4 Works

Data from: All is fish that comes to the net: metabarcoding for rapid fisheries catch assessment

Lorenzo Talarico, Tommaso Russo, Giulia Maiello, Charles Baillie, Giuliano Colosimo, Lorenzo D'Andrea, Federico Di Maio, Fabio Fiorentino, Simone Franceschini, Germana Garofalo, Dario Scannella, Stefano Cataudella & Stefano Mariani
AbstractMonitoring marine resource exploitation is a key activity in fisheries science and biodiversity conservation. Since research surveys are time-consuming and costly, fishery-dependent data (i.e. derived directly from fishing vessels) are increasingly credited with a key role in expanding the reach of ocean monitoring. Fishing vessels may be seen as widely ranging data-collecting platforms, which could act as a fleet of sentinels for monitoring marine life, in particular exploited stocks. Here, we investigate the possibility of...

Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection

Romina Salpini, Arianna Battisti, Lorenzo Piermatteo, Luca Carioti, Olympia E. Anastasiou, Upkar S. Gill, Domenico Di Carlo, Luna Colagrossi, Leonardo Duca, Ada Bertoli, Katia Yu La Rosa, Lavinia Fabeni, Alessandra Iuvara, Vincenzo Malagnino, Carlotta Cerva, Miriam Lichtner, Claudio M. Mastroianni, Giuseppe Maria De Sanctis, Maurizio Paoloni, Massimo Marignani, Caterina Pasquazzi, Nerio Iapadre, Giustino Parruti, Jacopo Vecchiet, Loredana Sarmati … & Valentina Svicher
Increasing evidences suggest that HBsAg-production varies across HBV-genotypes. HBsAg C-terminus plays a crucial role for HBsAg-secretion. Here, we evaluate HBsAg-levels in different HBV-genotypes in HBeAg-negative chronic infection, the correlation of specific mutations in HBsAg C-terminus with HBsAg-levels in-vivo, their impact on HBsAg-secretion in-vitro and on structural stability in-silico. HBsAg-levels were investigated in 323 drug-naïve HBeAg-negative patients chronically infected with HBV genotype-D(N = 228), -A(N = 65) and -E(N = 30). Genotype-D was characterized by HBsAg-levels...

Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection

Romina Salpini, Arianna Battisti, Lorenzo Piermatteo, Luca Carioti, Olympia E. Anastasiou, Upkar S. Gill, Domenico Di Carlo, Luna Colagrossi, Leonardo Duca, Ada Bertoli, Katia Yu La Rosa, Lavinia Fabeni, Alessandra Iuvara, Vincenzo Malagnino, Carlotta Cerva, Miriam Lichtner, Claudio M. Mastroianni, Giuseppe Maria De Sanctis, Maurizio Paoloni, Massimo Marignani, Caterina Pasquazzi, Nerio Iapadre, Giustino Parruti, Jacopo Vecchiet, Loredana Sarmati … & Valentina Svicher
Increasing evidences suggest that HBsAg-production varies across HBV-genotypes. HBsAg C-terminus plays a crucial role for HBsAg-secretion. Here, we evaluate HBsAg-levels in different HBV-genotypes in HBeAg-negative chronic infection, the correlation of specific mutations in HBsAg C-terminus with HBsAg-levels in-vivo, their impact on HBsAg-secretion in-vitro and on structural stability in-silico. HBsAg-levels were investigated in 323 drug-naïve HBeAg-negative patients chronically infected with HBV genotype-D(N = 228), -A(N = 65) and -E(N = 30). Genotype-D was characterized by HBsAg-levels...

Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection

Romina Salpini, Arianna Battisti, Lorenzo Piermatteo, Luca Carioti, Olympia E. Anastasiou, Upkar S. Gill, Domenico Di Carlo, Luna Colagrossi, Leonardo Duca, Ada Bertoli, Katia Yu La Rosa, Lavinia Fabeni, Alessandra Iuvara, Vincenzo Malagnino, Carlotta Cerva, Miriam Lichtner, Claudio M. Mastroianni, Giuseppe Maria De Sanctis, Maurizio Paoloni, Massimo Marignani, Caterina Pasquazzi, Nerio Iapadre, Giustino Parruti, Jacopo Vecchiet, Loredana Sarmati … & Valentina Svicher
Increasing evidences suggest that HBsAg-production varies across HBV-genotypes. HBsAg C-terminus plays a crucial role for HBsAg-secretion. Here, we evaluate HBsAg-levels in different HBV-genotypes in HBeAg-negative chronic infection, the correlation of specific mutations in HBsAg C-terminus with HBsAg-levels in-vivo, their impact on HBsAg-secretion in-vitro and on structural stability in-silico. HBsAg-levels were investigated in 323 drug-naïve HBeAg-negative patients chronically infected with HBV genotype-D(N = 228), -A(N = 65) and -E(N = 30). Genotype-D was characterized by HBsAg-levels...

Registration Year

  • 2020
    4

Resource Types

  • Text
    3
  • Dataset
    1

Affiliations

  • University of Rome Tor Vergata
    4
  • Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
    3
  • Sapienza University of Rome
    3
  • Bambino Gesù Children's Hospital
    3
  • IRCCS Ospedale San Raffaele
    3
  • Policlinico Tor Vergata
    3
  • Azienda USL di Pescara
    3
  • University of Bologna
    1
  • University of Salford
    1
  • San Diego Zoo Institute for Conservation Research
    1