7 Works

Data from: Occam's Razor in sensorimotor learning

Tim Genewein & Daniel A. Braun
A large number of recent studies suggest that the sensorimotor system employs probabilistic models to predict its environment and makes inferences about unobserved variables in line with Bayesian statistics. One of the important features of Bayesian statistics is Occam's Razor - an inbuilt preference for simpler models when comparing competing models that explain some observed data equally well. Here we test directly for Occam's Razor in sensorimotor control. We designed a sensorimotor task, where participants...

Data from: Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs

Hamid R. Noori, Lewis H. Mervin, Vahid Bokharaie, Özlem Durmus, Lisamon Egenrieder, Stefan Fritze, Britta Gruhlke, Guilia Reinhardt, Hans-Hendrik Schabel, Sabine Staudenmaier, Nikos K. Logothetis, Andreas Bender & Rainer Spanagel
Neuropsychiatric disorders are the third leading cause of global disease burden. Current pharmacological treatment for these disorders is inadequate, with often insufficient efficacy and undesirable side effects. One reason for this is that the links between molecular drug action and neurobehavioral drug effects are elusive. We use a big data approach from the neurotransmitter response patterns of 258 different neuropsychiatric drugs in rats to address this question. Data from experiments comprising 110,674 rats are presented...

Data from: Macaque monkeys perceive the flash lag illusion

Manivannan Subramaniyan, Alexander S. Ecker, Philipp Berens & Andreas S. Tolias
Transmission of neural signals in the brain takes time due to the slow biological mechanisms that mediate it. During such delays, the position of moving objects can change substantially. The brain could use statistical regularities in the natural world to compensate neural delays and represent moving stimuli closer to real time. This possibility has been explored in the context of the flash lag illusion, where a briefly flashed stimulus in alignment with a moving one...

Data from: Development of visual cortical function in infant macaques: a BOLD fMRI study

Tom Van Grootel, Alan Meeson, Matthias H.J. Munk, Zoe Kourtzi, J. Anthony Movshon, Nikos K. Logothetis, Lynne Kiorpes & Tom J. Van Grootel
Functional brain development is not well understood. In the visual system, neurophysiological studies in nonhuman primates show quite mature neuronal properties near birth although visual function is itself quite immature and continues to develop over many months or years after birth. Our goal was to assess the relative development of two main visual processing streams, dorsal and ventral, using BOLD fMRI in an attempt to understand the global mechanisms that support the maturation of visual...

Data from: Alcohol reduces muscle fatigue through atomistic interactions with nicotinic receptors

Hamid R. Noori, Christian Mücksch, Valentina Vengeliene, Kai Schönig, Tatiane T. Takahashi, Nuriya Mukhtasimova, Maryam Bagher Oskouei, Matias Mosqueira, Dusan Bartsch, Rainer Fink, Herbert M. Urbassek, Rainer Spanagel & Steven M. Sine
Alcohol consumption affects many organs and tissues, including skeletal muscle. However, the molecular mechanism of ethanol action on skeletal muscle remains unclear. Here, using molecular dynamics simulations and single channel recordings, we show that ethanol interacts with a negatively charged amino acid within an extracellular region of the neuromuscular nicotinic acetylcholine receptor (nAChR), thereby altering its global conformation and reducing the single channel current amplitude. Charge reversal of the negatively charged amino acid abolishes the...

Data from: Faster processing of moving compared to flashed bars in awake macaque V1 provides a neural correlate of the flash lag illusion

Manivannan Subramaniyan, Alexander S. Ecker, Saumil S. Patel, R. James Cotton, Matthias Bethge, Xaq Pitkow, Philipp Berens & Andreas S. Tolias
When the brain has determined the position of a moving object, due to anatomical and processing delays, the object will have already moved to a new location. Given the statistical regularities present in natural motion, the brain may have acquired compensatory mechanisms to minimize the mismatch between the perceived and the real position of moving objects. A well-known visual illusion — the flash lag effect — points towards such a possibility. Although many psychophysical models...

Data from: Ultra-slow oscillations in fMRI and resting-state connectivity: Neuronal and vascular contributions and technical confounds

Kevin Turner, Patrick Drew, Céline Matéo, David Kleinfeld & Yu Xin
Ultra-slow, ~0.1-Hz variations in the oxygenation level of brain blood are widely used as an fMRI-based surrogate of ‘‘resting-state’’ neuronal activity. The temporal correlations among these fluctuations across the brain are interpreted as ‘‘functional connections’’ for maps and neurological diagnostics. Ultra-slow variations in oxygenation follow a cascade. First, they closely track changes in arteriole diameter. Second, interpretable functional connections arise when the ultra-slow changes in amplitude of g-band neuronal oscillations, which are shared across even...

Registration Year

  • 2021
    1
  • 2019
    1
  • 2018
    2
  • 2017
    1
  • 2014
    1
  • 2013
    1

Resource Types

  • Dataset
    7

Affiliations

  • Max Planck Institute for Biological Cybernetics
    7
  • Rice University
    2
  • University of Cambridge
    2
  • University of Tübingen
    2
  • University of Pennsylvania
    1
  • University of California, San Diego
    1
  • New York University
    1
  • Central Institute of Mental Health
    1
  • Baylor College of Medicine
    1
  • Mayo Clinic
    1