50 Works

Extensive pollinator sharing does not promote character displacement in two orchid congeners

Nina Joffard
Pollinator sharing between close relatives can be costly, which can promote pollination niche partitioning and floral divergence. This should be reflected by a higher species divergence in sympatry than in allopatry. We tested this hypothesis in two orchid congeners with overlapping distributions and flowering times. We characterized floral traits and pollination niches and quantified pollen limitation in 15 pure and mixed populations, and we measured phenotypic selection on floral traits and performed controlled crosses in...

Quand le syntagme nominal prend ses marques

Peter Lauwers, Katia Paykin, Mihaela ILIOAIA, Machteld Meulleman & Pascale Hadermann
This volume brings together about twenty contributions on the syntax and semantics of predicates and arguments, written by international specialists in the field. The formal architecture of the predicate (verbal and nominal) and the morpho-syntactic means of marking its arguments are addressed, with particular attention to the dative. This book is mainly focused on French, while putting it in perspective with other languages, Romance (Spanish, Romanian), Germanic (Dutch, English) and Slavic (Russian), not to mention...

Economie politique du financement progressif de la protection sociale (LIEPP Working Paper n°38 )

Michaël Zemmour
This article investigates discrimination and the interplay of residential and ethnic stigma on the French housing market using two different methods, paired-testing au- dit study of real estate agencies and face-to-face interviews with real estate agents. The juxtaposition of their findings leads to a paradox: interviews reveal high levels of ethnic discrimination but little to none residential discrimination, while the audit study shows that living in deprived suburbs is associated with a lower probability of...

Additional file 1 of Frugal alignment-free identification of FLT3-internal tandem duplications with FiLT3r

Augustin Boudry, Sasha Darmon, Nicolas Duployez, Martin Figeac, Sandrine Geffroy, Maxime Bucci, Karine Celli-Lebras, Matthieu Duchmann, Romane Joudinaud, Laurène Fenwarth, Olivier Nibourel, Laure Goursaud, Raphael Itzykson, Hervé Dombret, Mathilde Hunault, Claude Preudhomme & Mikaël Salson
Additional file 1. supp file 1: filt3r-supp.pdf. supp file 2: results_sra.xlsx. supp file 3: accessions.csv. supp file 4: results-different-k.xlsx. supp file 5: results-small-k.xlsx. supp file 6: results-different-perc.xlsx. supp file 7: results-subsamples.xlsx. supp file 8: genescan_SRR15006459.pdf. supp file 9: genescan_SRR15006372.pdf. supp file 10: accessions-CCLE.csv. supp file 11: results_simulated_150bp.xlsx. supp file 12: results_simulated_250bp_hq.xlsx. supp file 13: results_simulated_250bp_lc.xlsx. supp file 14: results_simulated_250bp_lq.xlsx. supp file 15: results_simulated_250bp.xls.

Additional file 1 of Mild pulmonary hemodynamic alterations in patients with systemic sclerosis: relevance of the new 2022 ESC/ERS definition of pulmonary hypertension and impact on mortality

Sébastien Puigrenier, Jonathan Giovannelli, Nicolas Lamblin, Pascal De Groote, Marie Fertin, Jean-François Bervar, Antoine Lamer, Jean-Louis Edmé, Marie-Hélène Balquet, Vincent Sobanski, David Launay, Éric Hachulla & Sébastien Sanges
Additional file 1: Multivariate analysis after adjusting for age, sex, SSc type, disease duration, presence of ILD, NYHA functional class and treatment.

Hyperelastic modelling and simulation for forming process of the braided fabrics

Jinlei Li, Nahiene Hamila, Gildas L'Hostis, Eduardo Guzman Maldonado & Peng Wang

Efficacy of traumatic memory reactivation with or without propranolol in PTSD with high dissociative experiences

Pascal Roullet, Simon Taïb, Claire Thalamas, Guillaume Vaiva, Wissam El Hage, Antoine Yrondi & Philippe Birmes
Background: Post-traumatic stress disorder (PTSD) with dissociative symptoms is now a full-fledged subtype of this disorder. The dissociative subtype is associated with a greater number of psychiatric comorbidities. To date, the impact of dissociation on the efficacy of PTSD treatment remains unclear. Objective: The aim of this study was to compare the efficacy of a traumatic memory reactivation procedure with the administration of propranolol or a placebo once a week for six consecutive weeks in...

Hurdle technology based on the use of microencapsulated pepsin, trypsin and carvacrol to eradicate Pseudomonas aeruginosa and Enterococcus faecalis biofilms

Samah Mechmechani, Adem Gharsallaoui, Khaled El Omari, Alexandre Fadel, Monzer Hamze & Nour-Eddine Chihib
The biofilm lifestyle plays a major role in the resistance and virulence of Pseudomonas aeruginosa and Enterococcus faecalis. In this study, two microencapsulated proteases (pepsin ME-PEP and trypsin ME-TRYP) were evaluated for their biofilm dispersal activity and their synergistic effect with microencapsulated carvacrol (ME-CARV). Spray-drying was used to protect enzymes and essential oil and enhance their activities. Cell count analysis proved the synergistic activity of enzymes and carvacrol treatment as biofilms were further reduced after...

Tax cuts or social investment? Evaluating the opportunity cost of the French employment strategy (LIEPP Working Paper, n°31)

Clément Carbonnier, Bruno Palier & Michaël Zemmour
Tax expenditures are widely used by French governments as employment and social policies. Such programmes together amounted to more than 1.3 points of GDP in 2011. Thanks to a systematic review of academic policy evaluations, we assess the efficiency of the different parts of such policies, showing that at least €6 billion is used for policies whose cost is greater than €62,500 per year and job created, and €0.5 billion for policies whose cost is...

Additional file 1 of Outcomes of mild-to-moderate postresuscitation shock after non-shockable cardiac arrest and association with temperature management: a post hoc analysis of HYPERION trial data

Ines Ziriat, Aurélie Le Thuaut, Gwenhael Colin, Hamid Merdji, Guillaume Grillet, Patrick Girardie, Bertrand Souweine, Pierre-François Dequin, Thierry Boulain, Jean-Pierre Frat, Pierre Asfar, Bruno Francois, Mickael Landais, Gaëtan Plantefeve, Jean-Pierre Quenot, Jean-Charles Chakarian, Michel Sirodot, Stéphane Legriel, Nicolas Massart, Didier Thevenin, Arnaud Desachy, Arnaud Delahaye, Vlad Botoc, Sylvie Vimeux, Frederic Martino … & Jean Baptiste Lascarrou
Additional file 1: Fig. S1. Study flowchart. Table S1. Baseline characteristics and mortality in the groups with vs. without mild-to-moderate postresuscitation shock (PRS) at intensive-care-unit (ICU) admission. Table S2. Multivariate logistic regression modelling to identify admission variables associated with a favourable outcome on day 90 in the overall population (n = 532).

Additional file 1 of Outcomes of mild-to-moderate postresuscitation shock after non-shockable cardiac arrest and association with temperature management: a post hoc analysis of HYPERION trial data

Ines Ziriat, Aurélie Le Thuaut, Gwenhael Colin, Hamid Merdji, Guillaume Grillet, Patrick Girardie, Bertrand Souweine, Pierre-François Dequin, Thierry Boulain, Jean-Pierre Frat, Pierre Asfar, Bruno Francois, Mickael Landais, Gaëtan Plantefeve, Jean-Pierre Quenot, Jean-Charles Chakarian, Michel Sirodot, Stéphane Legriel, Nicolas Massart, Didier Thevenin, Arnaud Desachy, Arnaud Delahaye, Vlad Botoc, Sylvie Vimeux, Frederic Martino … & Jean Baptiste Lascarrou
Additional file 1: Fig. S1. Study flowchart. Table S1. Baseline characteristics and mortality in the groups with vs. without mild-to-moderate postresuscitation shock (PRS) at intensive-care-unit (ICU) admission. Table S2. Multivariate logistic regression modelling to identify admission variables associated with a favourable outcome on day 90 in the overall population (n = 532).

Outcomes of mild-to-moderate postresuscitation shock after non-shockable cardiac arrest and association with temperature management: a post hoc analysis of HYPERION trial data

Ines Ziriat, Aurélie Le Thuaut, Gwenhael Colin, Hamid Merdji, Guillaume Grillet, Patrick Girardie, Bertrand Souweine, Pierre-François Dequin, Thierry Boulain, Jean-Pierre Frat, Pierre Asfar, Bruno Francois, Mickael Landais, Gaëtan Plantefeve, Jean-Pierre Quenot, Jean-Charles Chakarian, Michel Sirodot, Stéphane Legriel, Nicolas Massart, Didier Thevenin, Arnaud Desachy, Arnaud Delahaye, Vlad Botoc, Sylvie Vimeux, Frederic Martino … & Jean Baptiste Lascarrou
Abstract Background Outcomes of postresuscitation shock after cardiac arrest can be affected by targeted temperature management (TTM). A post hoc analysis of the “TTM1 trial” suggested higher mortality with hypothermia at 33 °C. We performed a post hoc analysis of HYPERION trial data to assess potential associations linking postresuscitation shock after non-shockable cardiac arrest to hypothermia at 33 °C on favourable functional outcome. Methods We divided the patients into groups with vs. without postresuscitation (defined...

Frugal alignment-free identification of FLT3-internal tandem duplications with FiLT3r

Augustin Boudry, Sasha Darmon, Nicolas Duployez, Martin Figeac, Sandrine Geffroy, Maxime Bucci, Karine Celli-Lebras, Matthieu Duchmann, Romane Joudinaud, Laurène Fenwarth, Olivier Nibourel, Laure Goursaud, Raphael Itzykson, Hervé Dombret, Mathilde Hunault, Claude Preudhomme & Mikaël Salson
Abstract Background Internal tandem duplications in the FLT3 gene, termed FLT3-ITDs, are useful molecular markers in acute myeloid leukemia (AML) for patient risk stratification and follow-up. FLT3-ITDs are increasingly screened through high-throughput sequencing (HTS) raising the need for robust and efficient algorithms. We developed a new algorithm, which performs no alignment and uses little resources, to identify and quantify FLT3-ITDs in HTS data. Results Our algorithm (FiLT3r) focuses on the k-mers from reads covering FLT3...

Clinical outcome of wild-type AmpC-producing Enterobacterales infection in critically ill patients treated with β-lactams: a prospective multicenter study

Roman Mounier, Ronan Le Guen, Paul-Louis Woerther, Mathieu Nacher, Clément Bonnefon, Nicolas Mongardon, Olivier Langeron, Eric Levesque, Séverine Couffin, Stéphanie Houcke, Michel Wolff, Ariane Roujansky, Caroline Schimpf, Armand Mekontso Dessap, Fabrice Cook, Keyvan Razazi & Hatem Kallel
Abstract Background β-lactams are the main antibiotics used against wild-type AmpC-producing Enterobacterales (wtAE). However, they may fail or select AmpC-overproducing mutants. Our aim was to assess factors associated with clinical failure of β-lactams in the treatment of wtAE infection. Methods From September 2017 to December 2020, we prospectively included all consecutive patients treated by definitive β-lactams therapy for wtAE infection in four university ICUs. Clinical failure was defined as inadequate response to antimicrobial therapy leading...

sj-docx-1-eso-10.1177_23969873221140649 – Supplemental material for Internal carotid artery patency after mechanical thrombectomy for stroke due to occlusive dissection: Impact on outcome

Giuseppe Scopelliti, Arnaud Karam, Julien Labreuche, Nicolas Bricout, Federico Marrama, Marina Diomedi, Wagih Ben Hassen, Xavier Leclerc, Charlotte Cordonnier, Hilde Henon & Barbara Casolla
Supplemental material, sj-docx-1-eso-10.1177_23969873221140649 for Internal carotid artery patency after mechanical thrombectomy for stroke due to occlusive dissection: Impact on outcome by Giuseppe Scopelliti, Arnaud Karam, Julien Labreuche, Nicolas Bricout, Federico Marrama, Marina Diomedi, Wagih Ben Hassen, Xavier Leclerc, Charlotte Cordonnier, Hilde Henon and Barbara Casolla in European Stroke Journal

Nest architecture is linked with ecological success in songbirds

Iliana Medina, Daniela Perez, Ana C Afonso Silva, Justin Cally, Constanza Leon, Odile Maliet & Ignacio Quintero
Nests are essential constructions that directly determine fitness, yet their structure can vary substantially across bird species. While there is evidence supporting a link between nest architecture and the habitat a species occupies, we still ignore what ecological and evolutionary processes are linked to different nest types. Using information on 3175 species of songbirds, we show that – after controlling for latitude and body size – species that build domed nests (i.e., nests with a...

Additional file 1 of Mild pulmonary hemodynamic alterations in patients with systemic sclerosis: relevance of the new 2022 ESC/ERS definition of pulmonary hypertension and impact on mortality

Sébastien Puigrenier, Jonathan Giovannelli, Nicolas Lamblin, Pascal De Groote, Marie Fertin, Jean-François Bervar, Antoine Lamer, Jean-Louis Edmé, Marie-Hélène Balquet, Vincent Sobanski, David Launay, Éric Hachulla & Sébastien Sanges
Additional file 1: Multivariate analysis after adjusting for age, sex, SSc type, disease duration, presence of ILD, NYHA functional class and treatment.

MALDI-TOF MS spectra and sequence data of collagen of modern and archaeological flatfish from European waters

Katrien Dierickx, Samantha Presslee, Richard Hagan, Tarek Oueslati, Jennifer Harland, Jessica Hendy, David Orton, Michelle Alexander & Virginia Harvey
MALDI-TOF MS spectra, LC-MS/MS datafiles, and Mascot MZID files of modern bone collagen of 18 species of Pleuronectiformes as reference spectra that were used to develop peptide biomarkers for ZooMS (Zooarchaeology by Mass Spectrometry). Details on the samples used can be found in the file "Reference spectra information.csv". Further information on the method and results can be found in the manuscript. The file names contain the type of data file and the species name. MALDI-TOF...

Adherence to opioid agonist therapy predicts uptake of direct-acting antivirals in people who use drugs: results from the French national healthcare database (the ANRS FANTASIO study)

Benjamin Rolland, Caroline Lions, Vincent Di Beo, Patrizia Carrieri, Nicolas Authier, Tangui Barré, Jessica Delorme, Philippe Mathurin, François Bailly, Camelia Protopopescu & Fabienne Marcellin
Abstract Background Opioid agonist therapy (OAT) is associated with reduced injection, reduced HCV transmission, and more opportunities to initiate hepatitis C virus (HCV) treatment in people who use drugs (PWUD). We aimed to study the extent to which adherence to OAT was predictive of increased uptake of direct-acting antivirals (DAA) in PWUD with chronic HCV infection. Methods Using the French national healthcare system database, we targeted PWUD (i.e. with a history of OAT) who had...

Association between PTPN1 polymorphisms and obesity-related phenotypes in European adolescents: influence of physical activity - Supplementary datasets

Diego F Salazar-Tortosa, Idoia Labayen, Marcela Gonzalez-Gross, Miguel Seral-Cortes, Luis Moreno, Augusto G. Zapico, Kurt Widhalm, Aline Meirhaeghe, David Enard & Jonatan Ruiz
Results of the association between all polymorphisms and phenotypes along with physical activity interactions across the five inheritance models considered.

Association between PTPN1 polymorphisms and obesity-related phenotypes in European adolescents: influence of physical activity - Supplementary datasets

Diego F Salazar-Tortosa, Idoia Labayen, Marcela Gonzalez-Gross, Miguel Seral-Cortes, Luis Moreno, Augusto G. Zapico, Kurt Widhalm, Aline Meirhaeghe, David Enard & Jonatan Ruiz
Results of the association between all polymorphisms and phenotypes along with physical activity interactions across the five inheritance models considered.

A self-purifying microfluidic system for identifying drugs acting against adult schistosomes

Vincent Girod, Robin Houssier, Karin Sahmer, Marie-José Ghoris, Stéphanie Caby, Colette Dissous, Oleg Melnyk, Vincent Senez & Jérôme Vicogne
The discovery of novel antihelmintic molecules to combat the development and spread of schistosomiasis, a disease caused by several Schistosoma flatworm species, mobilizes significant research efforts worldwide. With a limited number of biochemical assays for measuring the viability of adult worms, the anti-schistosomicidal activity of molecules is usually evaluated by microscopic observation of worm mobility and/or integrity upon drug exposure. Even if these phenotypical assays enable multiple parameters analysis, they are often conducted during several...

Efficacy of traumatic memory reactivation with or without propranolol in PTSD with high dissociative experiences

Pascal Roullet, Simon Taïb, Claire Thalamas, Guillaume Vaiva, Wissam El Hage, Antoine Yrondi & Philippe Birmes
Background: Post-traumatic stress disorder (PTSD) with dissociative symptoms is now a full-fledged subtype of this disorder. The dissociative subtype is associated with a greater number of psychiatric comorbidities. To date, the impact of dissociation on the efficacy of PTSD treatment remains unclear. Objective: The aim of this study was to compare the efficacy of a traumatic memory reactivation procedure with the administration of propranolol or a placebo once a week for six consecutive weeks in...

Hurdle technology based on the use of microencapsulated pepsin, trypsin and carvacrol to eradicate Pseudomonas aeruginosa and Enterococcus faecalis biofilms

Samah Mechmechani, Adem Gharsallaoui, Khaled El Omari, Alexandre Fadel, Monzer Hamze & Nour-Eddine Chihib
The biofilm lifestyle plays a major role in the resistance and virulence of Pseudomonas aeruginosa and Enterococcus faecalis. In this study, two microencapsulated proteases (pepsin ME-PEP and trypsin ME-TRYP) were evaluated for their biofilm dispersal activity and their synergistic effect with microencapsulated carvacrol (ME-CARV). Spray-drying was used to protect enzymes and essential oil and enhance their activities. Cell count analysis proved the synergistic activity of enzymes and carvacrol treatment as biofilms were further reduced after...

sj-docx-1-eso-10.1177_23969873221140649 – Supplemental material for Internal carotid artery patency after mechanical thrombectomy for stroke due to occlusive dissection: Impact on outcome

Giuseppe Scopelliti, Arnaud Karam, Julien Labreuche, Nicolas Bricout, Federico Marrama, Marina Diomedi, Wagih Ben Hassen, Xavier Leclerc, Charlotte Cordonnier, Hilde Henon & Barbara Casolla
Supplemental material, sj-docx-1-eso-10.1177_23969873221140649 for Internal carotid artery patency after mechanical thrombectomy for stroke due to occlusive dissection: Impact on outcome by Giuseppe Scopelliti, Arnaud Karam, Julien Labreuche, Nicolas Bricout, Federico Marrama, Marina Diomedi, Wagih Ben Hassen, Xavier Leclerc, Charlotte Cordonnier, Hilde Henon and Barbara Casolla in European Stroke Journal

Registration Year

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  • University of Lille
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  • University of Angers
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  • François Rabelais University
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  • University of Burgundy
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  • Hôpital de la Croix-Rousse
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  • Centre Hospitalier Universitaire de Tours
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  • Lyon Neuroscience Research Center
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