479 Works

Association of delayed chemoradiotherapy with elevated Epstein-Barr virus DNA load and adverse clinical outcome in nasopharyngeal carcinoma treatment during the COVID-19 pandemic: a retrospective study

Cheng-Long Huang, Xue-Liang Fang, Yan-Ping Mao, Rui Guo, Wen-Fei Li, Si-Si Xu, Jun Ma, Lei Chen & Ling-Long Tang
Abstract Background: To summarize the impact of radiotherapy (RT) and chemotherapy delays on patients with nasopharyngeal carcinoma (NPC) during the COVID-19 pandemic. Methods: We retrospectively included 233 patients with stage II-IVa NPC treated with RT and chemotherapy between December 11, 2019 and March 11, 2020. The outcomes were elevation in the EBV DNA load between two adjacent cycles of chemotherapy or during RT, and 1-year disease-free survival (DFS). Results: RT delay occurred in 117 (50%)...

A Near Unit Root Test for High-Dimensional Nonstationary Time Series

Bo Zhang, Jiti Gao & Guangming Pan
This paper considers a p-dimensional time series model of the form x(t)-δ(t)=φ(x(t-1)-δ(t-1))+Σ^(1/2)y(t), 1≤t≤T, where y(t) = (y(t1),...,y(tp)) and Σ^(1/2) is the square root of a symmetric positive definite matrix. Here φ≤1 and T(1-φ) is bounded and the linear processes y(tj) is of the form Σb(k)z(t-k,j) where Σ|bi| < infinity and {z(ij)} are independent and identically distributed (i.i.d.) random variables with E(z(ij))=0, E|z(ij)|^2=1 and E|z(ij)|^4< infinity. We first investigate the asymptotic behavior of the first k...

Spiked Eigenvalues of High-Dimensional Separable Sample Covariance Matrices

Bo Zhang, Jiti Gao, Guangming Pan & Yanrong Yang
This paper establishes asymptotic properties for spiked empirical eigenvalues of sample covariance matrices for high-dimensional data with both cross-sectional dependence and a dependent sample structure. A new finding from the established theoretical results is that spiked empirical eigenvalues will reflect the dependent sample structure instead of the cross-sectional structure under some scenarios, which indicates that principal component analysis (PCA) may provide inaccurate inference for cross-sectional structures. An illustrated example is provided to show that some...

Additional file 17 of Evolution of different rice ecotypes and genetic basis of flooding adaptability in Deepwater rice by GWAS

Xueqiang Wang, Yan Zhao, Conghui Jiang, Libing Wang, Lei Chen, Fengmei Li, Yanhong Zhang, Yinghua Pan & Tianzhen Zhang
Additional file 17 Table S16. Genome-wide detection and functional annotation of selective sweep regions in the irrigated GJ rice.

Additional file 17 of Evolution of different rice ecotypes and genetic basis of flooding adaptability in Deepwater rice by GWAS

Xueqiang Wang, Yan Zhao, Conghui Jiang, Libing Wang, Lei Chen, Fengmei Li, Yanhong Zhang, Yinghua Pan & Tianzhen Zhang
Additional file 17 Table S16. Genome-wide detection and functional annotation of selective sweep regions in the irrigated GJ rice.

Additional file 19 of Evolution of different rice ecotypes and genetic basis of flooding adaptability in Deepwater rice by GWAS

Xueqiang Wang, Yan Zhao, Conghui Jiang, Libing Wang, Lei Chen, Fengmei Li, Yanhong Zhang, Yinghua Pan & Tianzhen Zhang
Additional file 19 Table S18. Genome-wide detection of highly differentiated loci between DW and UP-XI.

Additional file 22 of Evolution of different rice ecotypes and genetic basis of flooding adaptability in Deepwater rice by GWAS

Xueqiang Wang, Yan Zhao, Conghui Jiang, Libing Wang, Lei Chen, Fengmei Li, Yanhong Zhang, Yinghua Pan & Tianzhen Zhang
Additional file 22 Table S21. Significant association signals for deepwater in the full populaiton detected using FaST-LMM.

Additional file 10 of Evolution of different rice ecotypes and genetic basis of flooding adaptability in Deepwater rice by GWAS

Xueqiang Wang, Yan Zhao, Conghui Jiang, Libing Wang, Lei Chen, Fengmei Li, Yanhong Zhang, Yinghua Pan & Tianzhen Zhang
Additional file 10 Table S9. Genome-wide detection and functional annotation of selective sweep regions in the deepwater rice (DW).

Additional file 7 of Evolution of different rice ecotypes and genetic basis of flooding adaptability in Deepwater rice by GWAS

Xueqiang Wang, Yan Zhao, Conghui Jiang, Libing Wang, Lei Chen, Fengmei Li, Yanhong Zhang, Yinghua Pan & Tianzhen Zhang
Additional file 7 Table S6. Genome-wide detection of positive selection in deepwater (DW).

Additional file 2 of Evolution of different rice ecotypes and genetic basis of flooding adaptability in Deepwater rice by GWAS

Xueqiang Wang, Yan Zhao, Conghui Jiang, Libing Wang, Lei Chen, Fengmei Li, Yanhong Zhang, Yinghua Pan & Tianzhen Zhang
Additional file 2 Table S2. Summary of Annotation for genomic variation.

Evolution of different rice ecotypes and genetic basis of flooding adaptability in Deepwater rice by GWAS

Xueqiang Wang, Yan Zhao, Conghui Jiang, Libing Wang, Lei Chen, Fengmei Li, Yanhong Zhang, Yinghua Pan & Tianzhen Zhang
Abstract Background Rice is the world’s second largest food crop and accelerated global climate change due to the intensification of human activities has a huge impact on rice. Research on the evolution of different rice ecotypes is essential for enhancing the adaptation of rice to the unpredictable environments. Results The sequencing data of 868 cultivated and 140 wild rice accessions were used to study the domestication history and signatures of adaptation in the distinct rice...

Immune checkpoint inhibitors plus chemotherapy in patients with locally advanced or metastatic pulmonary sarcomatoid carcinoma: a multicentric real-world study

Fei Zhou, Haoyue Guo, Xiaolong Zhou, Huikang Xie, Tian Tian, Wencheng Zhao, Guanghui Gao, Anwen Xiong, Lei Wang, Wei Li, Xiaoxia Chen, Yan Zhang, Jue Fan, Fengying Wu, Yongchang Zhang & Caicun Zhou
Introduction:Immune checkpoint inhibitors (ICIs) have demonstrated promising efficacy as monotherapy in patients with pulmonary sarcomatoid carcinoma (PSC). We performed the current multi-institutional, real-world study to assess the efficacy of ICIs plus chemotherapy in patients with PSC.Methods:All consecutive patients with locally advanced or metastatic PSC from three centers treated with ICIs between January 2018 and July 2021 were enrolled. Programmed death ligand 1 (PD-L1) expression was stained and evaluated using immunohistochemical with 22C3. Single-cell RNA sequencing...

Additional file 2 of Association of education background with clinical pharmacists’ clinical pharmacy workload in tertiary hospitals of China

Qingran Sun, Lei Chen, Yuankai Huang & Xiaoyu Xi
Additional file 2: Appendix 2 Table 1. The score of clinical pharmacists’ workload.

Sprouty4 is epigenetically upregulated in human colorectal cancer

Alexei J. Stuckel, Shuai Zeng, Zhen Lyu, Wei Zhang, Xu Zhang, Urszula Dougherty, Reba Mustafi, Tripti Khare, Qiong Zhang, Trupti Joshi, Marc Bissonnette & Sharad Khare
Sprouty4 (SPRY4) has been frequently reported as a tumor suppressor and is therefore downregulated in various cancers. For the first time, we report that SPRY4 is epigenetically upregulated in colorectal cancer (CRC). In this study, we explored DNA methylation and hydroxymethylation levels of SPRY4 in CRC cells and patient samples and correlated these findings with mRNA and protein expression levels. Three loci within the promoter region of SPRY4 were evaluated for 5mC levels in CRC...

Additional file 3 of Emergency versus delayed hepatectomy following transarterial embolization in spontaneously ruptured hepatocellular carcinoma survivors: a systematic review and meta-analysis

Wei Zhang, Zhangkan Huang & Xu Che
Additional file 3: Supplemental file 3. Begg’s test and Egger's test for each outcome.

Emergency versus delayed hepatectomy following transarterial embolization in spontaneously ruptured hepatocellular carcinoma survivors: a systematic review and meta-analysis

Wei Zhang, Zhangkan Huang & Xu Che
Abstract Background Spontaneous rupture is a life-threatening complication of hepatocellular carcinoma (HCC). Recent trends in surgical treatments avoid emergency hepatectomy (EH) and favor emergency transarterial embolization (TAE) followed by delayed hepatectomy (DH). Still, there is debate on which is the better treatment option and whether delaying hepatectomy increases peritoneal metastasis. Aim To provide evidence-based references for the optimal management of patients with spontaneously ruptured HCC by comparing the outcomes of EH and DH. Methods Literature...

Additional file 1 of SIRPα-Fc fusion protein IMM01 exhibits dual anti-tumor activities by targeting CD47/SIRPα signal pathway via blocking the “don’t eat me” signal and activating the “eat me” signal

Jifeng Yu, Song Li, Dianze Chen, Dandan Liu, Huiqin Guo, Chunmei Yang, Wei Zhang, Li Zhang, Gui Zhao, Xiaoping Tu, Liang Peng, Sijin Liu, Xing Bai, Yongping Song, Zhongxing Jiang, Ruliang Zhang & Wenzhi Tian
Additional file 1. Supplement figures (Figs. S1–S15), materials and methods.

Supplemental Material - Epidemiological and clinical characteristics of vaccinated COVID-19 patients: A meta-analysis and systematic review

Wen Tian, Xingxiang Ren, Mei Han, Yuanyuan Zhang, Xu Gao, Zhihai Chen & Wei Zhang
Supplemental Material for Epidemiological and clinical characteristics of vaccinated COVID-19 patients: A meta-analysis and systematic review by Wen Tian, Xingxiang Ren, Mei Han, Yuanyuan Zhang, Xu Gao, Zhihai Chen, and Wei Zhang in International Journal of Immunopathology and Pharmacology

Epidemiological and clinical characteristics of vaccinated COVID-19 patients: A meta-analysis and systematic review

Wen Tian, Xingxiang Ren, Mei Han, Yuanyuan Zhang, Xu Gao, Zhihai Chen & Wei Zhang
Objective: With the global epidemic of coronavirus disease 2019 (COVID-19), vaccination rates are increasing globally. This study evaluated the relevant clinical manifestations of vaccinated COVID-19 patients. Methods: We searched carefully in 11 databases such as PubMed, Embase, Scopus, Cochrane Library, Web of Science, Ovid, China National Knowledge Infrastructure Database, Wan Fang Data, Sinomed, VIP Database, and Reading Showing Database up to 26 March 2022. To search for articles that have described the characteristics of vaccinated...

Epidemiological and clinical characteristics of vaccinated COVID-19 patients: A meta-analysis and systematic review

Wen Tian, Xingxiang Ren, Mei Han, Yuanyuan Zhang, Xu Gao, Zhihai Chen & Wei Zhang
Objective: With the global epidemic of coronavirus disease 2019 (COVID-19), vaccination rates are increasing globally. This study evaluated the relevant clinical manifestations of vaccinated COVID-19 patients. Methods: We searched carefully in 11 databases such as PubMed, Embase, Scopus, Cochrane Library, Web of Science, Ovid, China National Knowledge Infrastructure Database, Wan Fang Data, Sinomed, VIP Database, and Reading Showing Database up to 26 March 2022. To search for articles that have described the characteristics of vaccinated...

sj-docx-1-jet-10.1177_15266028221134895 – Supplemental material for Morphometric and Hemodynamic Analysis of the Compressed Iliac Vein

Hongyu Wang, Wei Jia, Yifeng Xi, Yuan Li, Yubo Fan, Xiaoyan Deng & Zengsheng Chen
Supplemental material, sj-docx-1-jet-10.1177_15266028221134895 for Morphometric and Hemodynamic Analysis of the Compressed Iliac Vein by Hongyu Wang, Wei Jia, Yifeng Xi, Yuan Li, Yubo Fan, Xiaoyan Deng and Zengsheng Chen in Journal of Endovascular Therapy

Efficient synthesis of 3-hydroxy chromones via oxidative cyclization mediated by lipase

Jiapeng Li, Yue Yu, Yaning Xu, Fengxi Li, Yuqi Liu, Yifei Sun, Chunyu Wang, Peng Chen & Lei Wang
In this work, an efficient synthesis of 3-hydroxy chromones was accomplished through oxidative cyclization mediated by lipase. This enzymatic process has salient features of environmental friendliness, mild reaction condition, satisfactory yield, green reusable biocatalyst, and short reaction time. The proposed method expands the application of lipase in organic synthesis.

Supplemental Material - ZIF-8 modified poly (m-phenylene isophthalamide) (PMIA) hybrid membrane for dye wastewater treatment

Kailu Yang, Xibo Liu, Xinya Wang, Tianxu Hao, Wei Zhang & Mingxing Chen
Supplemental Material for ZIF-8 modified poly (m-phenylene isophthalamide) (PMIA) hybrid membrane for dye wastewater treatment by Kailu Yang, Xibo Liu, Xinya Wang, Tianxu Hao, Wei Zhang, Mingxing Chen in Journal of Industrial Textiles

Additional file 6 of Effects of mitochondrial dysfunction on bone metabolism and related diseases: a scientometric study from 2003 to 2022

Wei Zhang, Chang-Liang Xia, Jun-Nan Ma, Jia-Xuan Li, Qi Chen, Shuan-Ji Ou, Yang Yang, Yong Qi & Chang-Peng Xu
Additional file 6: Supplementary Table 4. The top 10 institutions and cited institutions related to this field.

Additional file 4 of Effects of mitochondrial dysfunction on bone metabolism and related diseases: a scientometric study from 2003 to 2022

Wei Zhang, Chang-Liang Xia, Jun-Nan Ma, Jia-Xuan Li, Qi Chen, Shuan-Ji Ou, Yang Yang, Yong Qi & Chang-Peng Xu
Additional file 4: SupplementaryTable 2. The top 10 co-cited references related to this field

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