77 Works

High anal swab viral load predisposes adverse clinical outcomes in severe COVID-19 patients

Haibo Li, Lili Ren, Lulu Zhang, Yeming Wang, Li Guo, Conghui Wang, Yan Xiao, Ying Wang, Jian Rao, Xinming Wang, Ying Liu, Chaolin Huang, Xiaoying Gu, Guohui Fan, Hui Li, Binghuai Lu, Bin Cao & Jianwei Wang
To identify the association between the kinetics of viral load and clinical outcome in severe coronavirus disease 2019 (COVID-19) patients, a retrospective study was performed by involved 188 hospitalized severe COVID-19 patients in the LOTUS China trial. Among the collected 578 paired throat swab (TS) and anal swab (AS) samples, viral RNA was detected in 193 (33.4%) TS and 121 (20.9%) AS. A higher viral RNA load was found in TS than that of AS,...

Relationship between body composition and bone mineral density in postmenopausal women with type 2 diabetes mellitus

Lei Gao, Ping Zhang, Yan Wang, Wei Zhang, Jian Zhao, Ying Liu, Jing Liu & Shaoqiang He
Abstract Background The aim of the study were to analyze the lumbar volumetric bone mineral density (BMD), fat distribution and changes of skeletal muscle with quantitative computed tomography (QCT) in postmenopausal women with type 2 diabetes mellitus (T2DM), and to evaluate the relationship between body composition and BMD. Methods One hundred seventy-seven postmenopausal women with T2DM and 136 postmenopausal women without diabetes were included in the study and were divided into two groups according to...

Additional file 1 of Lipopolysaccharide downregulates the expression of ZO-1 protein through the Akt pathway

Peicen Zou, Fan Yang, Yijun Ding, Di Zhang, Ying Liu, Jinjing Zhang, Dan Wu & Yajuan Wang
Supplementary Material 1

High-performance visible-light active Sr-doped porous LaFeO3 semiconductor prepared via sol–gel method

Xi-Tao Yin, Hua Huang, Jie-Li Xie, Davoud Dastan, Jing Li, Ying Liu, Xiao-Ming Tan, Xiao-Chun Gao, Wahab Ali Shah & Xiao-Guang Ma
In this work, we have successfully fabricated Sr-doped porous LaFeO3 samples via sol–gel method. The results reveal that Sr2+ cation is effectively doped into LaFeO3 crystal lattice substituting La3+ cation. The visible light catalytic performance of the materials was evaluated by the degradation of 2,4-dichlorophenol (2,4-DCP) and Rhodamine B (RhB). The amount-optimized Sr-doped porous LaFeO3 sample exhibited outstanding visible-light catalytic performance for the degradation of the model pollutants compared to the porous LaFeO3 alone. The...

Molecular surveillance for anti-malarial drug resistance and genetic diversity of Plasmodium falciparum after chloroquine and sulfadoxine-pyrimethamine withdrawal in Quibdo, Colombia, 2018

Angela Patricia Guerra, Mario Javier Olivera, Liliana Jazmín Cortés, Stella M. Chenet, Alexandre Macedo de Oliveira & Naomi W. Lucchi
Abstract Background Resistance to anti-malarial drugs is associated with polymorphisms in target genes and surveillance for these molecular markers is important to detect the emergence of mutations associated with drug resistance and signal recovering sensitivity to anti-malarials previously used. Methods The presence of polymorphisms in genes associated with Plasmodium falciparum resistance to chloroquine and sulfadoxine-pyrimethamine was evaluated by Sanger sequencing, in 85 P. falciparum day of enrollment samples from a therapeutic efficacy study of artemether–lumefantrine...

Additional file 1 of Molecular surveillance for anti-malarial drug resistance and genetic diversity of Plasmodium falciparum after chloroquine and sulfadoxine-pyrimethamine withdrawal in Quibdo, Colombia, 2018

Angela Patricia Guerra, Mario Javier Olivera, Liliana Jazmín Cortés, Stella M. Chenet, Alexandre Macedo de Oliveira & Naomi W. Lucchi
Additional file 1: Table S1. Alleles found in samples from Quibdo, 2018. *Pfmdr1 data is already published (10). Tabular data with the alleles found in crt, dhfr, dphs, and mdr1 genes and 7 neutral microsatellites in 42 samples from Quibdo, Colombia, 2018. Red letter indicates a mutant allele. N/A indicates no allele amplification at that locus.

Child 3D anthropometry evaluation datasets

Karim Bougma, Zuguo Mei, Mireya Palmieri, Dickens Onyango, Jianmeng Liu, Karla Mesarina, Victor Akelo, Rael Mwando, Yubao Zhou, Ying Meng & Maria Elena Jefferds
Background: An efficacy evaluation of the AutoAnthro system to measure child (0–59 months) anthropometry in USA found three-dimensional imaging performed as well as gold-standard manual measurements for biological plausibility and precision. Objectives: Conduct an effectiveness evaluation of the accuracy of the AutoAnthro system to measure 0–59 months child anthropometry in population-based surveys and surveillance systems in households in Guatemala and Kenya, and in hospitals in China. Methods: The evaluation was done using health or nutrition...

Birth weight is associated with obesity and T2DM in adulthood among Chinese women

Pu Song, Hui Hui, Manqing Yang, Peng Lai, Yan Ye, Ying Liu & Xuekui Liu
Abstract Background Previous studies have indicated an association between birth weight (BW) and type 2 diabetes mellitus (T2DM), but few studies have explored this relationship under different conditions of obesity in adulthood. Methods A total of 4,005 individuals from ten provinces of China were randomly selected to participate in this study. We used a questionnaire to collect age, BW, current weight, height, T2DM history, age at T2DM diagnosis, and other variables. The participants were divided...

Additional file 1 of A Facile machine learning multi-classification model for Streptococcus agalactiae clonal complexes

Jingxian Liu, Jing Zhao, Chencui Huang, Jingxu Xu, Wei Liu, Jiajia Yu, Hongyan Guan, Ying Liu & Lisong Shen
Additional file 1: Figure S1. The distribution of feature weights in S&A model. The S&A model was constructed based on antibiotic resistance and serotypes of S. agalactiae for clonal complexes prediction. Characteristics with higher weight having a greater effect on the model. Table S1. Comparison of models based on different combination of features in three categories in predicting each CCs of S. agalactiae.

Data from: Microbiome sharing between children, livestock and household surfaces in western Kenya

Emily Mosites, Matt Sammons, Elkanah Otiang, Alexander Eng, Ceclia Noecher, Ohad Manor, Sarah Hilton, Samuel M. Thmbi, Clayton Onyango, Gemina Garland-Lewis, Douglas R. Call, M. Kariuki Njenga, Judith N. Wasserheit, Jennifer A. Zambriski, Judd L. Walson, Guy H. Palmer, Joel Montgomery, Elhanan Borenstein, Richard Omore, Peter M. Rabinowitz, Samuel M. Thumbi & Cecilia Noecker
The gut microbiome community structure and development are associated with several health outcomes in young children. To determine the household influences of gut microbiome structure, we assessed microbial sharing within households in western Kenya by sequencing 16S rRNA libraries of fecal samples from children and cattle, cloacal swabs from chickens, and swabs of household surfaces. Among the 156 households studied, children within the same household significantly shared their gut microbiome with each other, although we...

Data from: The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density

Hannah C. Slater, Amanda Ross, Ingrid Felger, Natalie E. Hofmann, Leanne Robinson, Jackie Cook, Bronner P. Gonçalves, Anders Björkman, Andre Lin Ouedraogo, Ulrika Morris, Mwinyi Msellem, Cristian Koepfli, Ivo Mueller, Fitsum Tadesse, Endalamaw Gadisa, Smita Das, Gonzalo Domingo, Melissa Kapulu, Janet Midega, Seth Owusu-Agyei, Cécile Nabet, Renaud Piarroux, Ogobara Doumbo, Safiatou Niare Doumbo, Kwadwo Koram … & Lucy C. Okell
Malaria infections occurring below the limit of detection of standard diagnostics are common in all endemic settings. However, key questions remain surrounding their contribution to sustaining transmission and whether they need to be detected and targeted to achieve malaria elimination. In this study we analyse a range of malaria datasets to quantify the density, detectability, course of infection and infectiousness of subpatent infections. Asymptomatically infected individuals have lower parasite densities on average in low transmission...

Design and synthesis of geosmin derivatives using organic synthesis strategies and application in antibody production

Penghui Zhou, Ying Liu, Ting Zhou, Hanwen Liu, Jianguo Li & Anping Deng
To develop a sensitive and specific ELISA for geosmin (GSM), the research of this study is focused on the design and synthesis of several GSM derivatives, which maintain the whole GSM structure as much as possible and contain a spacer arm with an active group at the end. To form the GSM backbone, tandem organic reaction strategies were used to replace the traditional Robinson cyclization reaction. Five GSM derivatives were synthesized and the formed GSM...

Design and synthesis of geosmin derivatives using organic synthesis strategies and application in antibody production

Penghui Zhou, Ying Liu, Ting Zhou, Hanwen Liu, Jianguo Li & Anping Deng
To develop a sensitive and specific ELISA for geosmin (GSM), the research of this study is focused on the design and synthesis of several GSM derivatives, which maintain the whole GSM structure as much as possible and contain a spacer arm with an active group at the end. To form the GSM backbone, tandem organic reaction strategies were used to replace the traditional Robinson cyclization reaction. Five GSM derivatives were synthesized and the formed GSM...

Additional file 2 of Effects of physiotherapeutic scoliosis-specific exercise in patients with mild juvenile scoliosis

Wangshu Yuan, Hai Wang, Keyi Yu, Jianxiong Shen, Lixia Chen, Ying Liu & Youxi Lin
Additional file 2: Supplementary table 2. Data of the subjects in the PSSE group

Additional file 1 of Effects of physiotherapeutic scoliosis-specific exercise in patients with mild juvenile scoliosis

Wangshu Yuan, Hai Wang, Keyi Yu, Jianxiong Shen, Lixia Chen, Ying Liu & Youxi Lin
Additional file 1: Supplementary table 1. Data of the subjects in the observation group

Additional file 2 of Effects of physiotherapeutic scoliosis-specific exercise in patients with mild juvenile scoliosis

Wangshu Yuan, Hai Wang, Keyi Yu, Jianxiong Shen, Lixia Chen, Ying Liu & Youxi Lin
Additional file 2: Supplementary table 2. Data of the subjects in the PSSE group

Integrated physiological and transcriptional dissection reveals the core genes involving nutrient transport and osmoregulatory substance biosynthesis in allohexaploid wheat seedlings under salt stress

Jun-fan Chen, Ying Liu, Tian-yu Zhang, Zheng-fu Zhou, Jin-yong Huang, Ting Zhou & Ying-peng Hua
Abstract Background Soil salinization has become a global problem restricting the seed yield and quality of crops, including wheat (Triticum aestivum L.). Salinity significantly alters plant morphology and severely disrupts physiological homeostasis. Salt tolerance of wheat has been widely studied whereas core ion transporters responsive to salt stress remain elusive. Results In this study, the wheat seedlings were subjected to salinity toxicity for morpho-physiological and transcriptomic analysis of wheat salt tolerance. There was a inversely...

Lipopolysaccharide downregulates the expression of ZO-1 protein through the Akt pathway

Peicen Zou, Fan Yang, Yijun Ding, Di Zhang, Ying Liu, Jinjing Zhang, Dan Wu & Yajuan Wang
Abstract Background Neonatal bacterial meningitis is a common neonatal disease with high morbidity, and can cause serious sequelae when left untreated. Escherichia coli is the common pathogen, and its endotoxin, lipopolysaccharide (LPS) can damage the endothelial cells, increasing the permeability of the blood-brain barrier (BBB), leading to intracranial inflammation. However, the specific mechanism of bacterial meningitis induced by LPS damaging BBB remains unclear. In this study, the mouse brain microvascular endothelial (bEND.3) cells were used...

Additional file 3 of Proactive community case management decreased malaria prevalence in rural Madagascar: results from a cluster randomized trial

Rila Ratovoson, Andres Garchitorena, Daouda Kassie, Jemima A. Ravelonarivo, Voahangy Andrianaranjaka, Seheno Razanatsiorimalala, Avotra Razafimandimby, Fanjasoa Rakotomanana, Laurie Ohlstein, Reziky Mangahasimbola, Sandro A. N. Randrianirisoa, Jocelyn Razafindrakoto, Catherine M. Dentinger, John Williamson, Laurent Kapesa, Patrice Piola, Milijaona Randrianarivelojosia, Julie Thwing, Laura C. Steinhardt & Laurence Baril
Additional file 3. Analyses and findings on anemia and PRO-CCM. Table S5. Prevalence of anemia among all women of reproductive age at baseline and endline, by study arm. Table S6. Unadjusted analyses of prevalence of anemia among all women of reproductive age at baseline, using logistic regression models. Table S7. Adjusted analyses of prevalence of anemia among all women of reproductive age at baseline, using logistic regression models.

Anxiety, depression, and sleep disturbances among people on long-term efavirenz-based treatment for HIV: a cross-sectional study in Beijing, China

Jing Xiao, Ying Liu, Bei Li, Leidan Zhang, Junyan Han & Hongxin Zhao
Abstract Background Efavirenz (EFV)-induced neuropsychiatric toxicity bothers people living with HIV (PLHIV). Neuropsychiatric adverse effects of EFV may differ by length of time on EFV-based antiretroviral treatment (ART). Methods A cross-sectional, single-center study was conducted at Beijing Ditan Hospital in China from June–August 2020 among ART-experienced PLHIV who were on long-term EFV-based ART. 424 eligible virological suppressed participants were enrolled and divided into four groups according to time on EFV-based ART: group A (0.5 ≤...

Glucose fluctuation promotes cardiomyocyte apoptosis by triggering endoplasmic reticulum (ER) stress signaling pathway in vivo and in vitro

Li-Da Wu, Ying Liu, Feng Li, Jia-Yi Chen, Jie Zhang, Ling-Ling Qian & Ru-Xing Wang
Glucose fluctuation is more harmful than sustained hyperglycemia, but the effect on cardiomyocyte apoptosis have not yet been clarified. In this study, we aim to identify the effect of glucose fluctuation on cardiomyocyte apoptosis and explore the underlying mechanism. Sprague-Dawley rats were intraperitoneally injected with streptozotocin (STZ) and divided into three groups: controlled diabetic group (C-STZ); uncontrolled diabetic group (U-STZ) and glucose fluctuated diabetic group (GF-STZ). After twelve weeks, echocardiography, Hematoxylin-eosin (HE) staining, and Masson...

A SERS-based immunochromatographic assay for ultrasensitive and quantitative detection of florfenicol using long wavelength absorption of Au nanocubes

Ying Liu, Ting Zhou, Penghui Zhou, Hanwen Liu, Jianguo Li & Anping Deng
An immunochromatographic assay (ICA) based on surface-enhanced Raman scattering (SERS) for ultrasensitive and quantitative detection of florfenicol (FF) in food samples was developed. Au nanocubers (AuNCs) with long wavelength absorption were synthesised, characterised and used as the substrate in SERS-ICA. Immunoprobe was prepared by linking Raman reporter and the antibody against FF on AuNCs. The SERS-ICA was completed in 15 min. By measuring the Raman intensities on T lines, quantitative detection of FF was achieved....

Effects of physiotherapeutic scoliosis-specific exercise in patients with mild juvenile scoliosis

Wangshu Yuan, Hai Wang, Keyi Yu, Jianxiong Shen, Lixia Chen, Ying Liu & Youxi Lin
Abstract Study design A combined retrospective and prospective analysis on the therapeutic effect of physiotherapeutic scoliosis-specific exercise (PSSE) in mild juvenile idiopathic scoliosis (JIS) patients. Background At present, patients with mild JIS are generally treated by observation without any interventional treatment. This study analyzed the effects of PSSE on mild JIS, which provided a new approach for the treatment of JIS. Method A total of 52 patients with mild JIS (Cobb angle 10–19°), aged 4–9...

sj-pdf-1-trj-10.1177_00405175221132327 - Supplemental material for Research on full color gamut mixing model constructed by CNC spinning and Stearns-Noechel color prediction method

Xianqiang Sun, Yuan Xue, Yuexing Liu, Guoqing Zhang, Lixia Liu & Liqiang Wang
Supplemental material, sj-pdf-1-trj-10.1177_00405175221132327 for Research on full color gamut mixing model constructed by CNC spinning and Stearns-Noechel color prediction method by Xianqiang Sun, Yuan Xue, Yuexing Liu, Guoqing Zhang, Lixia Liu and Liqiang Wang in Textile Research Journal

Integrated physiological and transcriptional dissection reveals the core genes involving nutrient transport and osmoregulatory substance biosynthesis in allohexaploid wheat seedlings under salt stress

Jun-fan Chen, Ying Liu, Tian-yu Zhang, Zheng-fu Zhou, Jin-yong Huang, Ting Zhou & Ying-peng Hua
Abstract Background Soil salinization has become a global problem restricting the seed yield and quality of crops, including wheat (Triticum aestivum L.). Salinity significantly alters plant morphology and severely disrupts physiological homeostasis. Salt tolerance of wheat has been widely studied whereas core ion transporters responsive to salt stress remain elusive. Results In this study, the wheat seedlings were subjected to salinity toxicity for morpho-physiological and transcriptomic analysis of wheat salt tolerance. There was a inversely...

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