressed genes in MaMel cell lines.

Registration Year

  • 2022
    164

Resource Types

  • Dataset
    84
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    38
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    32
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    8
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    2

Affiliations

  • University of Freiburg
    133
  • University Medical Center Freiburg
    53
  • German Cancer Research Center
    34
  • Cluster of Excellence livMatS, Freiburg Center for Interactive Materials and Bioinspired Technologies, University of Freiburg, Georges-Köhler-Allee 105, 79110 Freiburg, Germany
    30
  • Department of Microsystems Engineering, University of Freiburg, Georges-Köhler-Allee 103, 79110 Freiburg, Germany
    30
  • Department of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, PA 15261, USA
    14
  • Shanghai Jiao Tong University
    13
  • Affiliated Hospital of Jiangsu University
    13
  • Material, Physical and Chemical Sciences Center, Sandia National Laboratories, Albuquerque, NM 87123, USA
    12
  • Harvard University
    12