32 Works

The impact of genetic adaptation on chimpanzee subspecies differentiation

Joshua Schmidt, Sergi Castellano, Marc De Manuel, Aida Andrés & Tomas Marques-Bonet
Chimpanzees, humans’ closest relatives, are in danger of extinction. Aside from direct human impacts such as hunting and habitat destruction, a key threat is transmissible disease. As humans continue to encroach upon their habitats, which shrink in size and grow in density, the risk of inter-population and cross-species viral transmission increases, a point dramatically made in the reverse with the global HIV/AIDS pandemic. Inhabiting central Africa, the four subspecies of chimpanzees differ in demographic history...

Data from: Is it possible to reconstruct an accurate cell lineage using CRISPR recorders?

Irepan Salvador-Martínez, Marco Grillo, Michalis Averof & Maximilian J. Telford
Cell lineages provide the framework for understanding how multicellular organisms are built and how cell fates are decided during development. Describing cell lineages in most organisms is challenging, given the number of cells involved; even a fruit fly larva has ~50,000 cells and a small mammal has more than 1 billion cells. Recently, the idea of using CRISPR to induce mutations during development as heritable markers for lineage reconstruction has been proposed and trialled by...

Annual estimates of occupancy for bryophytes, lichens and invertebrates in the UK (1970-2015)

C.L. Outhwaite, G.D. Powney, T.A. August, R.E. Chandler, S. Rorke, O. Pescott, M. Harvey, H.E. Roy, R. Fox, K. Walker, D.B. Roy, K. Alexander, S. Ball, T. Bantock, T. Barber, B.C. Beckmann, T. Cook, J. Flanagan, A. Fowles, P. Hammond, P. Harvey, D. Hepper, D. Hubble, J. Kramer, P. Lee … & N.J.B. Isaac
This dataset provides annual estimates of species occupancy and species trend estimates in the form of growth rates for 5,293 UK invertebrate, bryophyte and lichen species for the period 1970 to 2015. Estimates are provided at the country level for England, Scotland, Wales and Northern Ireland as well as for the UK and Great Britain (GB) where possible. These data were generated using observations of species collated by UK recording schemes and societies as the...

Data from: Reprogramming the antigen specificity of B cells using genome-editing technologies

James E. Voss, Alicia Gonzalez-Martin, Raiees Andrabi, Roberta P. Fuller, Ben Murrell, Laura E. McCoy, Katelyn Porter, Deli Huang, Wenjuan Li, Devin Sok, Khoa Le, Bryan Briney, Morgan Chateau, Geoffrey Rogers, Lars Hangartner, Ann J. Feeney, David Nemazee, Paula Cannon & Dennis R. Burton
We have developed a method to introduce novel paratopes into the human antibody repertoire by modifying the immunoglobulin (Ig) genes of mature B cells directly using genome editing technologies. We used CRISPR-Cas9 in a homology directed repair strategy, to replace the heavy chain (HC) variable region in B cell lines with that from an HIV broadly neutralizing antibody, PG9. Our strategy is designed to function in cells that have undergone VDJ recombination using any combination...

Data from: Alien species richness is currently unbounded in all but the most urbanized bird communities

Toby P. Tsang, Ellie E. Dyer & Tim C. Bonebrake
Urban areas suffer high pressure of introductions of alien species compared to other habitats due to intensive human activities. As trading globally continues to rise, more species will likely be introduced into urban areas. To determine whether this increase in introduction pressure will lead to increased alien species richness in urban areas, or whether other processes would act to impose an upper limit on species richness, we examined how the shape of the relationship between...

Data from: Within- and between-group dynamics in an obligate cooperative breeder

Rosie Woodroffe, Helen O'Neill & Daniella Rabaiotti
1. Cooperative behaviour can have profound effects on demography. In many cooperative species, components of fitness (e.g. survival, reproductive success) are diminished in smaller social groups. These effects (termed group-level component Allee effects) may lead smaller groups to grow relatively slowly or fail to persist (termed group-level demographic Allee effects). 2. If these group-level effects were to propagate to the population level, small populations would grow slowly or decline to extinction (termed population-level demographic Allee...

Data from: Targeted next-generation sequencing panels in the diagnosis of Charcot Marie Tooth disease

Andrea Cortese, Janel Wilcox, James M. Polke, Roy Poh, Mariola Skorupinska, Alexader Rossor, Matilde Laura, Pedro J. Tomaselli, Henry Houlden, Michael E. Shy & Mary M. Reilly
Objective: To investigate the effectiveness of targeted NGS panels in achieving a molecular diagnosis in CMT and related disorders in a clinical setting Methods: We prospectively enrolled 220 patients from two tertiary referral centres, one in London, UK (n=120) and one in Iowa, US (n=100) in whom a targeted CMT NGS panel had been requested as a diagnostic test. PMP22 duplication/deletion was previously excluded in demyelinating cases. We reviewed the genetic and clinical data upon...

Registration Year

  • 2019
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Resource Types

  • Dataset
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Affiliations

  • University College London
    32
  • Imperial College London
    3
  • University of Zurich
    2
  • Royal Museum for Central Africa
    1
  • University of Baghdad
    1
  • Plymouth University
    1
  • London School of Hygiene & Tropical Medicine
    1
  • Ghent University
    1
  • New York University Abu Dhabi
    1
  • Université de Sherbrooke
    1