32 Works

Data from: The spectre of too many species

Adam D. Leache, Tianqi Zhu, Bruce Rannala & Ziheng Yang
Recent simulation studies examining the performance of Bayesian species delimitation as implemented in the BPP program have suggested that BPP may detect population splits but not species divergences and that it tends to over-split when data of many loci are analyzed. Here we confirm these results and provide the mathematical justifications. We point out that the distinction between population and species splits made in the protracted speciation model has no influence on the generation of...

Data from: The induction of the fibroblast extracellular senescence metabolome is a dynamic process

Emma N.L. James, Mark H. Bennett & Eric K. Parkinson
Cellular senescence is often associated with irreparable DNA double strand breaks (IrrDSBs) which accumulate with chronological age (IrrDSBsen). The removal of senescent cells ameliorates several age-related diseases in mice but the translation of these findings into a clinical setting would be aided by the characterisation of non-invasive biomarkers of senescent cells. Several serum metabolites are independent indicators of chronological age and some of these accumulate outside senescent fibroblasts independently of cell cycle arrest, repairable DNA...

Data from: Dietary choices are influenced by genotype, mating status, and sex in Drosophila melanogaster

M. Florencia Camus, Chun-Chen Huang, Max Reuter, Kevin Fowler & Chun-Cheng Huang
Mating causes many changes in physiology, behaviour and gene expression in a wide range of organisms. These changes are predicted to be sex-specific, influenced by the divergent reproductive roles of the sexes. In female insects, mating is associated with an increase in egg production which requires high levels of nutritional input with direct consequences for the physiological needs of individual females. Consequently, females alter their nutritional acquisition in line with the physiological demands imposed by...

Data from: Sporadic sampling not climatic forcing drives observed early hominin diversity

Simon J. Maxwell, Philip J. Hopley, Paul Upchurch & Christophe Soligo
The role of climate change in the origin and diversification of early hominins is hotly debated. Most accounts of early hominin evolution link observed fluctuations in species diversity to directional shifts in climate or periods of intense climatic instability. None of these hypotheses, however, have tested whether observed diversity patterns are distorted by variation in the quality of the hominin fossil record. Here, we present a detailed examination of early hominin diversity dynamics, including both...

Data from: Decision and navigation in mouse parietal cortex

Michael Krumin, Julie J. Lee, Kenneth D. Harris & Matteo Carandini
Posterior parietal cortex (PPC) has been implicated in navigation, in the control of movement, and in visually-guided decisions. To relate these views, we measured activity in PPC while mice performed a virtual navigation task driven by visual decisions. PPC neurons were selective for specific combinations of the animal's spatial position and heading angle. This selectivity closely predicted both the activity of individual PPC neurons, and the arrangement of their collective firing patterns in choice-selective sequences....

Data from: Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with DTI MRI

Ian F. Harrison, Bernard Siow, Aisha B. Akilo, Phoebe G. Evans, Ozama Ismail, Yolanda Ohene, Payam Nahavandi, David L. Thomas, Mark F. Lythgoe & Jack A. Wells
The glymphatics system describes a CSF-mediated clearance pathway for the removal of potentially harmful molecules, such as amyloid beta, from the brain. As such, its components may represent new therapeutic targets to alleviate aberrant protein accumulation that defines the most prevalent neurodegenerative conditions. Currently, however, the absence of any non-invasive measurement technique prohibits detailed understanding of glymphatic function in the human brain and in turn, it's role in pathology. Here, we present the first non-invasive...

Data from: An assessment of the role of the falx cerebri and tentorium cerebelli in the cranium of the cat (Felis silvestris catus)

Víctor Sellés De Lucas, Hugo Dutel, Susan E. Evans, Flora Gröning, Alana C. Sharp, Peter J. Watson & Michael J. Fagan
The falx cerebri and the tentorium cerebelli are two projections of the dura mater in the cranial cavity which ossify to varying degrees in some mammalian species. The idea that the ossification of these structures may be necessary to support the loads arising during feeding has been proposed and dismissed in the past, but never tested quantitatively. To address this, a biomechanical model of a domestic cat (Felis silvestris catus) skull was created and the...

Registration Year

  • 2018
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  • University College London
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