554 Works

Genetic Mouse Models of Liver Disease

Courtney Turpin
The liver is the largest internal organ in mammals and responsible for carrying out various processes, including lipid and carbohydrate metabolism, detoxification of chemicals, and production of serum proteins. Liver damage, which can be caused by a variety of agents including viral infection, environmental toxins, alcohol and excessive dietary fats, can cause dysregulation of these critical functions, leading to worsening liver pathophysiology and impacting health. However, the liver has the remarkable ability to regenerate when...

PARENT SCHOOL INVOLVEMENT, STUDENT SCHOOL ENGAGEMENT, AND ACADEMIC ACHIEVEMENT IN CHILDREN ADOPTED FROM FOSTER CARE BY LESBIAN AND GAY PARENTS

Cassandra Vázquez
Sparse research has examined academic outcomes of children adopted from foster care by lesbian and gay (LG) parents. Children who have experienced foster care are at greater risk for negative outcomes, but investment in academic achievement could help buffer potential adversity. Parent and student engagement with school peaks in middle childhood, so this may be an important period for understanding processes that influence academic achievement. This study explores how LG parents (N = 57) of...

Multiscale Finite Element Modeling of Active Contraction in Striated Muscle

Charles Mann
Greater than one in three American adults have at least one type of cardiovascular disease, a major cause of morbidity. Computational cardiac mechanics has become an important part of the research effort to understand the heart’s response to mechanical stimuli and as an extension, disease progression and potential therapies. To this end, the present work aims to extend these efforts by implementing a cell level contractile model in which active stress generation in muscle tissue...

Factors Associated with Lifestyle Modification for Type 2 Diabetes Self-Management and Prevention

Leigh Koonmen
Diabetes is the seventh leading cause of death in the United States, affecting roughly 13% of U.S. adults aged 18 years or older. Type 2 diabetes accounts for 90-95% of all diabetes cases and is characterized by the progressive development of insulin resistance leading to sustained elevated blood glucose levels. Management of type 2 diabetes includes risk-reduction strategies and continuous medical care to prevent the development of complications. Lifestyle is a major contributing factor to...

ASSESSING THE USE OF LIDAR AND UAV TECHNOLOGY FOR MONITORING GROWING ALFALFA

Tucker Sheffield
Alfalfa is a popularly grown crop because of its value as a nutritious feed source for livestock. The efficient production of an alfalfa crop relies on the monitoring of certain parameters, like height, quality, and yield. Traditionally, producers have used manual measurements of alfalfa plant height to estimate the nutritive quality and yield of a growing alfalfa crop. Manual measurements of plant height are often labor intensive and provide low resolution data that is not...

DEVELOPMENT OF TOOLS FOR ATOM-LEVEL INTERPRETATION OF STABLE ISOTOPE-RESOLVED METABOLOMICS DATASETS

Huan Jin
Metabolomics is the global study of small molecules in living systems under a given state, merging as a new ‘omics’ study in systems biology. It has shown great promise in elucidating biological mechanism in various areas. Many diseases, especially cancers, are closely linked to reprogrammed metabolism. As the end point of biological processes, metabolic profiles are more representative of the biological phenotype compared to genomic or proteomic profiles. Therefore, characterizing metabolic phenotype of various diseases...

Visceral organ growth in pigs from birth through 150 kg bodyweight

Merlin Lindemann
Visceral organs (VO) are essential for their role in the metabolism and distribution of consumed nutrients as well as other life functions in animals. Two experiments were conducted to assess the natural longitudinal changes that the VO undergo from birth through 150 kg body weight (BW). Results showed that both absolute and relative measurements (weight, volume, and length) of VO were dependent on the BW (age) of the pig.

Novel Mammalian Models for Understanding and Treating Spinal Cord Injury

Michael Orr
Spinal cord injury (SCI) is devastating and often leaves the injured individual with persistent dysfunction. The injury persists because humans have poor wound repair and there are no pharmacologic treatments to induce wound repair after SCI. The continued efforts to discover therapeutic targets and develop treatments heavily relies on animal models. The purpose of this project is to develop and study novel mammalian models of SCI to provide insights for the development and effective implementation...

PHARMACOKINETICS AND REWARD-RELATED BEHAVIORS OF ETHANOL IN MALE AND FEMALE JAPANESE QUAIL (COTURNIX JAPONICA)

Shannon Eaton
Ethanol is one of the most widely used and abused drugs. Problem use is associated with many different health problems and the economic burden is in the billions of dollars. Additionally, many people have difficulty controlling their ethanol consumption and about 5% of adults end up with an alcohol use disorder (AUD). Many people with an AUD often find themselves in a cycle of binge, remission, and relapse. Following ethanol consumption ethanol enters the bloodstream...

PREDICTING TOMORROW

Melissa Cantor
The leading causes of morbidity and mortality in preweaned dairy calves are diarrhea and bovine respiratory disease complex (BRD). The delayed detection of these diseases in calves can also delay intervention and disease recovery. The overarching objective of this dissertation was to follow a cohort of calves daily for the first 90 days of life for naturally occurring clinical BRD bouts and diarrheal bouts. The objective answered if feeding behaviors and activity levels were different...

Investigation of Multidrug Efflux Transporter AcrB in Escherichia coli

Prasangi Rajapaksha
The Resistant Nodulation Division (RND) super family member, tripartite AcrA-AcrB-TolC efflux pump, is a major contributor in conferring multidrug-resistance in Escherichia coli. The structure of the pump complex, and drug translocation by functional rotation mechanism have been widely studied. Despite of all these data, the dynamics of the assembly process of the pump and AcrB during functional rotation in the process of drug efflux remains poorly understood. My thesis focuses on understanding the pump assembly...

The Role of Live Conifer Fuels in Crown Fires Spread

Adnan Darwish Ahmad
Live foliage for some tree and shrub species can support flaming fire spread at much higher moisture content than dead fuel materials. However, the role of live fuels in forest fires has been controversial in the past decades. Although ignition and spread statistical data for live and dead fuels exist in the literature, a clear understanding of the fundamental difference in the burning behavior is missing. To illuminate the role of live fuel on forest...

THE USE OF MECHANOTHERAPY TO PROMOTE THE RECOVERY FROM DISUSE ATROPHY IN AGING RAT SKELETAL MUSCLE

Zachary Hettinger
The combination of age and disuse-related skeletal muscle atrophy predisposes older adults to reduced mobility, loss of independence, and poor quality of life. Poor health outcomes resulting from periods of disuse in older adults are exacerbated by an inability to fully recover, ultimately accelerating geriatric populations towards further functional decline. Aged-related changes to skeletal muscle viscoelastic properties, specifically of muscle extracellular matrix (ECM) stiffness, may not only impact how muscle responds during recovery, but also...

USGS 104b Grant Program

Emily Koyagi, Steve Evans & Lindell Ormsbee
The Kentucky Water Resources Research Institute (KWRRI) is one of 54 Water Resource Research Institutes or Centers located throughout the United States and its territories. The state water resources research institutes are authorized by the Water Resources Research Act of 1964 (P.L. 88-379 codified at 42 U.S.C. 10301 et seq.) through the Water Resources Research Institutes Program administered by the United States Geological Survey (USGS) and organized as the National Institutes for Water Resources (NIWR)....

Data for: PickMe: sample selection for species tree reconstruction using coalescent weighted quartets

Joseph Rusinko, Yu Cai, Allison Doherty, Katherine Thompson, Julien Boutte, Mark Fishbein & Shannon Straub
After collecting large data sets of many genes for many species for phylogenomics studies, researchers may make ad hoc decisions about which genes or samples to include in a species tree reconstruction analysis based on various parameters, including the amount of missing data. Optimally, sampling would be maximized, but it can be difficult for empiricists to determine where to draw the line for sample inclusion when data sets are incomplete. Under the multispecies coalescent model,...

EFFECTIVE FIELD THEORY APPLICATIONS: FROM DARK MATTER TO NEUTRINO NUCLEON SCATTERING

Qing Chen
Weakly-interacting-massive-particles (WIMPs) are a large class of viable dark matter candidates. We compute cross sections for electroweak-doublet WIMPs scattering on atomic nuclei, at leading and subleading order using heavy WIMP effective field theory. Neutrino-nucleon charged current elastic scattering is an important process in the detectors of long baseline accelerator neutrino oscillation experiments. We compute QED radiative corrections to this process employing soft-collinear effective field theory.

Three Essays on Grocery Sales Taxes

Lingxiao Wang
Grocery sales taxes represent a stable tax revenue stream for state and municipal government, but there is rare empirical evidence suggesting grocery taxes may adversely affect health. In addition, the how governments set grocery sales taxes is still unclear. Therefore, based on a novel national dataset of annual county and state-level grocery taxes from 2009 through 2016, the following three essays in the dissertation investigate the health impacts of grocery sales taxes and the causes...

MEETING THEIR EXPECTATIONS: STUDENT EXPECTATIONS AND PERCEPTIONS OF INSTRUCTOR CLARITY, CREDIBILITY, RAPPORT, AND CLIMATE IN ONLINE COURSES

Nicole Kowalski
Continued advancements in technology have steadily increased accessibility to online learning and have provided more tools with which instructors can communicate with their students. As our technology evolves, so too does the students’ expectations for how course content will be communicated. It is important to understand students’ expectations for their online learning experiences so that those expectations can be met. The field of instructional communication has demonstrated the importance of behaviors that establish an instructor’s...

TOWARDS A HOLISTIC RISK MODEL FOR SAFEGUARDING THE PHARMACEUTICAL SUPPLY CHAIN

Heather Campbell
Counterfeit, adulterated, and misbranded medicines in the pharmaceutical supply chain (PSC) are a critical problem. Regulators charged with safeguarding the supply chain are facing shrinking resources for inspections while concurrently facing increasing demands posed by new drug products being manufactured at more sites in the US and abroad. To mitigate risk, the University of Kentucky (UK) Central Pharmacy Drug Quality Study (DQS) tests injectable drugs dispensed within the UK hospital. Using FT-NIR spectrometry coupled with...

WASTE HEAT RECOVERY OF INDUSTRIAL REGENERATIVE THERMAL OXIDIZER (RTO), A CASE STUDY

James Jr. Trimpe
Industrial processes that utilize and release hazardous compounds into the atmosphere are required to break down those compounds before exhausting them from their facilities. An industry-recognized method to break down those hazardous compounds is through thermal oxidation. Thermal oxidation is a process where the compounds are exposed to their auto-ignition temperature in an oxygen-rich environment and combust. The output of thermal oxidation is carbon dioxide, water vapor, and heat. Thermal oxidizers are equipment that performs...

DELINEATING THE ROLE OF FATTY ACID METABOLISM TO IMPROVE THERAPEUTIC STRATEGIES FOR COLORECTAL CANCER

James Drury
Colorectal cancer (CRC) remains a leading cause of cancer-related deaths in the world, comprising over 1 million new cases each year and over 500,000 deaths. CRC, when detected at an early stage of disease development, can be effectively treated, with a 5-year survival rate of over 90%. Such standard treatments include surgical resection of the primary tumor in combination with adjuvant chemotherapy. However, even with advancements in surgical procedures and chemotherapeutic targets, when CRC progresses...

Proceedings of 2021 Kentucky Water Resources Annual Symposium

This symposium was planned and conducted as a part of the state water resources research institute annual program that is supported by Grant/Cooperative Agreement Number G20AS00025 from the United States Geological Survey (USGS). The contents of this proceedings document and the views and conclusions presented at the symposium are solely the responsibility of the individual authors and presenters and do not represent the official views of the USGS or of the symposium organizers and sponsors....

Optical Metasurfaces

Fatih Balli
Traditional optical elements, such as refractive lenses, mirrors, phase plates and polarizers have been used for various purposes such as imaging systems, lithographic printing, astronomical observations and display technology. Despite their long-term achievements, they can be bulky and not suitable for miniaturization. On the other hand, recent nanotechnology advances allowed us to manufacture micro and nanoscale devices with ultra-compact sizes. Metasurfaces, 2D engineered artificial interfaces, have emerged as candidates to replace traditional refractive lenses with...

THREE ESSAYS ON PRICE ANALYSIS AND INTERNATIONAL TRADE

Wei Zhang
The first chapter of this dissertation examines price discovery and volatility spillovers in the coffee spot-futures commodity market over the post-ICA period by employing the PT-IS and bivariate EGARCH models. This research covers two actively traded coffee types, Arabica and Robusta, and utilizes daily time-series price data over 1990:01-2020:04 for Arabica and over 2008:01-2020:04 for Robusta. The empirical results indicate that coffee spot markets play a dominant role in the coffee price discovery for both...

GLOBAL COMPETENCE AND DEEPER LEARNING

L. Amanda Siebert
Education has become increasingly global in recent years. Student and teacher global competence have been studied at length. School administrators’ application of global competencies in their administrative practice has not been explored until recently. Secondary school administrators’ global competencies were investigated under seven tenets. The aim of this study was to examine how secondary principals in one Intermountain school district perceived and implemented global competencies in their current professional practice. Further, this study explored how...

Registration Year

  • 2021
    554

Resource Types

  • Dissertation
    295
  • Text
    198
  • Dataset
    29
  • Report
    22
  • Journal Article
    5
  • Data Paper
    3
  • Book
    1
  • Conference Proceeding
    1

Affiliations

  • University of Kentucky
    554
  • Zhejiang University
    14
  • Sun Yat-sen University
    11
  • Xiamen University
    11
  • Sichuan University
    10
  • State Administration of Traditional Chinese Medicine of the People's Republic of China
    9
  • Chinese Academy of Tropical Agricultural Sciences
    9
  • Wenzhou Medical University
    9
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    9
  • Hebei Normal University
    8