4 Works

Data from: Development of the neurons controlling fertility in humans: new insights from 3D imaging and transparent fetal brains

Filippo Casoni, Samuel A. Malone, Morgane Belle, Federico Luzzati, Francis Collier, Cecile Allet, Erik Hrabovszky, Sowmyalakshmi Rasika, Vincent Prevot, Alain Chedotal & Paolo Giacobini
Fertility in mammals is controlled by hypothalamic neurons that secrete gonadotropin-releasing hormone (GnRH). These neurons differentiate in the olfactory placodes during embryogenesis and migrate from the nose to the hypothalamus before birth. Information regarding this process in humans is sparse. Here, we adapted new tissue-clearing and whole-mount immunohistochemical techniques to entire human embryos/fetuses to meticulously study this system during the first trimester of gestation in the largest series of human fetuses examined to date. Combining...

Data from: Interspecific shared collective decision-making in two forensically important species

Julien Boulay, Jean Louis Deneubourg, Valéry Hédouin & Damien Charabidzé
To date, the study of collective behaviour has mainly focused on intraspecific situations: the collective decision-making of mixed-species groups involving interspecific aggregation-segregation has received little attention. Here, we show that, in both conspecific and heterospecific groups, the larvae of two species (Lucilia sericata and Calliphora vomitoria, calliphorid carrion-feeding flies) were able to make a collective choice. In all groups, the choice was made within a few minutes and persisted throughout the experiment period. The monitoring...

Data from: Development of nuclear microsatellite loci and mitochondrial single nucleotide polymorphisms for the natterjack toad, Bufo (Epidalea) calamita (Bufonidae), using next generation sequencing and Competitive Allele Specific PCR (KASPar)

Leslie Faucher, Cecile Godé & Jean-Francois Arnaud
Amphibians are undergoing a major decline worldwide and the steady increase in the number of threatened species in this particular taxa highlights the need for conservation genetics studies using high-quality molecular markers. The natterjack toad, Bufo (Epidalea) calamita, is a vulnerable pioneering species confined to specialized habitats in Western Europe. To provide efficient and cost-effective genetic resources for conservation biologists, we developed and characterized 22 new nuclear microsatellite markers using next-generation sequencing. We also used...

Data from: Detection of human adaptation during the past 2000 years

Yair Field, Evan A. Boyle, Natalie Telis, Ziyue Gao, Kyle J. Gaulton, David Golan, Loic Yengo, Ghislain Rocheleau, Philippe Froguel, Mark I. McCarthy & Jonathan K. Pritchard
Detection of recent natural selection is a challenging problem in population genetics. Here we introduce the Singleton Density Score (SDS), a method to infer very recent changes in allele frequencies from contemporary genome sequences. Applied to data from the UK10K Project, SDS reflects allele frequency changes in the ancestors of modern Britons during the past ~2,000-3,000 years. We see strong signals of selection at lactase and the MHC, and in favor of blond hair and...

Registration Year

  • 2016

Resource Types

  • Dataset


  • University of Lille
  • Stanford University
  • Université Libre de Bruxelles
  • Inserm
  • Institute of Experimental Medicine
  • Oxford Centre for Diabetes, Endocrinology and Metabolism
  • University of Turin