Supplemental material, sj-docx-1-his-10.1177_11786329231153278 for Healthcare Costs and Health-Related Quality of Life in Older Multimorbid Patients After Hospitalization by Paola Salari, Séverine Henrard, Cian O’Mahony, Paco Welsing, Arjun Bhadhuri, Katharina Tabea Jungo, Thomas Beck, Denis O’Mahony, Stephen Byrne, Anne Spinewine, Wilma Knol, Nicolas Rodondi and Matthias Schwenkglenks in Health Services Insights

Objectives:We identified factors associated with healthcare costs and health-related quality of life (HRQoL) of multimorbid older adults with polypharmacy.Methods:Using data from the OPERAM (OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid older people) trial, we described the magnitude and composition of healthcare costs, and time trends of HRQoL, during 1-year after an acute-care hospitalization. We performed a cluster analysis to identify groups with different cost and HRQoL trends. Using multilevel models, we also...

Additional file 5: Quantitative PCR results comparing relative expression of NOS3 mRNA in cells transfected with the wild type and with the M035 mutated cDNA.

Additional file 1: Genealogical trees of to the 6 consanguineous MMA probands.

Additional file 5: Quantitative PCR results comparing relative expression of NOS3 mRNA in cells transfected with the wild type and with the M035 mutated cDNA.

Additional file 1: Figure S1. Genome integrity of hydrated and desiccated bdelloids respectively P. roseola, H. sp “Belgium”, A. editae: PFGE (A) and Photometric Scans (B). The two panels show pulsed-field gel electrophoresis patterns (PFGE) obtained for 1000 bdelloids individuals that were kept hydrated or submitted to 1, 14 and 30 days of desiccation as indicated. Migration parameters are documented under each gel. Chromosomes of S. cerevisiae are used as size markers. Photometric scans were...

Additional file 2. S2: Focus group interview schedules.

Abstract Background To investigate the possible influence of prolonged ketamine (K) or esketamine (ESK) infusion on the profile of liver cholestatic biomarkers in patients with COVID-19 infection. Methods A retrospective analysis was performed on 135 patients with COVID-19 related ARDS who received prolonged K or ESK infusion. They were compared to 15 COVID-19 ICU patients who did not receive K/ESK while being mechanically ventilated and 108 COVID-19 patients who did not receive mechanical ventilation nor...

Additional file 1: Figure S1. Genome integrity of hydrated and desiccated bdelloids respectively P. roseola, H. sp “Belgium”, A. editae: PFGE (A) and Photometric Scans (B). The two panels show pulsed-field gel electrophoresis patterns (PFGE) obtained for 1000 bdelloids individuals that were kept hydrated or submitted to 1, 14 and 30 days of desiccation as indicated. Migration parameters are documented under each gel. Chromosomes of S. cerevisiae are used as size markers. Photometric scans were...

This Trase dataset describes the supply chain of Brazilian beef from municipality of production to countries of import. The data provides volumes (in tonnes) and value of beef exports (in US dollars), as well as the deforestation exposure in the supply chain of companies and countries.

Abstract Background The COVID-19 pandemic has had major and potentially long-lasting effects on mental health and wellbeing across populations worldwide. However, these impacts were not felt equally, leading to an exacerbation of health inequalities, especially affecting vulnerable populations such as migrants, refugees and asylum seekers. Aiming to inform the adaptation and implementation of psychological intervention programmes, the present study investigated priority mental health needs in this population group. Methods Participants were adult asylum seekers, refugees...

Abstract Background Poor housing conditions have been associated with increased mortality. Our objective is to investigate the association between housing inequality and increased mortality in Belgium and to estimate the number of deaths that could be prevented if the population of the whole country faced the mortality rates experienced in areas that are least deprived in terms of housing. Methods We used individual-level mortality data extracted from the National Register in Belgium and relative to...

Additional file 1. S1: COREQ checklist.

Abstract Purpose Metastatic bone disease (MBD) is the most common form of metastases, most frequently deriving from prostate cancer. MBD is screened with bone scintigraphy (BS), which have high sensitivity but low specificity for the diagnosis of MBD, often requiring further investigations. Deep learning (DL) - a machine learning technique designed to mimic human neuronal interactions- has shown promise in the field of medical imaging analysis for different purposes, including segmentation and classification of lesions....

Abstract Background Alzheimer’s disease (AD) is the 5th leading cause of death in people 65 years and older. The ATN classification reflects a biological definition of AD pathology with markers of Aβ deposition (A), pathologic tau (T), and neurodegeneration (N). Little is known about the relationship between ATN status and the risk of mortality, leading us to examine this association in a relatively large population of patients seen at a memory clinic for cognitive disorders....

Additional file 1: Table S1 Indicator weights generated by factor analysis for the individual years. Table S2 Missing values across indicators prior and after imputing based on similar profile. Figure S1 Percentage of mortality attributable to housing inequality by the HDI 1991, sex and age group in a period of 1991-2000. Figure S2 Percentage of mortality attributable to housing inequality by the HDI 2001, sex and age group in a period of 2001-2010. Figure S3...

Abstract Background Moyamoya angiopathy (MMA) is a rare cerebrovascular condition leading to stroke. Mutations in 15 genes have been identified in Mendelian forms of MMA, but they explain only a very small proportion of cases. Our aim was to investigate the genetic basis of MMA in consanguineous patients having unaffected parents in order to identify genes involved in autosomal recessive MMA. Methods Exome sequencing (ES) was performed in 6 consecutive consanguineous probands having MMA of...

The interplay of forest stand and environmental factors shape soil organic C (SOC) storage in forest ecosystems but little is known about their relative impacts in different soil layers. Moreover, how environmental factors modulate the impact of stand factors, particularly species mixing, on SOC storage, is largely unexplored. In this study conducted in 21 forest triplets (two-species mixed stand and respective monocultures nearby) distributed in Europe, we tested the hypothesis that stand factors (functional identity...

Additional file 1. Results of elemental composition analyses, according to the analysis technique (PIXE, ICP-AES, SEM-EDS).

Additional file 3: Table S1. Output of the Phylogenetic Generalized Least Square (PGLS) model for effects on fecundity, measured as SD50, of habitat, desiccation, and radiation for the seven desiccation-tolerant species (adjusted R2 = 0.21 for A and 0.94 for B). The tables report the four predictors with estimates ± standard errors, t values and p values from the PGLS models. Table S2. GenBank Accession numbers of the sequences used for the study of the...

Additional file 3: Table S1. Output of the Phylogenetic Generalized Least Square (PGLS) model for effects on fecundity, measured as SD50, of habitat, desiccation, and radiation for the seven desiccation-tolerant species (adjusted R2 = 0.21 for A and 0.94 for B). The tables report the four predictors with estimates ± standard errors, t values and p values from the PGLS models. Table S2. GenBank Accession numbers of the sequences used for the study of the...

Additional file 4. Set of tests on potential correlates of survival capabilities, addressing whether the climatic conditions of the original habitat of each species could explain their susceptibility to desiccation or to radiation.

Additional file 1: Supplementary Table 1. Descriptions of the clinical profiles of participants experiencing functional decline at 6 months of follow-up on either b-ADL or i-ADL.

Abstract Background Moyamoya angiopathy (MMA) is a rare cerebrovascular condition leading to stroke. Mutations in 15 genes have been identified in Mendelian forms of MMA, but they explain only a very small proportion of cases. Our aim was to investigate the genetic basis of MMA in consanguineous patients having unaffected parents in order to identify genes involved in autosomal recessive MMA. Methods Exome sequencing (ES) was performed in 6 consecutive consanguineous probands having MMA of...

Additional file 3: Candidate homozygous variants identified in the 6 consanguineous probands.