71 Works

Two new cycloartane triterpenoid glycosides from the rhizomes of Actaea vaginata

Shunqin Zeng, Xiangyuan Li, Zixuan Zhao, Yan Lin, Yindi Zhu, Guoxu Ma, Xiaohong Zhao, Xudong Xu, Meichun Wu, Haifeng Wu, Qiongyu Zou & Yongtao Li
Two new cycloartane triterpenoid glycosides, soulieoside V (1) and 15-deacetylbeesioside O (2), together with one known compound, beesioside J (3), were isolated from the ethanolic extract of the rhizomes of Actaea vaginata. Their structures were elucidated by spectroscopic methods and by comparison with data reported in the literature. All the compounds were tested for their cytotoxic activities against human cancer cell lines.

Bitter taste receptor genes of primates

Ping Feng
Bitter taste perception plays a critical role in deterring animals from consuming harmful and toxic substances. To characterize the evolution of primate Tas2rs and test whether dietary preference has shaped the Tas2rs repertoire of primates, we identified Tas2r genes of 35 genomes including 16 Cercopithecidae species, 6 Hominidae species, 4 Cebidae species, 3 Lemuridae species, and other 6 species. The results showed that the total numbers of primates' Tas2rs ranged from 27 to 51, which...

Engineering Yarrowia lipolytica for the sustainable production of β-farnesene from waste oil feedstock

Yinghang Liu, Jin Zhang, Qingbin Li, Zhaoxuan Wang, Zhiyong Cui, Tianyuan Su, Xuemei Lu, Qingsheng Qi & Jin Hou
Abstract Background β-Farnesene is a sesquiterpene with versatile industrial applications. The production of β-farnesene from waste lipid feedstock is an attractive method for sustainable production and recycling waste oil. Yarrowia lipolytica is an unconventional oleaginous yeast, which can use lipid feedstock and has great potential to synthesize acetyl-CoA-derived chemicals. Results In this study, we engineered Y. lipolytica to produce β-farnesene from lipid feedstock. To direct the flux of acetyl-CoA, which is generated from lipid β-oxidation,...

No rebound effect after a course of clopidogrel in patients with acute TIA or minor stroke

Xinmiao Zhang, Jing Jing, Xingquan Zhao, Liping Liu, Anxin Wang, Yuesong Pan, David Wang, S. Claiborne Johnston, Yilong Wang, Yongjun Wang & Xia Meng
Previous studies demonstrated that discontinuation of clopidogrel in patients after ACS was associated with a rebound increase in risk of recurrent events. In this study, we aimed to investigate the rebound effect after discontinuation of clopidogrel therapy in patients with TIA or stroke. All patients with minor stroke or TIA were recruited from the Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events (CHANCE) trial. Patients were divided into two groups: patients who discontinued clopidogrel...

Additional file 1 of Effective hospital readmission prediction models using machine-learned features

Sacha Davis, Jin Zhang, Ilbin Lee, Mostafa Rezaei, Russell Greiner, Finlay A. McAlister & Raj Padwal
Supplementary Material 1

Adsorption Behavior of Vanadium Using Supported 1-Butyl-3-Methylimidazolium Chloride Ionic Liquid

Yu Liang, Shenxu Bao, Yimin Zhang, Bo Chen & Chen Yu
Imidazole-based ionic liquid 1-Butyl-3-methylimidazolium chloride was immobilized on polymer support by chemical grafting and utilized to separate vanadium (V) from a vanadium-containing solution. Characterizations with elementary analysis, Fourier transform infrared (FTIR), 13C nuclear magnetic resonance (NMR), scanning electron microscopy (SEM) and energy dispersive spectrometer (EDS) proved the successful loading of the ionic liquid on the surface of the support. The adsorption capacity toward V(V) reached 222.42 mg/g under experimental conditions, which was significantly higher than...

Spatio-temporal doubly periodic waves in phase-mismatched second-harmonic generation

Zhixiang Deng, Jin Zhang, Dianyuan Fan & LIFU ZHANG
In this Letter we present the analytical and numerical investigation to characterize the formation of quadratic doubly periodic waves, originating from coherent modulation instability in a dispersive quadratic media in the regime of cascading second-harmonic generation. Such an endeavor has not been undertaken before despite the growing relevance of double-periodic solutions as the precursor of highly localized wave structures. Unlike the case with cubic nonlinearity, the periodicity of these quadratic nonlinear waves can be also...

sj-docx-1-eso-10.1177_23969873221126000 – Supplemental material for Prognostic significance of atrial cardiopathy in patients with acute ischemic stroke

Yueyang Wu, Xiaomeng Yang, Jing Jing, Xia Meng, Zixiao Li, Yuesong Pan, Yong Jiang, Hongyi Yan, Xinying Huang, Liping Liu, Xingquan Zhao, Yilong Wang, Hao Li & Yongjun Wang
Supplemental material, sj-docx-1-eso-10.1177_23969873221126000 for Prognostic significance of atrial cardiopathy in patients with acute ischemic stroke by Yueyang Wu, Xiaomeng Yang, Jing Jing, Xia Meng, Zixiao Li, Yuesong Pan, Yong Jiang, Hongyi Yan, Xinying Huang, Liping Liu, Xingquan Zhao, Yilong Wang, Hao Li and Yongjun Wang in European Stroke Journal

Evaluation of Online Andrology Medical Services in Central Regions of China During the COVID-19 Pandemic: A Cross-Sectional Data Analysis Study

Zhi Liu, Chunyu Zhang, Cong Luo, Junlin Ou, Ming Song, Lingxiao Yang, Xin Wang, Jinbo Chen, Guilin Wang & Tao Guo
To provide an overview of the current situation, challenges, and trends in online medical services from the perspective of andrology and promote the development of online medical services. Users of the Learning Alliance of Urology, who mainly worked in central regions of China, were invited to complete the questionnaire that included information on the participants and their institutions and their involvement in and concerns for online medical services. We received 875 complete responses. The percentage...

Low serum 25-hydroxyvitamin D levels are associated with increased cardiovascular morbidity and mortality

Wei Luo, Dan Xu, Jin Zhang, Yao Zhou, Qin Yang, Qiuju Lv & Zhen Qu
There is controversy about the association between vitamin D and cardiovascular disease (CVD). This article aims to explore the association of serum 25-hydroxyvitaminD (25 OHD) with the risk of CVD. PubMed, EMBASE, Web of Science database, OVID, and Cochrane Library databases (last updated in August 2022) were systematically searched. The relationship between 25OHD and the risk of CVD was assessed by using the 95% confidence intervals (CI) and hazard ratio (HR). The effect model was...

Double-layer electrowetting-aided spinning for fabrication of metal-core piezoelectric-piezoresistive composite fiber

Yang Wang, Xiangdong Kong & Ping Yu
Metal core piezoelectric fiber (MPF) with excellent dynamic force response performance is a promising coaxial fiber, but its application in numerous occasions requiring simultaneous detecting of static and dynamic forces is limited due to its inability to detect static forces. To overcome this problem, this paper proposes a novel double-layer electrowetting-aided spinning to produce a metal-core piezoelectric piezoresistive composite fiber (MPPCF). The MPPCF is composed of seven layers from inside to outside including a metal...

Exogenous H2S reverses high glucose-induced endothelial progenitor cells dysfunction via regulating autophagy

Wenxue Ma, Tingting Zhong, Junqiu Chen, Xiao Ke, Huihua Zuo & Qiang Liu
This study aims to determine the effect of exogenous hydrogen sulfide (H2S) under high glucose (HG)-induced injury in endothelial progenitor cells (EPCs), and to explore the possible underlying mechanisms. Mononuclear cells were isolated from the peripheral blood of healthy volunteers by density-gradient centrifugation and identified as late EPCs by immunofluorescence and flow cytometry. EPCs were treated with high concentrations of glucose, H2S, Baf-A1, 3-MA or rapamycin. Cell proliferation, cell migration and tube formation were measured...

New insights into aging-associated characteristics of female subcutaneous adipose tissue through integrative analysis of multi-omics data

Zichao Li, Shun Wang, Shaojie Liu, Ziwen Xu, Xiaowei Yi, Hongtao Wang, Juanli Dang, Xinxin Wei, Bingyue Feng, Zinuo Liu, Ming Zhao, Qiong Wu & Dahai Hu
Aging could be critical in limiting the application of subcutaneous adipose tissue (SAT) in tissue repair and reconstruction. However, no systematic study on the characteristics of SAT aging has been conducted. In this study, a scanning electronic microscope was used to detect the structural and compositional changes of SAT collected from nine females in three age groups. Multi-omics data of SAT from 37 females were obtained from Gene Expression Omnibus database, and 1860 genes, 56...

New insights into aging-associated characteristics of female subcutaneous adipose tissue through integrative analysis of multi-omics data

Zichao Li, Shun Wang, Shaojie Liu, Ziwen Xu, Xiaowei Yi, Hongtao Wang, Juanli Dang, Xinxin Wei, Bingyue Feng, Zinuo Liu, Ming Zhao, Qiong Wu & Dahai Hu
Aging could be critical in limiting the application of subcutaneous adipose tissue (SAT) in tissue repair and reconstruction. However, no systematic study on the characteristics of SAT aging has been conducted. In this study, a scanning electronic microscope was used to detect the structural and compositional changes of SAT collected from nine females in three age groups. Multi-omics data of SAT from 37 females were obtained from Gene Expression Omnibus database, and 1860 genes, 56...

Sevoflurane reduces lipopolysaccharide-induced apoptosis and pulmonary fibrosis in the RAW264.7 cells and mice models to ameliorate acute lung injury by eliminating oxidative damages

Fushuang Zheng, Xiuying Wu, Jin Zhang, Zhiling Fu & Yan Zhang
Sevoflurane is identified as an effective candidate drug for acute lung injury (ALI) treatment, but its curing effects and detailed mechanisms have not been fully disclosed. The present study was designed to resolve this academic issue. The ALI mice models were established, and Hematoxylin-eosin staining assay was performed to examine tissue morphologies. Cell viability was determined by CCK-8 assay, and Annexin V-FITC/PI double staining assay was used to examine cell apoptosis. The expression levels of...

Additional file 1 of Engineering Yarrowia lipolytica for the sustainable production of β-farnesene from waste oil feedstock

Yinghang Liu, Jin Zhang, Qingbin Li, Zhaoxuan Wang, Zhiyong Cui, Tianyuan Su, Xuemei Lu, Qingsheng Qi & Jin Hou
Additional file 1: Figure S1. Screening β-farnesene synthase from different plants. A The evolutionary tree of β-farnesene synthase from different plants. B β-Farnesene production and biomass of strains containing different β-farnesene synthase. Data represent the mean ± SD of biological triplicate. Figure S2. The SDS-PAGE electrophoresis analysis of purified protein AanFSK197T/F180H and AanFS. Figure S3. The copy number and relative expression of AanFSK197T/F180H in Q6 and Q7 strains. Data represent the mean ± SD of...

Additional file 1 of Engineering Yarrowia lipolytica for the sustainable production of β-farnesene from waste oil feedstock

Yinghang Liu, Jin Zhang, Qingbin Li, Zhaoxuan Wang, Zhiyong Cui, Tianyuan Su, Xuemei Lu, Qingsheng Qi & Jin Hou
Additional file 1: Figure S1. Screening β-farnesene synthase from different plants. A The evolutionary tree of β-farnesene synthase from different plants. B β-Farnesene production and biomass of strains containing different β-farnesene synthase. Data represent the mean ± SD of biological triplicate. Figure S2. The SDS-PAGE electrophoresis analysis of purified protein AanFSK197T/F180H and AanFS. Figure S3. The copy number and relative expression of AanFSK197T/F180H in Q6 and Q7 strains. Data represent the mean ± SD of...

Key frames assisted hybrid encoding for photorealistic compressive video sensing

Honghao Huang, Jiajie Teng, Yu Liang, Chengyang Hu, Minghua Chen, Sigang Yang & Hongwei Chen
Snapshot compressive imaging (SCI) encodes high-speed scene video into a snapshot measurement and then computationally makes reconstructions, allowing for efficient high-dimensional data acquisition. Numerous algorithms, ranging from regularization-based optimization and deep learning, are being investigated to improve reconstruction quality, but they are still limited by the ill-posed and information-deficient nature of the standard SCI paradigm. To overcome these drawbacks, we propose a new key frames assisted hybrid encoding paradigm for compressive video sensing, termed KH-CVS,...

Additional file 1 of A high-quality Buxus austro-yunnanensis (Buxales) genome provides new insights into karyotype evolution in early eudicots

Zhenyue Wang, Ying Li, Pengchuan Sun, Mingjia Zhu, Dandan Wang, Zhiqiang Lu, Hongyin Hu, Renping Xu, Jin Zhang, Jianxiang Ma, Jianquan Liu & Yongzhi Yang
Additional file 1: Fig. S1. The previously reported topologies within eudicots. Fig. S2. 19-Kmer-based analysis to estimate the genome size of Buxus austro-yunnanensis. Fig. S3. Interaction frequency distribution of Hi-C links among chromosomes. Fig. S4. GC contents of five early-diverging eudicot species. Fig. S5. BUSCO results for six eudicots. Fig. S6. LTR insertion time of Buxus austro-yunnanensis. Fig. S7. Gene structures of Aquilegia, Buxus, Nelumbo, Trochodendron and Tetracentron. Fig. S8. The phylogenetic trees of the...

Additional file 1 of A high-quality Buxus austro-yunnanensis (Buxales) genome provides new insights into karyotype evolution in early eudicots

Zhenyue Wang, Ying Li, Pengchuan Sun, Mingjia Zhu, Dandan Wang, Zhiqiang Lu, Hongyin Hu, Renping Xu, Jin Zhang, Jianxiang Ma, Jianquan Liu & Yongzhi Yang
Additional file 1: Fig. S1. The previously reported topologies within eudicots. Fig. S2. 19-Kmer-based analysis to estimate the genome size of Buxus austro-yunnanensis. Fig. S3. Interaction frequency distribution of Hi-C links among chromosomes. Fig. S4. GC contents of five early-diverging eudicot species. Fig. S5. BUSCO results for six eudicots. Fig. S6. LTR insertion time of Buxus austro-yunnanensis. Fig. S7. Gene structures of Aquilegia, Buxus, Nelumbo, Trochodendron and Tetracentron. Fig. S8. The phylogenetic trees of the...

Genetic analysis of 55 cases with fetal skeletal dysplasia

Ying Bai, Yue Sun, Ning Liu, Li Wang, Zhihui Jiao, Yaqin Hou, Huikun Duan, Qianqian Li, Xiaofan Zhu, Jingjing Meng & Xiangdong Kong
Abstract Background Fetal skeletal dysplasia (SD) is a common congenital disability comprising a complex group of skeletal disorders with substantial clinical and genetic heterogeneity. Many of these defects are detected prenatally using ultrasound (US). However, the diagnostic accuracy of the US is limited. Methods We recruited 55 unrelated fetuses with US-detected skeletal anomalies and performed sequential tests using copy number variation sequencing, targeted skeletal gene panel sequencing, or whole exome sequencing. The detected variants were...

Additional file 1 of Effective hospital readmission prediction models using machine-learned features

Sacha Davis, Jin Zhang, Ilbin Lee, Mostafa Rezaei, Russell Greiner, Finlay A. McAlister & Raj Padwal
Supplementary Material 1

Effective hospital readmission prediction models using machine-learned features

Sacha Davis, Jin Zhang, Ilbin Lee, Mostafa Rezaei, Russell Greiner, Finlay A. McAlister & Raj Padwal
Abstract Background: Hospital readmissions are one of the costliest challenges facing healthcare systems, but conventional models fail to predict readmissions well. Many existing models use exclusively manually-engineered features, which are labor intensive and dataset-specific. Our objective was to develop and evaluate models to predict hospital readmissions using derived features that are automatically generated from longitudinal data using machine learning techniques. Methods: We studied patients discharged from acute care facilities in 2015 and 2016 in Alberta,...

sj-docx-1-inq-10.1177_00469580221134431 – Supplemental material for Evaluation of Online Andrology Medical Services in Central Regions of China During the COVID-19 Pandemic: A Cross-Sectional Data Analysis Study

Zhi Liu, Chunyu Zhang, Cong Luo, Junlin Ou, Ming Song, Lingxiao Yang, Xin Wang, Jinbo Chen, Guilin Wang & Tao Guo
Supplemental material, sj-docx-1-inq-10.1177_00469580221134431 for Evaluation of Online Andrology Medical Services in Central Regions of China During the COVID-19 Pandemic: A Cross-Sectional Data Analysis Study by Zhi Liu, Chunyu Zhang, Cong Luo, Junlin Ou, Ming Song, Lingxiao Yang, Xin Wang, Jinbo Chen, Guilin Wang and Tao Guo in INQUIRY: The Journal of Health Care Organization, Provision, and Financing

sj-docx-1-inq-10.1177_00469580221134431 – Supplemental material for Evaluation of Online Andrology Medical Services in Central Regions of China During the COVID-19 Pandemic: A Cross-Sectional Data Analysis Study

Zhi Liu, Chunyu Zhang, Cong Luo, Junlin Ou, Ming Song, Lingxiao Yang, Xin Wang, Jinbo Chen, Guilin Wang & Tao Guo
Supplemental material, sj-docx-1-inq-10.1177_00469580221134431 for Evaluation of Online Andrology Medical Services in Central Regions of China During the COVID-19 Pandemic: A Cross-Sectional Data Analysis Study by Zhi Liu, Chunyu Zhang, Cong Luo, Junlin Ou, Ming Song, Lingxiao Yang, Xin Wang, Jinbo Chen, Guilin Wang and Tao Guo in INQUIRY: The Journal of Health Care Organization, Provision, and Financing

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