3 Works

Data from: Anthropogenic extinction dominates Holocene declines of West Indian mammals

Siobhán B. Cooke, Liliana M. Dávalos, Alexis M. Mychajliw, Samuel T. Turvey & Nathan S. Upham
The extensive postglacial mammal losses in the West Indies provide an opportunity to evaluate extinction dynamics, but limited data have hindered our ability to test hypotheses. Here, we analyze the tempo and dynamics of extinction using a novel data set of faunal last-appearance dates and human first-appearance dates, demonstrating widespread overlap between humans and now-extinct native mammals. Humans arrived in four waves (Lithic, Archaic, Ceramic, and European), each associated with increased environmental impact. Large-bodied mammals...

Data from: Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults

Amar Jariwala, Anna Yakovleva, Carlos Geraldo Fraga, David J. Diemert, Doreen Campbell, Frederico Talles, Guangzhao Li, Janaína Freire, Jeffrey Bethony, Jill Brelsford, Jin Peng, Maria Flávia Gazzinelli, Maria Victoria Periago, Maria Elena Bottazzi, Martin Enk, Peter Hotez, Robert Hamilton, Rodrigo Correa-Oliveira, Shannon Grahek & Vanderson Valente
Necator americanus Glutathione-S-Transferase-1 (Na-GST-1) plays a role in the digestion of host hemoglobin by adult N. americanus hookworms. Vaccination of laboratory animals with recombinant Na-GST-1 is associated with significant protection from challenge infection. Recombinant Na-GST-1 was expressed in Pichia pastoris and adsorbed to aluminum hydroxide adjuvant (Alhydrogel) according to current Good Manufacturing Practice. Two Phase 1 trials were conducted in 142 healthy adult volunteers in the United States and Brazil, first in hookworm-naïve individuals and...

Data from: Factors associated with pulmonary impairment in HIV-infected South African adults

Akshay N. Gupte, Michelle L. Wong, Reginah Masandiwa, Grace L. Barnes, Jonathan Golub, Richard E. Chaisson, Christopher J. Hoffmann, Neil A. Martinson & Reginah Msandiwa
Background: HIV-infected individuals have increased risk of developing obstructive lung disease (OLD). Studies from developed countries report high viral load, low CD4 counts, and anti-retroviral therapy (ART) to be associated with OLD; but these findings may not be generalizable to populations in resource-limited settings. Methods: We conducted a prospective cohort study of lung function in 730 HIV-infected black South African adults. Pre-bronchodilator spirometry was performed at enrollment and repeated annually for three years. Logistic regression...

Registration Year

  • 2017
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Resource Types

  • Dataset
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Affiliations

  • Johns Hopkins University School of Medicine
    3
  • Stanford University
    1
  • Natural History Museum of Los Angeles County
    1
  • George Washington University
    1
  • Universidade Federal de Minas Gerais
    1
  • Zoological Society of London
    1
  • University of the Witwatersrand
    1
  • Yale University
    1
  • Children's Hospital
    1
  • Stony Brook University
    1