584 Works

Network Analysis of Trait Aggression - IPIP-NEO and BAQ

Samuel West & David Chester
This project seeks to determine where trait aggression belongs among the broader "Big 5" personality traits of openness to experience, conscientiousness, extroversion, agreeableness, and neuroticism. Data-driven approaches such as network analysis techniques allow for the estimation of the importance of certain variables (or “nodes”) in a given network. Recent advances in personality research have shown the utility of this analytic framework in the context of personality research, as networks of traits allow researchers to determine...

The Well's Programming and Substance Use Outcomes

Katori Jones, Abaiz Chaudhri, Amari Easter, Amy Adkins, Sally Kuo & Jessica Bourdon

Latent correlation between empathic affective dissonance and sadism

Drew Parton & David Chester
Empathy research has been bogged by unclear definitions and inconsistent scales that can conflate related constructs. Broadly, empathy has been conceptualized as two facets: affective empathy, the ability for an individual to experience the emotional and psychological states of others, and cognitive empathy, the ability to understand and perceive the emotional and psychological states of others. Empathy has generally been considered pro-social, and much of the research has focused on shared negative states--that is understanding...

Alteration of long non-coding RNAs and mRNAs expression profiles by compound heterozygous ASXL3 mutations in the mouse brain

Songhui Zhang, Fang Fu, Li Zhen, Ru Li & Can Liao
Compound mutations in the additional sex combs-like 3 (ASXL3) gene greatly impact the expression of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in mouse myocardial tissues. Little is known about ASXL3 mutation effects on lncRNAs and mRNAs expression in the cerebrum and cerebellum. This study aims to clarify this point using quantitative real-time polymerase chain reaction and Western blotting. Transcriptome analysis based on RNA-seq followed by bioinformatics analysis were used to compare lncRNA and...

A multivariate twin study of the genetic association between mindfulness and subjective well-being

Kirk Brown, Danielle Dick, Fazil Aliev, Sally Kuo, Morgan Driver & Thalia Eley
Considerable research (e.g., Brown, 2015; Quaglia et al., 2016) shows that mindfulness, a receptive attention to present events and experiences (Analayo, 2003; Brown & Ryan, 2003), is phenotypically correlated to subjective well-being (SWB), commonly regarded as higher life satisfaction along with a preponderence of positive over negative affect (Diener, 1984; 2000). Unknown is why the relation between these two dispositions exists. Intrapsychic phenomena have been invoked to explain their relation (e.g., Brown et al., 2007;...


MadhurBain Singh, Philip Vinh, Yi Zhou, Luis de Araujo, Brad Verhulst, Conor Dolan & Michael Neale
This is the public repository for the poster presented at 2022 NIDA Virtual Genetics and Epigenetics Cross-Cutting Research Team Meeting. Contributors: MadhurBain Singh (1,2), Philip Vinh (1,2), Yi (Daniel) Zhou (2,3), Luis F.S. Castro-de-Araujo (2), Brad Verhulst (4), Conor V. Dolan (5), and Michael C. Neale (1,2,3,5) Affiliations: 1. Department of Human & Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA; 2. Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA;...

Long non-coding RNA PMS2L2 is down-regulated in osteoarthritis and inhibits chondrocyte proliferation by up-regulating miR-34a

Fei Yang, Min Zhao, Qinghua Sang, Changhong Yan & Zhenjun Wang
Long non-coding RNA (lncRNA) PMS2L2 has been reported to participate in endotoxin-induced inflammatory responses. As these types of responses can promote osteoarthritis (OA), it was of interest to ascertain if PMS2L2 may be involved in OA. To explore any potential participation of PMS2L2 in OA, synovial fluid was extracted from both OA patients and healthy controls (n = 62 each) and PMS2L2 expression of each sample determined by RT-qPCR. In addition, as miR-34a has a...

Methyl-Sensitive Amplification Polymorphism (MSAP) Analysis Provides Insights into the DNA Methylation Underlying Heterosis in Kenaf (Hibiscus Cannabinus L.) Drought Tolerance

Dengjie Luo, Shan Cao, Zengqiang Li, Meiqiong Tang, Caijin Wang, Enerand Mackon, Zhen Huang, Jiao Pan, Xia Wu, Qijing Wu, Hui Zhang, Renxue Li, Xin Li, Ru Li & Peng Chen
Kenaf (Hibiscus cannabinus L.) is an industrial fiber crop with significant heterosis and tolerance to abiotic stresses. However, the mechanism underlying heterosis in kenaf under drought conditions is completely unknown. In this study, F1 hybrids were remarkably tolerant to drought stress. Through methylation-sensitive amplification polymorphism (MSAP) analysis, we highlighted that total DNA methylation level under drought decreased by 11.2% in F1 and increased by 29.7% and 13.1% in parents CP079 and CP071, respectively. Unlike parents,...

Using Item Response Theory to create a comprehensive vengefulness scale

Drew Parton, David Chester & Michael Crowe
Individuals differ in their predispositions toward seeking revenge—their vengefulness. Although the psychological antecedents and contextual factors that promote revenge have been widely studied, the structure of vengefulness has received less focus. The first phase of this project attempted to expand and clarify the taxonomy of vengefulness by using a hierarchical exploratory factor analysis on a battery of some of the most common vengefulness measures. This second phase will use Item Response Theory to distill a...

Analysis code

Drew Parton

Sleep and Marijuana Use

Brendan Jamieson, Kenza Benkirane, Jimmy Gilliam, Amy Adkins & Sarah Martey
This study examines correlations between sleep quality and marijuana use amongst a survey group of university students at Virginia Commonwealth University.

Within the COVID-19 pandemic are rates of depression within minoritized populations different compared to white individuals in the United States?

Aya Youssef, Amy Adkins, Jasmyne Khan, Andrea Arce Nunez & Pasha Farahi
The pandemic has caused many to be under tremendous amounts of stress, especially racial minorities due to having more financial, family, and health issues. With so much worry around the country the state of people’s mental health could be thought to decline as a result. The state of an individual's mental health is also in direct correlation to their chances of becoming depressed.

Assignment feedback in school choice mechanisms

Daniel Stephenson
This paper experimentally investigates the provision of real-time feedback about school assignments during the preference reporting period in three widely employed mechanisms: deferred acceptance, top trading cycles, and the Boston mechanism. Adaptive models predict that greater sensitivity to tentative assignments during the reporting period will produce more equilibrium assignments in all three mechanisms. Consistent with adaptive predictions, real-time assignment feedback consistently increased equilibrium assignments but did not increase truthful reporting. These findings suggest that providing...

Analysis code

Drew Parton

Cleaned data

Drew Parton

The Effect of Family Behaviors and Attitudinal Familism on Youth Externalizing Behaviors: Testing for Gene-Environment Interactions with a Twin Design

Angel Trevino, Jinni Su, Kathryn Lemery-Chalfant & José Causadias
Childhood externalizing behaviors represent a cluster of behavioral problems consisting of aggressive, hyperactive, and/or disruptive actions (Hinshaw, 1987). Childhood externalizing behaviors are developmental precursors to adolescent and adult problem behaviors such as criminal and violent behavior (Betz, 1995; Farrington, 1989; Moffitt, 1993) and substance use (Timmermans et al., 2008; King et al., 2004; Thompson et al., 2011). Understanding the etiology of externalizing behaviors in childhood has important implications for the development of early interventions that...

A Pilot Study of the Role of Mindfulness and Compassion in Parochial Empathy and Prosocial Behavior Toward Out-Groups

Denise Zheng
Denise Zheng's Master's thesis pilot study.

Methods and Study Materials

Richard Klein, Kate Ratliff, Brian Nosek, Michelangelo Vianello, Ronaldo Pilati, Thierry Devos, Elisa Galliani, Mark Brandt, Anna van 't Veer, Abraham Rutchick, Kathleen Schmidt, Štěpán Bahník, Marek Vranka, Hans IJzerman, Fred Hasselman, Jennifer Joy-Gaba, Jesse Chandler, Leigh Ann Vaughn, Claudia Brumbaugh, Lyn van Swol, Aaron Wichman, Grant Packard, Beach Brooks, Zeynep Cemalcilar, Justin Storbeck … & David Furrow

Cerulean Warbler light-level geolocator data

Douglas Raybuck, Than Boves, Scott Stoleson, Jeffery Larkin, Nicholas Bayly, Lesley Bulluck, Gregory George, Kate Slankard, Laura Kearns, Sharon Petzinger, John Cox & David Buehler
The Cerulean Warbler (Setophaga cerulea) is a declining Nearctic-Neotropical migratory species of conservation concern. Implementing full annual cycle conservation strategies to facilitate recovery has been difficult because we know little about the migratory period or connectivity between North American breeding regions and South American non-breeding regions. Between 2014–2017, we deployed geolocators on 282 males at 13 study sites throughout the species’ range with the objectives of a) evaluating the strength of connectivity between breeding and...

Physiological and affective concomitants of directly- and vicariously-experienced ostracism

Drew Parton & Kevin Pham
Humans are largely social beings with a fundamental need to belong. Social exclusion (i.e., ostracism) threatens our social connection with others, causing adverse emotional consequences on excluded individuals’ emotional states. Individuals could also be sensitive to the suffering of others, and some studies have found that people have similar negative effects after witnessing the exclusion of others. The present study will investigate parasympathetic (Heart Rate Variability) and sympathetic (Skin Conductance Level) activity, as well as...

Parental loss as a moderator of genetic risk for alcohol misuse

Rebecca Hoppe, Jessica E Salvatore & Nathaniel Thomas
Parental death, divorce, separation, and marital discord are common childhood adversities, and are associated with offspring alcohol use disorder (AUD) and related outcomes. National statistics suggest that 10.8% of children experience a parental death before the age of 25 (Judi’s House, 2020). Parental divorce and separation are also common, with 16% of American adults experiencing parental divorce or permanent non-marital parental separation prior to age 18 (Thompson et al., 2008). 2008). Moreover, it is well...

Profiles and Predictors of Functioning Among Adults in Recovery from Alcohol Use Disorders

Rebecca Smith, Danielle Dick, Wendy Kliewer, Fazil Aliev, Vivia McCutcheon, Thomas Bannard, Mary Loos, Dace Svikis, Sarah Colbert & Emma Johnson
The goal of this project is to elucidate the patterns, predictors, and processes of recovery from SUDs. In the proposed study, we will use a family-based, genetically informed dataset of adults that was enriched for risk of AUD, the Collaborative Study on the Genetics of Alcoholism (COGA) Prospective Study (N = 3,129). Based on the recent emphasis on understanding functioning and wellbeing among individuals beyond their remission status, we will characterize and predict patterns of...

Epidemiology and Correlates of Alcohol Use and Misuse in Early Midlife

Erin Gallert, Jessica E Salvatore & Danielle Dick

Substance Use Disorders and risk of suicide attempts: The role of genes and environment in a Swedish Population-Based Cohort

Séverine Lannoy, Mallory Stephenson & Alexis Edwards
Background: Previous studies have demonstrated substantial associations between Substance Use Disorders (SUD) and suicidal behavior (Edwards et al., 2020; Lynch et al., 2020), while others supported shared genetic liability and the influence of common environmental factors (Bridge et al., 1997; Edwards et al., 2018). Purpose: In this study, we seek to better understand the risk of suicide attempts in a sample of individuals with registrations for SUD, including alcohol use disorder and drug use disorders....

Clean Data

MadhurBain Singh, Eva Lancaster, Roseann Peterson, Roxann Roberson-Nay, Timothy York & Dana Lapato

Registration Year

  • 2023
  • 2022
  • 2021
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Resource Types

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  • Virginia Commonwealth University
  • Shanghai Jiao Tong University
  • Chinese Academy of Sciences
  • Southern Medical University
  • Shandong University
  • Zhejiang University
  • Jiangsu University
  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • Nanchang University
  • Yale University