175 Works

Past, present and future of chamois science

Luca Corlatti, Laura Iacolina, Toni Safner, Marco Apollonio, Elena Buzan, Francesco Ferretti, Sabine Hammer, Juan Herrero, Luca Rossi, Emmanuel Serrano, Mari Cruz Arnal, Francesca Brivio, Roberta Chirichella, Antonella Cotza, Barbara Crestanello, Johan Espunyes, Daniel Fernández De Luco, Saskia Friedrich, Dragan Gačić, Laura Grassi, Stefano Grignolio, Heidi Hauffe, Kresmir Kavčić, Andreas Kinser, Francesca Lioce … & Nikica Šprem
The chamois Rupicapra spp. is the most abundant mountain ungulate of Europe and the Near East, where it occurs as two species, the Northern chamois R. rupicapra and the Southern chamois R. pyrenaica. Here, we provide a state-of-the-art overview of research trends and the most challenging issues in chamois research and conservation, focusing on taxonomy and systematics, genetics, life history, ecology and behavior, physiology and disease, management, and conservation. Research on Rupicapra has a longstanding...

Impact of NAFLD on clinical outcomes in hepatocellular carcinoma treated with sorafenib: an international cohort study

Jessica Howell, Amit Samani, Binish Mannan, Saur Hajiev, Leila Motedayen Aval, Rebecca Abdelmalak, Vincent C. Tam, Dominik Bettinger, Robert Thimme, Tamar H. Taddei, David E. Kaplan, Max Seidensticker & Rohini Sharma
Background:The impact of nonalcoholic fatty liver disease (NAFLD) on overall survival (OS), treatment response and toxicity in patients with hepatocellular carcinoma (HCC) treated with sorafenib is unknown. We examined the impact of NAFLD on survival and toxicity in an international cohort of patients receiving sorafenib.Methods:Clinical and demographic data were collected from patients consecutively treated at specialist centres in Europe and North America. The impact of NAFLD on OS, sorafenib-specific survival and toxicity compared with other...

Additional file 1 of Early clinical course of biopsy-proven IgA vasculitis nephritis

Sarina Butzer, Imke Hennies, Charlotte Gimpel, Jutta Gellermann, Gesa Schalk, Sabine König, Anja K. Büscher, Anja Lemke & Martin Pohl
Additional file 1. Comparative subgroup analysis. Of 66 patients, we identified 28 children with crescentic glomeruli and/or nephrotic syndrome at onset of IgAVN. Referring to the German Society of Pediatric Nephology, a corticosteroid pulse therapy only would have been recommended. Of these 28 children, 17 received corticosteroid pulse therapy per protocol, 11 did not receive any immunosuppressive therapy. We therefore performed a comparative subgroup analysis which showed similar improvements of clinical symptoms and proteinuria.

Early clinical course of biopsy-proven IgA vasculitis nephritis

Sarina Butzer, Imke Hennies, Charlotte Gimpel, Jutta Gellermann, Gesa Schalk, Sabine König, Anja K. Büscher, Anja Lemke & Martin Pohl
Abstract Background IgA vasculitis (IgAV) is the most common form of systemic vasculitis in childhood and frequently involves the kidney. A minority of patients with IgA vasculitis nephritis (IgAVN), especially those presenting with heavy proteinuria and/or kidney failure at onset, are at risk of chronic end-stage kidney disease. For deciding upon treatment intensity, knowledge of the short-term clinical course of IgAVN is needed to improve treatment algorithms. Methods For this retrospective multicenter study, the medical...

Ultrananocrystalline diamond (UNCD)

Abhijeet Gujrati, Subarna R. Khanal, Lars Pastewka & Tevis D. B. Jacobs
UNCD surface from A. Gujrati, S.R. Khanal, L. Pastewka, T.D.B. Jacobs, "Combining TEM, AFM, and profilometry for quantitative topography characterization across all scales", ACS Appl. Mater. Interfaces 10(34), 29169-29178 (2018)

Hyalocyte origin, structure, and imaging

Peter Wieghofer, Michael Engelbert, Toco YP Chui, Richard B Rosen, Taiji Sakamoto & J Sebag
Hyalocytes have been recognized as resident tissue macrophages of the vitreous body since the mid-19th century. Despite this, knowledge about their origin, turnover, and dynamics is limited. Historically, initial studies on the origin of hyalocytes used light and electron microscopies. Modern investigations across species including rodents and humans will be described. Novel imaging is now available to study human hyalocytes in vivo. The shared ontogeny with retinal microglia and their eventual interdependence as well as...

Drilling overdeepened (Eastern) Alpine Valleys and Basins

Markus Fiebig , Flavio Anselmetti , Marius Büchi , Gerald Gabriel , Ernst Kroemer , Frank Preusser , Jürgen Reitner , Sebastian Schaller , Bennet Schuster , David Tanner & Ulrike Wielandt-Schuster
The panalpine project "DOVE" (Drilling Overdeepened Alpine Valleys), co-funded by the International Continental Scientific Drilling Program (ICDP), is drilling a series of overdeepened glacial troughs around the Alps that were formed by subglacial erosion during past glaciations. In the northeastern section of the DOVE project, we (re)investigate the inneralpine basin of Bad Aussee (Traun glacier area, Austria), the subalpine basin of the Salzach Foreland glacier (Neusillersdorf, Bavaria), and the tongue basin area of the Pleistocene...

Plant invasion modifies isohydricity in Mediterranean tree species

Simon Haberstroh, Raquel Lobo-Do-Vale, Maria C. Caldeira, Maren Dubbert, Matthias Cuntz & Christiane Werner
Understanding of plant hydraulic strategies (i.e., the degree of iso-/anisohydricity) is crucial to predict the response of plants to changing environmental conditions such as climate-change induced extreme drought. Several abiotic factors, including evaporative demand, have been shown to seasonally modify the isohydricity of plants. However, the impact of biotic factors such as plant-plant interactions on hydraulic strategies has seldom been explored. Here, we investigated adaptations and changes in hydraulic strategies of two woody species in...

Additional file 1 of COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection

Wei-Yu Chi, Yen-Der Li, Hsin-Che Huang, Timothy En Haw Chan, Sih-Yao Chow, Jun-Han Su, Louise Ferrall, Chien-Fu Hung & T.-C. Wu
Additional file 1: Table S1. Vaccine effectiveness against viral variants. Studies of vaccine effectiveness against viral variants. Related to Table 2.

Additional file 2 of COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection

Wei-Yu Chi, Yen-Der Li, Hsin-Che Huang, Timothy En Haw Chan, Sih-Yao Chow, Jun-Han Su, Louise Ferrall, Chien-Fu Hung & T.-C. Wu
Additional file 2: Table S2. Vaccine efficacy and effectiveness in children and adolescents

Psychometric properties of the rehabilitation treatment beliefs questionnaire for psychosomatic rehabilitation

Anne Nau, Gloria Metzner, Rieka von der Warth, Matthias Sehlbrede, Jürgen Bengel, Matthias Rudolph & Manuela Glattacker
Treatment beliefs play a crucial role for patient satisfaction and the treatment outcome in psychosomatic rehabilitation. The aim of this study was the development and the psychometric evaluation of an indication-specific questionnaire of beliefs about psychosomatic rehabilitation. The study was conducted at a psychosomatic rehabilitation clinic. The primary item list comprised k = 125 items. After a descriptive item analysis, we conducted an exploratory factor analysis. Furthermore, we tested reliability via McDonald’s Omega and construct...

Temporal regulation of notch activation improves arteriovenous fistula maturation

Qunying Guo, Guang Chen, Hunter Cheng, Ying Qing, Luan Truong, Quan Ma, Yun Wang & Jizhong Cheng
Abstract Background Arteriovenous fistula (AVF) maturation is a process involving remodeling of venous arm of the AVFs. It is a challenge to balance adaptive AVF remodeling and neointima formation. In this study we temporally controlled Notch activation to promote AVF maturation while avoiding neointima formation. Methods Temporal Notch activation was controlled by regulating the expression of Notch transcription factor, RBP-Jκ, or dnMAML1 (dominant negative MAML2) in vascular smooth muscle cells (VSMCs). AVF mouse model was...

Association of sex steroid hormones and new bone formation rate after iliac onlay grafting: a prospective clinical pilot study

Victoria Constanze Landwehr, Tobias Fretwurst, Julia Heinen, Kirstin Vach, Katja Nelson, Susanne Nahles & Gerhard Iglhaut
Abstract Purpose The present prospective study evaluates the association between new bone formation rate in the iliac onlay graft and sex steroid hormone serum levels. Methods A total of 15 partially or completely edentulous postmenopausal females and 9 males with less than 5 mm height of the remaining alveolar bone underwent iliac onlay grafting followed by dental implant placement using a two-stage approach. Sex hormone binding globulin and 17β-estradiol serum levels were investigated by electrochemiluminescence...

‘We just did it as a team’: Learning and working on a paediatric interprofessional training ward improves interprofessional competencies in the short- and in the long-term

Sebastian F. N. Bode, Sebastian Friedrich & Christine Straub
Interprofessional (IP) education is essential for healthcare professionals to prepare them for future IP collaboration. IP training wards (ITWs) have been established for work-based IP education. Short-term effects of ITW placements have been published but long-term results are scarce. There are no reports on ITWs in paediatrics. We established the Interprofessional Training Ward in Paediatrics (IPAPAED) for paediatric nursing trainees and medical students. The aim of the study is to evaluate both short- and long-term...

Empirical evidence of study design biases in nutrition randomised controlled trials: a meta-epidemiological study

Julia Stadelmaier, Isabelle Roux, Maria Petropoulou & Lukas Schwingshackl
Abstract Background Instruments to critically appraise randomised controlled trials (RCTs) are based on evidence from meta-epidemiological studies. We aim to conduct a meta-epidemiological study on the average bias associated with reported methodological trial characteristics such as random sequence generation, allocation concealment, blinding, incomplete outcome data, selective reporting, and compliance of RCTs in nutrition research. Methods We searched the Cochrane Database of Systematic Reviews, for systematic reviews of RCTs, published between 01 January 2010 and 31...

Empirical evidence of study design biases in nutrition randomised controlled trials: a meta-epidemiological study

Julia Stadelmaier, Isabelle Roux, Maria Petropoulou & Lukas Schwingshackl
Abstract Background Instruments to critically appraise randomised controlled trials (RCTs) are based on evidence from meta-epidemiological studies. We aim to conduct a meta-epidemiological study on the average bias associated with reported methodological trial characteristics such as random sequence generation, allocation concealment, blinding, incomplete outcome data, selective reporting, and compliance of RCTs in nutrition research. Methods We searched the Cochrane Database of Systematic Reviews, for systematic reviews of RCTs, published between 01 January 2010 and 31...

Additional file 3 of PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar & Melanie Boerries
Additional file 2. Table S2A–F. Over-expressed genes in MaMel cell lines.

Additional file 4 of PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar & Melanie Boerries
Additional file 3. Table S3A–F. Over-represented biological processes (GO-bp) among over-expressed genes in MaMel cell lines.

Additional file 7 of PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar & Melanie Boerries
Additional file 6. Table S6A, B. Over-represented hallmark gene sets among genes up- and down-regulated with increasing resistance in MaMel cell lines.

Additional file 9 of PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar & Melanie Boerries
Additional file 8. Table S8A–D. Over-represented biological processes (GO-bp) among gene clusters in MaMe21, MaMel63a, HEM, and HDF.

Prognostic value of tumor-infiltrating immune cells and immune checkpoints in elderly head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiotherapy

Alexander Rühle, Jovan Todorovic, Simon S. K. Spohn, Eleni Gkika, Christoph Becker, Andreas Knopf, Constantinos Zamboglou, Tanja Sprave, Martin Werner, Anca-Ligia Grosu, Gian Kayser & Nils H. Nicolay
Abstract Background and purpose Tumor-infiltrating lymphocytes (TILs) are associated with locoregional control (LRC) in head-and-neck squamous cell carcinoma (HNSCC) patients undergoing (chemo)radiotherapy. As immunosenescence results in reduced immune activity, the role of TILs in elderly HNSCC patients may differ compared to younger patients, providing a rationale to study the prognostic role of TILs and immune checkpoints (ICs) in this population. Material and methods Sixty-three HNSCC patients aged ≥ 65 years undergoing definitive (chemo)radiotherapy between 2010...

sj-docx-1-cpa-10.1177_07067437221128477 - Supplemental material for Trends in Involuntary Psychiatric Hospitalization in British Columbia: Descriptive Analysis of Population-Based Linked Administrative Data from 2008 to 2018

Jackson P. Loyal, M. Ruth Lavergne, Mehdi Shirmaleki, Benedikt Fischer, Ridhwana Kaoser, Jack Makolewksi & Will Small
Supplemental material, sj-docx-1-cpa-10.1177_07067437221128477 for Trends in Involuntary Psychiatric Hospitalization in British Columbia: Descriptive Analysis of Population-Based Linked Administrative Data from 2008 to 2018 by Jackson P. Loyal, M. Ruth Lavergne, Mehdi Shirmaleki, Benedikt Fischer, Ridhwana Kaoser, Jack Makolewksi and Will Small in The Canadian Journal of Psychiatry

Borrelia multiplex: a bead-based multiplex assay for the simultaneous detection of Borrelia specific IgG/IgM class antibodies

Julia Häring, Max J. Hassenstein, Matthias Becker, Julia Ortmann, Daniel Junker, André Karch, Klaus Berger, Tatia Tchitchagua, Olaf Leschnik, Manuela Harries, Daniela Gornyk, Pilar Hernández, Berit Lange, Stefanie Castell, Gérard Krause, Alex Dulovic, Monika Strengert & Nicole Schneiderhan-Marra
Abstract Background Lyme borreliosis (LB) is the most common tick-borne infectious disease in the northern hemisphere. The diagnosis of LB is usually made by clinical symptoms and subsequently supported by serology. In Europe, a two-step testing consisting of an enzyme-linked immunosorbent assay (ELISA) and an immunoblot is recommended. However, due to the low sensitivity of the currently available tests, antibody detection is sometimes inaccurate, especially in the early phase of infection, leading to underdiagnoses. Methods...

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism.

Claudio Bussi, Tiaan Heunis, Enrica Pellegrino, Elliott M Bernard, Nourdine Bah, Mariana Silva Dos Santos, Pierre Santucci, Beren Aylan, Angela Rodgers, Antony Fearns, Julia Mitschke, Christopher Moore, James I MacRae, Maria Greco, Thomas Reinheckel, Matthias Trost & Maximiliano G Gutierrez
Transient lysosomal damage after infection with cytosolic pathogens or silica crystals uptake results in protease leakage. Whether limited leakage of lysosomal contents into the cytosol affects the function of cytoplasmic organelles is unknown. Here, we show that sterile and non-sterile lysosomal damage triggers a cell death independent proteolytic remodelling of the mitochondrial proteome in macrophages. Mitochondrial metabolic reprogramming required leakage of lysosomal cathepsins and was independent of mitophagy, mitoproteases and proteasome degradation. In an in...

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism.

Claudio Bussi, Tiaan Heunis, Enrica Pellegrino, Elliott M Bernard, Nourdine Bah, Mariana Silva Dos Santos, Pierre Santucci, Beren Aylan, Angela Rodgers, Antony Fearns, Julia Mitschke, Christopher Moore, James I MacRae, Maria Greco, Thomas Reinheckel, Matthias Trost & Maximiliano G Gutierrez
Transient lysosomal damage after infection with cytosolic pathogens or silica crystals uptake results in protease leakage. Whether limited leakage of lysosomal contents into the cytosol affects the function of cytoplasmic organelles is unknown. Here, we show that sterile and non-sterile lysosomal damage triggers a cell death independent proteolytic remodelling of the mitochondrial proteome in macrophages. Mitochondrial metabolic reprogramming required leakage of lysosomal cathepsins and was independent of mitophagy, mitoproteases and proteasome degradation. In an in...

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Affiliations

  • University of Freiburg
    144
  • University Medical Center Freiburg
    53
  • German Cancer Research Center
    34
  • Cluster of Excellence livMatS, Freiburg Center for Interactive Materials and Bioinspired Technologies, University of Freiburg, Georges-Köhler-Allee 105, 79110 Freiburg, Germany
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  • Department of Microsystems Engineering, University of Freiburg, Georges-Köhler-Allee 103, 79110 Freiburg, Germany
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  • Shanghai Jiao Tong University
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  • Anhui Medical University
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  • Affiliated Hospital of Jiangsu University
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  • Jinan University
    15
  • First Affiliated Hospital of Chengdu Medical College
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