Additional file 1: Supplementary table 1. Patient cohort characteristics at baseline.

Additional file 5: Supplementary table 5a-b. Serum TLR4 activity and LPS bioactivity determined after neutralization by polymyxin B.

Abstract Background Dysbiotic intestinal and oral microbiota have been implicated in the pathogenesis of rheumatoid arthritis (RA), but the mechanisms how microbiota could impact disease activity have remained elusive. The aim of this study was to assess the association of the biological activity of serum lipopolysaccharides (LPS) with disease activity and likelihood of achieving remission in RA patients. Methods We measured Toll-like receptor (TLR) 4-stimulating activity of sera of 58 RA patients with a reporter...

Additional file 2: Supplementary table 2. The number of patients with missing data.

Additional file 3: Supplementary table 3a-e. Correlations of LPS-related biomarkers with RA disease activity, inflammatory biomarkers, and metabolic factors.

Additional file 4: Supplementary table 4. Measured LPS bioactivity and the concentrations of LBP, CD14, and CD163.

Additional file 4: Supplementary table 4. Measured LPS bioactivity and the concentrations of LBP, CD14, and CD163.

Additional file 2: Supplementary table 2. The number of patients with missing data.

Additional file 1: Supplementary table 1. Patient cohort characteristics at baseline.

Abstract Background Dysbiotic intestinal and oral microbiota have been implicated in the pathogenesis of rheumatoid arthritis (RA), but the mechanisms how microbiota could impact disease activity have remained elusive. The aim of this study was to assess the association of the biological activity of serum lipopolysaccharides (LPS) with disease activity and likelihood of achieving remission in RA patients. Methods We measured Toll-like receptor (TLR) 4-stimulating activity of sera of 58 RA patients with a reporter...

Additional file 5: Supplementary table 5a-b. Serum TLR4 activity and LPS bioactivity determined after neutralization by polymyxin B.

Additional file 3: Supplementary table 3a-e. Correlations of LPS-related biomarkers with RA disease activity, inflammatory biomarkers, and metabolic factors.