175 Works

Additional file 1 of An empirical evaluation of the impact scenario of pooling bodies of evidence from randomized controlled trials and cohort studies in medical research

Nils Bröckelmann, Julia Stadelmaier, Louisa Harms, Charlotte Kubiak, Jessica Beyerbach, Martin Wolkewitz, Jörg J. Meerpohl & Lukas Schwingshackl
Additional file 1: Appendix S1. Search strategy. Tables S1-S5. Table S1. Explanation and definition for PI/ECO similarity degree. Table S2. PI/ECO similarity degree. Table S3. Differences between published (reported) effect estimates and re-calculated effect estimates. Table S4. Reason for exclusion from the pooling scenario. Table S5. Pooling results. Figures S1-S118. Fig S1. Forest plot: Low sodium (Intervention/Exposure); All-cause mortality (Outcome). Fig. S2. Forest plot: Low sodium; Cardiovascular disease. Fig. S3. Forest plot: Intra-aortic balloon pump;...

Additional file 3 of PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar & Melanie Boerries
Additional file 2. Table S2A–F. Over-expressed genes in MaMel cell lines.

Additional file 6 of PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar & Melanie Boerries
Additional file 5. Table S5A, B. Over-represented biological processes (GO-bp) among genes up- and down-regulated with increasing resistance in MaMel cell lines.

Additional file 8 of PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar & Melanie Boerries
Additional file 7. Table S7A–D. Clustering of most variable genes in MaMe21, MaMel63a, HEM, and HDF.

Data for: Hermaphroditic origins of anisogamy

Jonathan Henshaw
This repository contains simulated datasets relating to the publication: Henshaw JM, Bittlingmaier M, Schärer L. Hermaphroditic origins of anisogamy. In this paper, we simulated the coevolution of sex allocation and gamete size in populations with pre-existing binary mating types. Under varying parameter combinations, we tracked the evolution of the following variables over multiple simulation runs, with each run lasting 10 000 generations: 1. The mean size of gametes of each mating type 2. The population...

Melt inclusions in zircon are powerful petrogenetic indicators and improve zircon thermometry

Dominik Gudelius , Armin Zeh , Renat R. Almeev , Allan H. Wilson , Lennart A. Fischer & Axel K. Schmitt
Melt inclusions in zircon (MIZ) directly reflect the physicochemical state of the magma during zircon growth. However, their potential as geothermometers and petrogenetic indicators is still poorly explored. Therefore, we investigated MIZ from well-characterized mafic and felsic rocks of the Bushveld Complex (South Africa) and acquired a novel dataset of major, trace and volatile element contents. Re-homogenized MIZ of all rock types display rhyolitic compositions (65-78 wt% SiO2) and similar H2O contents (1.6-4.0 wt%). Liquidus...

openCARP (v12.0)

, Christoph Augustin, Luca Azzolin, Jason Bayer, Martin Bishop, Patrick M. Boyle, Federica Caforio, Fernando Campos, Caroline Mendonca Costa, Andrew Crozier, Thomas Fastl, Karli Gillette, Matthias Gsell, Marie Houillon, Yung-Lin (Cary) Huang, Kristian Gregorius Hustad, Elias Karabelas, Jonathan Krauß, Axel Loewe, Laura Marx, Aurel Neic, Mark Nothstein, Gernot Plank, Anton Prassl, Gunnar Seemann … & Eike Moritz Wülfers
openCARP is an open cardiac electrophysiology simulator for in-silico experiments

Water extract from artichoke ameliorates high-fat diet-induced non-alcoholic fatty liver disease in rats

Aihua Deng, Fengying Liu, Xuchong Tang, Yun Wang, Peng Xie, Qifu Yang & Bing Xiao
Abstract Background The “multiple-hit” hypothesis is currently the most widely accepted theory for non-alcoholic fatty liver disease (NAFLD) pathogenesis. The present study aimed to investigate the effects of the water extract of artichoke (WEA) on NAFLD and its underlying mechanism. Methods Rats were fed a high-fat diet (HFD) for 8 weeks to induce NAFLD and then treated with WEA at three doses (0.4, 0.8, and 1.6 g/kg body weight, BW) for 8 weeks. At the...

Sequential Learning of Regression Models by Penalized Estimation

Wessel N. van Wieringen & Harald Binder
When data arrive in a sequence of two or more datasets, modeling on the most recent dataset should take previous datasets into account. We specifically investigate a strategy for regression modeling when parameter estimates from previous data can be used as anchoring points, yet may not be available for all parameters, thus, covariance information cannot be reused. A procedure that updates through targeted penalized estimation, which shrinks the estimator toward a nonzero value, is presented....

Self-affine synthetic surface

Tevis D. B. Jacobs, Till Junge & Lars Pastewka
This surface contains virtual measurements taken out of a large self-affine synthetic surface with Hurst exponent 0.8. The original surface had 50,000 x 50,000 data points and was created using a Fourier filtering algorithm. The surface was "measured" in block containing 500 x 500 data points with a variety of scan sizes ranging from almost the full surface with 100 μm width to 10 μm to 1 μm, with pixel sizes scaling accordingly. This surface...

Au biaxial compression 0% strain (initial surface)

Wolfram G. Nöhring, Adam R. Hinkle & Lars Pastewka
This surface is the result of a Molecular Dynamics simulation of bi-axial compression of single crystal Au. The initial configuration was an Au cube with side length 100 nm. The x- and y-directions of the simulation cell were parallel to the [-110] and [-1-12] directions of the crystal, respectively. The z-direction was parallel to the [111] crystal direction. The x- and y-directions were periodic, but the z-direction was free, hence the crystal had free surfaces...

Au uniaxial compression in x-direction 20 % engineering strain

Wolfram G. Nöhring, Adam R. Hinkle & Lars Pastewka
This surface is the result of a Molecular Dynamics simulation of uni-axial compression of single crystal Au. The initial configuration was an Au cube with side length 100 nm. The x- and y-directions of the simulation cell were parallel to the [-110] and [-1-12] directions of the crystal, respectively. The z-direction was parallel to the [111] crystal direction. The x- and y-directions were periodic, but the z-direction was free, hence the crystal had free surfaces...

CuZr biaxial compression 0% strain (initial surface)

Wolfram G. Nöhring, Adam R. Hinkle & Lars Pastewka
This surface is the result of a Molecular Dynamics simulation of bi-axial compression of a CuZr (50% Cu, 50% Zr) metallic glass. The initial configuration was a CuZr cube with side length 100 nm. The glass had been produced by quenching from the melt at a rate of 1e11 K/s under fully periodic boundary conditions. In the compression simulation, the x- and y-directions were periodic, but the z-direction was free, hence the glass had free...

CuZr biaxial compression 10% engineering strain

Wolfram G. Nöhring, Adam R. Hinkle & Lars Pastewka
This surface is the result of a Molecular Dynamics simulation of bi-axial compression of a CuZr (50% Cu, 50% Zr) metallic glass. The initial configuration was a CuZr cube with side length 100 nm. The glass had been produced by quenching from the melt at a rate of 1e11 K/s under fully periodic boundary conditions. In the compression simulation, the x- and y-directions were periodic, but the z-direction was free, hence the glass had free...

Ni36.67Co30Fe16.67Ti16.67 0% strain (initial surface)

Wolfram G. Nöhring, Adam R. Hinkle & Lars Pastewka
This surface is the result of a Molecular Dynamics simulation of bi-axial compression of a single crystal Ni36.67Co30Fe16.67Ti16.67 solid solution. The initial configuration was a Ni36.67Co30Fe16.67Ti16.67 cube with side length 100 nm. The x- and y-directions of the simulation cell were parallel to the [-34-1] and [-5-27] directions of the crystal, respectively. The z-direction was parallel to the [111] crystal direction. The x- and y-directions were periodic, but the z-direction was free, hence the crystal...

CuZr biaxial compression 30% engineering strain

Wolfram G. Nöhring, Adam R. Hinkle & Lars Pastewka
This surface is the result of a Molecular Dynamics simulation of bi-axial compression of a CuZr (50% Cu, 50% Zr) metallic glass. The initial configuration was a CuZr cube with side length 100 nm. The glass had been produced by quenching from the melt at a rate of 1e11 K/s under fully periodic boundary conditions. In the compression simulation, the x- and y-directions were periodic, but the z-direction was free, hence the glass had free...

Ni36.67Co30Fe16.67Ti16.67 30% engineering strain

Wolfram G. Nöhring, Adam R. Hinkle & Lars Pastewka
This surface is the result of a Molecular Dynamics simulation of bi-axial compression of a single crystal Ni36.67Co30Fe16.67Ti16.67 solid solution. The initial configuration was a Ni36.67Co30Fe16.67Ti16.67 cube with side length 100 nm. The x- and y-directions of the simulation cell were parallel to the [-34-1] and [-5-27] directions of the crystal, respectively. The z-direction was parallel to the [111] crystal direction. The x- and y-directions were periodic, but the z-direction was free, hence the crystal...

Ultrananocrystalline diamond (UNCD)

Abhijeet Gujrati, Subarna R. Khanal, Lars Pastewka & Tevis D. B. Jacobs
UNCD surface from A. Gujrati, S.R. Khanal, L. Pastewka, T.D.B. Jacobs, "Combining TEM, AFM, and profilometry for quantitative topography characterization across all scales", ACS Appl. Mater. Interfaces 10(34), 29169-29178 (2018)

Flexible diets enable pollinators to cope with changes in plant community composition

Teresa Morán López, Gita Benadi, Carlos Lara-Romero, Natalia Chacoff, Agustín Vitali, David Pescador, Silvia B Lomáscolo, Javier Morente-López, Diego P. Vázquez & Juan Manuel Morales
Switching plant species visited by pollinators (partner flexibility), has been proposed as a behavioural mechanism able to attenuate the negative impacts of shifts in plant communities on pollination. However, it is unclear if the magnitude of such response is generalizable or depends on the environmental context. Moreover, the ability of pollinators to exploit plants with dissimilar traits (trait flexibility) has been overlooked, even though it can affect the spectrum of new partners available. To shed...

Ultrananocrystalline Diamond TEM cross-section

Subarna R. Khanal, Abhijeet Gujrati, Sai Bharadwaj Vishnubhotla, Pawel Nowakowski, Cecile S. Bonifacio, Lars Pastewka & Tevis D. B. Jacobs
Cross-section UNCD surfaces for TEM from publication: S. R. Khanal, A. Gujrati, S. B. Vishnubhotla, P. Nowakowski, C. S. Bonifacio, L. Pastewka, T. D. B. Jacobs, "Characterization of small-scale surface topography using transmission electron microscopy", Surf. Topogr.: Metrol. Prop. 6 045004 (2018) See publication for details.

Rough sphere

Antoine Sanner & Lars Pastewka
Example illustrating the contact of a rough sphere that behaves as a nominally flat rough surface at small normal forces while it follows the Hertzian theory of smooth spheres at large normal forces. This dataset is similar to the simulations in https://doi.org/10.1063/1.4950802 The topographies were generated with the following Python code: ``` from SurfaceTopography.Generation import fourier_synthesis from SurfaceTopography.Special import make_sphere import numpy as np a0 = 1 # Pixel size radius = 10000 n =...

Additional file 5 of PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar & Melanie Boerries
Additional file 4. Table S4A, B. Genes up- and down-regulated with increasing resistance in MaMel cell lines.

Additional file 1 of Temporal regulation of notch activation improves arteriovenous fistula maturation

Qunying Guo, Guang Chen, Hunter Cheng, Ying Qing, Luan Truong, Quan Ma, Yun Wang & Jizhong Cheng
Additional file 1: Fig. S1. Photograph of the common carotid artery and AVF after surgery. A. Right common carotid artery in normal mice. B. This picture shows the anastomosis of common carotid artery with internal jugular vein in AVF after surgery. The yellow arrow points to the sutures. The inflated jugular vein indicates the patency of the AVF. Scale bars = 1 mm. Fig. S2. Notch signaling conducts signals between neighboring cells. There are 5...

Additional file 2 of Temporal regulation of notch activation improves arteriovenous fistula maturation

Qunying Guo, Guang Chen, Hunter Cheng, Ying Qing, Luan Truong, Quan Ma, Yun Wang & Jizhong Cheng
Additional file 2: Table S1. List of antibodies used in this study.

SLIT2 promoter hypermethylation predicts disease progression in chronic myeloid leukemia

De-long Wu, Yun Wang, Ting-juan Zhang, Ming-qiang Chu, Zi-jun Xu, Qian Yuan, Ji-chun Ma, Jiang Lin, Jun Qian & Jing-dong Zhou
Abstract Background Aberrant DNA methylation plays a crucial role in the progression of myeloid neoplasms. Previously, our literature reported that slit guidance ligand 2 (SLIT2) promoter methylation was associated with disease progression and indicated a poor prognosis in patients with myelodysplastic syndrome. Herein, we further investigated the clinical implications and role of SLIT2 promoter methylation in patients with chronic myeloid leukemia (CML). Methods The level of SLIT2 promoter methylation was determined in 104 CML patients,...

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Affiliations

  • University of Freiburg
    144
  • University Medical Center Freiburg
    53
  • German Cancer Research Center
    34
  • Cluster of Excellence livMatS, Freiburg Center for Interactive Materials and Bioinspired Technologies, University of Freiburg, Georges-Köhler-Allee 105, 79110 Freiburg, Germany
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  • Department of Microsystems Engineering, University of Freiburg, Georges-Köhler-Allee 103, 79110 Freiburg, Germany
    28
  • Shanghai Jiao Tong University
    17
  • Anhui Medical University
    17
  • Affiliated Hospital of Jiangsu University
    15
  • Jinan University
    15
  • First Affiliated Hospital of Chengdu Medical College
    15