2 Works

Data from: Very high MHC Class IIB diversity without spatial differentiation in the Mediterranean population of Greater Flamingos

Mark A. F. Gillingham, Arnaud Béchet, Alexandre Courtiol, Manuel Rendón-Martos, Juan A. Amat, Boudjéma Samraoui, Ortaç Onmuş, Simone Sommer & Frank Cézilly
Background: Selective pressure from pathogens is thought to shape the allelic diversity of major histocompatibility complex (MHC) genes in vertebrates. In particular, both local adaptation to pathogens and gene flow are thought to explain a large part of the intraspecific variation observed in MHC allelic diversity. To date, however, evidence that adaptation to locally prevalent pathogens maintains MHC variation is limited to species with limited dispersal and, hence, reduced gene flow. On the one hand...

Data from: Susceptibility to type 2 diabetes may be modulated by haplotypes in G6PC2, a target of positive selection

Nasser M. Al-Daghri, Chiara Pontremoli, Rachele Cagliani, Diego Forni, Majed S. Alokail, Omar S. Al-Attas, Shaun Sabico, Stefania Riva, Mario Clerici & Manuela Sironi
Background: The endoplasmic reticulum enzyme glucose-6-phosphatase catalyzes the common terminal reaction in the gluconeogenic/glycogenolytic pathways and plays a central role in glucose homeostasis. In most mammals, different G6PC subunits are encoded by three paralogous genes (G6PC, G6PC2, and G6PC3). Mutations in G6PC and G6PC3 are responsible for human mendelian diseases, whereas variants in G6PC2 are associated with fasting glucose (FG) levels. Results: We analyzed the evolutionary history of G6Pase genes. Results indicated that the three...

Registration Year

  • 2017
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Resource Types

  • Dataset
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Affiliations

  • King Saud University
    2
  • University of Milan
    1
  • Regional Government of Andalusia
    1
  • Ege University
    1
  • French National Centre for Scientific Research
    1
  • Spanish National Research Council
    1
  • University of Ulm
    1
  • Tour du Valat
    1
  • Leibniz Institute for Zoo and Wildlife Research
    1
  • Eugenio Medea
    1