Additional file 2: Figure S2. KLF7 expression in MCF7 cells. A. mRNA in KLF7 transfected MCF7 cells was strongly enhanced compared to control cells B. western blot of MCF7 protein lysate demonstrated increased protein level in KLF7OE cells. C. Densitometric quantification of western blots showed significantly higher KLF7 levels (n = 4). D. Nuclear localization of KLF7 in MCF7 cell spheres.

This surface is the result of a Molecular Dynamics simulation of bi-axial compression of single crystal Au. The initial configuration was an Au cube with side length 100 nm. The x- and y-directions of the simulation cell were parallel to the [-110] and [-1-12] directions of the crystal, respectively. The z-direction was parallel to the [111] crystal direction. The x- and y-directions were periodic, but the z-direction was free, hence the crystal had free surfaces...

This surface is the result of a Molecular Dynamics simulation of bi-axial compression of a single crystal Ni36.67Co30Fe16.67Ti16.67 solid solution. The initial configuration was a Ni36.67Co30Fe16.67Ti16.67 cube with side length 100 nm. The x- and y-directions of the simulation cell were parallel to the [-34-1] and [-5-27] directions of the crystal, respectively. The z-direction was parallel to the [111] crystal direction. The x- and y-directions were periodic, but the z-direction was free, hence the crystal...

This surface is the result of a Molecular Dynamics simulation of bi-axial compression of a single crystal Ni36.67Co30Fe16.67Ti16.67 solid solution. The initial configuration was a Ni36.67Co30Fe16.67Ti16.67 cube with side length 100 nm. The x- and y-directions of the simulation cell were parallel to the [-34-1] and [-5-27] directions of the crystal, respectively. The z-direction was parallel to the [111] crystal direction. The x- and y-directions were periodic, but the z-direction was free, hence the crystal...

NCD surface topography measured using TEM, AFM, and Stylus Profilometry

polished ruby tips used in adhesion testing material: Ruby manufacturer: Swissjewel

Microcrystalline diamond film deposited on silicon wafer Substrate Manufacturer : Advanced Diamond Technologies, Inc.

Nanocrystalline diamond film deposited on silicon wafer Substrate Manufacturer : Advanced Diamond Technologies, Inc.

eDNA metabarcoding has become a standard method for assessing wood-inhabiting fungi and bacteria, yet determination of dead-wood-inhabiting beetles still relies on time-consuming collection of beetle specimens. We thus tested whether beetle species can be identified by eDNA sequencing of wood in a mesocosm experiment that manipulated species assemblages. Dead wood samples were taken at exit holes of beetles and DNA was extracted and analyzed using two comparative methods: (i) metabarcoding with standard arthropod primers (421...

The chamois Rupicapra spp. is the most abundant mountain ungulate of Europe and the Near East, where it occurs as two species, the Northern chamois R. rupicapra and the Southern chamois R. pyrenaica. Here, we provide a state-of-the-art overview of research trends and the most challenging issues in chamois research and conservation, focusing on taxonomy and systematics, genetics, life history, ecology and behavior, physiology and disease, management, and conservation. Research on Rupicapra has a longstanding...

Understanding of plant hydraulic strategies (i.e., the degree of iso-/anisohydricity) is crucial to predict the response of plants to changing environmental conditions such as climate-change induced extreme drought. Several abiotic factors, including evaporative demand, have been shown to seasonally modify the isohydricity of plants. However, the impact of biotic factors such as plant-plant interactions on hydraulic strategies has seldom been explored. Here, we investigated adaptations and changes in hydraulic strategies of two woody species in...

Abstract Background Instruments to critically appraise randomised controlled trials (RCTs) are based on evidence from meta-epidemiological studies. We aim to conduct a meta-epidemiological study on the average bias associated with reported methodological trial characteristics such as random sequence generation, allocation concealment, blinding, incomplete outcome data, selective reporting, and compliance of RCTs in nutrition research. Methods We searched the Cochrane Database of Systematic Reviews, for systematic reviews of RCTs, published between 01 January 2010 and 31...

Abstract Background Instruments to critically appraise randomised controlled trials (RCTs) are based on evidence from meta-epidemiological studies. We aim to conduct a meta-epidemiological study on the average bias associated with reported methodological trial characteristics such as random sequence generation, allocation concealment, blinding, incomplete outcome data, selective reporting, and compliance of RCTs in nutrition research. Methods We searched the Cochrane Database of Systematic Reviews, for systematic reviews of RCTs, published between 01 January 2010 and 31...

Additional file 1: Table S1. Vaccine effectiveness against viral variants. Studies of vaccine effectiveness against viral variants. Related to Table 2.

Additional file 2: Table S2. Vaccine efficacy and effectiveness in children and adolescents

Supplemental material, sj-docx-1-cpa-10.1177_07067437221128477 for Trends in Involuntary Psychiatric Hospitalization in British Columbia: Descriptive Analysis of Population-Based Linked Administrative Data from 2008 to 2018 by Jackson P. Loyal, M. Ruth Lavergne, Mehdi Shirmaleki, Benedikt Fischer, Ridhwana Kaoser, Jack Makolewksi and Will Small in The Canadian Journal of Psychiatry

Background:The impact of nonalcoholic fatty liver disease (NAFLD) on overall survival (OS), treatment response and toxicity in patients with hepatocellular carcinoma (HCC) treated with sorafenib is unknown. We examined the impact of NAFLD on survival and toxicity in an international cohort of patients receiving sorafenib.Methods:Clinical and demographic data were collected from patients consecutively treated at specialist centres in Europe and North America. The impact of NAFLD on OS, sorafenib-specific survival and toxicity compared with other...

Hyalocytes have been recognized as resident tissue macrophages of the vitreous body since the mid-19th century. Despite this, knowledge about their origin, turnover, and dynamics is limited. Historically, initial studies on the origin of hyalocytes used light and electron microscopies. Modern investigations across species including rodents and humans will be described. Novel imaging is now available to study human hyalocytes in vivo. The shared ontogeny with retinal microglia and their eventual interdependence as well as...

Additional file 1. Comparative subgroup analysis. Of 66 patients, we identified 28 children with crescentic glomeruli and/or nephrotic syndrome at onset of IgAVN. Referring to the German Society of Pediatric Nephology, a corticosteroid pulse therapy only would have been recommended. Of these 28 children, 17 received corticosteroid pulse therapy per protocol, 11 did not receive any immunosuppressive therapy. We therefore performed a comparative subgroup analysis which showed similar improvements of clinical symptoms and proteinuria.

Abstract Background IgA vasculitis (IgAV) is the most common form of systemic vasculitis in childhood and frequently involves the kidney. A minority of patients with IgA vasculitis nephritis (IgAVN), especially those presenting with heavy proteinuria and/or kidney failure at onset, are at risk of chronic end-stage kidney disease. For deciding upon treatment intensity, knowledge of the short-term clinical course of IgAVN is needed to improve treatment algorithms. Methods For this retrospective multicenter study, the medical...

UNCD surface from A. Gujrati, S.R. Khanal, L. Pastewka, T.D.B. Jacobs, "Combining TEM, AFM, and profilometry for quantitative topography characterization across all scales", ACS Appl. Mater. Interfaces 10(34), 29169-29178 (2018)

Abstract Background and purpose Tumor-infiltrating lymphocytes (TILs) are associated with locoregional control (LRC) in head-and-neck squamous cell carcinoma (HNSCC) patients undergoing (chemo)radiotherapy. As immunosenescence results in reduced immune activity, the role of TILs in elderly HNSCC patients may differ compared to younger patients, providing a rationale to study the prognostic role of TILs and immune checkpoints (ICs) in this population. Material and methods Sixty-three HNSCC patients aged ≥ 65 years undergoing definitive (chemo)radiotherapy between 2010...

Additional file 2. Table S2A–F. Over-expressed genes in MaMel cell lines.

Additional file 3. Table S3A–F. Over-represented biological processes (GO-bp) among over-expressed genes in MaMel cell lines.

Additional file 6. Table S6A, B. Over-represented hallmark gene sets among genes up- and down-regulated with increasing resistance in MaMel cell lines.