43 Works

Hidden in the DNA: insights on how multiple historical processes and natural history traits shaped patterns of cryptic diversity in an Amazon leaf-litter lizard Loxopholis osvaldoi (Squamata: Gymnophthalmidae).

Sergio Marques De Souza, Katia Machado Pellegrino, Tuliana Oliveira Brunes, Ana Carnaval, Roberta Pacheco Damasceno, Manoela Lima De Oliveira Borges, Carlos Candia Gallardo & Miguel Rodrigues
Aim: To investigate cryptic diversity and diversification timing in the putatively low-dispersal Amazonian leaf-litter lizard Loxopholis osvaldoi, and to ask how geography (rivers, isolation by distance, IBD), ecological drivers (isolation by environment, IBE) and historical factors (climatic refugia) explain intraspecific genetic variation. Location: Central Amazonia, Brazil. Taxon: Squamata; Gymnophthalmidae; Loxopholis osvaldoi. Methods: We sequenced two mitochondrial and two nuclear markers in 157 individuals. Phylogeographic structure and the occurrence of independent evolving lineages where explored through...

EVALUATION OF MARKERS ASSOCIATED WITH PROTEOLYTIC PROCESSING IN BIOLOGICAL SAMPLES OF PATIENTS WITH MELANOMA

André Zelanis
Melanoma is an aggressive skin cancer and a lethal melanocytic neoplasm with increasing annual number of cases (faster than any other solid tumor). Since the protein composition (proteome) of tumoral cells may be regarded as a description of cellular status, the evaluation of protein expression patterns in biopsy samples may lead to the discovery of cancer-related markers and new drug targets. In the context of tumoral development, proteolytic processing plays an important role, favoring the...

Acesso à saúde e vulnerabilidades de migrantes internacionais no contexto de disseminação da COVID-19: uma pesquisa interinstitucional em rede colaborativa.

DENISE MARTIN
O avanço da pandemia de COVID-19 levou a Organização Mundial da Saúde (OMS) a decretar emergência internacional em janeiro de 2020. Em meados de março do mesmo ano, o Brasil, a exemplo de vários países do mundo, adotou o isolamento social e restrição à mobilidade como medida de prevenção e combate do contágio e disseminação do vírus no país, medida que vem sendo adotada contingencialmente até o momento. Tal situação gerou várias disputas entre grupos...

Data and codes from: Flight hampers the evolution of weapons in birds

João C. T. Menezes & Alexandre V. Palaoro
Birds are a remarkable example of how sexual selection can produce diverse ornaments and behaviors. Specialized fighting structures like deer’s antlers, in contrast, are mostly absent among birds. Here, we investigated if the birds’ costly mode of locomotion — powered flight — helps explain the scarcity of weapons among members of this clade. Our simulations of flight energetics predicted that the cost of bony spurs — a specialized avian weapon — should increase with time...

GLYCOCORTICOID SENSITIVITY AND ITS RELATIONSHIP TO COMPONENTS OF THE METABOLIC SYNDROME IN PATIENTS TREATED FOR CHILDHOOD ACUTE LYMPHOCYTIC LEUKEMIA

Adriana Siviero-Miachon
Acute lymphocytic leukemia (ALL) is the most prevalent cancer in childhood and glucocorticoid (GC) is an important drug in its treatment. The relationship between sensitivity to GC, response to treatment, determining toxicity and disease prognosis has already been studied and mechanisms that determine it have also been established (glucocorticoid receptor - GR isoforms and polymorphisms). However, the correlation between GC sensitivity and changes in its receptor with an unfavorable metabolic phenotype, determining obesity, insulin resistance...

Data from: Feeding effects on liver mitochondrial bioenergetics of Boa constrictor (Serpentes: Boidae)

Marina R. Sartori, Helena R. Da Mota Araujo, Claudia D.C. Navarro, Jose Eduardo De Carvalho & Andre Luis Da Cruz
Snakes are interesting examples of overcoming energy metabolism challenges as many species can endure long periods without feeding, and their eventual meals are of reasonably large sizes, thus exhibiting dual extreme adaptations. Consequently, metabolic rate increases considerably to attend to the energetic demand of digestion, absorption and, protein synthesis. These animals should be adapted to transition from these two opposite states of energy fairly quickly, and therefore we investigated mitochondrial function plasticity in these states....

Data from: Analysis of the PEBP gene family and identification of a novel FLOWERING LOCUS T orthologue in sugarcane

Julien Venail, Paolo Da Silva Santos, Joao Manechini, Leonardo Alves, Maximiliano Scarpari, Thais Falcao, Elisson Romanel, Michael Brito, Renato Vicentini, Luciana Pinto & Stephen Jackson
Sugarcane (Saccharum spp.) is an important economic crop for both sugar and biomass, the yields of which are negatively affected by flowering. The molecular mechanisms controlling flowering in sugarcane are nevertheless poorly understood. RNA-seq data analysis and database searches have enabled a comprehensive description of the PEBP gene family in sugarcane. It is shown to consist of at least 13 FLOWERING LOCUS T (FT)-like genes, two MOTHER OF FT AND TFL (MFT)-like genes, and four...

Data from: Evolutionary history of Scinax treefrogs on land-bridge islands in south-eastern Brazil

Rayna C. Bell, Cinthia A. Brasileiro, Celio F. B. Haddad & Kelly R. Zamudio
AIM: We investigated how Pleistocene refugia and recent (~12,000 years ago) sea level incursions shaped genetic differentiation in mainland and island populations of the Scinax perpusillus treefrog group. LOCATION: Brazilian Atlantic Forest, São Paulo state, southeastern Brazil. METHODS: Using mitochondrial and microsatellite loci, we surveyed population structure and genetic diversity in Scinax from five mainland populations and three land-bridge islands to understand the roles of Pleistocene forest fragmentation and sea level incursions on genetic differentiation....

SARS-CoV-2 non-pharmaceutical interventions in Brazilian municipalities

Andreza Aruska De Souza Santos, Darlan Da Silva Cândido, William Marciel De Souza, Lewis Buss, Sabrina Li, Rafael H. M. Pereira, Chieh-Hsi Wu, Ester Sabino & Nuno R. Faria
Brazil has one of the fastest-growing COVID-19 epidemics worldwide. Non-pharmaceutical interventions (NPIs) have been adopted on a municipal level, with asynchronous actions taken across 5,568 municipalities and the Federal District. This paper addresses this complexity reporting on a novel dataset with survey responses from 4,027 mayors, 72.3% of the total municipalities in the country. This dataset responds to the urgency to track and share findings on fragmented policies to tackle health crises like the COVID-19...

Data from: Copulatory function and development shape modular architecture of genitalia differently in males and females

Bruno C. Genevcius, Monique N. Simon, Tamara Moraes & Cristiano F. Schwertner
Genitalia are multitasking structures whose development is mediated by numerous regulatory pathways. This multi-factorial nature provides an avenue for multiple sources of selection. As a result, genitalia tend to evolve as modular systems comprising semi-independent subsets of structures, yet the processes that give rise to those patterns are still poorly understood. Here, we ask what are the relative roles of development and function in shaping modular patterns of genitalia within populations and across species of...

Diversification history of clown tree frogs in Neotropical rainforests (Anura, Hylidae, Dendropsophus leucophyllatus group)

Renata Pirani, Pedro Peloso, Joyce Prado, Érico Polo, Lacey Knowles, Santiago Ron, Miguel Rodrigues, Marcelo Sturaro & Fernanda Werneck
General consensus emphasizes that no single biological process can explain the patterns of species’ distributions and diversification in the Neotropics. Instead, the interplay of several processes across space and time must be taken into account. Here we investigated the phylogenetic relationships and biogeographic history of tree frogs in the Dendropsophus leucophyllatus species group (Amphibia: Hylidae), which is distributed across Amazonia and the Atlantic rainforests. Using Next Generation Sequencing (NGS) and double digest restriction-site associated DNA...

Variation in the production of plant tissues bearing extrafloral nectaries explains temporal patterns of ant attendance in Amazonian understory plants

Anselmo Nogueira, Fabricio Baccaro, Laura Leal, Pedro Rey, Lúcia Lohmann & Judith Bronstein
1. Information on direct and indirect drivers of temporal variation in ant-plant interactions is scarce, compromising our ability to predict the functioning of these ecologically important interactions. 2. We investigated the roles of precipitation, ant activity, abundance of young plant tissues bearing extrafloral nectaries (EFNs), and EFN phenotypes in the establishment of EFN-mediated ant-plant interactions throughout the year in Amazonia, Brazil. We hypothesized that the frequency of ant-plant interactions follows a predictable seasonal pattern, being...

Subjetividades lésbicas no cinema contemporâneo

Danusa Jeremin & Elisângela Oliveira
Cinema & Território: Revista Internacional de Arte e Antropologia das Imagens, nº 6, 2021, 76-87.

EVALUATION OF THE EFFECT OF HETEROTYPIC SIGNALING ON TUMOR PHENOTYPE MODULATION IN MELANOMA

André Zelanis
Melanoma is a type of skin cancer that can progress according to multifactorial disorders. The ability of melanoma cells to invade and metastasize to organs distant from the body suggests their adaptability to different microenvironments. The imbalance of cellular homeostasis during oncogenesis together with the high heterogeneity of stromal cells associated with the tumor have a marked effect on the repertoire of proteins secreted by malignant cells. The metastatic potential of cancer cells is determined...

Data from: Musculoskeletal pain as a marker of health quality. Findings from the epidemiological sleep study among the adult population of São Paulo city

Suely Roizenblatt, Altay L. Souza, Luciana Palombini, Luciana M. Godoy, Sergio Tufik & Lia Rita A. Bittencourt
Background: We are witnessing the growth of urban populations, particularly in the developing world. São Paulo, the largest city in South America, continues to grow, and this growth is dramatically effecting the environment and human health. The aim of this study was to estimate the point prevalence of chronic pain in São Paulo city dwellers and to explore the influence of aspects related to urbanicity. Methods: A two-stage cluster randomized sample included 1100 individuals of...

Data from: Ultraconserved elements sequencing as a low-cost source of complete mitochondrial genomes and microsatellite markers in non-model amniotes

Fábio Raposo Do Amaral, Leandro G. Neves, , Flávia Mobili, Cristina Y. Miyaki, Katia C. M. Pellegrino & Cibele Biondo
Sequence capture of ultraconserved elements (UCEs) associated with massively parallel sequencing has become a common source of nuclear data for studies of animal systematics and phylogeography. However, mitochondrial and microsatellite variation are still commonly used in various kinds of molecular studies, and probably will complement genomic data in years to come. Here we show that besides providing abundant genomic data, UCE sequencing is an excellent source of both sequences for microsatellite loci design and complete...

Data from: Barriers, rather than refugia, underlie the origin of diversity in toads endemic to the Brazilian Atlantic Forest

Maria Tereza C. Thomé, Kelly R. Zamudio, Célio F. B. Haddad & João Alexandrino
In this study, we investigated the relative contribution of geographic barriers and Pleistocene refuges in the diversification of the Rhinella crucifer species complex, a group of endemic toads with a widespread distribution in the Brazilian Atlantic Forest (AF). We used intensive sampling and multilocus DNA sequence data to compare nucleotide diversity between refuge and nonrefuge areas, investigate regional demographic patterns, estimate demographic parameters related to genetic breaks and test refuge versus barrier scenarios of diversification...

Data from: Dogs recognize dog and human emotions

Natalia Albuquerque, Kun Guo, Anna Wilkinson, Carine Savalli, Emma Otta & Daniel Mills
The perception of emotional expressions allows animals to evaluate the social intentions and motivations of each other. This usually takes place within species; however, in the case of domestic dogs, it might be advantageous to recognize the emotions of humans as well as other dogs. In this sense, the combination of visual and auditory cues to categorize others' emotions facilitates the information processing and indicates high-level cognitive representations. Using a cross-modal preferential looking paradigm, we...

Anatomical partitioning has little influence in topologies from Bayesian phylogenetic analyses of morphological data

Daniel Casali, Felipe Freitas & Fernando Perini
Morphological data is a fundamental source of evidence to reconstruct the Tree of Life, and Bayesian phylogenetic methods are increasingly being used for this task, along with, or instead of, traditional parsimony approaches. Bayesian phylogenetic analyses require the use of proper evolutionary models and their performance have been intensively studied in the past few years, with significant improvements to our knowledge regarding their performance. Notwithstanding, it was only recently that partitioned models for morphology received...

HETEROTYPIC SIGNALING IN MELANOMA PROGRESSION: FROM CELL CULTURE TO SYSTEMS-WIDE ANALYSES

André Zelanis
Melanoma is aggressive skin cancer and a lethal melanocytic neoplasm with an increasing annual number of cases (faster than any other solid tumor). As changes in the secreted proteins (secretome) composition of cancer cells might often represent a portrait of the cellular status during disease progression, the profiling of cancer secretomes can lead to the discovery of cancer-related biological markers and, eventually, to new drug targets. The secretion of bioactive molecules by primary tumors enables...

Proteomics and degradomics applied to the study of the effects of mannose in mutant and non-mutant B-RAF melanoma cell lines

André Zelanis
The high energy demand imposed by the oncogenic process has important consequences on the metabolism of transformed cells, as well as having a significant impact on diagnostic methods and therapies associated with the treatment of neoplasias. Mannose is an epimer of glucose and therefore is absorbed by the same transporters as glucose. Recent work using tumor cell lines has shown that this glucose epimer accumulates in cells in the form of the intermediate mannose-6-phosphate (M6P),...

Suplementação probiótica associada à intervenção dietética melhora na inflamação e a ingestão alimentar em adultos jovens obesos?

Glaice Aparecida Lucin
A obesidade é caracterizada pelo acúmulo de gordura que contribui para alterações endócrinas e metabólicas do tecido adiposo, influenciando a ingestão de alimentos e a homeostase energética. Considerando que todos esses fatores são modulados por hormônios intestinais, estudos apontam que a microbiota intestinal (MI) possa afetar o comportamento e os mecanismos centrais do cérebro, promovendo a regulação do apetite e da saciedade. Acreditamos que uma estratégia nutricional de restrição calórica associada a suplementação probiótica possa...

Spatial analysis of the vulnerability of water wells and aquifers in the Alto Tietê basin

Rodrigo Nehara
Groundwater is defined as waters located below ground level, which is considered an adequate source for supply, in addition to having advantages such as being a safe source in times of drought, excellent natural quality and great storage capacity in aquifers. However, contaminating activities of an anthropic nature directly affect their quality. One way to protect groundwater is to study, assess and know the vulnerability of the respective aquifers and water bodies, which guide the...

Processed microphysical profiles of convective cloud scenes from satellite over ATTO

AVIHAY EFRAIM, Oliver Lauer, Daniel Rosenfeld, Ramon Braga, Marco Franco, Leslie Kremper, Yannian Zhu, Ulrich Pöschl, Christopher Pöhlker, Meinrat Andreae, Paulo Artaxo, Alessandro De Araújo & Mira Pohlker
We present a new approach of analyzing and interpreting vertical profiles of cloud microstructure obtained by satellite remote sensing. The method is based on a spectral bin microphysics adiabatic parcel model and aims to elucidate the effects of aerosols on the evolution of convective clouds and related microphysical processes, including the activation of cloud condensation nuclei (CCN), the growth of cloud droplets, and the formation of precipitation. Characteristic features in the vertical profiles of effective...

Projeto: Habilidades Culinárias Domésticas no contexto do Programa Nacional de Alimentação Escolar - PNAE do município de São Paulo: Avaliação do nível de conhecimentos e elaboração de material instrucional para a Equipe da Alimentação Escolar

Aline Rissatto Teixeira
As Habilidades Culinárias Domésticas - HCD, têm sido valorizadas nas políticas públicas e em instrumentos contemporâneos nos diferentes setores da sociedade. O Guia Alimentar para a População Brasileira - GAPB traz diretrizes para a promoção da alimentação saudável, visando a diminuição do risco para adoecer. Neste documento as HCD ganham relevância nas orientações para os participantes do Programa Nacional de Alimentação Escolar - PNAE. Os manipuladores de alimentos e demais adultos participantes do PNAE devem...

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