78 Works

Comparative phylogeography reveals consistently shallow genetic diversity in a mitochondrial marker in Antarctic bdelloid rotifers

Diego Fontaneto, Zeyneb Vildan Cakil, Giuseppe Garlasché, Nataliia Iakovenko, Andrea Di Cesare, Ester M. Eckert, Roberto Guidetti, Lina Hamdan, Karel Janko, Dzmitry Lukashanets, Lorena Rebecchi, Stefano Schiaparelli, Tommaso Sforzi, Eva Štefková Kašparová, Alejandro Velasco-Castrillón & Elizabeth Walsh
Aim: The long history of isolation of the Antarctic continent, coupled with the harsh ecological conditions of freezing temperatures could affect the patterns of genetic diversity in the organisms living there. We aim (1) to test whether such pattern can be seen in a mitochondrial marker of bdelloid rotifers, a group of microscopic aquatic and limno-terrestrial animals, and (2) to speculate on the potential mechanisms driving the pattern. Location: focus on Antarctica. Taxon: Rotifera Bdelloidea....

Delivery indication matters for perinatal outcomes in late preterm newborns

Francesca Monari, Giuseppe Chiossi, Giancarlo Gargano, Michela Ballarini, Dante Baronciani, Alessandra Coscia & Fabio Facchinetti
The late preterm (LP) rate in Western countries is 3–6% of all births, accounting for about two-thirds of the entire preterm population. However, all LP babies are not the same. To identify pregnancies at risk for adverse outcomes in the LP period, we investigated how gestational age (GA) at delivery, delivery indication and prenatal risk factors may affect neonatal outcomes. Prospective cohort study among singleton infants born between 34 + 0 and 36 + 6...

Delivery indication matters for perinatal outcomes in late preterm newborns

Francesca Monari, Giuseppe Chiossi, Giancarlo Gargano, Michela Ballarini, Dante Baronciani, Alessandra Coscia & Fabio Facchinetti
The late preterm (LP) rate in Western countries is 3–6% of all births, accounting for about two-thirds of the entire preterm population. However, all LP babies are not the same. To identify pregnancies at risk for adverse outcomes in the LP period, we investigated how gestational age (GA) at delivery, delivery indication and prenatal risk factors may affect neonatal outcomes. Prospective cohort study among singleton infants born between 34 + 0 and 36 + 6...

Barriers in care pathways and unmet mental health needs in LGBTIQ + communities

Giada Silveri, Simone Schimmenti, Eleonora Prina, Lorenzo Gios, Massimo Mirandola, Manlio Converti, Andrea Fiorillo, Federica Pinna, Antonio Ventriglio, Gian Maria Galeazzi, Nigel Sherriff, Laetitia Zeeman & Francesco Amaddeo
Lesbian, gay, bisexual, transgender, intersex, queer people and minority gender identities and sexualities (LGBTIQ+) are often stigmatized and experience discrimination in health care settings, leading to poorer mental health outcomes and unmet needs compared to heterosexual and cisgendered peers. It is thus imperative that mental health providers consider and address structural challenges in order to reduce mental health inequalities of this population. This narrative review assessed the barriers that may prevent access to care and...

Structure-activity exploration of a small-molecule allosteric inhibitor of T790M/L858R double mutant EGFR

Francesca Foschi, Annachiara Tinivella, Valentina Crippa, Luca Pinzi, Luca Mologni, Daniele Passarella & Giulio Rastelli
EGFR is a protein kinase whose aberrant activity is frequently involved in the development of non-small lung cancer (NSCLC) drug resistant forms. The allosteric inhibition of this enzyme is currently one among the most attractive approaches to design and develop anticancer drugs. In a previous study, we reported the identification of a hit compound acting as type III allosteric inhibitor of the L858R/T790M double mutant EGFR. Herein, we report the design, synthesis and in vitro...

Additional file 1 of Effectiveness of early rhythm control in improving clinical outcomes in patients with atrial fibrillation: a systematic review and meta-analysis

Wengen Zhu, Zexuan Wu, Yugang Dong, Gregory Y. H. Lip & Chen Liu
Additional file 1: Supplemental Table 1. The preferred reporting items for systematic review and meta-analysis (PRISMA) 2020 statement. Supplemental Table 2. The search strategies of this meta-analysis until August 06, 2022. Supplemental Table 3. The excluded studies during the full-text screenings. Supplemental Table 4. The detailed characteristics of the included studies. Supplemental Table 6. Effect estimates and adjusted confounders of the included studies. Supplementary Table 7. Risk of bias assessment of the EAST-AFNET 4 trial....

Prediction of postoperative atrial fibrillation with postoperative epicardial electrograms

Louise Feilberg Rasmussen, Jan Jesper Andreasen, Sam Riahi, Gregory Y. H. Lip, Søren Lundbye-Christensen, Jacob Melgaard & Claus Graff
Objectives. New-onset postoperative atrial fibrillation (POAF) is a common complication after cardiac surgery. The arrhythmia often entails a longer hospital stay, greater risk of other complications, and higher mortality both short- and long-term. An investigation of the use of early atrial electrograms in predicting POAF in cardiac surgery was performed. Design. In this prospective observational study, a total of 99 consecutive adult patients undergoing coronary artery bypass grafting, valve surgery or both were included. On...

Effectiveness of early rhythm control in improving clinical outcomes in patients with atrial fibrillation: a systematic review and meta-analysis

Wengen Zhu, Zexuan Wu, Yugang Dong, Gregory Y. H. Lip & Chen Liu
Abstract Background Current guidelines recommend rhythm control for improving symptoms and quality of life in symptomatic patients with atrial fibrillation (AF). However, the long-term prognostic outcomes of rhythm control compared with rate control are still inconclusive. In this meta-analysis, we aimed to assess the effects of early rhythm control compared with rate control on clinical outcomes in newly diagnosed AF patients. Methods We systematically searched the PubMed and Embase databases up to August 2022 for...

Additional file 4 of Development of machine learning classifiers to predict compound activity on prostate cancer cell lines

Davide Bonanni, Luca Pinzi & Giulio Rastelli
Additional file 4. DU-145 initial dataset with the 123 RDKit descriptors calculated

Additional file 7 of Development of machine learning classifiers to predict compound activity on prostate cancer cell lines

Davide Bonanni, Luca Pinzi & Giulio Rastelli
Additional file 7. Python script to perform models training, validation and testing phase

Ultrasound screening for fetal anomalies in a single center: diagnostic performances twenty years after the Eurofetus Study

Filomena G. Sileo, Alessandra Finarelli, Giannina Contu, Licia Lugli, Vincenza Dipace, Michela Ballarini, Cristina Guidi, Fabio Facchinetti & Emma Bertucci
To establish the accuracy of ultrasound in detecting fetal anomalies looking at the concordance between prenatal and postnatal diagnosis. Retrospective analysis of concordance between prenatal and postnatal/autoptic diagnosis of fetuses with congenital abnormalities. Data are from a single center (Policlinico di Modena); all fetuses included were born between 2017 and 2018 and with a follow-up of at least 6 months. We included all deliveries (including perinatal deaths) and termination of pregnancy (TOP) for fetal indication....

Physiotherapy for patients on extracorporeal membrane oxygenation support: How, When, and Who. An international EuroELSO survey

Massimiliano Polastri, Allaina Eden, Antonio Loforte, Andrea Dell’Amore, Marta Velia Antonini, Jordi Riera, Nicholas A Barrett & Justyna Swol
Background and purposeExtracorporeal membrane oxygenation (ECMO) continues to play an essential role in organ support in cardiogenic shock or acute respiratory distress syndrome and bridging to transplantation. The main purpose of the present survey was to define which clinical and organizational practices are adopted for the administration of physiotherapy in adult patients undergoing ECMO support worldwide.MethodsThis international survey was conceived in November 2021. The survey launch was announced at the 10th EuroELSO (European ELSO chapter)...

Ultrasound screening for fetal anomalies in a single center: diagnostic performances twenty years after the Eurofetus Study

Filomena G. Sileo, Alessandra Finarelli, Giannina Contu, Licia Lugli, Vincenza Dipace, Michela Ballarini, Cristina Guidi, Fabio Facchinetti & Emma Bertucci
To establish the accuracy of ultrasound in detecting fetal anomalies looking at the concordance between prenatal and postnatal diagnosis. Retrospective analysis of concordance between prenatal and postnatal/autoptic diagnosis of fetuses with congenital abnormalities. Data are from a single center (Policlinico di Modena); all fetuses included were born between 2017 and 2018 and with a follow-up of at least 6 months. We included all deliveries (including perinatal deaths) and termination of pregnancy (TOP) for fetal indication....

Data from: Deciphering the roles of environment and development in the evolution of a Late Triassic assemblage of conodont elements

Pauline Guenser, Louise Souquet, Sylvain Dolédec, Michele Mazza, Manuel Rigo & Nicolas Goudemand
To assess evolutionary processes in deep-time, it is essential to understand the roles of development and environment, both recorded through the morphological variability of fossil assemblages. Thanks to their great abundance and the high temporal resolution of their fossil record, conodont elements are ideal to address this issue. In this paper, we present the first quantitative study of a Carnian-Norian (late Triassic) assemblage of closely related P1 conodont elements. Using geometric morphometrics (landmarks, sliding-landmarks and...

Self-harm and suicidality among LGBTIQ people: a systematic review and meta-analysis

Mattia Marchi, Elisa Arcolin, Gianluca Fiore, Antonio Travascio, Daniele Uberti, Francesco Amaddeo, Manlio Converti, Andrea Fiorillo, Massimo Mirandola, Federica Pinna, Antonio Ventriglio & Gian Maria Galeazzi
Research evidence has consistently documented a higher risk of suicidality in the Lesbian, Gay, Bisexual, Transgender, Intersex, and Queer (LGBTIQ) population. This systematic review and meta-analysis aimed to report a detailed description of research data regarding the risk of Attempted Suicide (SA), Suicide Ideation (SI), and Non-Suicidal Self-Injury (NSSI) behaviours for LGBTIQ people and their subgroups. Medline, Scopus, PsycINFO, and EMBASE were searched for studies reporting a comparative estimation of SA, SI, and NSSI rates...

BRCA mutation carriers’ perception about benefits and risks associated with combined hormonal contraceptives use

Giovanni Grandi, Francesca Monari, Valentina Boggio Sola, Laura Cortesi, Angela Toss, Maria Chiara del Savio, Chiara Melotti, Maria Grazia Centurioni, Claudio Gustavino, Liliana Varesco, Fabio Facchinetti & Fabio Barra
To evaluate the actual perceptions about combined hormonal contraceptives (CHCs) use in BRCA mutation carriers in comparison to women from the general population. This was a cross-sectional, observational study involving two Italian referral centres for hereditary cancers. An identical questionnaire investigating how CHC use could affect the risk of developing some types of cancer, specific diseases, and symptoms was administered to 85 BRCA mutation carriers and 85 healthy women without this genetic mutation (control group)....

Barriers in care pathways and unmet mental health needs in LGBTIQ + communities

Giada Silveri, Simone Schimmenti, Eleonora Prina, Lorenzo Gios, Massimo Mirandola, Manlio Converti, Andrea Fiorillo, Federica Pinna, Antonio Ventriglio, Gian Maria Galeazzi, Nigel Sherrif, Laetitia Zeeman & Francesco Amaddeo
Lesbian, gay, bisexual, transgender, intersex, queer people and minority gender identities and sexualities (LGBTIQ+) are often stigmatized and experience discrimination in health care settings, leading to poorer mental health outcomes and unmet needs compared to heterosexual and cisgendered peers. It is thus imperative that mental health providers consider and address structural challenges in order to reduce mental health inequalities of this population. This narrative review assessed the barriers that may prevent access to care and...

Additional file 10 of Development of machine learning classifiers to predict compound activity on prostate cancer cell lines

Davide Bonanni, Luca Pinzi & Giulio Rastelli
Additional file 10. Python script to setup algorithms input parameters for the hyperparameter tuning with GridSearchCV

Additional file 11 of Development of machine learning classifiers to predict compound activity on prostate cancer cell lines

Davide Bonanni, Luca Pinzi & Giulio Rastelli
Additional file 11. Additional tables and figures.

Additional file 3 of Development of machine learning classifiers to predict compound activity on prostate cancer cell lines

Davide Bonanni, Luca Pinzi & Giulio Rastelli
Additional file 3. PC-3 initial dataset with the 123 RDKit descriptors calculated

Additional file 1 of Effectiveness of early rhythm control in improving clinical outcomes in patients with atrial fibrillation: a systematic review and meta-analysis

Wengen Zhu, Zexuan Wu, Yugang Dong, Gregory Y. H. Lip & Chen Liu
Additional file 1: Supplemental Table 1. The preferred reporting items for systematic review and meta-analysis (PRISMA) 2020 statement. Supplemental Table 2. The search strategies of this meta-analysis until August 06, 2022. Supplemental Table 3. The excluded studies during the full-text screenings. Supplemental Table 4. The detailed characteristics of the included studies. Supplemental Table 6. Effect estimates and adjusted confounders of the included studies. Supplementary Table 7. Risk of bias assessment of the EAST-AFNET 4 trial....

Additional file 1 of Impact of mental disorders on the risk of atrial fibrillation in patients with diabetes mellitus: a nationwide population-based study

Nan Young Bae, So-Ryoung Lee, Eue-Keun Choi, Hyun Jin Ahn, Hyo-Jeong Ahn, Soonil Kwon, Kyung-Do Han, Kyu-Na Lee, Seil Oh & Gregory Y. H. Lip
Additional file 1: Table S1. Definition of covariates and outcomes. Table S2. Baseline characteristics of study patients with each mental disorder. Table S3. Sensitivity analysis. Table S4. Subgroup analysis of mental disorders. Table S5. Subgroup analysis of depression, insomnia, and anxiety.

Impact of mental disorders on the risk of atrial fibrillation in patients with diabetes mellitus: a nationwide population-based study

Nan Young Bae, So-Ryoung Lee, Eue-Keun Choi, Hyun Jin Ahn, Hyo-Jeong Ahn, Soonil Kwon, Kyung-Do Han, Kyu-Na Lee, Seil Oh & Gregory Y. H. Lip
Abstract Background It is unclear whether mental disorders are an independent risk factor for atrial fibrillation (AF) in patients with diabetes. We aimed to investigate whether patients with diabetes who have mental disorders have an increased risk for AF. Methods Using the Korea National Health Insurance Service database, we enrolled 2,512,690 patients diagnosed with diabetes without AF between 2009 and 2012. We assessed five mental disorders: depression, insomnia, anxiety, bipolar disorder, and schizophrenia. Newly diagnosed...

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  • University of Modena and Reggio Emilia
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