902 Works

Environmental variation and biotic interactions limit adaptation at ecological margins: lessons from rainforest Drosophila and European butterflies

Eleanor K. O'Brien, Greg M. Walter & Jon Bridle
Models of local adaptation to spatially varying selection predict that maximum rates of evolution are determined by the interaction between increased adaptive potential owing to increased genetic variation, and the cost genetic variation brings by reducing population fitness. We discuss existing and new results from our laboratory assays and field transplants of rainforest Drosophila and UK butterflies along environmental gradients, which try to test these predictions in natural populations. Our data suggest that: (i) local...

Desafios e ações para o manejo do fogo em áreas de cerrado no norte do estado de Minas Gerais

Lívia Caroline César Dias
O Cerrado é um domínio vegetacional, que no seu processo evolutivo, desenvolveu uma dependência do fogo necessitando do mesmo para manter seus processos ecológicos. Devido a este fator, suas características fitofisionômicas fazem com que este domínio apresente uma alta susceptibilidade à ocorrência de incêndios, seja por fatores bióticos ou abióticos. Considerando estas peculiaridades desse domínio vegetacional, são essenciais estratégias claras de manejo do fogo baseadas em conhecimentos técnico-científicos. No Brasil, de acordo com determinadas Leis,...

Stuck in Reverse

Allan Sikk
This report is part of the Transformation Index BTI 2022. The regional analysis covers the period from February 1, 2019 to January 31, 2021. The BTI assesses the transformation toward democracy and a market economy as well as the quality of governance in 137 countries. More on the BTI at https://www.bti-project.org

Nearly Two Years In: Pandemic Crime in England and Wales to end of 2021

Graham Farrell, Dixon Anthon & Shane Johnson
By the end of 2021, many crime types remained statistically significantly below expected rates, including theft, shoplifting, vehicle crime and violence, with robbery and burglary also low. Recorded crime rates per 10,000 population are in orange. Expected rates are dashed line with grey 95% confidence intervals. Antisocial behaviour’s return to expected levels likely reflects the removal of covid-related legal restrictions.

Polysaccharides from laminaria japonica protect memory abilities and neurogenesis in mice after cranial irradiation through ameliorating neuroinflammation and collagen IV degradation

Siqin Zhang, Shaoyong Chen, Pian ao, Rong Cai, Wenqi Liu & Li Wei
Background: Radiation-induced brain injury (RIBI) is one of the most common long-term complications for patients with malignant brain tumors after radiotherapy. At present, there is no effective treatment for RIBI. Recent studies have also confirmed that polysaccharides from laminaria japonica (LJP) display potential neuroprotective function. However, its mechanisms of neuroprotection remain unclear. Aim: In this study, we aimed to explore effect and underlying mechanism of LJP on neurogenesis in radiation-induced brain injury mice. Methods: SPF...

Simultaneous EEG data with passive motor stimulus from preterm infants

Tanya Poppe, Jucha Willers Moore, Mohammed Rupawala, Anthony N. Price, felipe godinez, Kimberley Whitehead, Sofia Dall'orso, A David Edwards, Lorenzo Fabrizi & Tomoki Arichi
Preprocessed EEG data - infants were fitted with neonatal 25-electrode EEG caps (29 - 32 cm head circumference) and connected to an MR-compatible system (EASYCAP and Brain Products GmbH). EEG data preprocessing was performed using Analyzer 2 software (Brain Products GmbH), with an initial 0.2 Hz high-pass filter used to remove slow frequency drift in the EEG data. After exclusion of TRs with visible motion on the raw EEG, MR gradient artifact was cleaned using...

Additional file 1 of VHHs as tools for therapeutic protein delivery to the central nervous system

Yessica Wouters, Tom Jaspers, Laura Rué, Lutgarde Serneels, Bart De Strooper & Maarten Dewilde
Additional file 1: Figure S1. Bivalent Nb62 fails to shuttle NT(8-13) into the brain. Mouse body temperature measurements are shown after 250 nmol/kg intravenous injections of the indicated VHH fused to NT(8-13). Bar graphs represent mean ± SEM (n = 3 per group). Statistical test: two-way ANOVA with repeated measures and Sidak’s multiple comparisons test. (significant time*treatment interaction effect ****p<0.0001).

Additional file 1 of VHHs as tools for therapeutic protein delivery to the central nervous system

Yessica Wouters, Tom Jaspers, Laura Rué, Lutgarde Serneels, Bart De Strooper & Maarten Dewilde
Additional file 1: Figure S1. Bivalent Nb62 fails to shuttle NT(8-13) into the brain. Mouse body temperature measurements are shown after 250 nmol/kg intravenous injections of the indicated VHH fused to NT(8-13). Bar graphs represent mean ± SEM (n = 3 per group). Statistical test: two-way ANOVA with repeated measures and Sidak’s multiple comparisons test. (significant time*treatment interaction effect ****p<0.0001).

Additional file 1 of Early brass from the Foyemiaowan-Xindiantai cemetery, 265–439 ce: the origin and diffusion of brass in ancient China

Qiangbing Wei, Yanxiang Li, Thilo Rehren, Honglian Ma, Xiuhui Li & Jianli Chen
Additional file 1: Table S1. Analysis results of brass inclusions.

Early brass from the Foyemiaowan-Xindiantai cemetery, 265–439 ce: the origin and diffusion of brass in ancient China

Qiangbing Wei, Yanxiang Li, Thilo Rehren, Honglian Ma, Xiuhui Li & Jianli Chen
Abstract The Foyemiaowan-Xindiantai cemetery, with more than 10,000 tombs, is located in north-west Gansu Province. The cemetery was active during the Sixteen-State Period of the Western Jin Dynasty (265–439 CE). As the largest ancient tomb group in the Dunhuang region, its cultural core is still mainly based on the cultural tradition of the Central Plains. Metal objects were texturally and chemically analyzed by optical microscopy (OM), scanning electron microscopy coupled with energy-dispersive spectrometry (SEM–EDS), and...

Additional file 5 of Costunolide is a dual inhibitor of MEK1 and AKT1/2 that overcomes osimertinib resistance in lung cancer

Xueli Tian, Rui Wang, Tingxuan Gu, Fayang Ma, Kyle Vaughn Laster, Xiang Li, Kangdong Liu, Mee-Hyun Lee & Zigang Dong
Supplementary Material 5

Additional file 8 of Costunolide is a dual inhibitor of MEK1 and AKT1/2 that overcomes osimertinib resistance in lung cancer

Xueli Tian, Rui Wang, Tingxuan Gu, Fayang Ma, Kyle Vaughn Laster, Xiang Li, Kangdong Liu, Mee-Hyun Lee & Zigang Dong
Supplementary Material 8

Costunolide is a dual inhibitor of MEK1 and AKT1/2 that overcomes osimertinib resistance in lung cancer

Xueli Tian, Rui Wang, Tingxuan Gu, Fayang Ma, Kyle Vaughn Laster, Xiang Li, Kangdong Liu, Mee-Hyun Lee & Zigang Dong
Abstract EGFR-TKI targeted therapy is one of the most effective treatments for lung cancer patients harboring EGFR activating mutations. However, inhibition response is easily attenuated by drug resistance, which is mainly due to bypass activation or downstream activation. Herein, we established osimertinib-resistant cells by stepwise dose-escalation in vitro and an osimertinib-resistant patient-derived xenograft model through persistent treatment in vivo. Phosphorylated proteomics identified that MEK1 and AKT1/2 were abnormally activated in resistant cells compared with parental...

Additional file 3 of Costunolide is a dual inhibitor of MEK1 and AKT1/2 that overcomes osimertinib resistance in lung cancer

Xueli Tian, Rui Wang, Tingxuan Gu, Fayang Ma, Kyle Vaughn Laster, Xiang Li, Kangdong Liu, Mee-Hyun Lee & Zigang Dong
Supplementary Material 3

Additional file 2 of Costunolide is a dual inhibitor of MEK1 and AKT1/2 that overcomes osimertinib resistance in lung cancer

Xueli Tian, Rui Wang, Tingxuan Gu, Fayang Ma, Kyle Vaughn Laster, Xiang Li, Kangdong Liu, Mee-Hyun Lee & Zigang Dong
Supplementary Material 2

Additional file 1 of The bacterial consortia promote plant growth and secondary metabolite accumulation in Astragalus mongholicus under drought stress

Yixian Lin, Hui Zhang, Peirong Li, Juan Jin & Zhefei Li
Supplementary Material 1

Additional file 2 of Identifying Child Anxiety Through Schools-identification to intervention (iCATS-i2i): protocol for a cluster randomised controlled trial to compare screening, feedback and intervention for child anxiety problems to usual school practice

Tessa Reardon, Obioha C. Ukoumunne, Mara Violato, Susan Ball, Paul Brown, Tamsin Ford, Alastair Gray, Claire Hill, Bec Jasper, Michael Larkin, Ian Macdonald, Fran Morgan, Jack Pollard, Michelle Sancho, Falko F. Sniehotta, Susan H. Spence, Paul Stallard, Jason Stainer, Lucy Taylor, Victoria Williamson, Emily Day, Jennifer Fisk, Iheoma Green, Gemma Halliday, Ciara Hennigan … & Cathy Creswell
Additional file 2: Supplement 2. Schedule of enrolment, intervention, and assessment.

Additional file 1 of Identifying Child Anxiety Through Schools-identification to intervention (iCATS-i2i): protocol for a cluster randomised controlled trial to compare screening, feedback and intervention for child anxiety problems to usual school practice

Tessa Reardon, Obioha C. Ukoumunne, Mara Violato, Susan Ball, Paul Brown, Tamsin Ford, Alastair Gray, Claire Hill, Bec Jasper, Michael Larkin, Ian Macdonald, Fran Morgan, Jack Pollard, Michelle Sancho, Falko F. Sniehotta, Susan H. Spence, Paul Stallard, Jason Stainer, Lucy Taylor, Victoria Williamson, Emily Day, Jennifer Fisk, Iheoma Green, Gemma Halliday, Ciara Hennigan … & Cathy Creswell
Additional file 1: Supplement 1. SPIRIT Checklist.

Additional file 3 of Identifying Child Anxiety Through Schools-identification to intervention (iCATS-i2i): protocol for a cluster randomised controlled trial to compare screening, feedback and intervention for child anxiety problems to usual school practice

Tessa Reardon, Obioha C. Ukoumunne, Mara Violato, Susan Ball, Paul Brown, Tamsin Ford, Alastair Gray, Claire Hill, Bec Jasper, Michael Larkin, Ian Macdonald, Fran Morgan, Jack Pollard, Michelle Sancho, Falko F. Sniehotta, Susan H. Spence, Paul Stallard, Jason Stainer, Lucy Taylor, Victoria Williamson, Emily Day, Jennifer Fisk, Iheoma Green, Gemma Halliday, Ciara Hennigan … & Cathy Creswell
Additional file 3: Supplement 3. Progression criteria assessed by the Programme Steering Committee prior to progressing to Phase 2.

cAMP signalling movies and optogenetics

Jonathan Chubb & Hugh Ford
Movies of single cell cAMP signalling over population scales. Movies of optogenetic activation of cAMP to control population dynamics.

Group 5: Challenge: Nanopore \"Defect detection in graphene sheets\"

Anna Bachs Herra, Aboulatif Cisse, Emilio Alexis de la Cruz Nunez Andrade, Philipp Deussen & Ivan Yankov
Graphene is a nanomaterial with excellent super conducting properties, is considered to be the strongest material available and is impermeable to gasses (even Helium-the smallest gas atom). Its properties find applications in fabrication of electronic and optoelectronic devices, gas sensors such as chemiresistors for detection of ammonium [1] and nitrogen dioxide [2], biosensors, composite materials and energy storage devices. Graphene has a regular structure- similar to a honey comb, which consists of fused six membered...

Additional file 1 of Neoplastic cell enrichment of tumor tissues using coring and laser microdissection for proteomic and genomic analyses of pancreatic ductal adenocarcinoma

Qing Kay Li, Yingwei Hu, Lijun Chen, Michael Schnaubelt, Daniel Cui Zhou, Yize Li, Rita Jui-Hsien Lu, Mathangi Thiagarajan, Galen Hostetter, Chelsea J. Newton, Scott D. Jewell, Gil Omenn, Ana I. Robles, Mehdi Mesri, Oliver F. Bathe, Bing Zhang, Li Ding, Ralph H. Hruban, Daniel W. Chan & Hui Zhang
Additional file 1: Table S1. Clinical information of study cases. Table S2. Expression of proteins from the PDAC tumors and NATs

Supplementary material;slide (1-7) from Uncovering commercial activity in informal cities

Daniel Straulino, Juan C. Saldarriaga, Jairo A. Gómez, Juan C. Duque & Neave O’Clery
appendix with more detail on methods/results, robustness checks, and tables for reference;Figures in the main paper

Investigation on bioactive metabolites produced by an endophytic fungus Trichoderma citrinoviride from the arils of Torreya grandis

Xiaohui Kong, Lin Xu, Xiaokang Ji, Shengli Yang & Hui Zhang
An endophytic fungus Trichoderma citrinoviride capable of producing active substances was isolated from the arils of Torreya grandis. Seven compounds were separated from the ethyl acetate extract of fermentation broth and mycelium by chromatography, respectively identified as trichomerol (1), bisorbicillinolide (2), sohirnone A (3), emodin (4), stigmasterol (5), ergosterol (6), daidzein (7). This study is the first to report of the isolation of the endophytic fungus T. citrinoviride from the arils of T. grandis with...

Behaviourally modulated hippocampal theta oscillations in the ferret persist during both locomotion and immobility - data

Soraya Dunn, Stephen Town, Jennifer Bizley & Daniel Bendor
Processed electrophysiological and behavioural data to accompany the paper "Behaviourally modulated hippocampal theta oscillations in the ferret persist during both locomotion and immobility" by Dunn et al. 2022.
Neural data are local field potentials (LFP) recorded with 32 channel Neuronexus probes. Neural data were collected during a localisation task. The files contain corresponding behavioural data for each recording session, including position tracking. Data were collected using the following acqusition systems: Neuralynx (rats), Multichannel systems...

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  • University College London
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