Section of a human cranium of a 5-month-old male with cranial synostosis.
Voxel size: 0.009 mm
The samples were retrieved following ethical approval and patient consent.

This video demonstrates our automatic trabecular segmentation method on the tibial epiphysis of a 20 week old CBA mouse. Details of this method can be found on our github repository: https://github.com/evaherbst/Trabecular_Segmentation_Avizo

This video demonstrates our automatic trabecular segmentation method on the tibial epiphysis of a 20 week old CBA mouse. Details of this method can be found on our github repository: https://github.com/evaherbst/Trabecular_Segmentation_Avizo

Objective: We assessed pre-operative structural brain networks and clinical characteristics of patients with drug resistant temporal lobe epilepsy (TLE) to identify correlates of post-surgical seizure recurrences. Methods: We examined data from 51 TLE patients who underwent anterior temporal lobe resection (ATLR) and 29 healthy controls. For each patient, using the preoperative structural, diffusion, and post-operative structural MRI, we generated two networks: ‘pre-surgery’ network and ‘surgically-spared’ network. Standardising these networks with respect to controls, we determined...

Catalytic data describing the production of formate from the hydrogenation of CO2 using iron-sulfide, iron-nickel-sulphide and nickel-sulfide catalysts prepared with different heat treatments under a range of reaction conditions. Catalyst characterisation of these materials include XRD analysis, giving an understanding of the violarite phase and crystallinity. XPS analysis gains understanding of the iron, nickel and sulphur species, and how sulphide and oxide species change under thermal oxidation. XAS analysis employed is vital to gain more...

This resource consists of data from a risky decision and happiness task that was part of The Great Brain Experiment (GBE) smartphone app. Data were collected from 47,067 participants aged 18+ between March 8, 2013 and October 5, 2015. These anonymous unpaid participants completed the task a total of 91,058 times making approximately 2.7 million choices and 1.1 million happiness ratings in total. This resource represents at least 6,000 hours of task data. A subset...

A critical aspect of toxicity evaluation is developmental and reproductive toxicity (DART) testing. Traditionally, DART testing has been conducted in vivo in mammalian model systems. New legislation aimed at reducing animal use and the prohibitive costs associated with DART testing, together with a need to understand the genetic pathways underlying developmental toxicity means there is a growing demand for alternative model systems for toxicity evaluation. Here we explore the potential of the eukaryotic social amoeba...

The bulk and surface properties of early transition metal silicon carbides as well as their activity towards the reduction of CO2 is examined in this first principles DFT study. Data for basal (0001) planes of Ti4C3Si, V4C3Si, Nb4C3Si & Zr4C3Si is stored in one .xlsx file. The first sheet gives formation energies for each silicon carbide as related to the parent monocarbide material. Sheet 2 gives the density of states for each material. Sheet 3...

To obtain information on characteristics, management, current objective nutritional status and perception of nutritional status of children with cerebral palsy (CP) from healthcare professionals (HCPs) and caregivers. A detailed survey of several items on eight main topics (general characteristics, motor function, comorbidities, therapies, anthropometry, feeding mode and problems and perceived nutritional status) was developed and tested for the study. Correlation between nutritional status and Gross Motor Function Classification System (GMFCS) levels was assessed using continuous...

Lepidosaurs include lizards, snakes, amphisbaenians and the tuatara, comprising a highly speciose evolutionary radiation with widely varying anatomical traits. Their stem-lineage originated by the late middle Permian 259 million years ago, but its early fossil record is poorly documented, obscuring the origins of key anatomical and functional traits of the group. Paliguana whitei, from the Early Triassic of South Africa, is an enigmatic fossil species with potential to provide information on this. However, its anatomy...

Numerous empirical studies suggest that individuals convey their commitment to communities and impart the qualities of being a reliable partner through costly behaviours. We collected religious practices data ranging from daily trivial practices to infrequent grand distant pilgrimages in an agricultural Tibetan village. We predict that 1) villagers who invest more in religious practices are more likely to be nominated as having various prosocial qualities. 2) Investment in grand distant pilgrimages has more efficacy than...

Purpose: The interest in exploiting Auger emitters in cancer therapy stems from their high linear energy transfer (LET)-type radiation damage to DNA. However, the design of Auger-emitter labeled vehicles that target the Auger cascade specifically to the DNA of tumour cells is challenging. Here we suggest a possible approach to evaluate tumour-targeting Auger-labeled conjugates by assessing the impact of a radioprotector known to be effective in protecting from low LET radiation, but not high LET...

Agriculture is fundamental to all three pillars of sustainability, environment, society, and economy. However, the definition of sustainable agriculture and capacities to measure it remain elusive. Independent and transparent measurements of national sustainability are needed to gauge progress, encourage accountability, and inform policy. Here, we developed a Sustainable Agriculture Matrix (SAM) to quantify national performance indicators in agriculture and to investigate the tradeoffs and synergies based on historical data for most countries of the world....

This paper is the first of four to explore results from UKERC’s Modelling Hub survey. Focusing on the UK energy modelling landscape, these initial findings detail who hosts and runs models, their methodologies and coverage, and their major outputs.

High dimensional cytometry is an innovative tool for immune monitoring in health and disease, it has provided novel insight into the underlying biology as well as biomarkers for a variety of diseases. However, the analysis of multiparametric “big data” usually requires specialist computational knowledge. Here we describe ImmunoCluster (https://github.com/kordastilab/ImmunoCluster) an R package for immune profiling cellular heterogeneity in high dimensional liquid and imaging mass cytometry, and flow cytometry data, designed to facilitate computational analysis by...

Free energy calculations of noble-gas containing liquid iron and silicate melts at 50 GPa (3500 K) and 135 GPa (4200 K). The chemical potentials of noble gases can be obtained from these calculations. The Gibbs free energy of a series of iron and silicate melts with different concentrations of He were calculated. Then the chemical potentials of He can be derived from the concentration dependent Gibbs free energies. The chemical potentials of Ne, Ar, Kr...

Monitoring bone tissue engineered constructs during their maturation is important to ensure the quality of applied protocols. Several destructive, mainly histochemical, methods are conventionally used to this aim, requiring the sacrifice of the investigated samples. This implies i) to plan several scaffold replicates, ii) expensive and time consuming procedures and iii) to infer the maturity level of a given tissue construct from a cognate replica. To solve these issues, non-destructive techniques such as light spectroscopy-based...

International multi-professional expert consensus was sought to develop best practice recommendations for clinical management of patients following cervical spinal cord injury with oropharyngeal dysphagia and associated complications. Additionally, risk factors for dysphagia were identified to support the development of a screening tool. A two-round Delphi study was undertaken with a 27-member panel of expert professionals in cervical spinal cord injury and complex dysphagia. They rated 85 statements across seven topic areas in round one, using...

Section of a human cranium of a 5-month-old male with cranial synostosis.
Voxel size: 0.009 mm
The samples were retrieved following ethical approval and patient consent.

CT stack of a male, 8-week-old STR/Ort mouse epiphysis.
Voxel size = 0.005 mm
Ethical approval for the animal procedures was carried out in accordance with the Animals (Scientific Procedures) Act 1986, an Act of Parliament of the United Kingdom, approved by the Royal Veterinary College Ethical Review Committee and the United Kingdom Government Home Office.

CT stack of a male, 8-week-old STR/Ort mouse epiphysis.
Voxel size = 0.005 mm
Ethical approval for the animal procedures was carried out in accordance with the Animals (Scientific Procedures) Act 1986, an Act of Parliament of the United Kingdom, approved by the Royal Veterinary College Ethical Review Committee and the United Kingdom Government Home Office.

Section of a human femur from a 77-year-old female.Voxel size: 0.01 mm
The samples was retrieved following ethical approval and patient consent.

Section of a human femur from a 77-year-old female.Voxel size: 0.01 mm
The samples was retrieved following ethical approval and patient consent.

CT stack of a male, 51-week-old STR/Ort mouse epiphysis .
Voxel size = 0.005 mm
Ethical approval for the animal procedures was carried out in accordance with the Animals (Scientific Procedures) Act 1986, an Act of Parliament of the United Kingdom, approved by the Royal Veterinary College Ethical Review Committee and the United Kingdom Government Home Office.

CT stack of a male, 19-week-old STR/Ort mouse epiphysis .
Voxel size = 0.005 mm
Ethical approval for the animal procedures was carried out in accordance with the Animals (Scientific Procedures) Act 1986, an Act of Parliament of the United Kingdom, approved by the Royal Veterinary College Ethical Review Committee and the United Kingdom Government Home Office.