175 Works

Impact of NAFLD on clinical outcomes in hepatocellular carcinoma treated with sorafenib: an international cohort study

Jessica Howell, Amit Samani, Binish Mannan, Saur Hajiev, Leila Motedayen Aval, Rebecca Abdelmalak, Vincent C. Tam, Dominik Bettinger, Robert Thimme, Tamar H. Taddei, David E. Kaplan, Max Seidensticker & Rohini Sharma
Background:The impact of nonalcoholic fatty liver disease (NAFLD) on overall survival (OS), treatment response and toxicity in patients with hepatocellular carcinoma (HCC) treated with sorafenib is unknown. We examined the impact of NAFLD on survival and toxicity in an international cohort of patients receiving sorafenib.Methods:Clinical and demographic data were collected from patients consecutively treated at specialist centres in Europe and North America. The impact of NAFLD on OS, sorafenib-specific survival and toxicity compared with other...

A climate risk index for marine life

Daniel Boyce, Derek Tittensor, Cristina Garilao, Stephanie Henson, Kristen Kaschner, Kathleen Kesner-Reyes, Alex Pigot, Rodolfo Reyes, Gabriel Reygondeau, Kathryn Schleit, Nancy Shackell, Patricia Sorongon-Yap & Boris Worm
Climate change is impacting virtually all marine life. Adaptation strategies will require a robust understanding of the risk to species and ecosystems and how those propagate to human societies. We develop a unified and spatially explicit index to comprehensively evaluate the climate risks to marine life. Under high emissions (SSP5-8.5), almost 90% of ~25,000 species are at high or critical risk, with species at risk across 85% of their native distributions. One-tenth of the ocean...

Trends in Involuntary Psychiatric Hospitalization in British Columbia: Descriptive Analysis of Population-Based Linked Administrative Data from 2008 to 2018

Jackson P. Loyal, M. Ruth Lavergne, Mehdi Shirmaleki, Benedikt Fischer, Ridhwana Kaoser, Jack Makolewksi & Will Small
IntroductionInvoluntary psychiatric hospitalization occurs when someone with a serious mental disorder requires treatment without their consent. Trends vary globally, and currently, there is limited data on involuntary hospitalization in Canada. We examine involuntary hospitalization trends in British Columbia, Canada, and describe the social and clinical characteristics of people ages 15 and older who were involuntarily hospitalized between 2008/2009 and 2017/2018.MethodWe used population-based linked administrative data to examine and compare trends in involuntary and voluntary hospitalizations...

Membrane fusion mediated by non-covalent binding of re-engineered cholera toxin assemblies to glycolipids

Sarah Wehrum, Lina Siukstaite, Daniel J. Williamson, Thomas R. Branson, Taras Sych, Josef Madl, Gemma C. Wildsmith, TKEV Dai, Erik Kempmann, James Ross, James Ross, Maren Thomsen, Michael Webb, Winfried Römer & Bruce Turnbull

Additional file 1 of SLIT2 promoter hypermethylation predicts disease progression in chronic myeloid leukemia

De-long Wu, Yun Wang, Ting-juan Zhang, Ming-qiang Chu, Zi-jun Xu, Qian Yuan, Ji-chun Ma, Jiang Lin, Jun Qian & Jing-dong Zhou
Additional file 1: Figure S1. Correlation between SLIT2 methylation density detected by BSP and SLIT2 methylation level detected by RT-qMSP.

Additional file 1 of SLIT2 promoter hypermethylation predicts disease progression in chronic myeloid leukemia

De-long Wu, Yun Wang, Ting-juan Zhang, Ming-qiang Chu, Zi-jun Xu, Qian Yuan, Ji-chun Ma, Jiang Lin, Jun Qian & Jing-dong Zhou
Additional file 1: Figure S1. Correlation between SLIT2 methylation density detected by BSP and SLIT2 methylation level detected by RT-qMSP.

Deep hydrochemical profile through the Alps – solute acquisition during distinct water-rock-interaction along the Sedrun section of the Gotthard Base Tunnel

Ingrid Stober & Kurt Bucher
During drilling of the Gotthard Base Tunnel through the Central Alps the exposed fractured rocks and the frequent water inflows provided a deep insight into regional hydrogeological processes in orogenic crystalline basements. Here we report data from the 10 km long central Sedrun section. 211 water samples were collected from frequent inflow points at 900 to 2350 m below the surface. The singular samples and data provide a comprehension of the deep hydrochemical cross-section through...

Additional file 1 of Association of sex steroid hormones and new bone formation rate after iliac onlay grafting: a prospective clinical pilot study

Victoria Constanze Landwehr, Tobias Fretwurst, Julia Heinen, Kirstin Vach, Katja Nelson, Susanne Nahles & Gerhard Iglhaut
Additional file 1. Supplement 1. Body mass index (BMI), 17β-estradiol, testosterone, sex hormone binding globulin and meannew bone formation (NBF) in female and male patients. Supplement 2. Reference ranges (a) of the body mass index (BMI), according to the World HealthOrganization (WHO, 2000), regardless of gender and (b) of the sex steroid hormone serumconcentrations according to the criteria of the Labor Berlin - Charité Vivantes GmbH.

Association of sex steroid hormones and new bone formation rate after iliac onlay grafting: a prospective clinical pilot study

Victoria Constanze Landwehr, Tobias Fretwurst, Julia Heinen, Kirstin Vach, Katja Nelson, Susanne Nahles & Gerhard Iglhaut
Abstract Purpose The present prospective study evaluates the association between new bone formation rate in the iliac onlay graft and sex steroid hormone serum levels. Methods A total of 15 partially or completely edentulous postmenopausal females and 9 males with less than 5 mm height of the remaining alveolar bone underwent iliac onlay grafting followed by dental implant placement using a two-stage approach. Sex hormone binding globulin and 17β-estradiol serum levels were investigated by electrochemiluminescence...

Additional file 5 of PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar & Melanie Boerries
Additional file 4. Table S4A, B. Genes up- and down-regulated with increasing resistance in MaMel cell lines.

Additional file 6 of PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar & Melanie Boerries
Additional file 5. Table S5A, B. Over-represented biological processes (GO-bp) among genes up- and down-regulated with increasing resistance in MaMel cell lines.

Additional file 7 of PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar & Melanie Boerries
Additional file 6. Table S6A, B. Over-represented hallmark gene sets among genes up- and down-regulated with increasing resistance in MaMel cell lines.

Additional file 1 of Prognostic value of tumor-infiltrating immune cells and immune checkpoints in elderly head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiotherapy

Alexander Rühle, Jovan Todorovic, Simon S. K. Spohn, Eleni Gkika, Christoph Becker, Andreas Knopf, Constantinos Zamboglou, Tanja Sprave, Martin Werner, Anca-Ligia Grosu, Gian Kayser & Nils H. Nicolay
Additional file 1: Table S1: Details about the antibodies used in the study.

Additional file 11 of PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar & Melanie Boerries
Additional file 10. Fig. S1. Cell cycle analysis and sensitivity to inhibitors in BRAFV600E mutant MaMel cells. Fig. S2. Apoptotic and proliferative response of BRAFV600E mutant MaMel cells under inhibition. Fig. S3. MITF/AXL ratios in BRAFV600E mutant MaMel cells. Fig. S4. Over-represented targets of transcription factors within groups of genes correlated with the degree of resistance in BRAFV600E mutant MaMel cells. Fig. S5. Transcriptome profiles of melanoma cells with different NRAS/BRAF mutation status and degrees...

Additional file 11 of PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar & Melanie Boerries
Additional file 10. Fig. S1. Cell cycle analysis and sensitivity to inhibitors in BRAFV600E mutant MaMel cells. Fig. S2. Apoptotic and proliferative response of BRAFV600E mutant MaMel cells under inhibition. Fig. S3. MITF/AXL ratios in BRAFV600E mutant MaMel cells. Fig. S4. Over-represented targets of transcription factors within groups of genes correlated with the degree of resistance in BRAFV600E mutant MaMel cells. Fig. S5. Transcriptome profiles of melanoma cells with different NRAS/BRAF mutation status and degrees...

Water extract from artichoke ameliorates high-fat diet-induced non-alcoholic fatty liver disease in rats

Aihua Deng, Fengying Liu, Xuchong Tang, Yun Wang, Peng Xie, Qifu Yang & Bing Xiao
Abstract Background The “multiple-hit” hypothesis is currently the most widely accepted theory for non-alcoholic fatty liver disease (NAFLD) pathogenesis. The present study aimed to investigate the effects of the water extract of artichoke (WEA) on NAFLD and its underlying mechanism. Methods Rats were fed a high-fat diet (HFD) for 8 weeks to induce NAFLD and then treated with WEA at three doses (0.4, 0.8, and 1.6 g/kg body weight, BW) for 8 weeks. At the...

Development of a novel circular mRNA vaccine of six protein combinations against Staphylococcus aureus

Fei Zhu, Shiyang Ma, Haicheng Wen, Mingjun Rao, Peipei Zhang, Wenzhong Peng, Yanhui Cui, Hang Yang, Caixia Tan, Jie Chen & Pinhua Pan
Staphylococcus aureus is an extraordinarily versatile pathogen, which is currently the most common cause of nosocomial and community infections. Considering that increased antibiotic resistance may hasten the spread of S. aureus, developing an effective vaccine can possibly aid in its control. The RNA vaccine coding immunodominance epitopes from bacteria provide a potential method to induce T and B cell immune responses by translating them into cells. Furthermore, using bioinformatics to create circular RNA vaccines can...

Additional file 1 of Water extract from artichoke ameliorates high-fat diet-induced non-alcoholic fatty liver disease in rats

Aihua Deng, Fengying Liu, Xuchong Tang, Yun Wang, Peng Xie, Qifu Yang & Bing Xiao
Additional file 1.

Small to Moderate Earthquakes and Microseisms recorded at Huainan Deep Underground Lab

Chang Chen, Wentao Wan & Yun Wang
This data set is several three-component seismic data observed in Huainan Deep Underground Lab, including several small to moderate earthquakes and microseisms. All the data are recorded by CMG-40TDE broadband seismometers, and has been preprocessed by removing the linear trend and mean, removing instrument response and filtering.

Management alters drought-induced mortality patterns in European beech (Fagus sylvatica L.) forests

Peter Meyer, Andreea Petronela Spînu, Andreas Mölder & Jürgen Bauhus
The high tree mortality during the dry and hot years 2018-2019 in Europe affected not only even-aged and monospecific conifer stands but also semi-natural Fagus sylvatica L. (European beech) forests. This has triggered concerns on the future of European beech forests under climate change and raised questions as to whether forest management may increase tree mortality rates through creating more open canopies. We compared long-term mortality rates of beech between strict forest reserves and adjacent...

Hot-headed peckers: thermographic changes during aggression among juvenile pheasants (Phasianus colchicus)

Sophia Knoch, Mark Whiteside, Joah Madden, Paul Rose & Tim Fawcett
In group-living vertebrates, dominance status often covaries with physiological measurements (e.g. glucocorticoid levels), but it is unclear how dominance is linked to dynamic changes in physiological state over a shorter, behavioural timescale. In this observational study, we recorded spontaneous aggression among captive juvenile pheasants (Phasianus colchicus) alongside infrared thermographic measurements of their external temperature, a non-invasive technique previously used to examine stress responses in non-social contexts, where peripheral blood is redirected towards the body core....

Tree movements, wind loading, and wind speeds

Kana Kamimura, Kazuki Nanko, Asako Matsumoto, Saneyoshi Ueno, James Gardiner & Barry Gardiner
In the future with climate change, we expect more forest and tree damage due to the increasing strength and changing trajectories of tropical cyclones (TCs). However, to date, we have limited information to estimate likely damage levels and, importantly, nobody has ever measured exactly how forest trees behave mechanically during a TC. In 2018, a category-5 TC destroyed trees in our on-going research plots, in which we were measuring tree movement and wind speed in...

The Zagros Mountain Front Flexure in Kurdistan Region of Iraq: Structural style and Late Pleistocene-Holocene Fault Slip Rates Derived from Structural Modeling and Luminescence Dating of River Terraces

Mjahid Zebari , Frank Preusser , Christoph Grützner , Payman Navabpour & Kamil Ustaszewski
The Zagros Mountain Front Flexure (MFF) makes a prominent topographic and structural step along the Zagros Fold-Thrust Belt that accommodates a significant amount of shortening between the Eurasian and Arabian plates. Here, the structural style below the MFF in the Kurdistan Region of Iraq was reconstructed using balanced cross-sections and forward modeling, and Late Pleistocene-Holocene fault-slip rates were calculated across several structures using luminescence dating of river terraces along the Greater Zab River. A balanced...

Au biaxial compression 10% engineering strain

Wolfram G. Nöhring, Adam R. Hinkle & Lars Pastewka
This surface is the result of a Molecular Dynamics simulation of bi-axial compression of single crystal Au. The initial configuration was an Au cube with side length 100 nm. The x- and y-directions of the simulation cell were parallel to the [-110] and [-1-12] directions of the crystal, respectively. The z-direction was parallel to the [111] crystal direction. The x- and y-directions were periodic, but the z-direction was free, hence the crystal had free surfaces...

Au biaxial compression 30% engineering strain

Wolfram G. Nöhring, Adam R. Hinkle & Lars Pastewka
This surface is the result of a Molecular Dynamics simulation of bi-axial compression of single crystal Au. The initial configuration was an Au cube with side length 100 nm. The x- and y-directions of the simulation cell were parallel to the [-110] and [-1-12] directions of the crystal, respectively. The z-direction was parallel to the [111] crystal direction. The x- and y-directions were periodic, but the z-direction was free, hence the crystal had free surfaces...

Registration Year

  • 2022
    175

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Affiliations

  • University of Freiburg
    144
  • University Medical Center Freiburg
    53
  • German Cancer Research Center
    34
  • Cluster of Excellence livMatS, Freiburg Center for Interactive Materials and Bioinspired Technologies, University of Freiburg, Georges-Köhler-Allee 105, 79110 Freiburg, Germany
    28
  • Department of Microsystems Engineering, University of Freiburg, Georges-Köhler-Allee 103, 79110 Freiburg, Germany
    28
  • Shanghai Jiao Tong University
    17
  • Anhui Medical University
    17
  • Affiliated Hospital of Jiangsu University
    15
  • Jinan University
    15
  • First Affiliated Hospital of Chengdu Medical College
    15