10 Works
Az Zabirah South Zone chemistry data
Paul Asimow
Tabular data for whole-rock chemistry of bauxite samples from the Az Zabirah South Zone bauxite deposit, Saudi Arabia.
Is COVID-19 associated with self-reported audio-vestibular symptoms?
Arwa AlJasser, Walid Alkeridy, Kevin J. Munro & Christopher J. Plack
To determine if a positive test for COVID-19 is associated with self-reported audio-vestibular symptoms. Self-reported changes in hearing, tinnitus, hyperacusis, and dizziness/rotatory vertigo were assessed in hospitalised and non-hospitalised COVID-19 patients during and after the acute phase of the disease and compared to non-COVID controls. There were 150 severe cases of COVID-19 requiring hospital admission and 150 mild cases that were managed at home. Controls were 267 adults, 32 of whom had been hospitalised for...
Is COVID-19 associated with self-reported audio-vestibular symptoms?
Arwa AlJasser, Walid Alkeridy, Kevin J. Munro & Christopher J. Plack
To determine if a positive test for COVID-19 is associated with self-reported audio-vestibular symptoms. Self-reported changes in hearing, tinnitus, hyperacusis, and dizziness/rotatory vertigo were assessed in hospitalised and non-hospitalised COVID-19 patients during and after the acute phase of the disease and compared to non-COVID controls. There were 150 severe cases of COVID-19 requiring hospital admission and 150 mild cases that were managed at home. Controls were 267 adults, 32 of whom had been hospitalised for...
Cytotoxicity and molecular docking analysis of racemolactone I, a new sesquiterpene lactone isolated from Inula racemosa
Perwez Alam, Rama Tyagi, Mohammad Abul Farah, Md. Tabish Rehman, Afzal Hussain, Mohamed Fahad AlAjmi, Nasir Ali Siddiqui, Khalid Mashay Al-Anazi, Saima Amin, Mohd. Mujeeb & Showkat R. Mir
Traditionally, Inula racemosa Hook. f. (Asteraceae) has been reported to be effective in cancer treatment which motivated the authors to explore the plant for novel anticancer compounds. To isolate and characterize new cytotoxic phytoconstituents from I. racemosa roots. The column chromatography of I. racemosa ethyl acetate extract furnished a novel sesquiterpene lactone whose structure was established by NMR (1D/2D), ES-MS and its cytotoxic properties were assessed on HeLa, MDAMB-231, and A549 cell lines using MTT...
Emetine, a potent alkaloid for the treatment of SARS-CoV-2 targeting papain-like protease and non-structural proteins: pharmacokinetics, molecular docking and dynamic studies
Mejdi Snoussi, Alaeddine Redissi, Amor Mosbah, Vincenzo De Feo, Mohd Adnan, Kaïss Aouadi, Mousa Alreshidi, Mitesh Patel, Adel Kadri & Emira Noumi
The main objective of this study is to find out the anti-SARS-CoV-2 potential of emetine by using molecular docking and dynamic simulation approaches. Interestingly, molecular docking studies suggest that Emetine showed significant binding affinity toward Nsp15 (-10.8 kcal/mol) followed by Nsp12 (-9.5 kcal/mol), RNA-dependent RNA polymerase, RdRp (-9.5 kcal/mol), Nsp16 (-9.4 kcal/mol), Nsp10 (-9.2 kcal/mol), Papain-like protein (-9.0 kcal/mol), Nsp13 (-9.0 kcal/mol), Nsp14 (-8.9 kcal/mol) and Spike Protein Receptor Domain (-8.8 kcal/mol) and chymotrypsin-like protease,...
COVID-19 Vaccination perceptions of HCWs
Mazin Barry
Objectives: This study aimed to identify COVID-19 vaccine perception, acceptance, confidence, hesitancy, and barriers among healthcare workers (HCW). Methods: An online national cross-sectional pilot-validated questionnaire was self-administered by HCW in Saudi Arabia, a nation with MERS-CoV experience. The main outcome variable was HCW’s acceptance of COVID-19 vaccine candidates. The associated factors of vaccination acceptance were identified through a logistic regression analysis and the level of anxiety using a validated instrument to measure general anxiety levels....
Cytotoxicity and molecular docking analysis of racemolactone I, a new sesquiterpene lactone isolated from Inula racemosa
Perwez Alam, Rama Tyagi, Mohammad Abul Farah, Md. Tabish Rehman, Afzal Hussain, Mohamed Fahad AlAjmi, Nasir Ali Siddiqui, Khalid Mashay Al-Anazi, Saima Amin, Mohd. Mujeeb & Showkat R. Mir
Traditionally, Inula racemosa Hook. f. (Asteraceae) has been reported to be effective in cancer treatment which motivated the authors to explore the plant for novel anticancer compounds. To isolate and characterize new cytotoxic phytoconstituents from I. racemosa roots. The column chromatography of I. racemosa ethyl acetate extract furnished a novel sesquiterpene lactone whose structure was established by NMR (1D/2D), ES-MS and its cytotoxic properties were assessed on HeLa, MDAMB-231, and A549 cell lines using MTT...
Emetine, a potent alkaloid for the treatment of SARS-CoV-2 targeting papain-like protease and non-structural proteins: pharmacokinetics, molecular docking and dynamic studies
Mejdi Snoussi, Alaeddine Redissi, Amor Mosbah, Vincenzo De Feo, Mohd Adnan, Kaïss Aouadi, Mousa Alreshidi, Mitesh Patel, Adel Kadri & Emira Noumi
The main objective of this study is to find out the anti-SARS-CoV-2 potential of emetine by using molecular docking and dynamic simulation approaches. Interestingly, molecular docking studies suggest that Emetine showed significant binding affinity toward Nsp15 (-10.8 kcal/mol) followed by Nsp12 (-9.5 kcal/mol), RNA-dependent RNA polymerase, RdRp (-9.5 kcal/mol), Nsp16 (-9.4 kcal/mol), Nsp10 (-9.2 kcal/mol), Papain-like protein (-9.0 kcal/mol), Nsp13 (-9.0 kcal/mol), Nsp14 (-8.9 kcal/mol) and Spike Protein Receptor Domain (-8.8 kcal/mol) and chymotrypsin-like protease,...
Animal lifestyle affects acceptable mass limits for attached tags
Rory Wilson, Kayleigh Rose, Richard Gunner, Mark Holton, Nikki Marks, Nigel Bennett, Stephen Bell, Joshua Twining, Jamie Hesketh, Carlos Duarte, Neil Bezodis, Milos Jezek, Michael Painter, Vaclav Silovsky, Margaret Crofoot, Roi Harel, John Arnould, Blake Allan, Desley Whisson, Abdulaziz Alagaili & David Scantlebury
Animal-attached devices have transformed our understanding of vertebrate ecology. To minimize any associated harm, researchers have long advocated that tag masses should not exceed 3% of carrier body mass. However, this ignores tag forces resulting from animal movement. Using data from collar-attached accelerometers on 10 diverse free-ranging terrestrial species from koalas to cheetahs, we detail a tag-based acceleration method to clarify acceptable tag mass limits. We quantify animal athleticism in terms of fractions of animal...