479 Works

TNFα and IFNγ rapidly activate PI3K-AKT signaling to drive glycolysis that confers mesenchymal stem cells enhanced anti-inflammatory property

Chenchang Xu, Chao Feng, Peiqing Huang, Yinghong Li, Rui Liu, Chunxiao Liu, Yuyi Han, Lei Chen, Yayun Ding, Changshun Shao & Yufang Shi
Abstract Background Mesenchymal stem/stromal cells (MSCs) acquire immunosuppressive capacity only in an inflammatory microenvironment. This can be recapitulated in vitro by treating MSCs with inflammatory cytokines TNFα and IFNγ, which induce indoleamine 2,3-dioxygenase (IDO) and TNF-stimulated gene-6 (TSG-6). However, the signaling pathways downstream of the cytokines remain to be elucidated. Methods Inflammatory bowel disease (IBD) mouse model was established by subjecting mice to dextran sulfate sodium (DSS) in drinking water for 7 days. Human UC-MSCs...

Evolutionary history constrains heat tolerance of native and exotic tropical Zingiberales

Georgia G. Hernández, Timothy M. Perez, Oscar M. Vargas, W. John Kress, Ramón Molina-Bravo, Roberto A. Cordero & Carlos García-Robledo
Tropical wet forest plants experience relatively stable temperatures throughout the year. However, tropical forests represent a mosaic of habitats characterized by different temperatures. Heat tolerances are expected to be adapted to temperatures specific to their habitats. Although the heat tolerance of species sharing similar environments is expected to be similar, it is also possible that heat tolerance is constrained by evolutionary history because closely related species usually display similar physiologies. When exotic species are introduced...

DFT study on Fe and N decorated graphene as the drug delivery system for β-lapachone anticancer drug

Wei Zhang
The β-lapachone anticancer drug performs efficiently in preventing the growth of cancer cells. Transporting the pharmaceutical compound to its target cell is a hot topic in target-direct treatment. Here, we propose a new kind of drug delivery, Fe and N decorated graphene (Fe-N-Graphene), based on density functional theory, showing high performance in the transportation of β-lapachone anticancer drugs. Results indicate Fe-N-Graphene exhibits high adsorption energies of 1.67–1.73 eV for β-lapachone molecules, which guarantees stability during...

A. caviae infection triggers IL-1β secretion through activating NLRP3 inflammasome mediated by NF-κB signaling pathway partly in a TLR2 dependent manner

Qiankun Yang, Jianguo Zhang, Feixue Liu, Huizhen Chen, Wei Zhang, Haitao Yang, Nana He, Jingquan Dong & Panpan Zhao
Aeromonas caviae, an important food-borne pathogen, induces serious invasive infections and inflammation. The pro-inflammatory IL-1β functions against pathogenic infections and is elevated in various Aeromonas infection cases. However, the molecular mechanism of A. caviae-mediated IL-1β secretion remains unknown. In this study, mouse macrophages (PMs) were used to establish A. caviae infection model and multiple strategies were utilized to explore the mechanism of IL-1β secretion. IL-1β was elevated in A. caviae infected murine serum, PMs lysates...

Additional file 1 of Diversification of phenolic glucosides by two UDP-glucosyltransferases featuring complementary regioselectivity

Fei Guo, Xingwang Zhang, Cai You, Chengjie Zhang, Fengwei Li, Nan Li, Yuwei Xia, Mingyu Liu, Zetian Qiu, Xianliang Zheng, Li Ma, Gang Zhang, Lianzhong Luo, Fei Cao, Yingang Feng, Guang-Rong Zhao, Wei Zhang, Shengying Li & Lei Du
Additional file 1. Supplementary tables and figures

Additional file 1 of Diversification of phenolic glucosides by two UDP-glucosyltransferases featuring complementary regioselectivity

Fei Guo, Xingwang Zhang, Cai You, Chengjie Zhang, Fengwei Li, Nan Li, Yuwei Xia, Mingyu Liu, Zetian Qiu, Xianliang Zheng, Li Ma, Gang Zhang, Lianzhong Luo, Fei Cao, Yingang Feng, Guang-Rong Zhao, Wei Zhang, Shengying Li & Lei Du
Additional file 1. Supplementary tables and figures

The Cauchy Combination Test under Arbitrary Dependence Structures

Mingya Long, Zhengbang Li, Wei Zhang & Qizhai Li
Combining individual p-values to perform an overall test is often encountered in statistical applications. The Cauchy combination test (CCT) (Journal of the American Statistical Association, 2020, 115, 393–402) is a powerful and computationally efficient approach to integrate individual p-values under arbitrary dependence structures for sparse signals. We revisit this test to additionally show that (i) the tail probability of the CCT can be approximated just as well when more relaxed assumptions are imposed on individual...

Supplementary document for Activity Enhancement of Photo-generated Carrier in CsPbBr3 Nanocrystals Improved by Cd Element - 6060264.pdf

Lianfei Yao, Xue Lou, Ning Sui, Wei Zhang, Hongwei Xiao, Xiaochun Chi, Hanzhuang Zhang & Yinghui Wang
Fitting methods and supplementary data

Turning up the heat on non-immunoreactive tumors: autophagy influences the immune microenvironment in pancreatic cancer

Si-Yuan Lu, Jie Hua, Jiang Liu, Miao-Yan Wei, Chen Liang, Qing-Cai Meng, Bo Zhang, Xian Jun Yu, Wei Wang & Jin Xu
Abstract Background Autophagy regulators play important roles in the occurrence and development of a variety of tumors and are involved in immune regulation and drug resistance. However, the modulatory roles and prognostic value of autophagy regulators in pancreatic cancer have not been identified. Methods Transcriptomic data and survival information from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were used to construct a risk score model. Important clinical features were analyzed to...

Additional file 2 of Turning up the heat on non-immunoreactive tumors: autophagy influences the immune microenvironment in pancreatic cancer

Si-Yuan Lu, Jie Hua, Jiang Liu, Miao-Yan Wei, Chen Liang, Qing-Cai Meng, Bo Zhang, Xian Jun Yu, Wei Wang & Jin Xu
Supplementary Material 2

A CT-based nomogram for predicting the risk of adenocarcinomas in patients with subsolid nodule according to the 2021 WHO classification

Qilong Song, Biao Song, Xiaohu Li, Bin Wang, Yuan Li, Wu Chen, Zhaohua Wang, Xu Wang, Yongqiang Yu, Xuhong Min & Dongchun Ma
Abstract Purpose To establish a nomogram for predicting the risk of adenocarcinomas in patients with subsolid nodules (SSNs) according to the 2021 WHO classification. Methods A total of 656 patients who underwent SSNs resection were retrospectively enrolled. Among them, 407 patients were assigned to the derivation cohort and 249 patients were assigned to the validation cohort. Univariate and multi-variate logistic regression algorithms were utilized to identity independent risk factors of adenocarcinomas. A nomogram based on...

sj-pdf-1-sri-10.1177_15533506211047011 – Supplemental Material for Comparison of the Postoperative Complications Between Robotic Total and Distal Gastrectomies for Gastric Cancer Using Clavien–Dindo Classification: A Propensity Score-matched Retrospective Cohort Study of 726 Patients

Zheng-yan Li, Yong-liang Zhao, Feng Qian, Bo Tang, Zi-yan Luo, Yan Wen, Yan Shi & Pei-wu Yu
Supplemental Material, sj-pdf-1-sri-10.1177_15533506211047011 for Comparison of the Postoperative Complications Between Robotic Total and Distal Gastrectomies for Gastric Cancer Using Clavien–Dindo Classification: A Propensity Score-matched Retrospective Cohort Study of 726 Patients by Zheng-yan Li, Yong-liang Zhao, Feng Qian, Bo Tang, Zi-yan Luo, Yan Wen, Yan Shi and Pei-wu Yu in Surgical Innovation

Additional file 2 of Role of bilirubin in the prognosis of coronary artery disease and its relationship with cardiovascular risk factors: a meta-analysis

Xiao-ling Li, Cun-rui Zhao, Chen-liang Pan, Gaxue Jiang & Bo Zhang
Additional file 2: Table S1. Quality assessment of the included study with Newcastle-Ottawa Quality Assessment Scale. Figure S1. A funnel plot showing the outcomes of Begg’s test. Appendix S1. Literature search strategy.

Additional file 5 of Candidate genes screening based on phenotypic observation and transcriptome analysis for double flower of Prunus mume

Huanhuan Zhu, Yan Shi, Junwei Zhang, Manzhu Bao & Jie Zhang
Additional file 5.

Candidate genes screening based on phenotypic observation and transcriptome analysis for double flower of Prunus mume

Huanhuan Zhu, Yan Shi, Junwei Zhang, Manzhu Bao & Jie Zhang
Abstract Background Prunus mume is an early spring flower of Rosaceae, which owns high application value in gardens. Being an excellent ornamental trait, the double flower trait has always been one of the important breeding goals of plant breeders. However, the key regulatory genes of double flower traits of P. mume are still unclear at present. Results The floral organs’ morphological differences of 20 single and 20 double flower cultivars of P. mume were compared...

Additional file 3 of Identification of tumor-associated antigens and immune subtypes of lower-grade glioma and glioblastoma for mRNA vaccine development

Zhi-liang Wang, Ruo-yu Huang, Bo Han, Fan Wu, Zhi-yan Sun, Guan-zhang Li, Wei Zhang, Zheng Zhao & Xing Liu
Additional file 3: Supplementary Figure 3.

Additional file 1 of Identification of tumor-associated antigens and immune subtypes of lower-grade glioma and glioblastoma for mRNA vaccine development

Zhi-liang Wang, Ruo-yu Huang, Bo Han, Fan Wu, Zhi-yan Sun, Guan-zhang Li, Wei Zhang, Zheng Zhao & Xing Liu
Additional file 1: Supplementary Figure 1.

Additional file 2 of Identification of tumor-associated antigens and immune subtypes of lower-grade glioma and glioblastoma for mRNA vaccine development

Zhi-liang Wang, Ruo-yu Huang, Bo Han, Fan Wu, Zhi-yan Sun, Guan-zhang Li, Wei Zhang, Zheng Zhao & Xing Liu
Additional file 2: Supplementary Figure 2.

Identification of tumor-associated antigens and immune subtypes of lower-grade glioma and glioblastoma for mRNA vaccine development

Zhi-liang Wang, Ruo-yu Huang, Bo Han, Fan Wu, Zhi-yan Sun, Guan-zhang Li, Wei Zhang, Zheng Zhao & Xing Liu
Abstract Background mRNA became a promising therapeutic approach in many diseases. This study aimed to identify the tumor antigens specifically expressed in tumor cells for lower-grade glioma (LGG) and glioblastoma (GBM) patients. Methods In this work, the mRNA microarray expression profile and clinical data were obtained from 301 samples in the Chinese Glioma Genome Atlas (CGGA) database, the mRNA sequencing data and clinical data of 701 samples were downloaded from The Cancer Genome Atlas (TCGA)...

Management guideline for the off-label use of medicine in China (2021)

Wei Zuo, Yajia Sun, Rongji Liu, Liping Du, Nan Yang, Wenjuan Sun, Ping Wang, Xiaowan Tang, Yunlan Liu, Yuanyuan Ma, Min Meng, Ruobing Lei, Xuelian Yan, Hua Peng, Qing Chang, Hui Pan, Bo Zhang, Yaolong Chen & Shuyang Zhang
Off-label drug use embodies a thorough clinical diagnosis and evaluation of treatment needs and should not be confused with unreasonable drug use, but it also faces potential risks with drug safety and legal issues. We first established a guideline working group. Following the guideline development process recommended by the World Health Organization Handbook and the Chinese Medical Association, the key questions were determined through literature searches of PubMed, CNKI (Chinese National Knowledge Infrastructure) and other...

Management guideline for the off-label use of medicine in China (2021)

Wei Zuo, Yajia Sun, Rongji Liu, Liping Du, Nan Yang, Wenjuan Sun, Ping Wang, Xiaowan Tang, Yunlan Liu, Yuanyuan Ma, Min Meng, Ruobing Lei, Xuelian Yan, Hua Peng, Qing Chang, Hui Pan, Bo Zhang, Yaolong Chen & Shuyang Zhang
Off-label drug use embodies a thorough clinical diagnosis and evaluation of treatment needs and should not be confused with unreasonable drug use, but it also faces potential risks with drug safety and legal issues. We first established a guideline working group. Following the guideline development process recommended by the World Health Organization Handbook and the Chinese Medical Association, the key questions were determined through literature searches of PubMed, CNKI (Chinese National Knowledge Infrastructure) and other...

Additional file 1 of Distribution and concordance of PD-L1 expression by routine 22C3 assays in East-Asian patients with non-small cell lung cancer

Fangqiu Fu, Chaoqiang Deng, Wenrui Sun, Qiang Zheng, Yan Jin, Yuan Li, Yang Zhang & Haiquan Chen
Additional file 1: Figure S1. Sankey diagram (A) and details (B) of PD-L1 expression using 22C3 assays in two multi-focal primary tumors. TPS: tumor proportion score.

Distribution and concordance of PD-L1 expression by routine 22C3 assays in East-Asian patients with non-small cell lung cancer

Fangqiu Fu, Chaoqiang Deng, Wenrui Sun, Qiang Zheng, Yan Jin, Yuan Li, Yang Zhang & Haiquan Chen
Abstract Background Currently, programmed death ligand-1 (PD-L1) expression has been widely applied in clinical trials and real-world clinical practice as a major biomarker for the efficacy of immune-checkpoint inhibitors. The purpose of this study is to reveal the distribution and concordance of PD-L1 expression in a large-scale consecutive cohort from East-Asian patients with non-small cell lung cancer (NSCLC). Methods PD-L1 testing was conducted using 22C3 assays, and cases were categorized into the high, low, and...

Draft genome of six Cuban Anolis lizards and insights into genetic changes during their diversification

Shunsuke Kanamori, Luis M. Díaz, Antonio Cádiz, Katsushi Yamaguchi, Shuji Shigenobu & Masakado Kawata
Abstract Background Detecting genomic variants and their accumulation processes during species diversification and adaptive radiation is important for understanding the molecular and genetic basis of evolution. Anolis lizards in the West Indies are good models for studying evolutionary mechanisms because of the repeated evolution of their morphology and the ecology. We performed de novo genome assembly of six Cuban Anolis lizards with different ecomorphs and thermal habitats (Anolis isolepis, Anolis allisoni, Anolis porcatus, Anolis allogus,...

Additional file 1 of Association of delayed chemoradiotherapy with elevated Epstein-Barr virus DNA load and adverse clinical outcome in nasopharyngeal carcinoma treatment during the COVID-19 pandemic: a retrospective study

Cheng-Long Huang, Xue-Liang Fang, Yan-Ping Mao, Rui Guo, Wen-Fei Li, Si-Si Xu, Jun Ma, Lei Chen & Ling-Long Tang
Supplementary Figure S1 and Table S1.

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