59 Works

No rebound effect after a course of clopidogrel in patients with acute TIA or minor stroke

Xinmiao Zhang, Jing Jing, Xingquan Zhao, Liping Liu, Anxin Wang, Yuesong Pan, David Wang, S. Claiborne Johnston, Yilong Wang, Yongjun Wang & Xia Meng
Previous studies demonstrated that discontinuation of clopidogrel in patients after ACS was associated with a rebound increase in risk of recurrent events. In this study, we aimed to investigate the rebound effect after discontinuation of clopidogrel therapy in patients with TIA or stroke. All patients with minor stroke or TIA were recruited from the Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events (CHANCE) trial. Patients were divided into two groups: patients who discontinued clopidogrel...

Sample Size Calculation and Timing of Dose Selection in a Multiple-Dose Clinical Trial

Liji Shen, Jin Zhang & Paul DeLucca
In a two-stage design for multiple-dose clinical trial, a dose that has the highest observed response rate is often chosen to carry to the next stage, then to compare against the control group. The observed response rate could overestimate the true response rate of the selected dose. If it is used to compare with the response rate of the control group without any adjustment, the Type I error of this statistical inference will not be...

One new triterpenoids from Momordica charantia L

Yue Jiang, Bing Liang, Qiong Wu, Jing-Ru Wang & Bing Liu
Momordica charantia L. (M. charantia) is an annual climbing herb in Cucurbitaceae. It is not only a food, but also a drug with a long history of application. This study aims to isolate and identify the chemical constituents form M. charantia and evaluate their inhibiting effect on Hcy-induced proliferation of VSMCs. Silica column chromatography, ODS silica column chromatography, Sephadex LH-20 column chromatography and semi-preparative HPLC were used to obtain one new compound (1). The inhibition...

Supplementary document for Spatio-temporal doubly periodic waves in phase-mismatched second-harmonic generation - 6094077.pdf

Zhixiang Deng, Jin Zhang, Dianyuan Fan & LIFU ZHANG
1. Transformation of the quadratic nonlinear system into the cubic nonlinear system in the regime of cascading limit;2. Doubly-periodic waves from the cubic nonlinearity

Supplementary document for Spatio-temporal doubly periodic waves in phase-mismatched second-harmonic generation - 6094077.pdf

Zhixiang Deng, Jin Zhang, Dianyuan Fan & LIFU ZHANG
1. Transformation of the quadratic nonlinear system into the cubic nonlinear system in the regime of cascading limit;2. Doubly-periodic waves from the cubic nonlinearity

A high-quality Buxus austro-yunnanensis (Buxales) genome provides new insights into karyotype evolution in early eudicots

Zhenyue Wang, Ying Li, Pengchuan Sun, Mingjia Zhu, Dandan Wang, Zhiqiang Lu, Hongyin Hu, Renping Xu, Jin Zhang, Jianxiang Ma, Jianquan Liu & Yongzhi Yang
Abstract Background Eudicots are the most diverse group of flowering plants that compromise five well-defined lineages: core eudicots, Ranunculales, Proteales, Trochodendrales, and Buxales. However, the phylogenetic relationships between these five lineages and their chromosomal evolutions remain unclear, and a lack of high-quality genome analyses for Buxales has hindered many efforts to address this knowledge gap. Results Here, we present a high-quality chromosome-level genome of Buxus austro-yunnanensis (Buxales). Our phylogenomic analyses revealed that Buxales and Trochodendrales...

Adsorption Behavior of Vanadium Using Supported 1-Butyl-3-Methylimidazolium Chloride Ionic Liquid

Yu Liang, Shenxu Bao, Yimin Zhang, Bo Chen & Chen Yu
Imidazole-based ionic liquid 1-Butyl-3-methylimidazolium chloride was immobilized on polymer support by chemical grafting and utilized to separate vanadium (V) from a vanadium-containing solution. Characterizations with elementary analysis, Fourier transform infrared (FTIR), 13C nuclear magnetic resonance (NMR), scanning electron microscopy (SEM) and energy dispersive spectrometer (EDS) proved the successful loading of the ionic liquid on the surface of the support. The adsorption capacity toward V(V) reached 222.42 mg/g under experimental conditions, which was significantly higher than...

Additional file 2 of Genetic analysis of 55 cases with fetal skeletal dysplasia

Ying Bai, Yue Sun, Ning Liu, Li Wang, Zhihui Jiao, Yaqin Hou, Huikun Duan, Qianqian Li, Xiaofan Zhu, Jingjing Meng & Xiangdong Kong
Additional file 2. Images of US examination of some fetuses in this study.

Prognostic significance of atrial cardiopathy in patients with acute ischemic stroke

Yueyang Wu, Xiaomeng Yang, Jing Jing, Xia Meng, Zixiao Li, Yuesong Pan, Yong Jiang, Hongyi Yan, Xinying Huang, Liping Liu, Xingquan Zhao, Yilong Wang, Hao Li & Yongjun Wang
Introduction:Whether atrial cardiopathy is associated with stroke prognosis remains unclear. We evaluated the association between atrial cardiopathy markers and outcomes in patients with ischemic stroke using a nationwide prospective registry.Patients and methods:Based on the Third China National Stroke Registry, we evaluated different atrial cardiopathy markers including increased P-wave terminal force in V1 (PTFV1), advanced interatrial block (aIAB), prolonged P-wave duration, prolonged P-wave dispersion, paroxysmal supraventricular tachycardia, premature atrial contractions, prolonged PR interval, and severe left...

Two new cycloartane triterpenoid glycosides from the rhizomes of Actaea vaginata

Shunqin Zeng, Xiangyuan Li, Zixuan Zhao, Yan Lin, Yindi Zhu, Guoxu Ma, Xiaohong Zhao, Xudong Xu, Meichun Wu, Haifeng Wu, Qiongyu Zou & Yongtao Li
Two new cycloartane triterpenoid glycosides, soulieoside V (1) and 15-deacetylbeesioside O (2), together with one known compound, beesioside J (3), were isolated from the ethanolic extract of the rhizomes of Actaea vaginata. Their structures were elucidated by spectroscopic methods and by comparison with data reported in the literature. All the compounds were tested for their cytotoxic activities against human cancer cell lines.

Sample Size Calculation and Timing of Dose Selection in a Multiple-Dose Clinical Trial

Liji Shen, Jin Zhang & Paul DeLucca
In a two-stage design for multiple-dose clinical trial, a dose that has the highest observed response rate is often chosen to carry to the next stage, then to compare against the control group. The observed response rate could overestimate the true response rate of the selected dose. If it is used to compare with the response rate of the control group without any adjustment, the Type I error of this statistical inference will not be...

Spatio-temporal doubly periodic waves in phase-mismatched second-harmonic generation

Zhixiang Deng, Jin Zhang, Dianyuan Fan & LIFU ZHANG
In this Letter we present the analytical and numerical investigation to characterize the formation of quadratic doubly periodic waves, originating from coherent modulation instability in a dispersive quadratic media in the regime of cascading second-harmonic generation. Such an endeavor has not been undertaken before despite the growing relevance of double-periodic solutions as the precursor of highly localized wave structures. Unlike the case with cubic nonlinearity, the periodicity of these quadratic nonlinear waves can be also...

Sample size calculation and timing of dose selection in an adaptive multiple-dose clinical trial

Liji Shen, Jin Zhang & Paul DeLucca
In a two-stage design for multiple-dose clinical trial, a dose that has the highest observed response rate is often chosen to carry to the next stage, then to compare against the control group. The observed response rate could overestimate the true response rate of the selected dose. If it is used to compare with the response rate of the control group without any adjustment, the Type I error of this statistical inference will not be...

A high-quality Buxus austro-yunnanensis (Buxales) genome provides new insights into karyotype evolution in early eudicots

Zhenyue Wang, Ying Li, Pengchuan Sun, Mingjia Zhu, Dandan Wang, Zhiqiang Lu, Hongyin Hu, Renping Xu, Jin Zhang, Jianxiang Ma, Jianquan Liu & Yongzhi Yang
Abstract Background Eudicots are the most diverse group of flowering plants that compromise five well-defined lineages: core eudicots, Ranunculales, Proteales, Trochodendrales, and Buxales. However, the phylogenetic relationships between these five lineages and their chromosomal evolutions remain unclear, and a lack of high-quality genome analyses for Buxales has hindered many efforts to address this knowledge gap. Results Here, we present a high-quality chromosome-level genome of Buxus austro-yunnanensis (Buxales). Our phylogenomic analyses revealed that Buxales and Trochodendrales...

Additional file 1 of Genetic analysis of 55 cases with fetal skeletal dysplasia

Ying Bai, Yue Sun, Ning Liu, Li Wang, Zhihui Jiao, Yaqin Hou, Huikun Duan, Qianqian Li, Xiaofan Zhu, Jingjing Meng & Xiangdong Kong
Additional file 1. Table S1: 811 genes of a genetic skeletal disease panel; Table S2: Primer sequence in this study; Table S3: Summary of clinical information and molecular results for 55 cases with skeletal abnormalities.

One new triterpenoids from Momordica charantia L

Yue Jiang, Bing Liang, Qiong Wu, Jing-Ru Wang & Bing Liu
Momordica charantia L. (M. charantia) is an annual climbing herb in Cucurbitaceae. It is not only a food, but also a drug with a long history of application. This study aims to isolate and identify the chemical constituents form M. charantia and evaluate their inhibiting effect on Hcy-induced proliferation of VSMCs. Silica column chromatography, ODS silica column chromatography, Sephadex LH-20 column chromatography and semi-preparative HPLC were used to obtain one new compound (1). The inhibition...

Prognostic significance of atrial cardiopathy in patients with acute ischemic stroke

Yueyang Wu, Xiaomeng Yang, Jing Jing, Xia Meng, Zixiao Li, Yuesong Pan, Yong Jiang, Hongyi Yan, Xinying Huang, Liping Liu, Xingquan Zhao, Yilong Wang, Hao Li & Yongjun Wang
Introduction:Whether atrial cardiopathy is associated with stroke prognosis remains unclear. We evaluated the association between atrial cardiopathy markers and outcomes in patients with ischemic stroke using a nationwide prospective registry.Patients and methods:Based on the Third China National Stroke Registry, we evaluated different atrial cardiopathy markers including increased P-wave terminal force in V1 (PTFV1), advanced interatrial block (aIAB), prolonged P-wave duration, prolonged P-wave dispersion, paroxysmal supraventricular tachycardia, premature atrial contractions, prolonged PR interval, and severe left...

Effects of encapsulated thymol and carvacrol mixture on growth performance, antioxidant capacity, immune function and intestinal health of broilers

Zhen Li, Xu Jin, Qiong Wu, Lingbo Long, Yang Li, Qingyue Zhang, Aidong Liu, Xingyong Chen, Zhaoyu Geng & Cheng Zhang
This study evaluated the effect of encapsulated thymol and carvacrol mixture (ETCM) on the growth performance, antioxidant capacity, immune function and intestinal health of broilers. In total, 400 one-day-old male Arbour Acres broilers were randomly allocated to two groups with eight replicates of 25 birds each and fed a basal diet (control) or a basal diet supplemented with 150 mg/kg ETCM. The trial lasted 42 days. ETCM supplementation significantly increased (p < .05) average daily...

Effects of encapsulated thymol and carvacrol mixture on growth performance, antioxidant capacity, immune function and intestinal health of broilers

Zhen Li, Xu Jin, Qiong Wu, Lingbo Long, Yang Li, Qingyue Zhang, Aidong Liu, Xingyong Chen, Zhaoyu Geng & Cheng Zhang
This study evaluated the effect of encapsulated thymol and carvacrol mixture (ETCM) on the growth performance, antioxidant capacity, immune function and intestinal health of broilers. In total, 400 one-day-old male Arbour Acres broilers were randomly allocated to two groups with eight replicates of 25 birds each and fed a basal diet (control) or a basal diet supplemented with 150 mg/kg ETCM. The trial lasted 42 days. ETCM supplementation significantly increased (p < .05) average daily...

Two new cycloartane triterpenoid glycosides from the rhizomes of Actaea vaginata

Shunqin Zeng, Xiangyuan Li, Zixuan Zhao, Yan Lin, Yindi Zhu, Guoxu Ma, Xiaohong Zhao, Xudong Xu, Meichun Wu, Haifeng Wu, Qiongyu Zou & Yongtao Li
Two new cycloartane triterpenoid glycosides, soulieoside V (1) and 15-deacetylbeesioside O (2), together with one known compound, beesioside J (3), were isolated from the ethanolic extract of the rhizomes of Actaea vaginata. Their structures were elucidated by spectroscopic methods and by comparison with data reported in the literature. All the compounds were tested for their cytotoxic activities against human cancer cell lines.

Bitter taste receptor genes of primates

Ping Feng
Bitter taste perception plays a critical role in deterring animals from consuming harmful and toxic substances. To characterize the evolution of primate Tas2rs and test whether dietary preference has shaped the Tas2rs repertoire of primates, we identified Tas2r genes of 35 genomes including 16 Cercopithecidae species, 6 Hominidae species, 4 Cebidae species, 3 Lemuridae species, and other 6 species. The results showed that the total numbers of primates' Tas2rs ranged from 27 to 51, which...

Engineering Yarrowia lipolytica for the sustainable production of β-farnesene from waste oil feedstock

Yinghang Liu, Jin Zhang, Qingbin Li, Zhaoxuan Wang, Zhiyong Cui, Tianyuan Su, Xuemei Lu, Qingsheng Qi & Jin Hou
Abstract Background β-Farnesene is a sesquiterpene with versatile industrial applications. The production of β-farnesene from waste lipid feedstock is an attractive method for sustainable production and recycling waste oil. Yarrowia lipolytica is an unconventional oleaginous yeast, which can use lipid feedstock and has great potential to synthesize acetyl-CoA-derived chemicals. Results In this study, we engineered Y. lipolytica to produce β-farnesene from lipid feedstock. To direct the flux of acetyl-CoA, which is generated from lipid β-oxidation,...

No rebound effect after a course of clopidogrel in patients with acute TIA or minor stroke

Xinmiao Zhang, Jing Jing, Xingquan Zhao, Liping Liu, Anxin Wang, Yuesong Pan, David Wang, S. Claiborne Johnston, Yilong Wang, Yongjun Wang & Xia Meng
Previous studies demonstrated that discontinuation of clopidogrel in patients after ACS was associated with a rebound increase in risk of recurrent events. In this study, we aimed to investigate the rebound effect after discontinuation of clopidogrel therapy in patients with TIA or stroke. All patients with minor stroke or TIA were recruited from the Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events (CHANCE) trial. Patients were divided into two groups: patients who discontinued clopidogrel...

Adsorption Behavior of Vanadium Using Supported 1-Butyl-3-Methylimidazolium Chloride Ionic Liquid

Yu Liang, Shenxu Bao, Yimin Zhang, Bo Chen & Chen Yu
Imidazole-based ionic liquid 1-Butyl-3-methylimidazolium chloride was immobilized on polymer support by chemical grafting and utilized to separate vanadium (V) from a vanadium-containing solution. Characterizations with elementary analysis, Fourier transform infrared (FTIR), 13C nuclear magnetic resonance (NMR), scanning electron microscopy (SEM) and energy dispersive spectrometer (EDS) proved the successful loading of the ionic liquid on the surface of the support. The adsorption capacity toward V(V) reached 222.42 mg/g under experimental conditions, which was significantly higher than...

Spatio-temporal doubly periodic waves in phase-mismatched second-harmonic generation

Zhixiang Deng, Jin Zhang, Dianyuan Fan & LIFU ZHANG
In this Letter we present the analytical and numerical investigation to characterize the formation of quadratic doubly periodic waves, originating from coherent modulation instability in a dispersive quadratic media in the regime of cascading second-harmonic generation. Such an endeavor has not been undertaken before despite the growing relevance of double-periodic solutions as the precursor of highly localized wave structures. Unlike the case with cubic nonlinearity, the periodicity of these quadratic nonlinear waves can be also...

Registration Year

  • 2022
    59

Resource Types

  • Text
    32
  • Collection
    17
  • Dataset
    10

Affiliations

  • Guangxi Normal University
    59
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    49
  • Sheng Jing Hospital
    35
  • Shandong University
    35
  • Zhejiang Chinese Medical University
    35
  • Yangzhou University
    33
  • Lanzhou University
    29
  • Fudan University
    28
  • Chinese Academy of Sciences
    28
  • Institute of Animal Sciences
    27