Additional file 6: Figure S4. Probability of target attainment for different levels of renal function with a cefoxitin dose of 6g/day.

Additional file 2: Supplemental Text.

Additional file 1. Verbatims from qualitative interviews with study participants.

Additional file 1. Verbatims from qualitative interviews with study participants.

Additional file 1: Supp Figure 1. MRI scans of two APP duplication carriers showing deep microbleeds (orange arrows). A: EXT_814 carrying a 5.7Mb duplication and B: EXT_1516 carrying a 0.95Mb duplication.

Abstract Background Postoperative atrial fibrillation (PoAF) after cardiac surgery has a high incidence of 30%, but its management is controversial. Two strategies are recommended without evidence of a superiority of one against the other: rate control with beta-blocker or rhythm control with amiodarone. Landiolol is a new-generation beta-blocker with fast onset and short half-life. One retrospective, single-center study compared landiolol to amiodarone for PoAF after cardiac surgery with a better hemodynamic stability and a higher...

Additional file 1. SPIRIT Checklist.

Additional file 3. Protocol use of landiolol and bisoprolol.

Additional file 3. Protocol use of landiolol and bisoprolol.

Additional file 1: Table S1. Characteristics and outcome of patients presenting with cefoxitin-susceptible-ESBL-PE infections admitted in the ICU during the study period.

Additional file 5: Figure S3. Probability of target attainment for various cefoxitin doses in patients with CCRIBW = 100 ml/min.

Additional file 6: Figure S4. Probability of target attainment for different levels of renal function with a cefoxitin dose of 6g/day.

Additional file 1: Table S1. Postoperative data related to pain and mobilization in patients operated on under general anesthesia.

Additional file 2: Supplementary Table S2. The principal component analysis of the qualitative food frequency questionnaire using the Varimax rotation.

Additional file 6: Supplementary Table S6. Baseline characteristics of the employees by indicators of atypical working hours in women between 2012-2017.

Additional file 1: Figures and Tables.

Additional file 2: Supplemental Text.

Abstract Background Dexamethasone is recommended for COVID-19 patients who require oxygen therapy. However, its effectiveness in reducing mortality and intubation, and its safety, remain debated. We aimed to investigate whether dexamethasone reduces day-28 mortality in unselected patients with critical COVID-19. Methods We performed an observational cohort study in consecutive COVID-19 patients admitted to any of 13 French intensive care units (ICUs) in 2020. The primary objective was to determine whether early dexamethasone therapy was associated...

Additional file 1: Appendix S1. List of the 13 participating intensive care units in France. Appendix S2. Supplementary Methods. Table S1. Multivariable analysis to identify factors associated with day-28 mortality. Table S2. Univariate analysis to identify factors associated with day-28 mortality among the 3 groups of patients (Early steroids, late steroids, and no steroids). e-Table S3. Multivariable analysis to identify factors associated with day-28 mortality among the 3 groups of patients (Early steroids, late steroids,...

Additional file 2: Figure S2. Flow chart

Additional file 4: Table S1. Procalcitonin serum levels and its evolution with or without adequate beta-lactam concentrations. Table S2. Beta lactam regimen and concentrations.

Additional file 1. Supplementary tables and figures.

Abstract Background In patients on mechanical ventilation, positive end-expiratory pressure (PEEP) can decrease cardiac output through a decrease in cardiac preload and/or an increase in right ventricular afterload. Increase in central blood volume by fluid administration or passive leg raising (PLR) may reverse these phenomena through an increase in cardiac preload and/or a reopening of closed lung microvessels. We hypothesized that a transient decrease in PEEP (PEEP-test) may be used as a test to detect...

BackgroundEarly detection can prevent the initial stages of fibrosis from progressing to cirrhosis.PurposeTo evaluate an algorithm combining three echographic indicators and elastographic measurements to screen for hepatic fibrosis in an unselected population.Material and MethodsFrom May 2017 to June 2018, all patients with no history and no known chronic liver disease who were referred for an ultrasound (US) were prospectively included in eight hospitals. The indicators being sought were liver surface irregularity, demodulation of hepatic veins,...

BackgroundEarly detection can prevent the initial stages of fibrosis from progressing to cirrhosis.PurposeTo evaluate an algorithm combining three echographic indicators and elastographic measurements to screen for hepatic fibrosis in an unselected population.Material and MethodsFrom May 2017 to June 2018, all patients with no history and no known chronic liver disease who were referred for an ultrasound (US) were prospectively included in eight hospitals. The indicators being sought were liver surface irregularity, demodulation of hepatic veins,...