Additional file 6: S6. Usual care exercise after cartilage or meniscus repair in the knee joint - week 7 postoperatively.

Additional file 1: Table 1. Participant characteristics. Figure 1. CONSORT flow diagram. Figure 2. Psychopathology and family burden. Figure 3. Response status at 16 weeks. Figure 4. Negative effects questionnaire. Supplemental Table 1. Detailed comorbidities. Supplemental Table 2. Psychopathology and family burden. Supplemental Table 3. Kidscreen-52. Supplemental Timeline. Supplemental Assumptions.

Abstract Background Neurological injury is the primary cause of death after out-of-hospital cardiac arrest. There is a lack of studies investigating cerebral injury beyond the immediate post-resuscitation phase in a controlled cardiac arrest experimental setting. Methods The aim of this study was to investigate temporal changes in measures of cerebral injury and metabolism in a cardiac arrest pig model with clinically relevant post-cardiac arrest intensive care. A cardiac arrest group (n = 11) underwent 7...

Abstract Objective To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. Methods CRC incidences were calculated in an intervention group comprising a cohort of confirmed carriers of pathogenic or likely pathogenic variants in mismatch repair genes (path_MMR) followed prospectively by the Prospective Lynch Syndrome Database (PLSD). All had colonoscopy surveillance, with...

Abstract Background Subjects with Type 1 diabetes mellitus (T1DM) have an increased incidence of heart failure (HF). Several pathophysiological mechanisms have been involved in its development. The aim of this study was to analyze the potential contribution of the advanced lipoprotein profile and plasma glycosylation (GlycA) to the presence of subclinical myocardial dysfunction in subjects with T1DM. Methods We included subjects from a Danish cohort of T1DM subjects (Thousand & 1 study) with either diastolic...

Additional file 2: S2. CERT (Consensus on Exercise Reporting Template).

Additional file 5: S5. Usual care exercise after cartilage or meniscus repair in the knee joint - week 3–6 postoperatively.

Additional file 7: S7. Supplementary results. S7 Table 1. Patient characteristics at 16 and 26-week assessment. S7 Table 2. Clinical application (adherence), training characteristics and pain at rest and during BFR-LLST added to usual care exercise. S7 Table 3. Change per week in thigh circumference, knee joint and quadriceps pain, perceived exertion and training load during the, on average, 11 weeks of BFR-LLST added to usual care exercise intervention period (15 sessions). S7 Table 4....

Additional file 1: S1. Checklist CONSORT extension to randomized pilot and feasibility trials.

Abstract Background Neurological injury is the primary cause of death after out-of-hospital cardiac arrest. There is a lack of studies investigating cerebral injury beyond the immediate post-resuscitation phase in a controlled cardiac arrest experimental setting. Methods The aim of this study was to investigate temporal changes in measures of cerebral injury and metabolism in a cardiac arrest pig model with clinically relevant post-cardiac arrest intensive care. A cardiac arrest group (n = 11) underwent 7...

Abstract Background Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder which affects up to 3% of children and adolescents. OCD in children and adolescents is generally treated with cognitive behavioural therapy (CBT), which, in more severely affected patients, can be combined with antidepressant medication. The TECTO trial aims to compare the benefits and harms of family-based CBT (FCBT) versus family-based psychoeducation/relaxation training (FPRT) in children and adolescents aged 8 to 17 years. This statistical analysis...

Abstract Background Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder which affects up to 3% of children and adolescents. OCD in children and adolescents is generally treated with cognitive behavioural therapy (CBT), which, in more severely affected patients, can be combined with antidepressant medication. The TECTO trial aims to compare the benefits and harms of family-based CBT (FCBT) versus family-based psychoeducation/relaxation training (FPRT) in children and adolescents aged 8 to 17 years. This statistical analysis...

Additional file 2: S2. CERT (Consensus on Exercise Reporting Template).

Additional file 6: S6. Usual care exercise after cartilage or meniscus repair in the knee joint - week 7 postoperatively.

Additional file 7: S7. Supplementary results. S7 Table 1. Patient characteristics at 16 and 26-week assessment. S7 Table 2. Clinical application (adherence), training characteristics and pain at rest and during BFR-LLST added to usual care exercise. S7 Table 3. Change per week in thigh circumference, knee joint and quadriceps pain, perceived exertion and training load during the, on average, 11 weeks of BFR-LLST added to usual care exercise intervention period (15 sessions). S7 Table 4....

Supplementary Material 1: Supplementary Fig. 1: Comparison of the distribution of the predicted probabilities showing the classification performance of the presence of MCD between two different models, being the x-axis the predicted probabilities for both classes and the y-axis the count of observations. A: Model 1 includes classical risk variables (age, sex, eGFR, NTproBNP, BMI, diabetes duration and systolic blood pressure >140mmHg). B: Model 2 includes classical risk variables and the NMR-assessed biomarkers. The inclusion...

To explore patient perspectives of participating in a pilot RCT evaluating feasibility and effect of anabolic steroid, physiotherapy and nutritional supplement following hip fracture. Semi-structured telephone-based interviews of 16 women and three men (average age 73 years) were conducted at baseline and after a 12-week intervention. Qualitative content analysis was performed. Two main categories were identified: (1) Trust and hope for a positive change with three sub-categories; reflections on anabolic steroids, anticipation of extra attention,...

Abstract Objective To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. Methods CRC incidences were calculated in an intervention group comprising a cohort of confirmed carriers of pathogenic or likely pathogenic variants in mismatch repair genes (path_MMR) followed prospectively by the Prospective Lynch Syndrome Database (PLSD). All had colonoscopy surveillance, with...

Additional file 1.

Additional file 1: S1. Checklist CONSORT extension to randomized pilot and feasibility trials.

Additional file 3: S3. Rehabilitation regimens - Cartilage (Steadman procedure) or meniscus repair.

Abstract Purpose Blood flow restriction – low load strength training (BFR-LLST) is theoretically superior to traditional heavy strength training when rehabilitating patients who cannot heavily load tissues following surgery. The main purpose of this study was to examine the feasibility of BFR-LLST added to usual care exercise early after cartilage or meniscus repair in the knee joint. Methods We included 42 patients with cartilage (n = 21) or meniscus repair (n = 21) of the...

Abstract Purpose Blood flow restriction – low load strength training (BFR-LLST) is theoretically superior to traditional heavy strength training when rehabilitating patients who cannot heavily load tissues following surgery. The main purpose of this study was to examine the feasibility of BFR-LLST added to usual care exercise early after cartilage or meniscus repair in the knee joint. Methods We included 42 patients with cartilage (n = 21) or meniscus repair (n = 21) of the...

Additional file 1: Table S1. Post-cardiac arrest intensive care protocol. Table S2 Haemoglobin, blood lactate and pH. Figure S1 Regions of interest displayed on T1 weighted MRI scan. Figure S2 Pressure and oxygen levels for both cardiac arrest groups and sham controls. Figure S3 Microdialysis data for both cardiac arrest groups and sham controls. Figure S4 MRI and MR spectroscopy for both cardiac arrest groups and sham controls. Figure S5 Neuronal injury markers for both...

Additional file 1: Table S1. Post-cardiac arrest intensive care protocol. Table S2 Haemoglobin, blood lactate and pH. Figure S1 Regions of interest displayed on T1 weighted MRI scan. Figure S2 Pressure and oxygen levels for both cardiac arrest groups and sham controls. Figure S3 Microdialysis data for both cardiac arrest groups and sham controls. Figure S4 MRI and MR spectroscopy for both cardiac arrest groups and sham controls. Figure S5 Neuronal injury markers for both...