7,407 Works

NLRC5 restricts dengue virus infection by promoting the autophagic degradation of viral NS3 through E3 ligase CUL2 (cullin 2)

Jiawei Hao, Jinqian Li, Zhenzhen Zhang, Yang Yang, Qing Zhou, Tiantian Wu, Tongling Chen, Zhongdao Wu, Ping Zhang, Jun Cui & Yi-Ping Li
NLRC5 has been reported to be involved in antiviral immunity; however, the underlying mechanism remains poorly understood. Here, we investigated the functional role of NLRC5 in the infection of a flavivirus, dengue virus (DENV). We found that the expression of NLRC5 was strongly induced by virus infection and IFNB or IFNG stimulation in different cell lines. Overexpression of NLRC5 remarkably suppressed DENV infection, whereas knockout of NLRC5 led to a significant increase in DENV infection....

Rapid and sensitive single-cell RNA sequencing with SHERRY2

Lin Di, Bo Liu, Yuzhu Lyu, Shihui Zhao, Yuhong Pang, Chen Zhang, Jianbin Wang, Hai Qi, Jie Shen & Yanyi Huang
Abstract Background Prevalent single-cell transcriptomic profiling (scRNA-seq) methods are mainly based on the synthesis and enrichment of full-length double-stranded complementary DNA. These approaches are challenging to generate accurate quantification of transcripts when their abundance is low or their full-length amplifications are difficult. Results Based on our previous finding that Tn5 transposase can directly cut-and-tag DNA/RNA hetero-duplexes, we present SHERRY2, a specifically optimized protocol for scRNA-seq without second-strand cDNA synthesis. SHERRY2 is free of pre-amplification and...

Additional file 1 of CD7-directed CAR T-cell therapy: a potential immunotherapy strategy for relapsed/refractory acute myeloid leukemia

Xuanqi Cao, Haiping Dai, Qingya Cui, Zheng Li, Wenhong Shen, Jinlan Pan, Hongjie Shen, Qinfen Ma, Mengyun Li, Sifan Chen, Juncheng Chen, Xiaming Zhu, Huimin Meng, Lin Yang, Depei Wu & Xiaowen Tang
Additional file 1: Figure S1. Cytotoxicity and cytokines analysis of the CD7 CAR T-cells. Figure S2. Diagrammatic sketch of the treatments and response. Figure S3. Infusion-related hepatic toxicities. Figure S4. Flow cytometry analysis of the fraction of T-cells and NK cells in the PB after infusion. Figure S5. Flow cytometry of the T-cell fractions in the PB after infusion of CART cells. Table S1. The result of SNP array (Cytoscan 750K/HD) at diagnosis. Table S2....

Functional Limitations and Physical Health in Community-Dwelling Medicare Advantage Beneficiaries: Variation by Race and Hispanic Subgroup

Jeff Luck, Diana Govier, Lan N. Ðoàn, Shyama Mahakalanda, Wei Zhang & Carolyn Mendez-Luck
Objectives: The objective is to examine racial and ethnic heterogeneity in older adults’ functional limitations and physical health. Methods: Data were from 2011 to 2015 Health Outcomes Survey of Medicare Advantage beneficiaries 65 and older (N = 828,946). Outcomes were Physical Component Summary (PCS) scores and need for assistance with activities of daily living (ADLs). Six non-Hispanic racial groups and five Hispanic subgroups were analyzed. Regression models adjusted for sociodemographic and health characteristics. Results: White...

Adalimumab for induction of remission in patients with Crohn's disease: a systematic review and meta-analysis

Juntao Yin, Yang Li, Yangyang Chen, Chaoyang Wang & Xiaoyong Song
Abstract Purpose A large number of people with Crohn's disease (CD) fail to recover from conventional therapy or biological therapy. Some studies showed that adalimumab (ADA) may be an effective alternative therapy for these patients. The aim of this study was to evaluate the efficacy and safety of ADA in inducing CD remission. Methods We performed search of Pubmed/MEDLINE, Embase, CENTRAL, the Cochrane IBD Group Specialized Register, and several other databases. Randomized controlled trials (RCTs)...

Additional file 4 of The rhizosphere bacterial community contributes to the nutritional competitive advantage of weedy rice over cultivated rice in paddy soil

Yue Wu, Jian Sun, Pengcheng Yu, Weiliang Zhang, Youze Lin & Dianrong Ma
Additional file 4. Table S2. Node names and their degree in co-occurrence network diagrams of different groups.

Two new thymol derivatives from Eupatorium fortunei

Jing Shi, Yan-peng Dai, Min Yuan, Xiao-man Sun, Chuan-jie Song & Yu-guo Liu
Two new thymol derivatives (1–2) were isolated from the aerial parts of Eupatorium fortunei. Their structures were elucidated on the basis of comprehensive spectroscopic data analysis as 8,9-dehydrothymol-3-O-β-glucoside (1), and 9-(acetyloxy)thymol-3-yl (3-methylbut-2-enoate) (2). All isolates were evaluated for cytotoxic activities with IC50 values greater than 50 μM in vitro against MCF-7, HeLa, A549, and Hep G-2 cancer cells.

Additional file 2 of Adalimumab for induction of remission in patients with Crohn's disease: a systematic review and meta-analysis

Juntao Yin, Yang Li, Yangyang Chen, Chaoyang Wang & Xiaoyong Song
Additional file 2: Figure S2. Forest plot for failure to achieve clinical remission at 4 weeks subgroup by concomitant medication in ADA and control groups.

Additional file 4 of Adalimumab for induction of remission in patients with Crohn's disease: a systematic review and meta-analysis

Juntao Yin, Yang Li, Yangyang Chen, Chaoyang Wang & Xiaoyong Song
Additional file 4: Figure S4. Forest plot for failure to achieve clinical response (100-point response) at 4 weeks subgroup by previous TNF-α exposure in ADA and control groups.

Additional file 4 of Adalimumab for induction of remission in patients with Crohn's disease: a systematic review and meta-analysis

Juntao Yin, Yang Li, Yangyang Chen, Chaoyang Wang & Xiaoyong Song
Additional file 4: Figure S4. Forest plot for failure to achieve clinical response (100-point response) at 4 weeks subgroup by previous TNF-α exposure in ADA and control groups.

Additional file 1 of Comparative analysis of mitochondrial genomes of maize CMS-S subtypes provides new insights into male sterility stability

Senlin Xiao, Jingfeng Xing, Tiange Nie, Aiguo Su, Ruyang Zhang, Yanxin Zhao, Wei Song & Jiuran Zhao
Additional file 1.

Additional file 3 of Comparative analysis of mitochondrial genomes of maize CMS-S subtypes provides new insights into male sterility stability

Senlin Xiao, Jingfeng Xing, Tiange Nie, Aiguo Su, Ruyang Zhang, Yanxin Zhao, Wei Song & Jiuran Zhao
Additional file 3.

Additional file 1 of 5-Methoxyflavone-induced AMPKα activation inhibits NF-κB and P38 MAPK signaling to attenuate influenza A virus-mediated inflammation and lung injury in vitro and in vivo

Sushan Yang, Linxin Wang, Xiping Pan, Yueyun Liang, Yuehan Zhang, Jing Li & Beixian Zhou
Additional file 1. Original images for western blot.

Additional file 9 of Comparative analysis of mitochondrial genomes of maize CMS-S subtypes provides new insights into male sterility stability

Senlin Xiao, Jingfeng Xing, Tiange Nie, Aiguo Su, Ruyang Zhang, Yanxin Zhao, Wei Song & Jiuran Zhao
Additional file 9.

Recurrent disability progression endpoints in multiple sclerosis clinical trials

Alexandra Bühler, Marcel Wolbers, Fabian Model, Qing Wang, Shibeshih Belachew, Marianna Manfrini, Johannes Lorscheider, Ludwig Kappos & Jan Beyersmann
Background:The current standard endpoint to assess disability accumulation in multiple sclerosis (MS) clinical trials is the time to the first confirmed disability progression, which excludes subsequent progression events. Including recurrent progression events may permit a more comprehensive assessment of treatment effects on disability progression.Objective:To propose a definition of recurrent disability progression events and to compare time-to-first and recurrent event analysis.Methods:Recurrent disability progression events were defined by expanding the recommended first event definition. Marginal recurrent event...

Recurrent disability progression endpoints in multiple sclerosis clinical trials

Alexandra Bühler, Marcel Wolbers, Fabian Model, Qing Wang, Shibeshih Belachew, Marianna Manfrini, Johannes Lorscheider, Ludwig Kappos & Jan Beyersmann
Background:The current standard endpoint to assess disability accumulation in multiple sclerosis (MS) clinical trials is the time to the first confirmed disability progression, which excludes subsequent progression events. Including recurrent progression events may permit a more comprehensive assessment of treatment effects on disability progression.Objective:To propose a definition of recurrent disability progression events and to compare time-to-first and recurrent event analysis.Methods:Recurrent disability progression events were defined by expanding the recommended first event definition. Marginal recurrent event...

Enhance the Efficiency of Graphene-based THz Modulator by Optimizing the Brewster Angle

Xingyue Li, zhaohui zhang, Xiaoyan Zhao, Tianyao Zhang, Luqi Tao, Zhengyong Huang, Ying Li, Xianhao Wu, Lu Yin & Yuan Yuan
The gate-controllable electronical property of graphene provides a possibility of active tuning property for THz modulator. However, the common modulation technology which only depends on voltage cannot solve the problem of power consumption limitation in communication applications. Here, we demonstrated a Brewster angle-controlled graphene-based THz modulator, which could achieve a relatively high modulation depth with low voltage. First, we explored the complex relationships among the Brewster angles, reflection coefficients and the conductivities of graphene. Then,...

Additional file 1 of Construction and yield optimization of a cinnamylamine biosynthesis route in Escherichia coli

Qi Wang, Linlin Ma, Zhiguo Wang, Quan Chen, Qian Wang & Qingsheng Qi
Additional file 1: Table S1. Bacterial strains used in this study.

Additional file 5 of Construction and yield optimization of a cinnamylamine biosynthesis route in Escherichia coli

Qi Wang, Linlin Ma, Zhiguo Wang, Quan Chen, Qian Wang & Qingsheng Qi
Additional file 5: Figure S2. Intracellular NADH content of MER-oE strains under different medium conditions. Data represent mean ± S.D. (error bars) from three independent experiments.

Additional file 8 of miR-146a-5p-modified hUCMSC-derived exosomes facilitate spinal cord function recovery by targeting neurotoxic astrocytes

Xunwei Lai, Yang Wang, Xiaokang wang, Bin Liu & Limin Rong
Additional file 8. The other 4 abundant miRNAs mimics’ effects on mRNA expression of neurotoxic astrocyte markers. Quantitative analysis of mRNA expression of C3 and Lcn2 in astrocytes, neurotoxic astrocytes and neurotoxic astrocytes treated with 50 nM mimics of miR-21-5p(a), miR-22-3p(b), miR-24-3p(c), miR-26a-5p(d) by RT-QPCR. Data above are represented as mean ± SD. *, p < 0.05; **, p < 0.01; #, p>0.05. C3 complement c3, Lcn2 lipocalin-2.

A nomogram to predict nosocomial infection in patients on venoarterial extracorporeal membrane oxygenation after cardiac surgery

Xiyuan Li, Liangshan Wang, Chenglong Li, Xiaomeng Wang, Xing Hao, Zhongtao Du, Haixiu Xie, Feng Yang, Hong Wang & Xiaotong Hou
IntroductionAfter cardiac surgery, patients on venoarterial extracorporeal membrane oxygenation (VA-ECMO) have a higher risk of nosocomial infection in the intensive care unit (ICU). We aimed to establish an intuitive nomogram to predict the probability of nosocomial infection in patients on VA-ECMO after cardiac surgery.MethodsWe included patients on VA-ECMO after cardiac surgery between January 2011 and December 2020 at a single center. We developed a nomogram based on independent predictors identified using univariate and multivariate logistic...

sj-docx-1-tah-10.1177_20406207221127532 – Supplemental material for Avatrombopag for the treatment of thrombocytopenia post hematopoietic stem-cell transplantation

Meng Zhou, Jiaqian Qi, Chengyuan Gu, Hong Wang, Ziyan Zhang, Depei Wu & Yue Han
Supplemental material, sj-docx-1-tah-10.1177_20406207221127532 for Avatrombopag for the treatment of thrombocytopenia post hematopoietic stem-cell transplantation by Meng Zhou, Jiaqian Qi, Chengyuan Gu, Hong Wang, Ziyan Zhang, Depei Wu and Yue Han in Therapeutic Advances in Hematology

sj-docx-1-tah-10.1177_20406207221127532 – Supplemental material for Avatrombopag for the treatment of thrombocytopenia post hematopoietic stem-cell transplantation

Meng Zhou, Jiaqian Qi, Chengyuan Gu, Hong Wang, Ziyan Zhang, Depei Wu & Yue Han
Supplemental material, sj-docx-1-tah-10.1177_20406207221127532 for Avatrombopag for the treatment of thrombocytopenia post hematopoietic stem-cell transplantation by Meng Zhou, Jiaqian Qi, Chengyuan Gu, Hong Wang, Ziyan Zhang, Depei Wu and Yue Han in Therapeutic Advances in Hematology

Avatrombopag for the treatment of thrombocytopenia post hematopoietic stem-cell transplantation

Meng Zhou, Jiaqian Qi, Chengyuan Gu, Hong Wang, Ziyan Zhang, Depei Wu & Yue Han
Background:Thrombocytopenia post hematopoietic stem-cell transplantation (HCT) usually contributes to poor outcomes with no standardized treatment. Eltrombopag and romiplostim can be feasible for post-HCT thrombocytopenia, but the use of avatrombopag has not yet been evaluated.Objectives:We aimed to evaluate the efficacy and safety of avatrombopag treatment in patients diagnosed with post-HCT thrombocytopenia.Design:In this retrospective study, we evaluated the efficacy and safety of avatrombopag treatment in a cohort of 61 patients diagnosed with thrombocytopenia post HCT in our...

sj-docx-1-tct-10.1177_15330338221124658 - Supplemental material for In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells

Mike Y. Chen, Jing Li, Nianli Zhang, Erik I. Waldorff, James T. Ryaby, Philip Fedor, Yongsheng Jia & Yujun Wang
Supplemental material, sj-docx-1-tct-10.1177_15330338221124658 for In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells by Mike Y. Chen, Jing Li, Nianli Zhang and Erik I. Waldorff, James T. Ryaby, Philip Fedor, Yongsheng Jia, Yujun Wang in Technology in Cancer Research & Treatment

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  • Chinese Academy of Medical Sciences & Peking Union Medical College
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