24 Works

Prolonged cardiac monitoring for stroke prevention: A systematic review and meta-analysis of randomized-controlled clinical trials

Georgios Tsivgoulis, Lina Palaiodimou, Sokratis Triantafyllou, Martin Köhrmann, Polychronis Dilaveris, Konstantinos Tsioufis, Gkikas Magiorkinis, Christos Krogias, Peter D Schellinger, Valeria Caso, Maurizio Paciaroni, Mukul Sharma, Robin Lemmens, David J Gladstone, Tommaso Sanna, Rolf Wachter, Gerasimos Filippatos & Aristeidis H Katsanos
Introduction:Prolonged cardiac monitoring (PCM) substantially improves the detection of subclinical atrial fibrillation (AF) among patients with history of ischemic stroke (IS), leading to prompt initiation of anticoagulants. However, whether PCM may lead to IS prevention remains equivocal.Patients and methods:In this systematic review and meta-analysis, randomized-controlled clinical trials (RCTs) reporting IS rates among patients with known cardiovascular risk factors, including but not limited to history of IS, who received PCM for more than 7 days versus...

The role of bone marrow on the mechanical properties of trabecular bone: a systematic review

Fangxing Wang, Florian Metzner, Georg Osterhoff, Leyu Zheng & Stefan Schleifenbaum
Abstract Background Accurate evaluation of the mechanical properties of trabecular bone is important, in which the internal bone marrow plays an important role. The aim of this systematic review is to investigate the roles of bone marrow on the mechanical properties of trabecular bone to better support clinical work and laboratory research. Methods A systematic review of the literature published up to June 2022 regarding the role of bone marrow on the mechanical properties of...

Additional file 1 of The effect of high-polyphenol Mediterranean diet on visceral adiposity: the DIRECT PLUS randomized controlled trial

Hila Zelicha, Nora Kloting, Alon Kaplan, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Yoash Chassidim, Matthias Bluher, Uta Ceglarek, Berend Isermann, Michael Stumvoll, Rita Nana Quayson, Martin von Bergen, Beatrice Engelmann, Ulrike E. Rolle-Kampczyk, Sven-Bastiaan Haange, Kieran M. Tuohy, Camilla Diotallevi, Ilan Shelef, Frank B. Hu, Meir J. Stampfer & Iris Shai
Additional file 1: S1. Adherence to the intervention. S2. Sensitivity analysis. S3. Inclusion and Exclusion criteria. S4. Physical activity recommendations protocol. S5. Polyphenol-rich foods, provided at no cost to participants. S6. Magnetic resonance imaging. S7. Clinical parameters, laboratory methodology, and blood and urine polyphenols assessments. S8. Sample size and power calculations. Fig. S1. DIRECT PLUS flow chart. Fig. S2. Heatmap of abdominal adipose depots and metabolic and cardiovascular parameters at baseline. Fig. S3. The effect...

sj-docx-1-pss-10.1177_09567976221118541 – Supplemental material for Today’s Older Adults Are Cognitively Fitter Than Older Adults Were 20 Years Ago, but When and How They Decline Is No Different Than in the Past

Denis Gerstorf, Nilam Ram, Johanna Drewelies, Sandra Duezel, Peter Eibich, Elisabeth Steinhagen-Thiessen, Stefan Liebig, Jan Goebel, Ilja Demuth, Arno Villringer, Gert G. Wagner, Ulman Lindenberger & Paolo Ghisletta
Supplemental material, sj-docx-1-pss-10.1177_09567976221118541 for Today’s Older Adults Are Cognitively Fitter Than Older Adults Were 20 Years Ago, but When and How They Decline Is No Different Than in the Past by Denis Gerstorf, Nilam Ram, Johanna Drewelies, Sandra Duezel, Peter Eibich, Elisabeth Steinhagen-Thiessen, Stefan Liebig, Jan Goebel, Ilja Demuth, Arno Villringer, Gert G. Wagner, Ulman Lindenberger and Paolo Ghisletta in Psychological Science

Prognostic value of tumor-infiltrating immune cells and immune checkpoints in elderly head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiotherapy

Alexander Rühle, Jovan Todorovic, Simon S. K. Spohn, Eleni Gkika, Christoph Becker, Andreas Knopf, Constantinos Zamboglou, Tanja Sprave, Martin Werner, Anca-Ligia Grosu, Gian Kayser & Nils H. Nicolay
Abstract Background and purpose Tumor-infiltrating lymphocytes (TILs) are associated with locoregional control (LRC) in head-and-neck squamous cell carcinoma (HNSCC) patients undergoing (chemo)radiotherapy. As immunosenescence results in reduced immune activity, the role of TILs in elderly HNSCC patients may differ compared to younger patients, providing a rationale to study the prognostic role of TILs and immune checkpoints (ICs) in this population. Material and methods Sixty-three HNSCC patients aged ≥ 65 years undergoing definitive (chemo)radiotherapy between 2010...

Prolonged cardiac monitoring for stroke prevention: A systematic review and meta-analysis of randomized-controlled clinical trials

Georgios Tsivgoulis, Lina Palaiodimou, Sokratis Triantafyllou, Martin Köhrmann, Polychronis Dilaveris, Konstantinos Tsioufis, Gkikas Magiorkinis, Christos Krogias, Peter D Schellinger, Valeria Caso, Maurizio Paciaroni, Mukul Sharma, Robin Lemmens, David J Gladstone, Tommaso Sanna, Rolf Wachter, Gerasimos Filippatos & Aristeidis H Katsanos
Introduction:Prolonged cardiac monitoring (PCM) substantially improves the detection of subclinical atrial fibrillation (AF) among patients with history of ischemic stroke (IS), leading to prompt initiation of anticoagulants. However, whether PCM may lead to IS prevention remains equivocal.Patients and methods:In this systematic review and meta-analysis, randomized-controlled clinical trials (RCTs) reporting IS rates among patients with known cardiovascular risk factors, including but not limited to history of IS, who received PCM for more than 7 days versus...

The role of bone marrow on the mechanical properties of trabecular bone: a systematic review

Fangxing Wang, Florian Metzner, Georg Osterhoff, Leyu Zheng & Stefan Schleifenbaum
Abstract Background Accurate evaluation of the mechanical properties of trabecular bone is important, in which the internal bone marrow plays an important role. The aim of this systematic review is to investigate the roles of bone marrow on the mechanical properties of trabecular bone to better support clinical work and laboratory research. Methods A systematic review of the literature published up to June 2022 regarding the role of bone marrow on the mechanical properties of...

Data from: Comparison of T2*-weighted and QSM contrasts in Parkinson's disease to visualize the STN with MRI

Anneke Alkemade, Gilles De Hollander, Max C. Keuken, Andreas Schäfer, Derek V.M. Ott, David Weise, Sonja A. Kotz, Birte U. Forstmann & Derek V. M. Ott
The subthalamic nucleus (STN) plays a crucial role in the surgical treatment of Parkinson's disease (PD). Studies investigating optimal protocols for STN visualization using state of the art magnetic resonance imaging (MRI) techniques have shown that susceptibility weighted images, which display the magnetic susceptibility distribution, yield better results than T1-weighted, T2-weighted, and T2*-weighted contrasts. However, these findings are based on young healthy individuals, and require validation in elderly individuals and persons suffering from PD. Using...

The effect of high-polyphenol Mediterranean diet on visceral adiposity: the DIRECT PLUS randomized controlled trial

Hila Zelicha, Nora Kloting, Alon Kaplan, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Yoash Chassidim, Matthias Bluher, Uta Ceglarek, Berend Isermann, Michael Stumvoll, Rita Nana Quayson, Martin von Bergen, Beatrice Engelmann, Ulrike E. Rolle-Kampczyk, Sven-Bastiaan Haange, Kieran M. Tuohy, Camilla Diotallevi, Ilan Shelef, Frank B. Hu, Meir J. Stampfer & Iris Shai
Abstract Background Mediterranean (MED) diet is a rich source of polyphenols, which benefit adiposity by several mechanisms. We explored the effect of the green-MED diet, twice fortified in dietary polyphenols and lower in red/processed meat, on visceral adipose tissue (VAT). Methods In the 18-month Dietary Intervention Randomized Controlled Trial PoLyphenols UnproceSsed (DIRECT-PLUS) weight-loss trial, 294 participants were randomized to (A) healthy dietary guidelines (HDG), (B) MED, or (C) green-MED diets, all combined with physical activity....

sj-docx-1-pss-10.1177_09567976221118541 – Supplemental material for Today’s Older Adults Are Cognitively Fitter Than Older Adults Were 20 Years Ago, but When and How They Decline Is No Different Than in the Past

Denis Gerstorf, Nilam Ram, Johanna Drewelies, Sandra Duezel, Peter Eibich, Elisabeth Steinhagen-Thiessen, Stefan Liebig, Jan Goebel, Ilja Demuth, Arno Villringer, Gert G. Wagner, Ulman Lindenberger & Paolo Ghisletta
Supplemental material, sj-docx-1-pss-10.1177_09567976221118541 for Today’s Older Adults Are Cognitively Fitter Than Older Adults Were 20 Years Ago, but When and How They Decline Is No Different Than in the Past by Denis Gerstorf, Nilam Ram, Johanna Drewelies, Sandra Duezel, Peter Eibich, Elisabeth Steinhagen-Thiessen, Stefan Liebig, Jan Goebel, Ilja Demuth, Arno Villringer, Gert G. Wagner, Ulman Lindenberger and Paolo Ghisletta in Psychological Science

Prognostic value of tumor-infiltrating immune cells and immune checkpoints in elderly head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiotherapy

Alexander Rühle, Jovan Todorovic, Simon S. K. Spohn, Eleni Gkika, Christoph Becker, Andreas Knopf, Constantinos Zamboglou, Tanja Sprave, Martin Werner, Anca-Ligia Grosu, Gian Kayser & Nils H. Nicolay
Abstract Background and purpose Tumor-infiltrating lymphocytes (TILs) are associated with locoregional control (LRC) in head-and-neck squamous cell carcinoma (HNSCC) patients undergoing (chemo)radiotherapy. As immunosenescence results in reduced immune activity, the role of TILs in elderly HNSCC patients may differ compared to younger patients, providing a rationale to study the prognostic role of TILs and immune checkpoints (ICs) in this population. Material and methods Sixty-three HNSCC patients aged ≥ 65 years undergoing definitive (chemo)radiotherapy between 2010...

sj-docx-1-eso-10.1177_23969873221139410 – Supplemental material for Prolonged cardiac monitoring for stroke prevention: A systematic review and meta-analysis of randomized-controlled clinical trials

Georgios Tsivgoulis, Lina Palaiodimou, Sokratis Triantafyllou, Martin Köhrmann, Polychronis Dilaveris, Konstantinos Tsioufis, Gkikas Magiorkinis, Christos Krogias, Peter D Schellinger, Valeria Caso, Maurizio Paciaroni, Mukul Sharma, Robin Lemmens, David J Gladstone, Tommaso Sanna, Rolf Wachter, Gerasimos Filippatos & Aristeidis H Katsanos
Supplemental material, sj-docx-1-eso-10.1177_23969873221139410 for Prolonged cardiac monitoring for stroke prevention: A systematic review and meta-analysis of randomized-controlled clinical trials by Georgios Tsivgoulis, Lina Palaiodimou, Sokratis Triantafyllou, Martin Köhrmann, Polychronis Dilaveris, Konstantinos Tsioufis, Gkikas Magiorkinis, Christos Krogias, Peter D Schellinger, Valeria Caso, Maurizio Paciaroni, Mukul Sharma, Robin Lemmens, David J Gladstone, Tommaso Sanna, Rolf Wachter, Gerasimos Filippatos and Aristeidis H Katsanos in European Stroke Journal

Genomic basis for skin phenotype and cold adaptation in the extinct Steller's sea cow

Diana Le Duc, Akhil Velluva, Molly Cassatt-Johnstone, Remi-Andre Olsen, Sina Baleka, Chen-Ching Lin, Johannes R. Lemke, John R. Southon, Alexander Burdin, Ming-Shan Wang, Sonja Grunewald, Wilfried Rosendahl, Ulrich Joger, Sereina Rutschmann, Thomas B. Hildebrandt, Guido Fritsch, James A. Estes, Janet Kelso, Love Dalén, Michael Hofreiter, Beth Shapiro & Torsten Schöneberg
Steller’s sea cow, an extinct sirenian and one of the largest Quaternary mammals, was described by Georg Steller in 1741 and eradicated by humans within 27 years. Here, we complement Steller’s descriptions with paleogenomic data from 12 individuals. We identified convergent evolution between Steller’s sea cow and cetaceans but not extant sirenians, suggesting a role of several genes in adaptation to cold environments. Among these are inactivations of lipoxygenase genes, which in humans and mouse...

The effect of high-polyphenol Mediterranean diet on visceral adiposity: the DIRECT PLUS randomized controlled trial

Hila Zelicha, Nora Kloting, Alon Kaplan, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Yoash Chassidim, Matthias Bluher, Uta Ceglarek, Berend Isermann, Michael Stumvoll, Rita Nana Quayson, Martin von Bergen, Beatrice Engelmann, Ulrike E. Rolle-Kampczyk, Sven-Bastiaan Haange, Kieran M. Tuohy, Camilla Diotallevi, Ilan Shelef, Frank B. Hu, Meir J. Stampfer & Iris Shai
Abstract Background Mediterranean (MED) diet is a rich source of polyphenols, which benefit adiposity by several mechanisms. We explored the effect of the green-MED diet, twice fortified in dietary polyphenols and lower in red/processed meat, on visceral adipose tissue (VAT). Methods In the 18-month Dietary Intervention Randomized Controlled Trial PoLyphenols UnproceSsed (DIRECT-PLUS) weight-loss trial, 294 participants were randomized to (A) healthy dietary guidelines (HDG), (B) MED, or (C) green-MED diets, all combined with physical activity....

Today’s Older Adults Are Cognitively Fitter Than Older Adults Were 20 Years Ago, but When and How They Decline Is No Different Than in the Past

Denis Gerstorf, Nilam Ram, Johanna Drewelies, Sandra Duezel, Peter Eibich, Elisabeth Steinhagen-Thiessen, Stefan Liebig, Jan Goebel, Ilja Demuth, Arno Villringer, Gert G. Wagner, Ulman Lindenberger & Paolo Ghisletta
History-graded increases in older adults’ levels of cognitive performance are well documented, but little is known about historical shifts in within-person change: cognitive decline and onset of decline. We combined harmonized perceptual-motor speed data from independent samples recruited in 1990 and 2010 to obtain 2,008 age-matched longitudinal observations (M = 78 years, 50% women) from 228 participants in the Berlin Aging Study (BASE) and 583 participants in the Berlin Aging Study II (BASE-II). We used...

Today’s Older Adults Are Cognitively Fitter Than Older Adults Were 20 Years Ago, but When and How They Decline Is No Different Than in the Past

Denis Gerstorf, Nilam Ram, Johanna Drewelies, Sandra Duezel, Peter Eibich, Elisabeth Steinhagen-Thiessen, Stefan Liebig, Jan Goebel, Ilja Demuth, Arno Villringer, Gert G. Wagner, Ulman Lindenberger & Paolo Ghisletta
History-graded increases in older adults’ levels of cognitive performance are well documented, but little is known about historical shifts in within-person change: cognitive decline and onset of decline. We combined harmonized perceptual-motor speed data from independent samples recruited in 1990 and 2010 to obtain 2,008 age-matched longitudinal observations (M = 78 years, 50% women) from 228 participants in the Berlin Aging Study (BASE) and 583 participants in the Berlin Aging Study II (BASE-II). We used...

Additional file 1 of Prognostic value of tumor-infiltrating immune cells and immune checkpoints in elderly head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiotherapy

Alexander Rühle, Jovan Todorovic, Simon S. K. Spohn, Eleni Gkika, Christoph Becker, Andreas Knopf, Constantinos Zamboglou, Tanja Sprave, Martin Werner, Anca-Ligia Grosu, Gian Kayser & Nils H. Nicolay
Additional file 1: Table S1: Details about the antibodies used in the study.

sj-docx-1-eso-10.1177_23969873221139410 – Supplemental material for Prolonged cardiac monitoring for stroke prevention: A systematic review and meta-analysis of randomized-controlled clinical trials

Georgios Tsivgoulis, Lina Palaiodimou, Sokratis Triantafyllou, Martin Köhrmann, Polychronis Dilaveris, Konstantinos Tsioufis, Gkikas Magiorkinis, Christos Krogias, Peter D Schellinger, Valeria Caso, Maurizio Paciaroni, Mukul Sharma, Robin Lemmens, David J Gladstone, Tommaso Sanna, Rolf Wachter, Gerasimos Filippatos & Aristeidis H Katsanos
Supplemental material, sj-docx-1-eso-10.1177_23969873221139410 for Prolonged cardiac monitoring for stroke prevention: A systematic review and meta-analysis of randomized-controlled clinical trials by Georgios Tsivgoulis, Lina Palaiodimou, Sokratis Triantafyllou, Martin Köhrmann, Polychronis Dilaveris, Konstantinos Tsioufis, Gkikas Magiorkinis, Christos Krogias, Peter D Schellinger, Valeria Caso, Maurizio Paciaroni, Mukul Sharma, Robin Lemmens, David J Gladstone, Tommaso Sanna, Rolf Wachter, Gerasimos Filippatos and Aristeidis H Katsanos in European Stroke Journal

Data from: Development and validation of a score to detect paroxysmal atrial fibrillation after stroke

Timo Uphaus, Mark Weber-Krüger, Martin Grond, Gerrit Toenges, Anke Jahn-Eimermacher, Marek Jauss, Paulus Kirchhof, Rolf Wachter & Klaus Gröschel
Objective: Prolonged monitoring times (72h) are recommended to detect paroxysmal atrial fibrillation (pAF) after ischemic stroke, but not yet clinical practice; therefore, an individual patient selection for prolonged ECG monitoring might increase the diagnostic yield of pAF in a resource-saving manner. Methods: We used individual patient data from three prospective studies (ntotal=1556) performing prolonged Holter ECG monitoring (at least 72h) and centralized data evaluation after TIA or stroke in patients with sinus rhythm. Based on...

Qualification and teaching of peer-student tutors in undergraduate medical education: Does it affect the understanding and acquiring of CanMEDS competencies?

Maike Brathuhn, Anja Zimmermann, Cornelia Enzenbach & Daisy Rotzoll
Objective: The Canadian Medical Education Directives for Specialists (CanMEDS), described by scientists of the Royal College of Physicians and Surgeons of Canada, specify the competencies that medical students should acquire during their studies of human medicine. These include the skills of Medical Expert, Communicator, Collaborator, Manager, Professional, Health Advocate and Scholar. We investigated the opinion of former student tutors that are currently active as clinical residents to understand whether they acquired and applied the CanMEDS...

Additional file 1 of The effect of high-polyphenol Mediterranean diet on visceral adiposity: the DIRECT PLUS randomized controlled trial

Hila Zelicha, Nora Kloting, Alon Kaplan, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Yoash Chassidim, Matthias Bluher, Uta Ceglarek, Berend Isermann, Michael Stumvoll, Rita Nana Quayson, Martin von Bergen, Beatrice Engelmann, Ulrike E. Rolle-Kampczyk, Sven-Bastiaan Haange, Kieran M. Tuohy, Camilla Diotallevi, Ilan Shelef, Frank B. Hu, Meir J. Stampfer & Iris Shai
Additional file 1: S1. Adherence to the intervention. S2. Sensitivity analysis. S3. Inclusion and Exclusion criteria. S4. Physical activity recommendations protocol. S5. Polyphenol-rich foods, provided at no cost to participants. S6. Magnetic resonance imaging. S7. Clinical parameters, laboratory methodology, and blood and urine polyphenols assessments. S8. Sample size and power calculations. Fig. S1. DIRECT PLUS flow chart. Fig. S2. Heatmap of abdominal adipose depots and metabolic and cardiovascular parameters at baseline. Fig. S3. The effect...

Additional file 1 of Prognostic value of tumor-infiltrating immune cells and immune checkpoints in elderly head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiotherapy

Alexander Rühle, Jovan Todorovic, Simon S. K. Spohn, Eleni Gkika, Christoph Becker, Andreas Knopf, Constantinos Zamboglou, Tanja Sprave, Martin Werner, Anca-Ligia Grosu, Gian Kayser & Nils H. Nicolay
Additional file 1: Table S1: Details about the antibodies used in the study.

Additional file 1 of The role of bone marrow on the mechanical properties of trabecular bone: a systematic review

Fangxing Wang, Florian Metzner, Georg Osterhoff, Leyu Zheng & Stefan Schleifenbaum
Additional file 1: Table S1. List of excluded literature that did not meet the inclusion criteria.

Additional file 1 of The role of bone marrow on the mechanical properties of trabecular bone: a systematic review

Fangxing Wang, Florian Metzner, Georg Osterhoff, Leyu Zheng & Stefan Schleifenbaum
Additional file 1: Table S1. List of excluded literature that did not meet the inclusion criteria.

Registration Year

  • 2022
    20
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    2
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  • 2017
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Resource Types

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    10
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Affiliations

  • University Hospital Leipzig
    24
  • Leipzig University
    13
  • Max Planck Institute for Human Cognitive and Brain Sciences
    5
  • University of Potsdam
    5
  • Helmholtz Centre for Environmental Research
    4
  • Charité - University Medicine Berlin
    4
  • Soroka Medical Center
    4
  • Humboldt-Universität zu Berlin
    4
  • University of Geneva
    4
  • University of Freiburg
    4