126 Works

Data from: Linking a mutation to survival in wild mice

Rowan D. H. Barrett, Stefan Laurent, Ricardo Mallarino, Susanne P. Pfeifer, Charles C. Y. Xu, Matthieu Foll, Kazumasa Wakamatsu, Jonathan S. Duke-Cohan, Jeffrey D. Jensen & Hopi E. Hoekstra
Adaptive evolution in new or changing environments can be difficult to predict because the functional connections between genotype, phenotype, and fitness are complex. Here, we make these explicit connections by combining field and laboratory experiments in wild mice. We first directly estimate natural selection on pigmentation traits and an underlying pigment locus, Agouti, by using experimental enclosures of mice on different soil colors. Next, we show how a mutation in Agouti associated with survival causes...

sj-docx-1-tah-10.1177_20406207221127532 – Supplemental material for Avatrombopag for the treatment of thrombocytopenia post hematopoietic stem-cell transplantation

Meng Zhou, Jiaqian Qi, Chengyuan Gu, Hong Wang, Ziyan Zhang, Depei Wu & Yue Han
Supplemental material, sj-docx-1-tah-10.1177_20406207221127532 for Avatrombopag for the treatment of thrombocytopenia post hematopoietic stem-cell transplantation by Meng Zhou, Jiaqian Qi, Chengyuan Gu, Hong Wang, Ziyan Zhang, Depei Wu and Yue Han in Therapeutic Advances in Hematology

sj-docx-1-tah-10.1177_20406207221127532 – Supplemental material for Avatrombopag for the treatment of thrombocytopenia post hematopoietic stem-cell transplantation

Meng Zhou, Jiaqian Qi, Chengyuan Gu, Hong Wang, Ziyan Zhang, Depei Wu & Yue Han
Supplemental material, sj-docx-1-tah-10.1177_20406207221127532 for Avatrombopag for the treatment of thrombocytopenia post hematopoietic stem-cell transplantation by Meng Zhou, Jiaqian Qi, Chengyuan Gu, Hong Wang, Ziyan Zhang, Depei Wu and Yue Han in Therapeutic Advances in Hematology

Avatrombopag for the treatment of thrombocytopenia post hematopoietic stem-cell transplantation

Meng Zhou, Jiaqian Qi, Chengyuan Gu, Hong Wang, Ziyan Zhang, Depei Wu & Yue Han
Background:Thrombocytopenia post hematopoietic stem-cell transplantation (HCT) usually contributes to poor outcomes with no standardized treatment. Eltrombopag and romiplostim can be feasible for post-HCT thrombocytopenia, but the use of avatrombopag has not yet been evaluated.Objectives:We aimed to evaluate the efficacy and safety of avatrombopag treatment in patients diagnosed with post-HCT thrombocytopenia.Design:In this retrospective study, we evaluated the efficacy and safety of avatrombopag treatment in a cohort of 61 patients diagnosed with thrombocytopenia post HCT in our...

sj-docx-1-hol-10.1177_09596836221131694 – Supplemental material for Hydro-climatic aspects of prehistoric human dynamics in the drylands of the Asian interior

Kangkang Li, Xiaoguang Qin, Bing Xu, Zhiqiang Yin, Yong Wu, Guijin Mu, Dong Wei, Xiaohong Tian, Huiqiu Shao, Chunxue Wang, Hongjuan Jia, Wen Li, Haoze Song, Jiaqi Liu & Yingxin Jiao
Supplemental material, sj-docx-1-hol-10.1177_09596836221131694 for Hydro-climatic aspects of prehistoric human dynamics in the drylands of the Asian interior by Kangkang Li, Xiaoguang Qin, Bing Xu, Zhiqiang Yin, Yong Wu, Guijin Mu, Dong Wei, Xiaohong Tian, Huiqiu Shao, Chunxue Wang, Hongjuan Jia, Wen Li, Haoze Song, Jiaqi Liu and Yingxin Jiao in The Holocene

Hydro-climatic aspects of prehistoric human dynamics in the drylands of the Asian interior

Kangkang Li, Xiaoguang Qin, Bing Xu, Zhiqiang Yin, Yong Wu, Guijin Mu, Dong Wei, Xiaohong Tian, Huiqiu Shao, Chunxue Wang, Hongjuan Jia, Wen Li, Haoze Song, Jiaqi Liu & Yingxin Jiao
The causes of prehistoric human migrations in the drylands of the Asian interior have long been debated among multidisciplinary scholars. The Bronze Age Xiaohe settlements (ca. 4000–3300 cal yr BP) are situated in the extremely arid Tarim Basin of northwest China and exemplify a societal collapse which included a long-distance movement along river catchments. Here, we present the results of stable carbon isotope values (δ13C) of archaeobotanical remains, sedimentary faces analysis from the Tarim River...

Association of H3K9me3 with breast cancer prognosis by estrogen receptor status

Meng Zhou, Jin-qi Yan, Qian-xin Chen, Yuan-zhong Yang, Yue-lin Li, Yue-xiang Ren, Zi-jin Weng, Xiao-fang Zhang, Jie-xia Guan, Lu-ying Tang & Ze-fang Ren
Abstract Background Cellular experiments revealed that a decreased histone H3 lysine 9 trimethylation (H3K9me3) level was associated with the upregulation of oncogenes in breast cancer cells. Moreover, the role of H3K9me3 in breast cancer was closely associated with estrogen receptor (ER) status. Therefore, we aimed to examine the prognostic value of H3K9me3 on breast cancer by ER status. The level of H3K9me3 in tumors were evaluated with tissue microarrays by immunohistochemistry for 917 women diagnosed...

Characteristics of population structure, antimicrobial resistance, virulence factors, and morphology of methicillin-resistant Macrococcus caseolyticus in global clades

Yu Zhang, Shengyi Min, Yuxuan Sun, Jiaquan Ye, Zhemin Zhou & Heng Li
Abstract Macrococcus caseolyticus is an opportunistic pathogen that is frequently isolated from dairy products and veterinary infections. Recent studies have reported the possibility of methicillin resistance that be transferred among staphylococcal species in foods. The present study examined the population structure, antimicrobial resistance, virulence factors, and morphology of methicillin-resistant M. caseolyticus by investigation of 94 genomes derived from both isolates in beef (n = 7) and pork (n = 2) at Shanghai and those deposited...

Additional file 1 of Efficacy of resistive exercise on skeletal muscle-related outcomes in cancer survivors: a systematic review protocol

Jacqueline K. Dawson, Dong-Woo Kang, Oscar Barnes, Rebekah L. Wilson, Mary K. Norris & Christina M. Dieli-Conwright
Additional file 1. PRISMA-P Checklist.

Additional file 2 of Efficacy of resistive exercise on skeletal muscle-related outcomes in cancer survivors: a systematic review protocol

Jacqueline K. Dawson, Dong-Woo Kang, Oscar Barnes, Rebekah L. Wilson, Mary K. Norris & Christina M. Dieli-Conwright
Additional file 2. Study inclusion spreadsheet.

sj-docx-1-ict-10.1177_15347354221140498 – Supplemental material for The Managing Cancer and Living Meaningfully (CALM) Intervention Alleviates Chemotherapy-Related Cognitive Impairment in Patients with Breast Cancer by Modulating Pan-Immune-Inflammation Values

Senbang Yao, Ke Ding, Shaochun Liu, Qianqian Zhang, Wen Li, Lingxue Tang, Sheng Yu, Lulian Pang, Xiangxiang Yin & Huaidong Cheng
Supplemental material, sj-docx-1-ict-10.1177_15347354221140498 for The Managing Cancer and Living Meaningfully (CALM) Intervention Alleviates Chemotherapy-Related Cognitive Impairment in Patients with Breast Cancer by Modulating Pan-Immune-Inflammation Values by Senbang Yao, Ke Ding, Shaochun Liu, Qianqian Zhang, Wen Li, Lingxue Tang, Sheng Yu, Lulian Pang, Xiangxiang Yin and Huaidong Cheng in Integrative Cancer Therapies

Additional file 2 of Association of body mass index and inflammatory dietary pattern with breast cancer pathologic and genomic immunophenotype in the nurses’ health study

Sarah Asad, Adrienne Damicis, Yujing J. Heng, Kathryn Kananen, Katharine A. Collier, Elizabeth J. Adams, Kevin H. Kensler, Gabrielle M. Baker, Robert Wesolowski, Sagar Sardesai, Margaret Gatti-Mays, Bhuvaneswari Ramaswamy, A. Heather Eliassen, Susan E. Hankinson, Fred K. Tabung, Rulla M. Tamimi & Daniel G. Stover
Additional file 2: Supplementary Table S2. Immune Gene Expression Scores. Gene expression scores for all samples used in analyses.

Prognostic significance of malnutrition risk in elderly patients with acute kidney injury in the intensive care unit

Na Wang, Ping Wang, Wen Li, Li Jiang, Meiping Wang, Bo Zhu & Xiuming Xi
Abstract Background Malnutrition is common in critically ill patients, but nutrition status in critically ill patients with acute kidney injury (AKI) has been poorly studied. Our study aimed to investigate the relationship between malnutrition risk and the occurrence and prognosis of AKI in elderly patients in the intensive care unit (ICU). Methods Data were extracted from the Beijing Acute Kidney Injury Trial (BAKIT). A total of 1873 elderly patients were included and compared according to...

Additional file 1 of High-efficiency secretory expression and characterization of the recombinant type III human-like collagen in Pichia pastoris

Zhi-Xiang Xiang, Jin-Song Gong, Jin-Hao Shi, Chun-Fang Liu, Heng Li, Chang Su, Min Jiang, Zheng-Hong Xu & Jin-Song Shi
Additional file 1: Table S1. List of primers involved in this work. Table S2. List of primers involved in RT-PCR. Fig. S1. SDS-PAGE analysis of 2# recombinant strain. Lanes 1-3 were the blank control (GS115/pPIC9K), lanes 4-6 were the 2# recombinant strain (GS115/pPIC9K-col), and lane M was standard molecular weights. Fig. S2. Target gene copy number of double-driving recombinant strain. Fig. S3. N-terminal sequencing results of the target protein. Fig. S4. C-terminal sequencing results of...

sj-docx-1-pmj-10.1177_02692163221136641 – Supplemental material for An emergency department nurse led intervention to facilitate serious illness conversations among seriously ill older adults: A feasibility study

Kei Ouchi, Rachel S. Lee, Susan D. Block, Emily L. Aaronson, Mohammad A. Hasdianda, Wei Wang, Sarah Rossmassler, Ruth Palan Lopez, Donna Berry, Rebecca Sudore, Mara A. Schonberg & James A. Tulsky
Supplemental material, sj-docx-1-pmj-10.1177_02692163221136641 for An emergency department nurse led intervention to facilitate serious illness conversations among seriously ill older adults: A feasibility study by Kei Ouchi, Rachel S. Lee, Susan D. Block, Emily L. Aaronson, Mohammad A. Hasdianda, Wei Wang, Sarah Rossmassler, Ruth Palan Lopez, Donna Berry, Rebecca Sudore, Mara A. Schonberg and James A. Tulsky in Palliative Medicine

An emergency department nurse led intervention to facilitate serious illness conversations among seriously ill older adults: A feasibility study

Kei Ouchi, Rachel S. Lee, Susan D. Block, Emily L. Aaronson, Mohammad A. Hasdianda, Wei Wang, Sarah Rossmassler, Ruth Palan Lopez, Donna Berry, Rebecca Sudore, Mara A. Schonberg & James A. Tulsky
Background:Serious illness conversations may lead to care consistent with patients’ goals near the end of life. The emergency department could serve as an important time and location for these conversations.Aim:To determine the feasibility of an emergency department-based, brief motivational interview to stimulate serious illness conversations among seriously ill older adults by trained nurses.Design:A pre-/post-intervention studySettings/participants:In an urban, tertiary care, academic medical center and a community hospital from January 2021 to January 2022, we prospectively enrolled...

Genomic footprints of activated telomere maintenance mechanisms in cancer

Lina Sieverling, Chen Hong, Sandra D Koser, Philip Ginsbach, Kortine Kleinheinz, Barbara Hutter, Delia M Braun, Isidro Cortés-Ciriano, Ruibin Xi, Rolf Kabbe, Peter J Park, Roland Eils, Matthias Schlesner, Kadir C Akdemir, Eva G Alvarez, Adrian Baez-Ortega, Rameen Beroukhim, Paul C Boutros, David DL Bowtell, Benedikt Brors, Kathleen H Burns, Peter J Campbell, Kin Chan, Ken Chen, Ana Dueso-Barroso … & Christian von Mering
Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we dissect whole-genome sequencing data of over 2500 matched tumor-control samples from 36 different tumor types aggregated within the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium to characterize the genomic footprints of these mechanisms. While the...

sj-docx-1-jls-10.1177_0261927X231151408 - Supplemental material for Bonding Through Language Imitation: Influence of Social Ostracism on Structural Priming

Heng Li
Supplemental material, sj-docx-1-jls-10.1177_0261927X231151408 for Bonding Through Language Imitation: Influence of Social Ostracism on Structural Priming by Heng Li in Journal of Language and Social Psychology

Plant community responses to alterations in soil abiotic and biotic conditions are decoupled for above- and belowground traits

Chenguang Gao, T. Martijn Bezemer, Peter M. Van Bodegom, Hans C. Cornelissen, Richard van Logtestijn, Xiangyu Liu, Riccardo Mancinelli, Harrie van der Hagen, Meng Zhou & Nadejda A. Soudzilovskaia
File containing plant functional traits data and plant composition data used for analyzing the responses of plant functional traits to soil inoculation treatments.

The attributable mortality of sepsis for acute kidney injury: a propensity-matched analysis based on multicenter prospective cohort study

Hui-Miao Jia, Yi-Jia Jiang, Xi Zheng, Wen Li, Mei-Ping Wang, Xiu-Ming Xi & Wen-Xiong Li
Both sepsis and AKI are diseases of major concern in intensive care unit (ICU). This study aimed to evaluate the excess mortality attributable to sepsis for acute kidney injury (AKI). A propensity score-matched analysis on a multicenter prospective cohort study in 18 Chinese ICUs was performed. Propensity score was sequentially conducted to match AKI patients with and without sepsis on day 1, day 2, and day 3–5. The primary outcome was hospital death of AKI...

Data from: Significance Analysis of Prognostic Signatures

Andrew H. Beck, Nicholas W. Knoblauch, Marco M. Hefti, Jennifer Kaplan, Stuart J. Schnitt, Aedin C. Culhane, Markus S. Schroeder, John Quackenbush, Benjamin Haibe-Kains & Thomas Risch
A major goal in translational cancer research is to identify biological signatures driving cancer progression and metastasis. A common technique applied in genomics research is to cluster patients using gene expression data from a candidate prognostic gene set, and if the resulting clusters show statistically significant outcome stratification, to associate the gene set with prognosis, suggesting its biological and clinical importance. Recent work has questioned the validity of this approach by showing in several breast...

Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo: RNAseq dataset

Eben Estell, Phuong T Le, Yosta Vegting, Hyeonwoo Kim, Christiane Wrann, Mary L Bouxsein, Kenichi Nagano, Roland Baron, Bruce M Spiegelman & Clifford J Rosen
Irisin, a skeletal-muscle secreted myokine, facilitates muscle-bone crosstalk and skeletal remodeling in part by its action on osteoblasts and osteocytes. In this study, we investigated whether irisin directly regulates osteoclasts. In vitro, irisin (2–10 ng/mL) increased osteoclast differentiation in C57BL/6J mouse bone marrow progenitors; however, this increase was blocked by a neutralizing antibody to integrin αVβ5. Irisin also increased bone resorption on several substrates in situ. RNAseq revealed differential gene expression induced by irisin including...

STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth

Hongwu Li, Ping Liu, Dapeng Li, Zixi Wang, Zhao Ding, Meng Zhou, Xu Chen, Manli Miao, Junli Ding, Wei Lin, Yehai Liu & Xiaojun Zha
Abstract Background Aberrantly activated mammalian target of rapamycin complex 1 (mTORC1) plays a vital role in tumor angiogenesis, but its precise mechanisms are still unclear. Methods Micro-RNA-130b-3p (miR-130b-3p) expression in mTORC1-activated and control cells was examined by quantitative real-time PCR (qRT-PCR). MiR-130b-3p levels and their correlation with mTORC1 activity were evaluated by analyzing publicly available databases and in-house head and neck squamous cell carcinoma (HNSCC) tissues. The role of miR-130b-3p in mTORC1-mediated angiogenesis and tumor...

Additional file 2 of STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth

Hongwu Li, Ping Liu, Dapeng Li, Zixi Wang, Zhao Ding, Meng Zhou, Xu Chen, Manli Miao, Junli Ding, Wei Lin, Yehai Liu & Xiaojun Zha
Additional file 2: Supplementary Table 1. Clinical features of 60 HNSCC patients. Supplementary Table 2. Oligonucleotide sequences used in this study. Supplementary Table 3. Antibodies used in this study. Supplementary Table 4. Primer sequences used for qRT-PCR in this study. Supplementary Table 5. Primers used for luciferase reporter in this study. Supplementary Table 6. Primers used for ChIP Assays in this study.

Additional file 5 of STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth

Hongwu Li, Ping Liu, Dapeng Li, Zixi Wang, Zhao Ding, Meng Zhou, Xu Chen, Manli Miao, Junli Ding, Wei Lin, Yehai Liu & Xiaojun Zha
Additional file 5: Supplementary Table 9. List of the downregulated differentially expressed genes from DEGs in angiofibroma(AF) of TSC patients vs. normal skin. All genes were identified with FDR-adjusted p-value < 0.05 and absolute value of log2(FC) > 1.

Registration Year

  • 2023
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Resource Types

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    69
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Affiliations

  • Dana-Farber Cancer Institute
    126
  • Harvard University
    78
  • Shanghai Jiao Tong University
    62
  • Huazhong University of Science and Technology
    59
  • Wenzhou Medical University
    52
  • Fudan University
    52
  • Sun Yat-sen University
    50
  • Nanjing Medical University
    50
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    44
  • Sichuan University
    43