74 Works

Transposable element landscape in Drosophila populations selected for longevity

Daniel Fabian, Handan Melike Dönertas, Matías Fuentealba, Linda Partridge & Janet Thornton
Transposable elements (TEs) inflict numerous negative effects on health and fitness as they replicate by integrating into new regions of the host genome. Even though organisms employ powerful mechanisms to demobilize TEs, transposons gradually lose repression during aging. The rising TE activity causes genomic instability and was implicated in age-dependent neurodegenerative diseases, inflammation and the determination of lifespan. It is therefore conceivable that long-lived individuals have improved TE silencing mechanisms resulting in reduced TE expression...

Data from: Vertebrate responses to human land use are influenced by their proximity to climatic tolerance limits

Jessica Williams & Tim Newbold
Aim: Land-use change leads to local climatic changes, which can induce shifts in community composition. Indeed, human-altered land uses favour species able to tolerate greater temperature and precipitation extremes. However, environmental changes do not impact species uniformly across their distributions, and most research exploring the impacts of climatic changes driven by land use has not considered potential within-range variation. We explored whether a population’s climatic position (the difference between species’ thermal and precipitation tolerance limits...

UK Theses Online?

Frederick J. Friend
Librarians from a number of UK universities, together with representation from the British Library, have formed the University Theses Online Group to explore the feasibility of an online service for the location and delivery of theses in electronic format. A survey of authors and supervisors of theses has been conducted in order to understand better the way in which theses are used and attitudes towards electronic submission. The Group is encouraged by the support it...

The influence of instrumental parameters on the particle-surface interaction measurements using colloidal probe AFM in viscous liquids

Yao Lu, Jurriaan Gillissen, Anastasia Papadopoulou, Guanjie He & Manish Tiwari
Understanding surface adhesion in liquids is of great significance for both fundamental study of suspension rheology and industry such as suspension mixing. However, the key factors that influence adhesion between non-deformable particles and surfaces in highly viscous fluids have not been well understood. Here we used colloidal probe atomic force microscope (AFM) techniques to study the adhesion forces △F in viscous liquids by tuning the instrumental parameters such as contact force, contact time, approach and...

Epidemiology of epilepsy in Nigeria: A community-based study from 3 sites

Musa Mamman Watila, Salisu A. Balarabe, Morenikeji A. Komolafe, Stanley C. Igwe, Michael B. Fawale, Willem M. Otte, Eric Van Diessen, Olaitan Okunoye, Anthony A. Mshelia, Ibrahim Abdullahi, Joseph Musa, Erick W. Hedima, Yakub W. Nyandaiti, Gagandeep Singh, Andrea S. Winkler & Josemir W. Sander
Background: We determined the prevalence, incidence, and risk factors for epilepsy in Nigeria. Methods: We conducted a door-to-door survey to identify cases of epilepsy in three regions. We estimated age-standardized prevalence adjusted for non-response and sensitivity and the one-year retrospective incidence for active epilepsy. To assess potential risk factors, we conducted a case-control study by collecting sociodemographic and risk factor data. We estimated odds ratios (ORs) using logistic regression analysis and corresponding population attributable fractions...

Characterizing the clinical features and atrophy patterns of MAPT-related frontotemporal dementia with disease progression modelling (Supplementary Data)

Jonathan Rohrer
Background and Objective: Mutations in the MAPT gene cause frontotemporal dementia (FTD). Most previous studies investigating the neuroanatomical signature of MAPT mutations have grouped all different mutations together and shown an association with focal atrophy of the temporal lobe. However, the variability in atrophy patterns between each particular MAPT mutation is less well characterised. We aimed to investigate whether there were distinct groups of MAPT mutation carriers based on their neuroanatomical signature. Methods: We applied...

Biometric conversion factors as a unifying platform for comparative assessment of invasive freshwater bivalves

Neil Coughlan, Eoghan Cunningham, Ross Cuthbert, Patrick Joyce, Pedro Anastacio, Filipe Banha, Nicolás Bonel, Stephanie Bradbeer, Elizabeta Briski, Vincent Butitta, Zuzana Čadková, Jaimie Dick, Karel Douda, Lawrence Eagling, Noé Ferreira-Rodríguez, Leandro Hünicken, Mattias Johansson, Louise Kregting, Anna Labecka, Deliang Li, Florencia Liquin, Jonathan Marescaux, Todd Morris, Patrycja Nowakowska, Małgorzata Ożgo … & Francisco Sylvester
1. Invasive bivalves continue to spread and negatively impact freshwater ecosystems worldwide. As different metrics for body size and biomass are frequently used within the literature to standardise bivalve related ecological impacts (e.g. respiration and filtration rates), the lack of broadly applicable conversion equations currently hinders reliable comparison across bivalve populations. To facilitate improved comparative assessment amongst studies originating from disparate geographic locations, we report body size and biomass conversion equations for six invasive freshwater...

Energy Modelling in the UK: The construction, maintenance and transparency of models

Pei-Hao Li & Neil Strachan
This paper is the third of four to explore results from UKERC’s Modelling Hub survey. It considers how models are constructed in terms of costs, funding sources, and resulting impacts. It looks at how models are maintained in terms of costs, users and model updates. It also explores model accessibility and transparency levels.

HDBR Atlas: Gene Expression in Early Human Development

Janet Kerwin, YuZhu Cheng, Steven Lisgo, Andrew Copp & Deborah Henderson
Gene expression studies in early human development from 3 to 19 post conceptional weeks (PCW).

Data from: European common frog (Rana temporaria) recolonised Switzerland from multiple glacial refugia in northern Italy via trans- and circum-Alpine routes

Alexandra Jansen Van Rensburg, Mathieu Robin, Barret Phillips & Josh Van Buskirk
The high mountain ranges of western Europe had a profound effect on the biotic recolonisation of Europe from glacial refugia. The Alps present a particularly interesting case because they form an absolute barrier to dispersal for most taxa, obstructing recolonisation from multiple refugia in northern Italy. Here we investigate the effect of the European Alps on the phylogeographic history of the European common frog Rana temporaria. Based on partial cytochrome b and COXI sequences from...

NEXMIF encephalopathy: DeNovogear output of WES data of the family

Maria Cristina Cioclu, Antonietta Coppola, Manuela Tondelli, Anna Elisabetta Vaudano, Giada Giovannini, S. Krithika, Michele Iacomino, Federico Zara, Sanjay Sisodiya & Stefano Meletti
The developmental and epileptic encephalopathies (DEE) are the most severe group of epilepsies. Recently, NEXMIF mutations have been shown to cause a DEE in females, characterized by myoclonic–atonic epilepsy and recurrent nonconvulsive status. Here we used advanced neuroimaging techniques in a patient with a novel NEXMIF de novo mutation presenting with recurrent absence status with eyelid myoclonia, to reveal brain structural and functional changes that can bring the clinical phenotype to alteration within specific brain...

Causal coupling between European and UK markets triggered by announcements of monetary policy decisions

Tomaso Aste
We investigate high-frequency reactions in the Eurozone stock market and the UK stock market during the time period surrounding the European Central Bank (ECB) and the Bank of England (BoE)'s interest rate decisions assessing how these two markets react and co-move influencing each other. The effects are quantified by measuring linear and non-linear transfer entropy combined with a Bivariate Empirical Mode Decomposition (BEMD) from a dataset of 1-minute prices for the Euro Stoxx 50 and...

Data from: New information on the Jurassic lepidosauromorph Marmoretta oxoniensis

Elizabeth Griffiths, David Ford, Roger Benson & Susan E. Evans
The earliest known crown-group lepidosaurs are known from the Middle Triassic, however their stem group is poorly sampled, with only a few representative fossils found. This is partly due to the small size and delicate bones of early stem-lepidosaurs (=lepidosauromorphs) which make both preservation in the fossil record and subsequent discovery less likely. The mid Jurassic lepidosauromorph Marmoretta oxoniensis Evans 1991 is re-examined using high-resolution µCT scanning to reveal parts of the skull anatomy that...

210Pb-dated historical lake sediment metal concentrations from Greater Glasgow, Scotland (mid-19th century to 2016)

S.D. Turner, H. Yang, N.L. Rose, J. Shilland, H. Bennion, V. Jones, C. Sayer & A. Baker
Measurements of sediment properties (including organic and carbonate content), radionuclides (210Pb, 137Cs, 241Am) and elements (including mercury, nickel, copper, zinc, and lead) in lake sediment successions. Radionuclide dating provides a reliable chronology of sediment ages from the mid-19th century (sometimes only 20th century) to the present (2016). The dataset comprises a standardised matrix of multiple measured sediment variables (element values per mass) against stratigraphic depth for 8 lakes. In some water bodies multiple core datasets...

Productivity, niche availability, species richness and extinction risk: Untangling relationships using individual-based simulations

Euan Furness, Russell Garwood, Philip Mannion & Mark Sutton
It has been widely hypothesised that the productivity of an ecosystem affects the number of species that it can support. Despite decades of study, the nature, extent, and underlying mechanisms of this relationship are unclear. One suggested mechanism is the “more individuals” hypothesis (MIH). This proposes that productivity controls the number of individuals in the ecosystem, and that more individuals can be divided into a greater number of species before their population size is sufficiently...

Diversity, equity, and inclusion in engineering education: an exploration of European higher education institutions’ strategic frameworks, resources, and initiatives

I. Direito, Shannon Chance, L. Clemmensen, S. Craps, S.B. Economides, S.R. Isaac, A.M. Jolly, F.R. Truscott & N. Wint

The closure of the Neotethys in two episodes: first. as a result of Jurassic to Early Cretaceous obduction and second, as a result of Early Palaeocene collision; a comparison of surface geology and tomography (Central Internal Hellenides, Greece)

Rudolph Scherreiks & Camille BouDagher-Fadel
This contribution concerns Neotethys palaeogeography in the Central Internal Hellenides. Neotethys oceanic crust is represented in the Vardar zone of the Hellenides by the ophiolites of the Almopias sub-zone. Contrary to numerous tectonic models in the literature, we show that the Almopias ocean closed in two episodes.

Data from: Meiotic drive does not cause condition-dependent reduction of the sexual ornament in stalk-eyed flies

Sam Finnegan, Matteo Mondani, Kevin Fowler & Andrew Pomiankowski
Meiotic drive systems are associated with low frequency chromosomal inversions. These are expected to accumulate deleterious mutations due to reduced recombination and low effective population size. We test this prediction using the “sex-ratio” (SR) meiotic drive system of the Malaysian stalk-eyed fly Teleopsis dalmanni.SR is associated with a large inversion (or inversions) on the X chromosome. In particular, we study eyespan in males carrying the SR chromosome, as this trait is a highly exaggerated, sexually...

Cerebral small vessel disease and functional outcome prediction after intracerebral haemorrhage

David Werring, Ghil Schwarz & Isabel Hostettler
Background. It is unknown whether adding cerebral small vessel disease (SVD) biomarkers can improve the performance of intracerebral hemorrhage (ICH) outcome predictive scores. Purpose. To determine whether: (1) CT-based SVD biomarkers are associated with 6-month functional outcome after ICH and (2) whether these biomarkers improve the performance of pre-existing ICH score. Methods. We included 864 patients with acute ICH from a multicentre, hospital-based prospective cohort study. We evaluated CT-based SVD biomarkers (white matter hypodensities [WMH];...

Spatial modulation of visual responses arises in cortex with active navigation

, Charu Bai Reddy, Sylvia Schröder, Tomaso Muzzu, Kenneth D. Harris, Aman B. Saleem & Matteo Carandini
During navigation, the visual responses of neurons in mouse primary visual cortex (V1) are modulated by the animal’s spatial position. Here we show that this spatial modulation is similarly present across multiple higher visual areas but negligible in the main thalamic pathway into V1. Similar to hippocampus, spatial modulation in visual cortex strengthens with experience and with active behavior. Active navigation in a familiar environment, therefore, enhances the spatial modulation of visual signals starting in...

Sudden Unexpected Death in Epilepsy: A Personalized Prediction Tool

Ashwani Jha, Cheongeun Oh, Dale Hesdorffer, Beate Diehl, Sasha Devore, Martin Brodie, Torbjörn Tomson, Josemir W. Sander, Thaddeus S. Walczak & Orrin Devinsky
Objective: To develop and validate a tool for individualised prediction of Sudden Unexpected Death in Epilepsy (SUDEP) risk, we re-analysed data from one cohort and three case-control studies undertaken 1980-2005. Methods: We entered 1273 epilepsy cases (287 SUDEP, 986 controls) and 22 clinical predictor variables into a Bayesian logistic regression model. Results: Cross-validated individualized model predictions were superior to baseline models developed from only average population risk or from generalised tonic-clonic seizure frequency (pairwise difference...

Historical analysis of seagrass loss in the United Kingdom

Alix E. Green, Michael A. Chadwick, Richard K.F. Unsworth & Peter J.S. Jones
This dataset includes empirical and qualitative data from a multitude of sources using systematic review methods to provide analysis on seagrass occurrence and loss in the United Kingdom. We document 8,493 ha of recently mapped seagrass in the UK since 1998.

Data associated with: Going round the twist – An empirical analysis of shell coiling in helicospiral gastropods

Katie S. Collins, Roman Klapaukh, James S. Crampton, Michael F. Gazley, C. Ian Schipper, Anton Maksimenko & Benjamin R. Hines
The logarithmic helicospiral has been the most widely accepted model of regularly coiled mollusc form since it was proposed by Moseley (1838) and popularised by Thompson (1942) and Raup (1966). It is based on an explicit assumption that shells are isometric and grow exponentially, and an implicit assumption that the external form of the shell follows the internal shape, which implies that the parameters of the spiral could, theoretically, be reconstructed from the external whorl...

A non-coding indel polymorphism in the fruitless gene of Drosophila melanogaster exhibits antagonistically pleiotropic fitness effects

Michael Jardine, Filip Ruzicka, Charlotte Diffley, Kevin Fowler & Max Reuter
The amount of genetic variation for fitness within populations tends to exceed that expected under mutation-selection-drift balance. Several mechanisms have been proposed to actively maintain polymorphism and account for this discrepancy, including antagonistic pleiotropy (AP), where allelic variants have opposing effects on different components of fitness. Here we identify a non-coding indel polymorphism in the fruitless gene of Drosophila melanogaster and measure survival and reproductive components of fitness in males and females of replicate lines...

A 5.3-million-year history of monsoonal precipitation in northwestern Australia

Jan-Berend Willem Stuut , Patrick De Deckker , Mariem Saavedra-Pellitero , Franck Bassinot , Anna Joy Drury , Maureen Walczak & Kana Nagashima
NIOZ - Royal Netherlands Institute for Sea Research, and Utrecht University, Texel, the Netherlands (1); MARUM – Center for Marine Environmental Sciences, Bremen University, Bremen, Germany (2); Department of Earth Sciences, Faculty of Science, Vrije Universiteit Amsterdam, The Netherlands (3); ANU – Australian National University, Research School of Earth Sciences, Canberra, Australia (4); School of Geography, Earth and Environmental Sciences at University of Birmingham, Edgbaston Birmingham, United Kingdom (5); LSCE - Laboratoire des Sciences du...

Registration Year

  • 2021

Resource Types

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  • Conference Paper
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  • University College London
  • The Francis Crick Institute
  • King's College London
  • University of Leeds
  • Centre national de la recherche scientifique
  • University of Glasgow
  • University of Cambridge
  • University of Birmingham
  • Cardiff University
  • University of Oxford