29 Works

ETHICAL: Ethnic Disparities In COVID-19 Admissions in east London

Yize Wan

Data from: Validation of serum neurofilaments as prognostic & potential pharmacodynamic biomarkers for ALS

Michael Benatar, Lanyu Zhang, Lily Wang, Volkan Granit, Jeffrey Statland, Richard Barohn, Andrea Swenson, John Ravitz, Carlayne Jackson, Ted Burns, Jaya Trivedi, Erik Pioro, James Caress, Jonathan Katz, Jacob McCauley, Rosa Rademakers, Andrea Malaspina, Lyle Ostrow & Joanne Wuu
Objective. Identify preferred neurofilament assays, and clinically validate serum NfL and pNfH as prognostic and potential pharmacodynamic biomarkers relevant to ALS therapy development. Methods. Prospective, multi-center, longitudinal observational study of patients with ALS (n=229), primary lateral sclerosis (PLS, n=20) and progressive muscular atrophy (PMA, n=11). Biological specimens were collected, processed and stored according to strict standard operating procedures (SOPs) 1. Neurofilament assays were performed in a blinded manner by independent contract research organizations (CROs). Results....

Teaching and learning in ecology: a horizon scan of emerging challenges and solutions

Zenobia Lewis, Julia Cooke, Yoseph Araya, Karen Bacon, Joanna Bagniewska, Lesley Batty, Tom Bishop, Moya Burns, Magda Charalambous, David Daversa, Liam Dougherty, Miranda Dyson, Adam Fisher, Dan Forman, Cristina Garcia, Ewan Harney, Thomas Hesselberg, Elizabeth John, Robert Knell, Kadmiel Maseyk, Alice Mauchline, Julie Peacock, Angelo Pernetto, Jeremy Pritchard, William Sutherland … & Nicholas Worsfold
We currently face significant, anthropogenic, global environmental challenges and therole of ecologists in mitigating these challenges is arguably more important than ever. Consequently there is an urgent need to recruit and train future generations of ecologists, both those whose main area is ecology, but also those involved in the geological, biological and environmental sciences. Here we present the results of a horizon scanning exercise that identified current and future challenges facing the teaching of ecology,...

Data from: Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study

Lina Cai, Eleanor Wheeler, Nicola D. Kerrison, Jian'an Luan, Panos Deloukas, Paul W. Franks, Pilar Amiano, Eva Ardanaz, Catalina Bonet, Guy Fagherazzi, Leif C. Groop, Rudolf Kaaks, José María Huerta, Giovanna Masala, Peter M. Nilsson, Kim Overvad, Valeria Pala, Salvatore Panico, Miguel Rodriguez-Barranco, Olov Rolandsson, Carlotta Sacerdote, Matthias B. Schulze, Annemieke M.W. Spijkeman, Anne Tjonneland, Rosario Tumino … & Nicholas J. Wareham
Type 2 diabetes (T2D) is a global public health challenge. Whilst the advent of genome-wide association studies has identified >400 genetic variants associated with T2D, our understanding of its biological mechanisms and translational insights is still limited. The EPIC-InterAct project, centred in 8 countries in the European Prospective Investigations into Cancer and Nutrition study, is one of the largest prospective studies of T2D. Established as a nested case-cohort study to investigate the interplay between genetic...

CORSMAL Containers Manipulation

Alessio Xompero, Ricardo Sanchez-Matilla, Riccardo Mazzon & Andrea Cavallaro

Estimated surgical requirements in England after COVID-19: a modelling study using hospital episode statistics

Yize Wan

International Surgical Outcomes Study (ISOS) sub-study: post-operative infection (Statistical Analysis Plan)

Yize Wan

Fish mock community with 41 species from 13 orders

Jose Sergio Hleap, Joanne E. Littlefair, Dirk Steinke, Paul D. N. Hebert & Melania E. Cristescu
Tissue extracts of 41 North American fish species were obtained from the Ministère des Forêts, de la Faune et des Parcs (Québec). The selected species were chosen to represent a diversity of families within the Actinopterygii, and to include some species known to be present at the Experimental Lakes Area. Muscle or fin tissue was extracted using Qiagen Blood and Tissue kits and equimolarised to 15ng/µl. Library preparation and next-generation sequencing (NGS) was performed by...

A Statistical Analysis Plan: Validity of ROX index for Nasal High Flow Therapy in Critical Care Patients, including those with hypercapnic respiratory failure

Robbins Alex

The Populist Politics of Foreign Policy

Toby Greene

Data from: Does rapid glacial recession affect feeding habits of alpine stream insects?

Mirela Sertić Perić, Jens M. Nielsen, Carsten J. Schubert & Christopher T. Robinson
1. Glacial retreat, accompanied by shifts in riparian vegetation and glacier meltwater inputs, alters the energy supply and trophic structure of alpine stream food webs. Our goal in this study was to enhance understanding of dietary niches of macroinvertebrates inhabiting different alpine streams with contrasting glacial and non-glacial (groundwater, precipitation, snowmelt) water inputs in conjunction with seasonal and habitat-specific variation in basal resource availability. 2. We measured a range of stream physico-chemical attributes as well...

Foraging shifts and visual preadaptation in ecologically diverse bats

Kalina T. J. Davies, Laurel R. Yohe, Jesus Almonte, Miluska K. R. Sánchez, Edgardo M. Rengifo, Elizabeth R. Dumont, Karen E. Sears, Liliana M. Dávalos & Stephen J. Rossiter
Changes in behaviour may initiate shifts to new adaptive zones, with physical adaptations for novel environments evolving later. While new mutations are commonly considered engines of adaptive change, sensory evolution enabling access to new resources might also arise from standing genetic diversity, and even gene loss. We examine the relative contribution of molecular adaptations, measured by positive and relaxed selection, acting on eye expressed genes associated with shifts to new adaptive zones in ecologically diverse...

Dire wolves were the last of an ancient New World canid lineage

Laurent Frantz & Ardern Hulme-Beaman
Dire wolves are considered one of the most common and widespread large carnivores in Pleistocene America, yet relatively little is known about their evolution or extinction. To reconstruct the evolutionary history of dire wolves, we sequenced five genomes from sub-fossil bones dating from 13,000 to over 50,000 years ago. Our results indicate that though they were similar morphologically to the extant gray wolf, dire wolves were a highly divergent lineage that split from living canids...

Population genetic structure of the insular Ryukyu flying fox Pteropus dasymallus

Shiang-Fan Chen, Chung-Hao Juan, Stephen J. Rossiter, Teruo Kinjo, Dai Fukui, Kuniko Kawai, Susan M. Tsang, Maria Josefa Veluz, Hiroko Sakurai, Hua-Ching Lin, Nian-Hong Jang-Liaw, Keiko Osawa, Wen-Ya Ko & Masako Izawa
Small isolated populations are vulnerable to both stochastic events and the negative consequences of genetic drift. For threatened species, the genetic management of such populations has therefore become a crucial aspect of conservation. Flying foxes (Pteropus spp, Chiroptera) are keystone species with essential roles in pollination and seed dispersal in tropical and subtropical ecosystems. However, many flying fox species are also threatened, having experienced dramatic population declines driven by habitat loss and hunting. The insular...

Thermal stratification and fish thermal preference explain vertical eDNA distributions in lakes

Joanne Littlefair, Lee Hrenchuk, Paul Blanchfield, Michael Rennie & Melania Cristescu
Significant advances have been made towards surveying animal and plant communities using DNA isolated from environmental samples. Despite rapid progress, we lack a comprehensive understanding of the “ecology” of environmental DNA (eDNA), particularly its temporal and spatial distribution and how this is shaped by abiotic and biotic processes. Here, we tested how seasonal variation in thermal stratification and animal habitat preferences influence the distribution of eDNA in lakes. We sampled eDNA depth profiles of five...

Diffusion segregation and the disproportionate incidence of COVID-19 in African American communities

Vincenzo Nicosia, Aleix Bassolas & Sandro Sousa
Each network corresponds to a metropolitan area, where nodes represent census tracts. For each tract we report information about the number of people belonging to each of the seven high-level ethnic groups defined in the US Census. Physical adjacency networks are undirected and unweighted, and an edge between two tracts A and B indicates that A and B are bordering each other. Commuting flow graphs are undirected and weighted, and the weight of an the...

Data from: Phenotypic responses to temperature in the ciliate Tetrahymena thermophila

Vanessa Weber De Melo, Robert Lowe, Paul J. Hurd & Owen L. Petchey
Understanding the effects of temperature on ecological and evolutionary processes is crucial for generating future climate adaptation scenarios. Using experimental evolution, we evolved the model ciliate Tetrahymena thermophila in an initially novel high temperature environment for more than 35 generations, closely monitoring population dynamics and morphological changes. We observed initially long lag phases in the high temperature environment that over about 26 generations reduced to no lag phase, a strong reduction in cell size and...

Data from: A randomized, placebo-controlled phase 2 trial of laquinimod in primary progressive multiple sclerosis

Gavin Giovannoni, Volker Knappertz, Joshua R. Steinerman, Aaron P. Tansy, Thomas Li, Stephen Krieger, Antonio Uccelli, Bernard M. J. Uitdehaag, Xavier Montalban, Hans-Peter Hartung, Maria Pia Sormani, Bruce A. C. Cree, Fred Lublin & Frederik Barkhof
Objective: To evaluate efficacy, safety, and tolerability of laquinimod in patients with primary progressive multiple sclerosis (PPMS). Methods: In the randomized, double-blind, placebo-controlled, phase 2 study ARPEGGIO (A Randomized Placebo-controlled trial Evaluating laquinimod in PPMS, Gauging Gradations In MRI and clinical Outcomes), eligible PPMS patients were randomized 1:1:1 to receive once-daily oral laquinimod 0.6 mg or 1.5 mg or matching placebo. Percentage brain volume change (PBVC; primary endpoint) from baseline to week 48 was assessed...

Data from: The evolution of competitive ability for essential resources

Joey R. Bernhardt, Pavel Kratina, Aaron Pereira, Manu Tamminen, Mridul K. Thomas & Anita Narwani
Competition for limiting resources is among the most fundamental ecological interactions and has long been considered a key driver of species coexistence and biodiversity. Species' minimum resource requirements, their R*s, are key traits that link individual physiological demands to the outcome of competition. However, a major question remains unanswered - to what extent are species’ competitive traits able to evolve in response to resource limitation? To address this knowledge gap, we performed an evolution experiment...

Urea-to-creatinine ratio trajectories in multi-organ failure: a reanalysis of the REDOXS trial statistical analysis plan

Ryan Haines

Socioeconomic deprivation and surgical outcomes: ISOS and VISION-UK sub-study (Statistical Analysis Plan)

Yize Wan

Trophic resource partitioning drives fine-scale coexistence in cryptic bat species

Orly Razgour, Roberto Novella-Fernandez, Carlos Ibáñez, Javier Juste, Beth Clare & C. Patrick Doncaster
Understanding the processes that enable species coexistence has important implications for assessing how ecological systems will respond to global change. Morphology and functional similarity increase the potential for competition, and therefore, co-occurring morphologically similar but genetically unique species are a good model system for testing coexistence mechanisms. We used DNA metabarcoding and High Throughput Sequencing to characterise for the first time the trophic ecology of two recently-described cryptic bat species with parapatric ranges, Myotis escalerai...

Asymmetric contextual effects in age perception dataset

Deema Awad
Perception is context dependent. For example, the perceived orientation of a bar changes depending on the presence of oriented bars around it. Contextual effects have also been demonstrated for more complex judgements, such as facial attractiveness or expression, although it remains unclear how these contextual facial effects depend on the types of faces surrounding the target face.To examine this, we measured the perceived age (a quantifiable measure) of a target face in the presence of...

Supplementary Material for thesis ‘Instruments and access: The role of instruments in music and disability’

Jacob Harrison

CORSMAL Containers

Alessio Xompero, Ricardo Sanchez-Matilla, Riccardo Mazzon & Andrea Cavallaro

Registration Year

  • 2020
    29

Resource Types

  • Dataset
    23
  • Data Paper
    5
  • Audiovisual
    1

Affiliations

  • Queen Mary University of London
    29
  • University of Oxford
    3
  • Swiss Federal Institute of Aquatic Science and Technology
    2
  • University of Cambridge
    2
  • McGill University
    2
  • University of Southampton
    2
  • University of Exeter
    2
  • Imperial College London
    2
  • University of Liverpool
    2
  • University of Bristol
    2