131 Works

Exploring high aspect ratio gold nanotubes as cytosolic agents: structural engineering and uptake into mesothelioma cells - dataset

Sunjie Ye, Arsalan Azad, Joseph Chambers, Alison Beckett, Lucien Roach, Samuel Moorcroft, Zabeada Aslam, Ian Prior, Alexander Markham, Louise P. Coletta, Stefan Marciniak & Stephen Evans
The generation of effective and safe nanoagents for biological applications requires their physicochemical characteristics to be tunable, and their cellular interactions to be well characterized. Here, the controlled synthesis is developed for preparing high‐aspect ratio gold nanotubes (AuNTs) with tailorable wall thickness, microstructure, composition, and optical characteristics. The modulation of optical properties generates AuNTs with strong near infrared absorption. Surface modification enhances dispersibility of AuNTs in aqueous media and results in low cytotoxicity. The uptake...

Dataset associated with 'Gene expression signatures of synovial fluid multipotential stromal cells (MSCs) in advanced knee osteoarthritis and following knee joint distraction'

Clara Sanjurjo-Rodríguez, Ala Altaie, Simon Mastbergen, Thomas Baboolal, Tim Welting, Floris Lafeber, Hemant Pandit, Dennis McGonagle & Elena Jones

A major combustion aerosol event had a negligible impact on the atmospheric ice-nucleating particle population

Michael Adams, Mark Tarn, Alberto Sanchez-Marroquin, Grace Porter, Daniel O'Sullivan, Alexander Harrison, Zhiqiang Cui, Jesús Vergara Temprado, Federico Carotenuto, Mark Holden, Martin Daily, Thomas Whale, Sebastien Sikora, Ian Burke, Jung-uk Shim, Jim McQuaid & Benjamin Murray
Clouds containing supercooled water are important for both climate and weather, but our knowledge of which aerosol particle types nucleate ice in these clouds is far from complete. Combustion aerosols have strong anthropogenic sources and if these aerosol types were to nucleate ice in clouds they might exert a climate forcing. Here, we quantified the atmospheric ice-nucleating particle (INP) concentrations during the UK’s annual Bonfire Night celebrations, which are characterised by strong anthropogenic emissions of...

Agent-based model of heterogeneous T cell activation in vitro (supplementary material)

Grant Lythe, Shamik Majumdar, carmen molina-parís & Dipankar Nandi

Data associated with ‘Molecular Characterization of Strongly and Weakly Interfacially Active Asphaltenes by High-Resolution Mass Spectrometry’

Dewi Ballard, Martha L. Chacón-Patiño, Peiqi Qiao, Kevin Roberts, Robert Rae, Peter Dowding, Zhenghe Xu & David Harbottle
Asphaltenes are a complex mixture of molecular structures with a variety of functionalities, which in turn impacts their physical properties. Discriminating between asphaltenes that are strongly and weakly interfacially active is providing new direction to mitigate asphaltene-related problems. Whole asphaltenes (WA) were extracted from a South American heavy crude oil, further fractionated into interfacially active asphaltenes (IAA) and remaining asphaltenes (RA), and molecularly characterized by positive-ion (+) atmospheric pressure photoionization (APPI) using a 9.4 tesla...

Dataset associated with 'Quantification of Ebola virus replication kinetics in vitro'

Laura Liao, Jonathan Carruthers, Sophie J. Smither, , Simon A. Weller, Diane Williamson, Thomas R. Laws, Isabel Garcia-Dorival, Julian Hiscox, Benjamin P. Holder, Catherine Beauchemin, Alan S. Perelson, MARTIN LOPEZ-GARCIA, Grant Lythe, John Barr & carmen molina-parís
This dataset is associated with ‘Quantification of Ebola virus replication kinetics in vitro’. In the paper, a mathematical model is developed to describe the replication of Ebola virus in Vero cells. The model is parametrised using measurements of total and infectious extracellular virus at three different multiplicities of infection. The results provide insights into the distribution of time an infected cell spends in the eclipse phase (the period between infection and the start of virus...

Data package from 'Pantropical variability in tree crown allometry' Global Ecology and Biogeography 2021. DOI: 10.1111/geb.13231

Grace Jopaul Loubota Panzou, Adeline Fayolle, Tommaso Jucker, Oliver Phillips, Stephanie Bohlman, Lindsay F. Banin, Simon L. Lewis, Kofi Affum-Baffoe, Luciana F. Alves, Cécile Antin, Eric Arets, Luzmila Arroyo, Timothy R. Baker, Nicolas Barbier, Hans Beeckman, Uta Berger, Yannick Enock Bocko, Frans Bongers, Sam Bowers, Thom Brade, Eduardo S. Brondizio, Arthur Chantrain, Jerome Chave, Halidou Compaore & David Coomes

Data from: Longevity, body dimension and reproductive mode drive differences in aquatic versus terrestrial life history strategies

Pol Capdevila, Maria Beger, Simone Blomberg, Bernat Hereu, Cristina Linares & Roberto Salguero-Gómez
1. Aquatic and terrestrial environments display stark differences in key environmental factors and phylogenetic composition but their consequences for the evolution of species’ life history strategies remain poorly understood. 2. Here, we examine whether and how life history strategies vary between terrestrial and aquatic species. We use demographic information for 685 terrestrial and 122 aquatic animal and plant species to estimate key life history traits. We then use phylogenetically corrected least squares regression to explore...

Data from: Upper Toarcian (Lower Jurassic) marine gastropods from the Cleveland Basin, England: systematics, palaeobiogeography and contribution to biotic recovery from the early Toarcian extinction event

Mariel Ferrari, Crispin Little & Jed Atkinson
Here we describe a new late Toarcian (Lower Jurassic) marine gastropod fauna from rocks of the Cleveland Basin exposed on the North Yorkshire coast of England. The fossil assemblage comprises sixteen species, of which three are new: Katosira? bicarinata sp. nov., Turritelloidea stepheni sp. nov. and Striactaenonina elegans sp. nov. Four species are described in open nomenclature as Tricarilda? sp., Jurilda sp., Cylindrobullina sp. and Cossmannina sp. The other species have previously been described: Coelodiscus...

Data associated with 'Reaction Rate Governs the Viscoelasticity and Nanostructure of Folded Protein Hydrogels'

Anders Aufderhorst-Roberts
Hydrogels constructed from folded protein domains are of increasing interest as resilient and responsive biomaterials, but their optimisation for applications requires time-consuming and costly molecular design. Here, we explore a complementary approach to control their properties by examining the influence of crosslinking rate on the structure and viscoelastic response of a model hydrogel constructed from photo-chemically crosslinked bovine serum albumin (BSA). Gelation is observed to follow a heterogeneous nucleation pathway in which BSA monomers crosslink...

Estimation of environmental, genetic and parental age at conception effects on telomere length in a wild mammal

Sil H.J. Van Lieshout, Alexandra M. Sparks, Amanda Bretman, Chris Newman, Christina D. Buesching, Terry Burke, David W. Macdonald & Hannah L. Dugdale
Understanding individual variation in fitness-related traits requires separating the environmental and genetic determinants. Telomeres are protective caps at the ends of chromosomes that are thought to be a biomarker of senescence as their length predicts mortality risk and reflect the physiological consequences of environmental conditions. The relative contribution of genetic and environmental factors to individual variation in telomere length is however unclear, yet important for understanding its evolutionary dynamics. In particular, the evidence for transgenerational...

Reliably predicting pollinator abundance: challenges of calibrating process-based ecological models

Emma Gardner, Tom Breeze, Yann Clough, Henrik Smith, Katherine Baldock, Alistair Campbell, Michael Garratt, Mark Gillespie, William Kunin, Megan McKerchar, Jane Memmott, Simon Potts, Deepa Senapathi, Graham Stone, Felix Wäckers, Duncan Westbury, Andrew Wilby & Thomas Oliver
1. Pollination is a key ecosystem service for global agriculture but evidence of pollinator population declines is growing. Reliable spatial modelling of pollinator abundance is essential if we are to identify areas at risk of pollination service deficit and effectively target resources to support pollinator populations. Many models exist which predict pollinator abundance but few have been calibrated against observational data from multiple habitats to ensure their predictions are accurate. 2. We selected the most...

Anti-Social Behaviour Trends in the Pandemic

Anthony Dixon, Emily Sheard & Graham Farrell

Data from: Maxwell-Cattaneo magnetoconvection dataset

David Hughes, Ibrahim Eltayeb & Michael Proctor
We study the instability of a Bénard layer subject to a vertical uniform magnetic field, in which the fluid obeys the Maxwell-Cattaneo (MC) heat flux-temperature relation. We extend the work of Bissell (Proc. R. Soc. A, 472: 20160649, 2016) to non-zero values of the magnetic Prandtl number pm. With non-zero pm, the order of the dispersion relation is increased, leading to considerably richer behaviour. An asymptotic analysis at large values of the Chandrasekhar number Q...

Timescapes Data and Secondary Analysis: Working across the Projects

Sarah Irwin & Mandy Winterton
Timescapes Working Paper Series, 5

Sexism of Fat: Is it sufficient to use only one sex in obesity research?

Amanda MacCannell, Anna Whitehead, Amy Moran & Lee Roberts
There is a weight issue weighing down the public health care systems across the world. Although obesity is prevalent in both males and females, the location of fat and impact on cardiometabolic health is strikingly different. These differences are apparent in the clinical setting, but there remains a bias towards using a single sex in mouse models to create simpler and cheaper experiments. The bias towards using a single sex in experiments skews the results...

(Re)Writing Self-killing in the Old English Lives of Saint Margaret

Kayla Kemhadjian
This poster compares five manuscripts – three written in Old English and two in Latin – in order to unravel nuanced perceptions of self-killing in Early Medieval England. All five texts generally follow the same story. When about to executed, Margaret’s executioner, Malchus, sees that she is holy and does not want to kill her. Margaret, set on martyrdom, orders Malchus to kill her. Trembling, Malchus cuts her head off with his sword. Afterward, each...

Developing a quick, cost-effective genetic screen for enamel disease

Ummey Hany, Georgios Nikolopoulos, Claire Smith, Christopher Mark Watson, Christopher Inglehearn & Alan Mighell
Amelogenesis imperfecta (AI) refers to a group of rare, inherited disorders characterised by abnormal enamel formation. According to the AI Leiden Open Variant Database (LOVD) hosted by Leeds University (http://dna2.leeds.ac.uk/LOVD/), there are 19 genes involved in non-syndromic AI that account for >90% of the known AI-causing mutations. Conventionally the identification of inherited gene mutations in a family would be done through family studies. However, with technological improvements and decreasing costs, next generation sequencing (NGS) technology...

Data associated with ‘Development of a specimen-specific in vitro pre-clinical simulation model of the human cadaveric knee with appropriate soft tissue constraints’

Aiqin Liu, William J Sanderson, Eileen Ingham, John Fisher & Louise Jennings
The dataset will include all the data. for figures in the manuscripts as shown in the followings: 1) Kinematic input profiles for the human cadaveric knee. 2) Average AP displacement and TR angle of the 4 human knee specimens in a human walking gait cycle (both AP and TR force driven condition). 3) Typical kinematic profiles from one donor under different spring conditions for different spring rates and free lengths/degrees 4) Comparison of kinematic profiles...

The First Local Lockdown

Dixon Anthony, Bowers Kate, Nick Tilley & Graham Farrell

Network Growth and Structural Characteristics of Globular Protein Hydrogels - Data and Analysis

Benjamin Hanson & Lorna Dougan
Folded protein-based hydrogels are a novel class of biomaterials which combine the useful viscoelastic properties of individual proteins together with the prospect of rational design principles. This data deposit provides that simulation scripts and resultant data required to reproduce and continue on from our published results

RAINFOR field manual for plot establishment and remeasurement (Amazon Forest Inventory Network, 2018)

Oliver L. Phillips, Tim R. Baker, Ted R. Feldpausch & Roel J.W. Brienen
RAINFOR (The Amazon Forest Inventory Network, Rede Amazônica de Inventários Florestais, Red Amazónica de Inventarios Forestales) is an attempt to utilise long-term permanent sample plots (PSPs) to monitor forest biomass and dynamics, and relate these observation to soil and climate across the Amazon forest region. Many of these plots were established in the past to investigate specific local ecological or forest management questions. However, by compiling and comparing these studies on a regional scale a...

Data for `Spatial localisation beyond steady states in the neighbourhood of the Takens-Bogdanov bifurcation’

Haifaa Alrihieli, Alastair Rucklidge & Priya Subramanian
Three movies for different solutions discussed in the associated paper. Figure5b_loc_SS_MW_rad0p7_th280 : An example of localized steady state with modulated wave (MW) solutions background obtained from time stepping. The blue and red curves refer to u and ut , respectively. See the paper for details of system parameters and more details. Figure10a_loc_TW_T_rad0p1_th200 : An example of localised travelling wave (LTW) with trivial state (TS) background. The blue and red curves refer to $u$ and $u_t$,...

Registration Year

  • 2020

Resource Types

  • Dataset
  • Text
  • Model
  • Collection
  • Data Paper


  • University of Leeds
  • University of Exeter
  • University of Oxford
  • University of Cambridge
  • Cardiff University
  • Swiss Federal Institute of Aquatic Science and Technology
  • Deutsche Gesellschaft für Internationale Zusammenarbeit
  • University of Edinburgh
  • Imperial College London
  • Royal Holloway University of London