1,146 Works

sj-docx-5-aut-10.1177_13623613221139373 – Supplemental material for Gendered play behaviours in autistic and non-autistic children: A population-based cohort study

Laura Hull, Hein Heuvelman, Jean Golding, William Mandy & Dheeraj Rai
Supplemental material, sj-docx-5-aut-10.1177_13623613221139373 for Gendered play behaviours in autistic and non-autistic children: A population-based cohort study by Laura Hull, Hein Heuvelman, Jean Golding, William Mandy and Dheeraj Rai in Autism

Gendered play behaviours in autistic and non-autistic children: A population-based cohort study

Laura Hull, Hein Heuvelman, Jean Golding, William Mandy & Dheeraj Rai
Gender-typical play is observed throughout childhood for non-autistic children. However, there has been limited research into the gender typicality of autistic children’s play compared to that of non-autistic children. In a longitudinal population-based cohort, we compared gendered play behaviours in autistic and non-autistic children using standardised parent-report (30, 42 and 57 months) and child-report (8 years) data (N = 11,251). We observed no difference in gendered play behaviours between girls with or without autism at...

Additional file 1 of AQP5 complements LGR5 to determine the fates of gastric cancer stem cells through regulating ULK1 ubiquitination

Rou Zhao, Baoyu He, Qingli Bie, Jinghe Cao, Haoran Lu, Zhixin Zhang, Jing Liang, Li Wei, Huabao Xiong & Bin Zhang
Additional file 1: Figure S1. Expression of marker genes in gastric cancer tissue epithelial/stem cellsand cultured adherent/spheroid cells. Figure S2. AQP5 expression in AGS/HGC-27/GES-1 spheroids and adherent cells. Figure S3. AQP5 promotes gastric cancer development in vitro and in vivo. Figure S4. Expression of AQP5 in GC-CSCs. Figure S5. AQP5 promotes the stemness of GC-CSCs. Figure S6. Effect of AQP5 on LGR5 expression.Figure S7. Cellular pathways affected by AQP5. Figure S8. ATG7 is the key...

Additional file 2 of DNA methylation-based detection and prediction of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer with the WID™-qCIN test

Chiara Herzog, Karin Sundström, Allison Jones, Iona Evans, James E. Barrett, Jiangrong Wang, Elisa Redl, Lena Schreiberhuber, Laura Costas, Sonia Paytubi, Lukas Dostalek, Michal Zikan, David Cibula, Gaby Sroczynski, Uwe Siebert, Joakim Dillner & Martin Widschwendter
Additional file 2: Original data for calculations in the manuscript.

Multi-ancestry meta-analysis of host genetic susceptibility to tuberculosis identifies shared genetic architecture

Haiko Schurz, Vivek Naranbhai, Tom A. Yates, James J. Gilchrist, Tom Parks, Peter J. Dodd, Marlo Möller, Eileen G. Hoal, Andrew P. Morris & Adrian V. S. Hill
The heritability of susceptibility to tuberculosis disease (TB) has been well recognized. Over one-hundred genes have been studied as candidates for TB susceptibility, and several variants were identified by genome-wide association studies (GWAS), but few replicates. We established the International Tuberculosis Host Genetics Consortium (ITHGC) to perform a multi-ancestry meta-analysis of GWAS including 14,153 cases and 19,536 controls of African, Asian, and European ancestry. Our analyses demonstrate a substantial degree of heritability (pooled polygenic h2=26.3%...

Electroretinogram raw waveforms for control and autism

Paul Constable, Fernando Marmolejo-Ramos, Dorothy Thompson & Marek Brabec
Raw waveform data used for individual trajectory anaylsis of the ascending limb of the b-wave in control and ASD individuals. Excel contains the dataset ffrom which a subsetof waveforms were analysed using the Rcode provided to estimate factors of scale and location.

Additional file 1 of Bioinformatics tools and data resources for assay development of fluid protein biomarkers

Katharina Waury, Eline A. J. Willemse, Eugeen Vanmechelen, Henrik Zetterberg, Charlotte E. Teunissen & Sanne Abeln
Additional file 1: Use cases for dementia protein biomarkers. PDF document of extended use cases for three biomarker candidates of Alzheimer's Disease: neurogranin, tau and TREM2. For each biomarker a suitability survey was performed and then compared to the current knowledge of these proteins. The document contains figures and results of the used bioinformatics tools and data resources as well as our interpretation of these results.

Additional file 1 of Bioinformatics tools and data resources for assay development of fluid protein biomarkers

Katharina Waury, Eline A. J. Willemse, Eugeen Vanmechelen, Henrik Zetterberg, Charlotte E. Teunissen & Sanne Abeln
Additional file 1: Use cases for dementia protein biomarkers. PDF document of extended use cases for three biomarker candidates of Alzheimer's Disease: neurogranin, tau and TREM2. For each biomarker a suitability survey was performed and then compared to the current knowledge of these proteins. The document contains figures and results of the used bioinformatics tools and data resources as well as our interpretation of these results.

Airborne eDNA documents a diverse and ecologically complex tropical bat and other mammal community

Nina Garrett, Jonathan Watkins, Nancy Simmons, M. Brock Fenton, Alejandro Maeda-Obregon, Daniel Sanchez, Emma Froehlich, Faith Walker, Joanne Littlefair & Elizabeth Clare
Environmental (e)DNA has rapidly become a powerful biomonitoring tool, particularly in aquatic ecosystems. This approach has not been as widely adopted in terrestrial communities where the methods of vertebrate eDNA collection have varied from the use of secondary collectors such as blood-feeding parasites and spider webs to washing surfaces of leaves and soil sampling. Recent studies have demonstrated the potential of direct collection of eDNA from air sampling, but none have tested how effective airborne...

Additional file 1 of Computation and molecular pharmacology to trace the anti-rheumatoid activity of Angelicae Pubescentis Radix

Junhao Zhang, Rui Wang, Xiao Liang, Hao Tian Bai, Ya Lan Li, Shuhui Sun, Qianqian Zhang & Jing Yang
Additional file 1: Figure S1. Original picture of protein expression level.

sj-pdf-7-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg & Florian Deisenhammer
Supplemental material, sj-pdf-7-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

sj-pdf-9-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg & Florian Deisenhammer
Supplemental material, sj-pdf-9-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

Gamma Test Dataset

Robin Matzner
This set of data houses the 5000 graphs used for testing the gamma model that has been trained on the gamma dataset. It houses topologies generated via SNR-BA [1] with nodes scattered uniformly randomly with a minimum radius of 100km between them over a grid the size of north america. The throughput labels are calculated via maximising the routing and wavelength assignment with zero blocking using first-fit k-shortest-paths and implementing the physical layer impairments using...

Additional file 1 of Evidence of individual differences in the long-term social, psychological, and cognitive consequences of child maltreatment

Rosa S. Wong, Keith T. S. Tung, Ko Ling Chan, Wilfred H. S. Wong, Hing Wai Tsang, Clare H. Y. Chow, Gilbert T. Chua, Winnie W. Y. Tso, Jason C. Yam, Ian C. K. Wong & Patrick lp
Additional file 1: Table S1. Comparison of long-term outcomes between exposed and unexposed individuals (based on original data). Table S2. Comparison of long-term outcomes between exposed and unexposed individuals (based on imputed data) stratified by follow-up time and age of onsetTable S3.Comparison of long-term outcomes between exposed and unexposed individuals (based on original data) stratified by follow-up time and age of onset

BA Test Datset

Robin Matzner
This dataset consists of 25-45 node graphs generated via BA [1] with uniformly randomly scattered nodes over a grid the size of north america with a minimim of 100km between nodes. This is a test dataset to test how the model reacts to different structures of graphs.
[1] A.-L. Barabasi and R. Albert, ‘Emergence of scaling in random networks’, Science, vol. 286, no. 5439, pp. 509–512, Oct. 1999, doi: 10.1126/science.286.5439.509.

Technical Supplement - \"Arterial pulse wave modelling and analysis for vascular age studies: a review from VascAgeNet\"

Jordi Alastruey, Peter Charlton, Vasiliki Bikia, Birutė Paliakaite, Bernhard Hametner, Rosa Maria Bruno, Marijn P. Mulder, Samuel Vennin, Senol Piskin, Ashraf W. Khir, Andrea Guala, Christopher C. Mayer, JONATHAN MYNARD, Alun Hughes, Patrick Segers & Berend Westerhof
This document provides a derivation of all equations mentioned in the main text of the article "Arterial pulse wave modelling and analysis for vascular age studies: a review from VascAgeNet". Starting from the full three-dimensional (3-D) Navier Stokes equations, we provide a detailed derivation of (i) the nonlinear one-dimensional (1-D) governing equations of arterial blood flow (Section 2.1), (ii) their theoretical analysis using the method of characteristics from which several pulse wave analysis methods can...

sj-docx-3-aut-10.1177_13623613221139373 – Supplemental material for Gendered play behaviours in autistic and non-autistic children: A population-based cohort study

Laura Hull, Hein Heuvelman, Jean Golding, William Mandy & Dheeraj Rai
Supplemental material, sj-docx-3-aut-10.1177_13623613221139373 for Gendered play behaviours in autistic and non-autistic children: A population-based cohort study by Laura Hull, Hein Heuvelman, Jean Golding, William Mandy and Dheeraj Rai in Autism

VPS dependency after aneurysmal subarachnoid haemorrhage and influence of admission hyperglycaemia

Isabel Charlotte Hostettler, Nicole Lange, Nina Schwendinger, Gareth Ambler, Theresa Hirle, Samira Frangoulis, Dominik Trost, Jens Gempt, Kornelia Kreiser, Bernhard Meyer, Christof Winter & Maria Wostrack
Introduction:Hydrocephalus after aneurysmal subarachnoid haemorrhage (aSAH) is a common complication which may lead to insertion of a ventriculoperitoneal shunt (VPS). Our aim is to evaluate a possible influence of specific clinical and biochemical factors on VPS dependency with special emphasis on hyperglycaemia on admission.Patients and methods:Retrospective analysis of a monocentric database of aSAH patients. Using univariable and multivariable logistic regression analysis we evaluated factors influencing VPS dependency, with a special focus on hyperglycaemia on blood...

Avian seed dispersal may be insufficient for plants to track future temperature change on tropical mountains - data

Larissa Nowak, Matthias Schleuning, Irene M. A. Bender, Katrin Böhning-Gaese, D. Matthias Dehling, Susanne A. Fritz, W. Daniel Kissling, Thomas Mueller, Eike Lena Neuschulz, Alex L. Pigot, Marjorie C. Sorensen & Isabel Donoso
Abstract Aim: Climate change causes species’ range shifts globally. Terrestrial plant species often lag behind temperature shifts, and it is unclear to what extent animal-dispersed plants can track climate change. Here, we estimate the ability of bird-dispersed plant species to track future temperature change on a tropical mountain. Location: Tropical elevational gradient (500–3500 m a.s.l.) in the Manú biosphere reserve, Peru Time period: 1960–1990 to 2061–2080 Taxa: Fleshy-fruited plants, avian frugivores Methods: Using simulations based...

Inter-Linkage between Macroeconomic factors and Stock Market: A comparative study between the U.S and India

Sanjana Nagpal
It is irrefutable that stock markets provide a barometer that can be relied upon to measure the economic condition of a country. As countries increasingly integrating, there is an urgent need for an ongoing and detailed study of the stock market. The stock market of a country plays a pivotal role in transferring funds from surplus units to deficit units. Any unfavourable news within the stock market may not only impact on market...

BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) promotes lung adenocarcinoma by interacting with Zinc Finger Protein ZNF143 and regulating glycolysis

Xiaolei Zhou, Yanli Yuan, Hongping Kuang, Bingxiang Tang, Hui Zhang & Manlin Zhang
Lung adenocarcinoma (LUAD) is one of the most common causes of cancer death in men. BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B) has been reported to contribute to the initiation and development of several cancers. Here, we aimed to explore the potential role of BUB1B in LUAD. We found BUB1B was upregulated in LUAD, suggesting its potential role as a biomarker for LUAD diagnosis. Significantly, LUAD patients with high BUB1B expression had a shorter survival...

Impact of the covid-19 pandemic on amyotrophic lateral sclerosis care in the UK

Lucy S. Musson, Alexis Collins, Sarah Opie-Martin, Andrea Bredin, Esther V. Hobson, Emily Barkhouse, Mark C. Coulson, Theocharis Stavroulakis, Rebecca L. Gould, Ammar Al-Chalabi & Christopher J. McDermott
The Covid-19 pandemic has impacted healthcare. Our aim was to identify how amyotrophic lateral sclerosis (ALS) care in the UK has been affected by the pandemic by exploring the experiences of people living with ALS (plwALS), healthcare professionals (HCPs) working with plwALS, and ALS care centers. Three surveys were carried out to explore the experiences of plwALS, HCPs and ALS care centers during the pandemic. Quantitative data were analyzed using descriptive and inferential statistics and...

Polysaccharides from Laminaria japonica protect memory abilities and neurogenesis in mice after cranial irradiation through ameliorating neuroinflammation and collagen IV degradation

Siqin Zhang, Shaoyong Chen, Pian Ao, Rong Cai, Wenqi Liu & Li Wei
Radiation-induced brain injury (RIBI) is one of the most common long-term complications for patients with malignant brain tumors after radiotherapy. At present, there is no effective treatment for RIBI. Recent studies have also confirmed that polysaccharides from laminaria japonica (LJP) display potential neuroprotective function. However, its mechanisms of neuroprotection remain unclear. In this study, we aimed to explore the effect and underlying mechanism of LJP on neurogenesis in radiation-induced brain injury mice. SPF two-month-old male...

Polysaccharides from Laminaria japonica protect memory abilities and neurogenesis in mice after cranial irradiation through ameliorating neuroinflammation and collagen IV degradation

Siqin Zhang, Shaoyong Chen, Pian Ao, Rong Cai, Wenqi Liu & Li Wei
Radiation-induced brain injury (RIBI) is one of the most common long-term complications for patients with malignant brain tumors after radiotherapy. At present, there is no effective treatment for RIBI. Recent studies have also confirmed that polysaccharides from laminaria japonica (LJP) display potential neuroprotective function. However, its mechanisms of neuroprotection remain unclear. In this study, we aimed to explore the effect and underlying mechanism of LJP on neurogenesis in radiation-induced brain injury mice. SPF two-month-old male...

UCL CPOM CryoSat2 Polar Ocean Significant Wave Height 2011-2019

Harold Heorton
We present the significant ocean surface wave heights in the Arctic and Southern Oceans from CryoSat-2 data. We use a semi-analytical model for an idealised synthetic aperture satellite radar or pulse-limited radar altimeter echo power. We develop a processing methodology that specifically considers both the Synthetic Aperture and Pulse Limited modes of the radar that change close to the sea ice edge within the Arctic Ocean. All CryoSat-2 echoes to date were matched by our...

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