555 Works

Development of naringenin-O-alkylamine derivatives as multifunctional agents for the treatment of Alzheimer’s disease

Jing Yang, Yi Zhou, Yujuan Ban, Jing Mi, Ying He, Xinjuan Li, Zhengwei Liu, Keren Wang, Gaofeng Zhu, Wenmin Liu, Zhenghuai Tan & Zhipei Sang
In this study, a series of naringenin-O-alkylamine derivatives were designed and obtained by introducing an alkylamine fragment into the naringenin skeleton. The in vitro biological activity results revealed that compounds 5f and 7k showed good antioxidant activity with ORAC values of 2.3eq and 1.2eq, respectively. Compounds 5f and 7k were reversible and excellent huAChE inhibitors with IC50 values of 0.91 μM and 0.57 μM, respectively. Moreover, compounds 5f and 7k could inhibit self-induced Aβ1–42 aggregation...

The motivations of older adult peer-volunteers: a scoping review protocol

Helena Bilsborough, Chris Todd & Helen Hawley-Hague
A protocol for a scoping review summarising the motivations of older adults who are peer-volunteers within community-based settings, particularly within schemes that focus upon physical activity.

After The Music

Carlyn Murray, Hannah Guest, Chris Plack & Garreth Prendergast
Prolonged exposure to sounds at high levels causes temporary auditory shifts: reductions in outer-hair-cell function and elevations in audiometric thresholds that typically return to baseline in the hours or days following exposure. The degree of auditory shift is variable, seemingly depending not only on level and duration of exposure but other factors. One factor may be the degree of long-term "conditioning" noise exposure experienced by the individual, which may "toughen up" their ears and reduce...

The robots have landed! An introduction to robotic process automation (RPA) in our library

Ian Gifford
During this session we will look at what RPA is and why it’s nothing to be afraid of. We will share examples of how we are currently using it and explore ideas for how it could be used to further support different teams across the Library.

Human teratogens and their impact on the developing brain: a scoping review

Matthew Bluett-Duncan & Rebecca Bromley
The impact of certain medication exposures in utero can be observed in the physical development of the fetus (e.g. patterns of congenital malformations or dysmorphic features) or in the form of growth disruption. Developmental trajectories within the fetal brain can also be susceptible to alteration and can manifest as lifelong neurodevelopmental impairments. Despite growing recognition of its importance as an outcome, a lack of coherence within the investigation of the neurodevelopmental outcomes remains. Important methodological...

Design, synthesis, and evaluation of novel O-alkyl ferulamide derivatives as multifunctional ligands for treating Alzheimer’s disease

Gaofeng Zhu, Ping Bai, Keren Wang, Jing Mi, Jing Yang, Jiaqi Hu, Yujuan Ban, Ran Xu, Rui Chen, Changning Wang, Lei Tang & Zhipei Sang
Herein, a series of novel O-alkyl ferulamide derivatives were designed and synthesised through the multi-target-directed ligands (MTDLs) strategy. The biological activities in vitro showed that compounds 5a, 5d, 5e, 5f, and 5h indicated significantly selective MAO-B inhibitory potency (IC50 = 0.32, 0.56, 0.54, 0.73, and 0.86 μM, respectively) and moderate antioxidant activity. Moreover, compounds 5a, 5d, 5e, 5f, and 5h showed potent anti-inflammatory properties, remarkable effects on self-induced Aβ1-42 aggregation, and potent neuroprotective effect on...

Understanding suicidal thoughts and behaviours using common assessment measures: views of women and healthcare professionals

Kerry Hozhabrafkan
Two qualitative studies will be carried out, exploring communication about suicidal experiences in the perinatal period. The research aims specifically to investigate the use of brief, suicide questionnaire measures with women in this population. Participants will be asked to complete a selection of measures and will be interviewed about the process of doing so. In addition to understanding the appropriateness and acceptability of this method of assessing suicidality, the research also aims to understand how...

The Role of Secondary Memory in the Reading Span Task

Freya Amsbury & Antje Heinrich
Reading Span Tasks (RSTs) are used commonly within speech perception research as measures of working memory (WM). Following Baddeley and Hitch (1974), WM consists of storage components for the different modalities, also collectively known as short-term memory, and a processing component called central executive (CE). However, examining the RST as a psychologist, it seems likely it also relies on (and is therefore also a test of) long-term memory (LTM), or secondary memory (SM). Additionally, different...

BC-PREDICT Technical Report final.docx

Andrew Jerrison & Matthew Machin
This report describes the software implementation for the BC-PREDICT project. It is designed to be read in conjunction with the source code of the PROCAS2 Collator software published on the University of Manchester’s FigShare site. It is a record of the software and procedures created by Research IT and used in the BC-PREDICT project. It also records how the software interacts with other 3rd party supplied software.
The report also highlights areas that were...

BC-PREDICT Technical Report final.docx

Andrew Jerrison & Matthew Machin
This report describes the software implementation for the BC-PREDICT project. It is designed to be read in conjunction with the source code of the PROCAS2 Collator software published on the University of Manchester’s FigShare site. It is a record of the software and procedures created by Research IT and used in the BC-PREDICT project. It also records how the software interacts with other 3rd party supplied software.
The report also highlights areas that were...

A CT-based nomogram for differentiating invasive fungal disease of the lung from bacterial pneumonia

Meilin Gong, Jingmei Xu, Kang Li, Ke Li, Yuwei Xia, Yang Jing, Jiafei Chen, Jing Li, Jing Yang, Mingshan Du, Wenjing Hou, Yuan Ou, Lian Li & Wei Chen
Abstract Background There is an annual increase in the incidence of invasive fungal disease (IFD) of the lung worldwide, but it is always a challenge for physicians to make an early diagnosis of IFD of the lung. Computed tomography (CT) may play a certain role in the diagnosis of IFD of the lung, however, there are no specific imaging signs for differentiating IFD of lung from bacterial pneumonia (BP). Methods A total of 214 patients...

SEM - Zeiss EVO 50 II

James Bird
Confirmation that morphology of dropcast MXene suspension (product) and sediment components align with XRD findings using EDX

UV-Visible Spectroscopy for concentration calculation

James Bird
Establish a calibration curve of Ti3C2 MXene for UV-Visible spectroscopy

XRD analysis of dropcast MXene and MAX phase/MXene suspensions - PANalytical X'Pert Pro I

James R.T. Bird
Run typical, coupled θ:2θ scans of dropcast MXene synthesis product and sediment to confirm successful synthesis and monitor sample oxidation

Additional file 3 of Developing principles for sharing information about potential trial intervention benefits and harms with patients: report of a modified Delphi survey

Martina Svobodova, Nina Jacob, Kerry Hood, Katie Gillies, Rachel Hale, Jennifer Bostock, Peter Bower, Adrian Edwards, Penelope Farthing, Sarah Rawlinson, Shaun Treweek & Jeremy Howick
Additional file 3. Full round 1 results.

Additional file 4 of Developing principles for sharing information about potential trial intervention benefits and harms with patients: report of a modified Delphi survey

Martina Svobodova, Nina Jacob, Kerry Hood, Katie Gillies, Rachel Hale, Jennifer Bostock, Peter Bower, Adrian Edwards, Penelope Farthing, Sarah Rawlinson, Shaun Treweek & Jeremy Howick
Additional file 4. Summary round 1 results.

Additional file 5 of Developing principles for sharing information about potential trial intervention benefits and harms with patients: report of a modified Delphi survey

Martina Svobodova, Nina Jacob, Kerry Hood, Katie Gillies, Rachel Hale, Jennifer Bostock, Peter Bower, Adrian Edwards, Penelope Farthing, Sarah Rawlinson, Shaun Treweek & Jeremy Howick
Additional file 5. Full round 2 results.

Additional file 7 of Developing principles for sharing information about potential trial intervention benefits and harms with patients: report of a modified Delphi survey

Martina Svobodova, Nina Jacob, Kerry Hood, Katie Gillies, Rachel Hale, Jennifer Bostock, Peter Bower, Adrian Edwards, Penelope Farthing, Sarah Rawlinson, Shaun Treweek & Jeremy Howick
Additional file 7. Round 1 & 2 free-text comments.

Additional file 8 of Developing principles for sharing information about potential trial intervention benefits and harms with patients: report of a modified Delphi survey

Martina Svobodova, Nina Jacob, Kerry Hood, Katie Gillies, Rachel Hale, Jennifer Bostock, Peter Bower, Adrian Edwards, Penelope Farthing, Sarah Rawlinson, Shaun Treweek & Jeremy Howick
Additional file 8. Round 1 free-text comments.

Additional file 1 of Does United Kingdom parliamentary attention follow social media posts?

John Bollenbacher, Niklas Loynes & John Bryden
Supplementary information (PDF 53 kB)

SetaramSetasysEvolutionTGAInert_Ti3C2

James Bird
TGA analyses collected in argon atmosphere, 5K/min heating rate to 1000C of Ti3C2.

Additional file 1 of Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Pål Møller, Toni Seppälä, James G. Dowty, Saskia Haupt, Mev Dominguez-Valentin, Lone Sunde, Inge Bernstein, Christoph Engel, Stefan Aretz, Maartje Nielsen, Gabriel Capella, Dafydd Gareth Evans, John Burn, Elke Holinski-Feder, Lucio Bertario, Bernardo Bonanni, Annika Lindblom, Zohar Levi, Finlay Macrae, Ingrid Winship, John-Paul Plazzer, Rolf Sijmons, Luigi Laghi, Adriana Della Valle, Karl Heinimann … & Mark A. Jenkins
Additional file 1.

Additional file 1 of Adherence to metformin in adults with type 2 diabetes: a combined method approach

Nadia Farhanah Syafhan, Rosemary Donnelly, Roy Harper, Janet Harding, Ciara Mulligan, Anita Hogg, Michael Scott, Glenda Fleming, Claire Scullin, Ahmed F. Hawwa, Gaoyun Chen, Carole Parsons & James C. McElnay
Additional file 1: Fig. S1. Example of simulated metformin concentrations derived from PopPK model for patient aged 76 years old with lean body weight 47 kg and serum creatinine level 124 µmol/L who was receiving an immediate-release formulation of metformin at a dose of 1 g twice daily.

DEM: Shear zones 4. Deformation on a material with inclusions: The effect of shear zone width

Emma Finch
These experiments investigate the effect of the width of a localisation zone for failure on shear deformation between two constraining plates using a discrete element method. The media is 400x35 units, containing 43,565 circular elements with varying radii between 0.25 and 0.5 unit. It has circular boundary conditions so that an element on a boundary in x experiences a force from elements on the opposing boundary and considers them to be neighbouring elements. The media...

SEM - FEI Quanta 200 II

James R.T. Bird
Obtain micrographs to reassess vacuum oven-dried Ti3C2 film homogeneity with a combination of backscatter and secondary electron detection

Registration Year

  • 2022
    555

Resource Types

  • Text
    190
  • Dataset
    156
  • Collection
    112
  • Audiovisual
    40
  • Image
    34
  • Other
    17
  • Software
    5
  • Journal Article
    1

Affiliations

  • University of Manchester
    555
  • Shanghai Jiao Tong University
    109
  • Huazhong Agricultural University
    109
  • Sichuan University
    103
  • Harbin Medical University
    103
  • Air Force Medical University
    99
  • Chongqing University
    99
  • Renmin Hospital of Wuhan University
    99
  • Jiangsu Province Hospital
    99
  • Zhengzhou University
    99