11 Works

Chemical evidence of preserved collagen in a 54-million-year-old fish vertebrae

Suryendu Dutta, Sumit Kumar, Hukam Singh, Mahasin Khan, Amalan Barai, Anuradha Tewari, Rajendra Rana, Subir Bera, Shamik Sen & Ashoke Sahni
Collagens are the most abundant protein in the animal kingdom. Collagens form the structural framework of connective tissues such as bones, tendons and skin and play important biomechanical role in supporting tissue functions. The preservation of collagen in deep time is a topic of intense debate. Here we provide indisputable evidence of the presence of collagen in Early Eocene fish vertebrae using online pyrolysis-comprehensive two dimensional gas chromatography-time-of-flight mass spectrometry and immunofluorescence studies. The presence...

Identification of DPYD variants and estimation of uracil and dihydrouracil in a healthy Indian population - Supplementary File

Poornima Sivamani, Vishnu Eriyat, Sumith K Mathew, Ashish Singh, Rekha Aaron, Raju Titus Chacko, Anjana Joel, Ratna Prabha & Binu Susan Mathew
Background: 5-fluorouracil (5-FU) is a medicine used in cancer treatment. It is eliminated from body by the enzyme DPD. Identifying deficiency in DPD before initiating 5-FU can save patients from oral, intestinal, and bone marrow toxic effects. Methods: The uracil and dihydrouracil (DHU, produced by DPD enzyme action) levels were measured and DPD gene (for identifying defects) was sequenced in 100 healthy adults. Results: Participants with DPD gene sequence that is known to be defective...

Raw images of targeted gearshifting in actin-based active nematic liquid crystals

Steven Redford, Rui Zhang, Paul Ruijgrok, Nitin Kumar, Ali Mozaffari, Sasha Zemsky, Aaron Dinner, Vincenzo Vitelli, Zev Bryant, Margaret Gardel & Juan De Pablo
Active materials are capable of converting free energy into mechanical work to produce autonomous motion, and exhibit striking collective dynamics that biology relies on for essential functions. Controlling those dynamics and transport in synthetic systems has been particularly challenging. Here, we introduce the concept of spatially structured activity as a means to control and manipulate transport in active nematic liquid crystals consisting of actin filaments and light-sensitive myosin motors. Simulations and experiments are used to...

Additional file 1 of Choice of intraoperative ultrasound adjuncts for brain tumor surgery

Manoj Kumar, Santosh Noronha, Narayan Rangaraj, Aliasgar Moiyadi, Prakash Shetty & Vikas Kumar Singh
Additional file 1. Correlation matrices and details of the redesigned variables.

Additional file 1 of Choice of intraoperative ultrasound adjuncts for brain tumor surgery

Manoj Kumar, Santosh Noronha, Narayan Rangaraj, Aliasgar Moiyadi, Prakash Shetty & Vikas Kumar Singh
Additional file 1. Correlation matrices and details of the redesigned variables.

Choice of intraoperative ultrasound adjuncts for brain tumor surgery

Manoj Kumar, Santosh Noronha, Narayan Rangaraj, Aliasgar Moiyadi, Prakash Shetty & Vikas Kumar Singh
Abstract Background Gliomas are among the most typical brain tumors tackled by neurosurgeons. During navigation for surgery of glioma brain tumors, preoperatively acquired static images may not be accurate due to shifts. Surgeons use intraoperative imaging technologies (2-Dimensional and navigated 3-Dimensional ultrasound) to assess and guide resections. This paper aims to precisely capture the importance of preoperative parameters to decide which type of ultrasound to be used for a particular surgery. Methods This paper proposes...

Data from: Discovery of proteinaceous moieties in Late Cretaceous dinosaur eggshells

Harsha Dhiman, Suryendu Dutta, Sumit Kumar, Vishal Verma & Guntupalli Prasad
The documentation of proteinaceous soft tissues in fossils from deep time remains controversial. Often this has been attributed to the laboratory or other modes of modern contamination. Here we provide incontrovertible evidence for the preservation of proteinaceous moieties in the Maastrichtian dinosaur eggshells using pyrolysis-GC×GC-TOFMS. The presence of nitrogen-bearing organic molecules along with diketodipyrrole suggest that the proteinaceous moieties can survive diagenesis. The preservation of these proteinaceous moieties has been attributed to deposition in a...

Data from: Low fossilization potential of keratin protein revealed by experimental taphonomy

Evan T. Saitta, Chris Rogers, Richard A. Brooker, Geoffrey D. Abbott, Sumit Kumar, Shane S. O'Reilly, Paul Donohoe, Suryendu Dutta, Roger E. Summons & Jakob Vinther
Recent studies have suggested the presence of keratin in fossils dating back to the Mesozoic. However, ultrastructural studies revealing exposed melanosomes in many fossil keratinous tissues suggest that keratin should rarely, if ever, be preserved. In this study, keratin's stability through diagenesis was tested using microbial decay and maturation experiments on various keratinous structures. The residues were analysed using pyrolysis-gas chromatography-mass spectrometry and compared to unpublished feather and hair fossils and published fresh and fossil...

Data from: A four-component model of the action potential in mouse detrusor smooth muscle cell

Mithun Padmakumar, Keith L. Brain, John S. Young & Rohit Manchanda
Detrusor smooth muscle cells (DSMCs) of the urinary bladder are electrically connected to one another via gap junctions and form a three dimensional syncytium. DSMCs exhibit spontaneous electrical activity, including passive depolarizations and action potentials. The shapes of spontaneous action potentials (sAPs) observed from a single DSM cell can vary widely. The biophysical origins of this variability, and the precise components which contribute to the complex shapes observed are not known. To address these questions,...

Identification of DPYD variants and estimation of uracil and dihydrouracil in a healthy Indian population - Supplementary File

Poornima Sivamani, Vishnu Eriyat, Sumith K Mathew, Ashish Singh, Rekha Aaron, Raju Titus Chacko, Anjana Joel, Ratna Prabha & Binu Susan Mathew
Background: 5-fluorouracil (5-FU) is a medicine used in cancer treatment. It is eliminated from body by the enzyme DPD. Identifying deficiency in DPD before initiating 5-FU can save patients from oral, intestinal, and bone marrow toxic effects. Methods: The uracil and dihydrouracil (DHU, produced by DPD enzyme action) levels were measured and DPD gene (for identifying defects) was sequenced in 100 healthy adults. Results: Participants with DPD gene sequence that is known to be defective...

Choice of intraoperative ultrasound adjuncts for brain tumor surgery

Manoj Kumar, Santosh Noronha, Narayan Rangaraj, Aliasgar Moiyadi, Prakash Shetty & Vikas Kumar Singh
Abstract Background Gliomas are among the most typical brain tumors tackled by neurosurgeons. During navigation for surgery of glioma brain tumors, preoperatively acquired static images may not be accurate due to shifts. Surgeons use intraoperative imaging technologies (2-Dimensional and navigated 3-Dimensional ultrasound) to assess and guide resections. This paper aims to precisely capture the importance of preoperative parameters to decide which type of ultrasound to be used for a particular surgery. Methods This paper proposes...

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