313 Works

The functional diversity of marsupial limbs is influenced by both ecology and developmental constraint

Spencer Pevsner, David Grossnickle & Zhe-Xi Luo
Extant marsupials are less ecologically diverse than placentals, and this is reflected by placentals exhibiting a greater diversity of locomotor modes, including powered flight and fully aquatic swimming. One proposed explanation for this discrepancy is that the development of more disparate marsupial forelimbs is prevented by the neonate’s crawl to the pouch, which requires precocious forelimb development for climbing adaptations. To test predictions of this Developmental Constraint Hypothesis, we pursue a comparative morphometric study on...

SCiL 2022 Editors' Note

Allyson Ettinger, Tim Hunter & Brandon Prickett

Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China

Jieming Qu, Jing Zhang, Yu Chen, Yi Huang, Yusang Xie, Min Zhou, Yuping Li, Dongwei Shi, Jinfu Xu, Qiuyue Wang, Bei He, Ning Shen, Bin Cao, Danyang She, Yi Shi, Xin Su, Hua Zhou, Hong Fan, Feng Ye, Qiao Zhang, Xinlun Tian & Guoxiang Lai
Severe Community Acquired Pneumonia (SCAP) challenges public health globally. Considerable improvements in molecular pathogen testing emerged in the last few years. Our prospective study combinedly used traditional culture, antigen tests, PCR and mNGS in SCAP pathogen identification with clinical outcomes. From June 2018 to December 2019, we conducted a multi-centre prospective study in 17 hospitals of SCAP patients within 48 hours of emergency room stay or hospitalization in China. All clinical data were uploaded into...

Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China

Jieming Qu, Jing Zhang, Yu Chen, Yi Huang, Yusang Xie, Min Zhou, Yuping Li, Dongwei Shi, Jinfu Xu, Qiuyue Wang, Bei He, Ning Shen, Bin Cao, Danyang She, Yi Shi, Xin Su, Hua Zhou, Hong Fan, Feng Ye, Qiao Zhang, Xinlun Tian & Guoxiang Lai
Severe Community Acquired Pneumonia (SCAP) challenges public health globally. Considerable improvements in molecular pathogen testing emerged in the last few years. Our prospective study combinedly used traditional culture, antigen tests, PCR and mNGS in SCAP pathogen identification with clinical outcomes. From June 2018 to December 2019, we conducted a multi-centre prospective study in 17 hospitals of SCAP patients within 48 hours of emergency room stay or hospitalization in China. All clinical data were uploaded into...

Synthesis and evaluation of novel 1-(((6-substitutedbenzo[d]thiazol-2-yl)amino)(heteroaryl)methyl)naphthalen-2-ol as pesticidal agents

Junfeng Shang, Yuxin Li, Na Yang, Lixia Xiong & Baolei Wang
To discover new agrochemicals with prominent pesticidal properties, a series of novel β-naphthol derivatives containing benzothiazolylamino and various heteroaryl groups (8a-q) were efficiently synthesised via Betti reaction. The bioassay results showed that most of the synthesised compounds exhibited favourable insecticidal potentials, particularly towards oriental armyworm (50–100% at 200 mg·L−1) and diamondback moth (50–95% at 10 mg·L−1). Compounds 8 b, 8f, 8 g, 8j, 8k, 8n, and 8o possessed LC50 values of 0.0988–5.8864 mg·L−1 against diamondback...

Efficient Learning of Quadratic Variance Function Directed Acyclic Graphs via Topological Layers

Wei Zhou, Xin He, Wei Zhong & Junhui Wang
Directed acyclic graph (DAG) models are widely used to represent casual relationships among random variables in many application domains. This article studies a special class of non-Gaussian DAG models, where the conditional variance of each node given its parents is a quadratic function of its conditional mean. Such a class of non-Gaussian DAG models are fairly flexible and admit many popular distributions as special cases, including Poisson, Binomial, Geometric, Exponential, and Gamma. To facilitate learning,...

Data from: Evidence for divergence in phenology over morphology in response to limiting similarity in montane communities of Rhododendron

Qin Li, Ji Wang, Ryan Fuller, Yaowu Xing, Jianquan Liu & Rick Ree
1. The coexistence of closely related species is key to understanding the nature of biodiversity hotspots where in situ diversification has yielded rich communities of close relatives. Limiting similarity predicts that co-occurring species are differentiated in their niches; identifying the axes of differentiation in sympatric close relatives can thus help reveal the eco-evolutionary dynamics of community assembly. For flowering plants, these axes may be temporal (related to reproductive phenology) or morphological (related to functional traits)....

Self-reported effects of perceived social support on marital quality in balanced translocation patients and their spouses undergoing preimplantation genetic testing in China: actor–partner interdependence model

Fengyi Mo, Xiaorui Hu, Qing Ma, Li Zhang & Lanfeng Xing
This study aimed to analyse the relationship between perceived social support and marital quality in balanced translocation patients and their spouses undergoing a preimplantation genetic testing (PGT) treatment cycle in China. The authors assessed the actor and partner effects of perceived social support on marital quality in patient–spouse dyads using a dyadic analysis approach. In total, 59 couples were assessed using self-report questionnaires for marital quality and perceived social support. There were significant differences in...

The nuclear receptor REV-ERBα regulates CYP2E1 expression and acetaminophen hepatotoxicity

Li Zhang, Fugui Zhang, Yifei Xiao, Jianhao Du, Xingwang Zhang, Min Chen & Baojian Wu
CYP2E1 plays an important role in drug metabolism and drug-induced hepatotoxicity. Here, we aimed to investigate a potential role for the nuclear receptor REV-ERBα in regulation of CYP2E1 expression and acetaminophen (APAP)-induced hepatotoxicity, and to determine the underlying mechanisms.Regulatory effects of REV-ERBα on CYP2E1 expression were assessed in vivo (using Rev-erbα-/- mice) and in vitro (using AML12 and HepG2 cells). In vitro microsomal CYP2E1 activity was probed using its specific substrate p-nitrophenol. Pharmacokinetic and acute...

The nuclear receptor REV-ERBα regulates CYP2E1 expression and acetaminophen hepatotoxicity

Li Zhang, Fugui Zhang, Yifei Xiao, Jianhao Du, Xingwang Zhang, Min Chen & Baojian Wu
CYP2E1 plays an important role in drug metabolism and drug-induced hepatotoxicity. Here, we aimed to investigate a potential role for the nuclear receptor REV-ERBα in regulation of CYP2E1 expression and acetaminophen (APAP)-induced hepatotoxicity, and to determine the underlying mechanisms.Regulatory effects of REV-ERBα on CYP2E1 expression were assessed in vivo (using Rev-erbα-/- mice) and in vitro (using AML12 and HepG2 cells). In vitro microsomal CYP2E1 activity was probed using its specific substrate p-nitrophenol. Pharmacokinetic and acute...

Plain language summary for the manuscript: Health-related quality of life outcomes with tofacitinib treatment in patients with ulcerative colitis in the open-label extension study, OCTAVE Open

Luc Biedermann, Marla C. Dubinsky, Séverine Vermeire, Marc Fellmann, Sean Gardiner, Peter Hur, Rajiv Mundayat, Julian Panés & David T. Rubin
This is a plain language summary (PLS) of an article published in a peer-reviewed scientific journal. This PLS is not peer-reviewed. The publisher of the original manuscript was not involved in the preparation of this PLS and has neither reviewed nor approved its content.

The causes and ecological context of rapid morphological evolution in birds

Nicholas Crouch & Joseph Tobias
Episodic pulses in morphological diversification are a prominent feature of evolutionary history, driven by factors that remain widely disputed. Resolving this question has proved challenging because comprehensive species-level data are generally unavailable at sufficient scale. Combining global phylogenetic and morphological data for birds, we show that pulses of diversification in lineages and traits tend to occur independently and in different contexts. Speciation pulses are preceded by greater differentiation in overall morphology and habitat niche, then...

Additional file 1 of Tannin coordinated nanozyme composite-based hybrid hydrogel eye drops for prophylactic treatment of multidrug-resistant Pseudomonas aeruginosa keratitis

Hongwei Wang, Fangying Song, Jing Feng, Xia Qi, Li Ma, Lixin Xie, Weiyun Shi & Qingjun Zhou
Additional file 1: Figure S1. SEM of TCNH. Figure S2. EDS of TCN. Figure S3. Optimization of the H2O2 and TCNH concentrations. Figure S4. In vitro antibacterial activity of TCNH against MDR P. aeruginosa (20059, 21173, 21715). Representative photographs of bacterial colonies after intervened by saline, H2O2, TCNH, and TCNH+H2O2. Figure S5. Immunostaining analysis of macrophages and neutrophils in mouse corneas after saline, H2O2, TCNH, and TCNH+H2O2 interventions. Figure S6. In vivo antibacterial activities of...

Additional file 1 of Relationship between freshwater harmful algal blooms and neurodegenerative disease incidence rates in South Korea

Seungjun Lee, Boseung Choi, Sung Jae Kim, Jinnam Kim, Dayun Kang & Jiyoung Lee
Additional file 1: Supplementary Table 1. Results of GLM that examined the relationships between HABs and neurodegenerative diseasesα with different sizes of radius. Supplementary Fig. 1. Microscopic images (× 400) of cyanobacteria were captured from an outer layer of the personal mask from a fisherman working downstream of the Nakdong River (Daedong Dock (35.239992 (latitude), 128.996558 (longitude)). Supplementary Table 2. Concentrations of microcystins and BMAA from the air and water samples collected downstream of Nakdong...

Determination of Persistent Organic Pollutants (POPs) in Atmospheric Gases and Particles by Solid-Phase Extraction (SPE) and Gas Chromatography–Tandem Mass Spectrometry (GC–MS/MS)

Zhenzhen Lv, Faqin Dong, Wen Zhang, Shanyu Chen, Fei Zheng, Lin Zhou, Mingxue Liu & Tingting Huo
Persistent organic pollutants (POPs) are harmful to the environment and human health. A simple method was developed for the determination of 58 POPs, including 16 polycyclic aromatic hydrocarbons (PAHs), 18 polychlorinated biphenyls (PCBs), and 24 organochlorine pesticides (OCPs), in atmospheric gaseous and particle-phase samples. Different extraction solvents, solid-phase extraction (SPE) cartridges and elution steps were used and compared to optimize the extraction efficiency. The POPs were isolated from the atmospheric samples by Soxhlet extraction using...

Additional file 3 of Bacteriomes in lesions of pulmonary tuberculosis and its association with status of Mycobacterium tuberculosis excretion

Weili Du, Yingli Zhao, Li Zhang, Jialu Che, Zichen Liu, Kun Li & Nanying Che
Additional file 3: Supplemental Figure 1. Boxplots showing the abundance of Menaquinone biosynthesis, Chorismate biosynthesis, Penicillin resistance and Heme biosynthesis in TB-E and TB-NE samples.

Three new tyrosol derivatives from Huangjing wine

Yan-Bin Ren, Xing-Wen Wang, Jia-Xuan Bai, Chang Liu, Si-Lin Yu, Yue Zhou, Cong-Cong Lin, Da-Hong Yao, Jian Huang & Jin-Hui Wang
Phytochemical investigation on the concentrate of Huangjing wine, resulted in the isolation of three new tyrosol derivatives 4′′′-hydroxyphenethyl 2-(R)-hydroxy-3-phenylpropionate (1), 4′′′-hydroxyphenethyl(4′-hydroxy-3′-methoxyphenyl)propionate (2) and 4′′-hydroxyphenethyl ethyl succinate (3), together with 5 known compounds, ferulic acid (4), L-phenyllactic acid (5), hydroxytyrosol (6), dihydroferulic acid (7), cyclo(L-Pro-D-Tyr) (8). Their structures were elucidated using spectroscopic analysis and by comparison with the literature data. All compounds displayed antioxidant effect in the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical. Among them, the new compound 2...

Personal exposure to household air pollution and lung function in rural Bangladesh: A population-based cross-sectional study

Shyfuddin Ahmed, Muhammad Ashique Haider Chowdhury, Shirmin Bintay Kader, Mohammad Hasan Shahriar, Bilkis A Begum, Mahbubul Eunus, Golam Sarwar, Tariqul Islam, Dewan S Alam, Faruque Parvez, Rubhana Raqib, Habibul Ahsan & Md Yunus
We assessed whether personal exposure to household air pollution [PM2.5 and black carbon (BC)] is associated with lung functions (FEV1, FVC, and their ratio) in non-smoking adults in rural Bangladesh. We measured personal exposure to PM2.5 using gravimetric analysis of PM2.5 mass and BC by reflectance measurement between April 2016 and June 2019. The average 24-hour PM2.5 and BC concentration was 141.0μgm−3 and 13.8μgm−3 for females, and 91.7 μgm−3 and 10.1 μgm−3 for males, respectively....

Additional file 1 of Quantitative proteomics identified circulating biomarkers in lung adenocarcinoma diagnosis

Hongyu Chen, Xiaoqin Lai, Yihan Zhu, Hong Huang, Lingyan Zeng & Li Zhang
Additional file 1: Table S1. Differentially expressed proteins identified in plasma samples.

Data and code for: Diversity-dependent diversification in the history of marine animals

Michael Foote
By comparing detrended estimates of diversity (taxonomic richness) and rates of origination, extinction, and net diversification, I show that, at the global scale over the course of the Phanerozoic Eon, rates of diversification and origination are negatively correlated with diversity. By contrast, extinction rates are only weakly correlated with diversity for the most part. These results hold for both genus- and species-level data and for many alternative analytical protocols. The asymmetry between extinction on the...

sj-docx-1-isp-10.1177_00207640221141784 – Supplemental material for Social anxiety and depression symptoms in Chinese left-behind children after the lifting of COVID-19 lockdown: A network analysis

Kuiliang Li, Lei Ren, Lei Zhang, Chang Liu, Mengxue Zhao, Xiaoqing Zhan, Ling Li, Xi Luo & Zhengzhi Feng
Supplemental material, sj-docx-1-isp-10.1177_00207640221141784 for Social anxiety and depression symptoms in Chinese left-behind children after the lifting of COVID-19 lockdown: A network analysis by Kuiliang Li, Lei Ren, Lei Zhang, Chang Liu, Mengxue Zhao, Xiaoqing Zhan, Ling Li, Xi Luo and Zhengzhi Feng in International Journal of Social Psychiatry

Social anxiety and depression symptoms in Chinese left-behind children after the lifting of COVID-19 lockdown: A network analysis

Kuiliang Li, Lei Ren, Lei Zhang, Chang Liu, Mengxue Zhao, Xiaoqing Zhan, Ling Li, Xi Luo & Zhengzhi Feng
Background:Returning to social life after the lifting of COVID-19 lockdown may increase risk of social anxiety, which is highly co-morbid with depression. However, few studies have reported the association between them.Aims:To explore the complex relationship between social anxiety and depression symptoms in left-behind children after the lifting of the COVID-19 lockdown.Methods:A cross-sectional survey was conducted 6 months after the lockdown removal. A total of 3,107 left-behind children completed the survey with a mean age of...

sj-pdf-1-jva-10.1177_11297298221131395 – Supplemental material for Venipuncture-related traumatic neuroma of the ulnar nerve on the dorsal of a hand: A case report

Yidan Chen, Linfang Zhao & Chang Liu
Supplemental material, sj-pdf-1-jva-10.1177_11297298221131395 for Venipuncture-related traumatic neuroma of the ulnar nerve on the dorsal of a hand: A case report by Yidan Chen, Linfang Zhao and Chang Liu in The Journal of Vascular Access

Propagating spatio-temporal activity patterns across macaque motor cortex carry kinematic information

Nicholas Hatsopoulos, Wei Liang, Karthikeyan Balasubramanian & Vasileios Papadourakis
Propagating spatio-temporal neural patterns are widely evident across sensory, motor and association cortical areas. However, it remains unclear whether any characteristics of neural propagation carry information about specific behavioral details. Here, we provide the first evidence for a link between the direction of cortical propagation and specific behavioral features of an upcoming movement on a trial-by-trial basis. We recorded local field potentials (LFPs) from multi-electrode arrays implanted in the primary motor cortex of two rhesus...

Profiling the transcriptomic signatures and identifying the patterns of zygotic genome activation – a comparative analysis between early porcine embryos and their counterparts in other three mammalian species

Yanhui Zhai, Hao Yu, Xinglan An, Zhiren Zhang, Meng Zhang, Sheng Zhang, Qi Li & Ziyi Li
Abstract Background The transcriptional changes around zygotic genome activation (ZGA) in preimplantation embryos are critical for studying mechanisms of embryonic developmental arrest and searching for key transcription factors. However, studies on the transcription profile of porcine ZGA are limited. Results In this study, we performed RNA sequencing in porcine in vivo developed (IVV) and somatic cell nuclear transfer (SCNT) embryo at different stages and compared the transcriptional activity of porcine embryos with mouse, bovine and...

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