Data from: Myelin basic protein induces neuron-specific toxicity by directly damaging the neuronal plasma membrane

Jie Zhang, Xin Sun, Sixin Zheng, Xiao Liu, Jinghua Jin, Yi Ren & Jianhong Luo
The central nervous system (CNS) insults may cause massive demyelination and lead to the release of myelin-associated proteins including its major component myelin basic protein (MBP). MBP is reported to induce glial activation but its effect on neurons is still little known. Here we found that MBP specifically bound to the extracellular surface of the neuronal plasma membrane and induced neurotoxicity in vitro. This effect of MBP on neurons was basicity-dependent because the binding was...

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  • Zhejiang University
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  • Johns Hopkins University School of Medicine
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  • Florida State University
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