Data from: Caspr3-deficient mice exhibit low motor learning during the early phase of the accelerated rotarod taskHaruna Hirata, Aki Takahashi, Yasushi Shimoda & Tsuyoshi Koide
Caspr3 (Contactin-associated protein-like 3, Cntnap3) is a neural cell adhesion molecule belonging to the Caspr family. We have recently shown that Caspr3 is expressed abundantly between the first and second postnatal weeks in the mouse basal ganglia, including the striatum, external segment of the globus pallidus, subthalamic nucleus, and substantia nigra. However, its physiological role remains largely unknown. In this study, we conducted a series of behavioral analyses on Capsr3-knockout (KO) mice and equivalent wild-type...
Data from: Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumptionKristopher McEown, Yohko Takata, Yoan Cherasse, Nanae Nagata, Kosuke Aritake & Michael Lazarus
Rapid eye movement (REM) sleep loss is associated with increased consumption of weight-promoting foods. The prefrontal cortex (PFC) is thought to mediate reward anticipation. However, the precise role of the PFC in mediating reward responses to highly palatable foods (HPF) after REM sleep deprivation is unclear. We selectively reduced REM sleep in mice over a 25–48 hr period and chemogenetically inhibited the medial PFC (mPFC) by using an altered glutamate-gated and ivermectin-gated chloride channel that...
Data from: The effect of sitagliptin on carotid artery atherosclerosis in Type 2 Diabetes: the PROLOGUE randomized controlled trialJun-Ichi Oyama, Koichi Node, Atsushi Tanaka, Toyoaki Murohara, Masafumi Kitakaze, Tomoko Ishizu, Yasunori Sato, Haruo Kamiya, Masaharu Ishihara, Koji Maemura, Hirofumi Tomiyama, Yukihito Higashi, Hirotsugu Yamada, Kentaro Yamashita, Yasuko K. Bando, Shinichiro Ueda & Teruo Inoue
Background: Experimental studies have suggested that dipeptidyl peptidase-4 (DPP-4) inhibitors provide cardiovascular protective effects. We performed a randomized study to evaluate the effects of sitagliptin added on to the conventional therapy compared with conventional therapy alone (diet, exercise, and/or drugs, except for incretin-related agents) on the intima-media thickness (IMT) of the carotid artery, a surrogate marker for the evaluation of atherosclerotic cardiovascular disease, in people with type 2 diabetes mellitus (T2DM). Methods and Findings: We...
Plant–animal mutualistic networks are characterized by highly heterogeneous degree distributions. The majority of species interact with few partner species, while a small number are highly connected to form network hubs that are proposed to play an important role in community stability. It has not been investigated, however, if or how the degree distributions vary among types of mutualisms or communities, or between plants and animals in the same network. Here, we evaluate the degree distributions...
Data from: Diurnal transcriptional regulation of endosymbiotically derived genes in the chlorarachniophyte Bigelowiella natansShigekatsu Suzuki, Ken-Ichiro Ishida & Yoshihisa Hirakawa
Chlorarachniophyte algae possess complex plastids acquired by the secondary endosymbiosis of a green alga, and the plastids harbor a relict nucleus of the endosymbiont, the so-called nucleomorph. Due to massive gene transfer from the endosymbiont to the host, many proteins involved in plastid and nucleomorph are encoded by the nuclear genome. Genome sequences have provided a blueprint for the fate of endosymbiotically derived genes; however, transcriptional regulation of these genes remains poorly understood. To gain...
Data from: Conserved but attenuated parental gene expression in allopolyploids: constitutive zinc hyperaccumulation in the allotetraploid Arabidopsis kamchaticaTimothy Paape, Masaomi Hatakeyama, Rie Shimizu-Inatsugi, Teo Cereghetti, Onda Yoshihiko, Tanaka Kenta, Jun Sese & Kentaro K. Shimizu
Allopolyploidization combines parental genomes and often confers broader species distribution. However, little is known about parentally transmitted gene expression underlying quantitative traits following allopolyploidization because of the complexity of polyploid genomes. The allopolyploid species Arabidopsis kamchatica is a natural hybrid of the zinc hyperaccumulator A. halleri and of the nonaccumulator A. lyrata. We found that A. kamchatica retained the ability to hyperaccumulate zinc from A. halleri and grows in soils with both low and high...
Background: Kinetoplastea is a diverse protist lineage composed of several of the most successful parasites on Earth, organisms whose metabolisms have coevolved with those of the organisms they infect. Parasitic kinetoplastids have emerged from free-living, non-pathogenic ancestors on multiple occasions during the evolutionary history of the group. Interestingly, in both parasitic and free-living kinetoplastids, the heme pathway—a core metabolic pathway in a wide range of organisms—is incomplete or entirely absent. Indeed, Kinetoplastea investigated thus far...
University of Tsukuba7
Hyogo College of Medicine1
Kihara Institute for Biological Research1
Tokyo Medical University1
University of Münster1
Nagaoka University of Technology1
National Institute of Advanced Industrial Science and Technology1
National Cerebral and Cardiovascular Center1