Additional file 2: Table S1. List of antibodies used in this study.

Additional file 1: Appendix S1. Search strategy. Tables S1-S5. Table S1. Explanation and definition for PI/ECO similarity degree. Table S2. PI/ECO similarity degree. Table S3. Differences between published (reported) effect estimates and re-calculated effect estimates. Table S4. Reason for exclusion from the pooling scenario. Table S5. Pooling results. Figures S1-S118. Fig S1. Forest plot: Low sodium (Intervention/Exposure); All-cause mortality (Outcome). Fig. S2. Forest plot: Low sodium; Cardiovascular disease. Fig. S3. Forest plot: Intra-aortic balloon pump;...

Additional file 2. Table S2A–F. Over-expressed genes in MaMel cell lines.

Additional file 5. Table S5A, B. Over-represented biological processes (GO-bp) among genes up- and down-regulated with increasing resistance in MaMel cell lines.

Additional file 7. Table S7A–D. Clustering of most variable genes in MaMe21, MaMel63a, HEM, and HDF.

This repository contains simulated datasets relating to the publication: Henshaw JM, Bittlingmaier M, Schärer L. Hermaphroditic origins of anisogamy. In this paper, we simulated the coevolution of sex allocation and gamete size in populations with pre-existing binary mating types. Under varying parameter combinations, we tracked the evolution of the following variables over multiple simulation runs, with each run lasting 10 000 generations: 1. The mean size of gametes of each mating type 2. The population...

The high tree mortality during the dry and hot years 2018-2019 in Europe affected not only even-aged and monospecific conifer stands but also semi-natural Fagus sylvatica L. (European beech) forests. This has triggered concerns on the future of European beech forests under climate change and raised questions as to whether forest management may increase tree mortality rates through creating more open canopies. We compared long-term mortality rates of beech between strict forest reserves and adjacent...

In group-living vertebrates, dominance status often covaries with physiological measurements (e.g. glucocorticoid levels), but it is unclear how dominance is linked to dynamic changes in physiological state over a shorter, behavioural timescale. In this observational study, we recorded spontaneous aggression among captive juvenile pheasants (Phasianus colchicus) alongside infrared thermographic measurements of their external temperature, a non-invasive technique previously used to examine stress responses in non-social contexts, where peripheral blood is redirected towards the body core....

In the future with climate change, we expect more forest and tree damage due to the increasing strength and changing trajectories of tropical cyclones (TCs). However, to date, we have limited information to estimate likely damage levels and, importantly, nobody has ever measured exactly how forest trees behave mechanically during a TC. In 2018, a category-5 TC destroyed trees in our on-going research plots, in which we were measuring tree movement and wind speed in...

The Zagros Mountain Front Flexure (MFF) makes a prominent topographic and structural step along the Zagros Fold-Thrust Belt that accommodates a significant amount of shortening between the Eurasian and Arabian plates. Here, the structural style below the MFF in the Kurdistan Region of Iraq was reconstructed using balanced cross-sections and forward modeling, and Late Pleistocene-Holocene fault-slip rates were calculated across several structures using luminescence dating of river terraces along the Greater Zab River. A balanced...

This surface is the result of a Molecular Dynamics simulation of bi-axial compression of single crystal Au. The initial configuration was an Au cube with side length 100 nm. The x- and y-directions of the simulation cell were parallel to the [-110] and [-1-12] directions of the crystal, respectively. The z-direction was parallel to the [111] crystal direction. The x- and y-directions were periodic, but the z-direction was free, hence the crystal had free surfaces...

This surface is the result of a Molecular Dynamics simulation of bi-axial compression of single crystal Au. The initial configuration was an Au cube with side length 100 nm. The x- and y-directions of the simulation cell were parallel to the [-110] and [-1-12] directions of the crystal, respectively. The z-direction was parallel to the [111] crystal direction. The x- and y-directions were periodic, but the z-direction was free, hence the crystal had free surfaces...

1. Wild bees importantly pollinate both crop and wild plants. Yet, in intensive agricultural landscapes, wild bees are rare due to resource limitations of nectar and pollen. Flower strips and hedges are often used as resource enhancements for wild bees to overcome this shortage, but provide floral resources only during specific time periods. To sustain diverse and stable bee communities, bee-attractive flowers need to be available during the entire growing season. This may be achieved...

Pesticide exposure and food stress are major threats to bees, but their potential synergistic impacts under field-realistic conditions remain poorly understood and are not considered in current pesticide risk assessments. We conducted a semi-field experiment to examine the single and interactive effects of the novel insecticide flupyradifurone (FPF) and nutritional stress on fitness proxies in the solitary bee Osmia bicornis. Individually marked bees were released into flight cages with monocultures of either buckwheat, wild mustard...

polished UNCD on silicon wafer Substrate Manufacturer : Advanced Diamond Technologies, Inc.

polished ruby tips used in adhesion testing material: Ruby manufacturer: Swissjewel

Melt inclusions in zircon (MIZ) directly reflect the physicochemical state of the magma during zircon growth. However, their potential as geothermometers and petrogenetic indicators is still poorly explored. Therefore, we investigated MIZ from well-characterized mafic and felsic rocks of the Bushveld Complex (South Africa) and acquired a novel dataset of major, trace and volatile element contents. Re-homogenized MIZ of all rock types display rhyolitic compositions (65-78 wt% SiO2) and similar H2O contents (1.6-4.0 wt%). Liquidus...

openCARP is an open cardiac electrophysiology simulator for in-silico experiments

Abstract Background The “multiple-hit” hypothesis is currently the most widely accepted theory for non-alcoholic fatty liver disease (NAFLD) pathogenesis. The present study aimed to investigate the effects of the water extract of artichoke (WEA) on NAFLD and its underlying mechanism. Methods Rats were fed a high-fat diet (HFD) for 8 weeks to induce NAFLD and then treated with WEA at three doses (0.4, 0.8, and 1.6 g/kg body weight, BW) for 8 weeks. At the...

Hyalocytes have been recognized as resident tissue macrophages of the vitreous body since the mid-19th century. Despite this, knowledge about their origin, turnover, and dynamics is limited. Historically, initial studies on the origin of hyalocytes used light and electron microscopies. Modern investigations across species including rodents and humans will be described. Novel imaging is now available to study human hyalocytes in vivo. The shared ontogeny with retinal microglia and their eventual interdependence as well as...

IntroductionInvoluntary psychiatric hospitalization occurs when someone with a serious mental disorder requires treatment without their consent. Trends vary globally, and currently, there is limited data on involuntary hospitalization in Canada. We examine involuntary hospitalization trends in British Columbia, Canada, and describe the social and clinical characteristics of people ages 15 and older who were involuntarily hospitalized between 2008/2009 and 2017/2018.MethodWe used population-based linked administrative data to examine and compare trends in involuntary and voluntary hospitalizations...

Abstract Background Forestry plays a major role in climate change mitigation. However, which intensity of logging is best suited for that task remains controversial. We contribute to the debate by quantitatively analyzing three different forest management scenarios in Germany—a baseline scenario which represents a continuation of current forest management practice as well as an intensive and an extensive logging scenario. We assess whether increased carbon storage in wood products and substitution of other emission-intensive materials...

Additional file 1: Figure S1. Expression of mRNA of ribosomal proteins in MDA-MB-231 cells. qPCR of the depicted genes in KLF7 transfected MDA-MB-231 cells reveal downregulation of RPL34 and RPL27 mRNA.

Additional file 1: Figure S1. Expression of mRNA of ribosomal proteins in MDA-MB-231 cells. qPCR of the depicted genes in KLF7 transfected MDA-MB-231 cells reveal downregulation of RPL34 and RPL27 mRNA.

Additional file 2: Figure S2. KLF7 expression in MCF7 cells. A. mRNA in KLF7 transfected MCF7 cells was strongly enhanced compared to control cells B. western blot of MCF7 protein lysate demonstrated increased protein level in KLF7OE cells. C. Densitometric quantification of western blots showed significantly higher KLF7 levels (n = 4). D. Nuclear localization of KLF7 in MCF7 cell spheres.