To explore and describe medical students, postgraduate medical trainees, and medical specialists’ perceptions of creativity, the importance they attach to creativity in contemporary healthcare, and, by extension, how they feel creativity can be taught in medical education. The authors conducted seven semi-structured focus groups with medical students (n = 10), postgraduate medical trainees (n = 11) and medical specialists (n = 13). Participants had a trifurcated perception of creativity, which they described as a form...

Abstract Background Right ventricular (RV) dysfunction is common in critically ill patients and is associated with poor outcomes. RV function is usually evaluated by Tricuspid Annular Plane Systolic Excursion (TAPSE) which can be obtained using critical care echocardiography (CCE). Myocardial deformation imaging, measuring strain, is suitable for advanced RV function assessment and has widely been studied in cardiology. However, it is relatively new for the Intensive Care Unit (ICU) and little is known about RV...

Supplemental material, sj-docx-1-eso-10.1177_23969873221143570 for The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial by Anna Kopczak, Michael S Stringer, Hilde van den Brink, Danielle Kerkhofs, Gordon W Blair, Maud van Dinther, Laurien Onkenhout, Karolina A Wartolowska, Michael J Thrippleton, Marco Duering, Julie Staals, Martin Middeke, Elisabeth André, Bo Norrving, Marie-Germaine Bousser, Ulrich Mansmann, Peter M Rothwell, Fergus N...

Additional file 4. Results from post hoc sensitivity analysis.

Additional file 5. A5. Included prevalence sources with additional risk factors and the prevalence of HIV coinfection, people who inject drugs and male incarcerated individuals (n=92; 36 countries).

Supplemental material, sj-pdf-2-prf-10.1177_02676591211042563 for International survey of neuromonitoring and neurodevelopmental outcome in children and adults supported on extracorporeal membrane oxygenation in Europe by Mirjana Cvetkovic, Giovanni Chiarini, Mirko Belliato, Thijs Delnoij, Paolo Zanatta, Fabio Silvio Taccone, Dinis dos Reis Miranda, Mark Davidson, Nashwa Matta, Carl Davis, Hanneke IJsselstijn, Matthieu Schmidt, Lars Mikael Broman, Dirk W Donker, Dirk Vlasselaers, Piero David, Matteo Di Nardo, Ralf M Muellenbach, Thomas Mueller, Nicholas A Barrett, Roberto Lorusso, Jan Belohlavek...

Background:Adverse neurological events during extracorporeal membrane oxygenation (ECMO) are common and may be associated with devastating consequences. Close monitoring, early identification and prompt intervention can mitigate early and late neurological morbidity. Neuromonitoring and neurocognitive/neurodevelopmental follow-up are critically important to optimize outcomes in both adults and children.Objective:To assess current practice of neuromonitoring during ECMO and neurocognitive/neurodevelopmental follow-up after ECMO across Europe and to inform the development of neuromonitoring and follow-up guidelines.Methods:The EuroELSO Neurological Monitoring and Outcome...

ObjectivePatient preferences are important in designing optimal rehabilitation care. The aim of this study is to assess preferences for rehabilitation care among two groups of respondents.DesignAn online discrete choice experiment survey was carried out.SettingWe use data for Lebanon, a country where rehabilitation care is still underdeveloped.ParticipantsPatients who have undergone or are currently undergoing rehabilitation treatment (users) and those who have not (yet) used rehabilitation care (non-users).InterventionPatients were asked to repeatedly choose between two hypothetical rehabilitation...

ObjectivePatient preferences are important in designing optimal rehabilitation care. The aim of this study is to assess preferences for rehabilitation care among two groups of respondents.DesignAn online discrete choice experiment survey was carried out.SettingWe use data for Lebanon, a country where rehabilitation care is still underdeveloped.ParticipantsPatients who have undergone or are currently undergoing rehabilitation treatment (users) and those who have not (yet) used rehabilitation care (non-users).InterventionPatients were asked to repeatedly choose between two hypothetical rehabilitation...

Supplemental Material for Extracorporeal life support provision in COVID-19 patients - An international EuroELSO 2022 update survey by Marcel Fleig, Thomas Müller, Velia M Antonini, Jordi Riera, Mirko Belliato, Lars Mikael Broman, Jo-Anne Fowles, Jan Belohlavek, Roberto Lorusso, Leen Vercaemst, Tim Jones, Peter P Roeleveld, Matteo Di Nardo, Nicholas Barrett and Justyna Swol in Perfusion

Supplemental Material for Extracorporeal life support provision in COVID-19 patients - An international EuroELSO 2022 update survey by Marcel Fleig, Thomas Müller, Velia M Antonini, Jordi Riera, Mirko Belliato, Lars Mikael Broman, Jo-Anne Fowles, Jan Belohlavek, Roberto Lorusso, Leen Vercaemst, Tim Jones, Peter P Roeleveld, Matteo Di Nardo, Nicholas Barrett and Justyna Swol in Perfusion

IntroductionAn analysis on the ECLS use for patients with respiratory or cardiac support in COVID-19 based on an international response to EuroELSO survey, aims to generate a more comprehensive understanding of ECLS role during the recent viral pandemic.MethodsEuroELSO announced the survey at the 10th annual congress in London, May 2022. The survey covered 26 multiple-choice questions.ResultsThe survey returned 69 questionnaires from 62 centers across 22 European countries and seven centers across five non-European countries. Most...

Abstract Background Throughout the psychotherapeutic and coaching literature, the client-therapist or coach-coachee working alliance has been highlighted as key force driving positive outcome. The Working Alliance Inventory Short form (WAI-S) for coaching charts the quality of working alliance throughout coaching sessions and is broadly applied in coaching research. Due to a shortfall in research on psychometric properties of the WAI-S, the purpose of this study was to examine (a) if the theorized three-factor structure of...

Additional file 5. A5. Included prevalence sources with additional risk factors and the prevalence of HIV coinfection, people who inject drugs and male incarcerated individuals (n=92; 36 countries).

Abstract Background Glioblastoma (GBM), the most common glial primary brain tumour, is without exception lethal. Every year approximately 600 patients are diagnosed with this heterogeneous disease in The Netherlands. Despite neurosurgery, chemo -and radiation therapy, these tumours inevitably recur. Currently, there is no gold standard at time of recurrence and treatment options are limited. Unfortunately, the results of dedicated trials with new drugs have been very disappointing. The goal of the project is to obtain...

Additional file 2. A2. Year of publication of included sources.

Supplemental material, sj-docx-1-eso-10.1177_23969873221145771 for Association between type of intervention center and outcomes after endovascular treatment for acute ischemic stroke: Results from the MR CLEAN Registry by Susanne GH Olthuis, Wouter H Hinsenveld, Florentina ME Pinckaers, Marzyeh Amini, Hester F Lingsma, Julie Staals, Tobien HCML Schreuder, Wouter J Schonewille, Lonneke SF Yo, Yvo BWEM Roos, Alida A Postma, Diederik WJ Dippel, Wim H van Zwam, Robert J van Oostenbrugge and Inger R de Ridder in European...

Denoising of CT scans has attracted the attention of many researchers in the medical image analysis domain. Encoder–decoder networks are deep learning neural networks that have become common for image denoising in recent years. Shortcuts between the encoder and decoder layers are crucial for some image-to-image translation tasks. However, are all shortcuts necessary for CT denoising? To answer this question, we set up two encoder–decoder networks representing two popular architectures and then progressively removed shortcuts...

IntroductionA cross-sectional survey GENERATE (GEospatial aNalysis of ExtRacorporeal membrane oxygenATion in Europe) initiated on behalf of the European chapter of the Extracorporeal Life Support Organization (EuroELSO), aims to provide a systematic, detailed description of contemporary Extracorporeal Life Support (ECLS) provision in Europe, map the spatial distribution of ECLS centers, and the accessibility of ECLS.MethodsStructured data collection forms were used to create a narrative description of ECLS provision in EuroELSO affiliated countries. This consisted of both...

Fatigue is frequently reported in people with a non-communicable chronic disease. More insight in the nature of this symptom may enhance targeted treatment of fatigue. In this study, we aimed to gain more insight in the prevalence of different types of fatigue and in current prescribed treatment strategies to reduce fatigue in non-communicable chronic diseases. People with non-communicable chronic diseases were contacted via public, non-profit, disease-specific health funds and patient associations and invited to complete...

Cardiovascular disease is a significant cause of morbidity and mortality in COPD. Endothelial dysfunction is suggested to be involved in cardiovascular disease pathogenesis, and multiple studies report endothelial dysfunction in COPD. This article summarized the current knowledge on endothelial function in COPD patients. Databases were screened until November 2022 for studies using ultrasound-based flow-mediated dilation in patients with stable COPD. Pooled effect sizes were calculated using random effects model. Meta-regression analyses assessed the effects of...

Objective: To identify a plasma metabolomic biomarker signature for migraine. Methods: Plasma samples from 8 Dutch cohorts (n = 10,153: 2,800 migraine patients and 7,353 controls) were profiled on a 1H-NMR-based metabolomics platform, to quantify 146 individual metabolites (e.g., lipids, fatty acids, and lipoproteins) and 79 metabolite ratios. Metabolite measures associated with migraine were obtained after single-metabolite logistic regression combined with a random-effects meta-analysis performed in a nonstratified and sex-stratified manner. Next, a global test...

Supplemental material, sj-docx-1-jdr-10.1177_00220345221129806 for Bioinspired Anti-demineralization Enamel Coating for Orthodontics by S. Peng, T. Sang, H. Wang, Y. Guan, Y. Deng, P. Wang, Z. Huang, Z. Ye and J. Wu in Journal of Dental Research

White spot lesions and enamel cracks are the 2 most prominent diseases that occur after orthodontic treatment and are caused by enamel demineralization from accumulated bacterial biofilms and/or enamel damage caused by the removal of residual adhesive after bracket debonding. Inspired by the self-assembled amelogenin nanoribbons in enamel, we developed an enamel coating with a self-assembling antimicrobial peptide, D-GL13K, to simultaneously reduce demineralization and residual adhesive. The self-assembled amphiphilic nanoribbons significantly increased the hydrophobicity of...

Abstract Background Right ventricular (RV) dysfunction is common in critically ill patients and is associated with poor outcomes. RV function is usually evaluated by Tricuspid Annular Plane Systolic Excursion (TAPSE) which can be obtained using critical care echocardiography (CCE). Myocardial deformation imaging, measuring strain, is suitable for advanced RV function assessment and has widely been studied in cardiology. However, it is relatively new for the Intensive Care Unit (ICU) and little is known about RV...