S-type granites constitute an important component of the Paleoproterozoic Khondalite Belt in the North China Craton. Here we present results from petrography, geochemistry and isotope geochronology on the porphyritic garnet-bearing syenogranite and garnet-bearing monzogranite samples in the Jining-Liangcheng area. The geochemical characteristics of these samples indicate formation through partial anatexis of the khondalites, with heat and material input from mantle-derived magma. Geochemical similarities between the porphyritic garnet-bearing syenogranite, garnet-bearing monzogranite, and metapelitic gneiss suggest their...

Bortezomib (BTZ) is a first-generation proteasome inhibitor with anti-tumor properties for multiple myeloma and mantle cell lymphoma. Increasing evidence has shown that BTZ exhibits toxic effects on diverse tumor cells, including non-small cell lung cancer (NSCLC) cells. However, the mechanism has not been fully evaluated. Here, we examined the regulatory effect of BTZ on cellular senescence, a potent tumor suppressive mechanism, in NSCLC cell lines. SA-β-gal staining assay showed that BTZ caused a significant increase...

Additional file 1: Supplementary Fig. 1. Residual dry weight biomass after a 56-day incubation. The figure shows that three incubations diverge in terms of biomass degradation. Supplementary Fig. 2. Phylogenetic tree reconstructed based on 49 core universal genes defined by Clusters of Orthologous Groups (COGs) using maximum likelihood. The tree was reconstructed on KBase. Supplementary Fig. 3. Gene proportion per MAG for selected GHs. MAGs with a completeness above 30% and contamination level lower than...

Additional file 1: Fig. S1. Specific primer of FENDRR were designed by NCBI; subcellular localization of FENDRR predicted by lncATLAS website and secondary structure of FENDRR. Fig. S2. Overexpression efficiency of FENDRR; the protein levels of Caspase-4 and Caspase-11. Fig. S3. FENDRR ASO enhances cell pyroptosis in HPAECs. Fig. S4. Interference efficiency and overexpression efficiency of DRP1. Fig. S5. Interference efficiency of YTHDC1. Fig. S6. Conservative analysis of the functional fragment TFO2 of FENDRR (464–516);...

Abstract Background Pyroptosis is a form of programmed cell death involved in the pathophysiological progression of hypoxic pulmonary hypertension (HPH). Emerging evidence suggests that N6-methyladenosine (m6A)-modified transcripts of long noncoding RNAs (lncRNAs) are important regulators that participate in many diseases. However, whether m6A modified transcripts of lncRNAs can regulate pyroptosis in HPH progression remains unexplored. Methods The expression levels of FENDRR in hypoxic pulmonary artery endothelial cells (HPAECs) were detected by using quantitative real-time polymerase...

Arnicolide B and arnicolide C are two sesquiterpene lactones isolated and identified from Centipeda minima, but the anti-inflammatory effects and mechanisms of these two compounds have not been reported. In this study, LPS was used to establish RAW 264.7 macrophages inflammatory response model. Griess, ELISA, Western blot were used to investigate the anti-inflammatory effects in vitro and the molecular mechanisms of these two active compounds. The results showed that arnicolide B and arnicolide C could...

Abstract Background Autophagy regulators play important roles in the occurrence and development of a variety of tumors and are involved in immune regulation and drug resistance. However, the modulatory roles and prognostic value of autophagy regulators in pancreatic cancer have not been identified. Methods Transcriptomic data and survival information from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were used to construct a risk score model. Important clinical features were analyzed to...

Supporting data

This study reports magnetic graphene oxide composite microspheres (MGO) were firstly synthesized via one step miniemulsion polymerization. α-FeOOH rods were then loaded onto MGO via a facile hydrothermal method to prepare α-FeOOH@MGO, which was served as the photocatalyst for the Fenton reaction. Subsequently, the properties of the resulting α-FeOOH@MGO were characterized by FT-IR, XRD, SEM, VSM and UV-vis DRS analysis methods. The influence of various parameters was investigated, such as dye type, dye concentration, H2O2...

Additional File 1. 4DCT image acquisition

Additional File 2. Genetic algorithm

Additional File 4. Tumor response after CCRT in the low-risk and high-risk group

This file contains the datasets presented in the paper titled "Radiative Anti-Parity-Time Plasmonics".

Supplemental material, sj-pdf-4-wso-10.1177_17474930221125993 for Effect of the Shanghai Stroke Service System (4S) on the quality of stroke care and outcomes: A prospective quality improvement project by Jiawen Xu, Yanan Xie, Kun Fang, Xin Wang, Shengdi Chen, Xueyuan Liu, Yuwu Zhao, Yangtai Guan, Dingfang Cai, Gang Li, Jianmin Liu, JianRen Liu, Jianhua Zhuang, Ying Xian, Haipeng Shen, Hao Li, David Z Wang, Bruce CV Campbell, Mark W Parsons, Yi Dong and Qiang Dong in International Journal...

Additional file 2: Supplementary figure 2. The relationship between immune-related function and prognosis of CLL patients.

Additional file 1: Table S1. Genes were synthesized in this study. Table S2. Primers used in this study. Fig. S1. Influence of truncation the SmF3′H and ScCPR.

The temperature dependence of the critical stress of R→B19’ transformation in NiTi shape memory alloys remains unclear due to the difficulties in precisely identifying the phase constitution and acquiring sole R phase. Here we investigate the thermally- and stress-induced martensitic transformation in a near-equiatomic nanocrystalline NiTi alloy. In situ synchrotron X-ray diffraction is used to identify the phase evolution such that the temperature window for sole R phase is firmly determined. We find that the...

Animation of FIg. 3

It is known that phase conjugation technique is achieved by the nonlinearity of materials, and widely adopted in various applications, such as high-resolution imaging, signal amplification, and target detecting. Here, we have proposed a field-enhancement method for the degenerate four wave mixing (FWM) for phase conjugation purpose. In this method, a thin metasurface with nonlinear property is utilized to confine and guide the pumps, achieving the enhanced FWM within a flexible structure. Compared to existing...

A heterogeneous structure by designing soft/hard domains with dramatically different strengths is effective to maintain the high ductility of metals but it sacrifices the yield strength. Here we first demonstrate a simultaneous enhancement of yield strength and tensile elongation by ∼20% in graphene nanosheet (GNS)/Al-Cu-Mg nano-laminated composites, with a tensile strength of ∼687 MPa and elongation over 10%, by designing heterogeneous domains with a little difference. The underlying mechanism was investigated by microstructural characterizations and...

Supplemental material, sj-jpg-3-jbm-10.1177_03936155221132292 for Development and validation of a nomogram involving immunohistochemical markers for prediction of recurrence in early low-risk endometrial cancer by Wei Kong, Yuan Tu, Peng Jiang, Yuzhen Huang, Jingni Zhang, Shan Jiang, Ning Li and Rui Yuan in The International Journal of Biological Markers

Additional file 10. Review history.

Additional file 10. Review history.

Additional file 8: Figure S8. Anuclear blastomeres and fragments. A) Phylogenetic tree based on reassembled mitochondrial genomes of 11 anuclear blastomeres and two anuclear fragments, showing a common ancestor for sequenced blastomeres and fragments retrieved from the same embryo. One anuclear blastomere was not included. B) Box plots and median values of the number of raw reads per 10 Mb bin (y-axis) per chromosome (chr1 - chrX) and for the mitochondrial DNA (chrM) (x-axis) as...

Additional file 9: Figure S9. Genome-wide composition of blastocysts following multipolar zygotic division. Circos plots of six embryos that developed to the blastocyst stage following multipolar zygotic division in which each circle represents the interpreted genome constitution per chromosome (1 - X) of a sampled single cell. The interpreted genome spanning the largest part of the chromosome was chosen as overall interpretation per chromosome, as such, segmental chromosomal errors are not depicted. On the left...