12 Works

Quantification of Bone Marrow Compartments in Histological Sections

Josefine Tratwal & Olaia Naveiras
Away from the Mouse H&E quantification, the current version of MarrowQuant was tested on a small set of H&E bone marrow biopsies from anonymised patients. The tool performs in a comparable way as compared to the gold standard (Pathologists’ scorings), but it needs many optimisations before validating at the level of the human bone marrow biopsies quantifications and in clinical context.

Diversity, equity, and inclusion in engineering education: an exploration of European higher education institutions’ strategic frameworks, resources, and initiatives

I. Direito, Shannon Chance, L. Clemmensen, S. Craps, S.B. Economides, S.R. Isaac, A.M. Jolly, F.R. Truscott & N. Wint

Long term irrigation experiment

Arun Bose, Andreas Rigling, Arthur Gessler, Frank Hagedorn, Ivano Brunner, Linda Feichtinger, Christof Bigler, Simon Egli, Sophia Etzold, Martin Gossner, Claudia Guidi, Mathieu Lévesque, Katrin Meusburger, Martina Peter, Matthias Saurer, Daniel Scherrer, Patrick Schleppi, Leonie Schönbeck, Michael Vogel, Georg Von Arx, Beat Wermelinger, Thomas Wohlgemuth, Roman Zweifel & Marcus Schaub
Climate change exposes ecosystems to strong and rapid changes in their environmental boundary conditions mainly due to the altered temperature and precipitation patterns. It is still poorly understood how fast interlinked ecosystem processes respond to altered environmental conditions, if these responses occur gradually or suddenly when thresholds are exceeded, and if the patterns of the responses will reach a stable state. We conducted an irrigation experiment in the Pfynwald, Switzerland from 2003-2018. A naturally dry...

Monetary Commitment and the Level of Public Debt

Stefano Gnocchi & Luisa Lambertini
We analyze the interaction between committed monetary policy and discretionary fiscal policy in a model with public debt, endogenous government expenditures, distortive taxation and nominal rigidities. Fiscal decisions lack commitment but are Markov-perfect. Monetary commitment to an interest rate path leads to a unique level of debt. This level of debt is positive if the central bank adopts closed-loop strategies that raise the real interest rate when inflation is above target owing to fiscal deviations....

Drainage Canals in Southeast Asian Peatland

Nathan Dadap, Alison M Hoyt, Alexander R Cobb, Doruk Oner, Mateusz Kozinski, Pascal V Fua, Krishna Rao, Charles F Harvey & Alexandra G Konings
These images depict drainage canals and roads in peatlands in Borneo, Sumatra, and Peninsular Malaysia at 5 meter resolution. These canals were detected from July-September 2017 Planet Basemaps satellite imagery using a convolutional neural network. Please contact Nathan Dadap (ndadap@stanford.edu) with any questions.

Both diversity and functional composition affect productivity and water use efficiency in experimental temperate grasslands

Charlotte Grossiord, Manuel Walde, Eric Allan, Seraina L. Cappelli, Margaux Didion‐Gency, Arthur Gessler, Marco M. Lehmann & Noémie A. Pichon
Many experiments have shown that biodiversity promotes ecosystem functioning and stability and that this relationship varies with resource availability. However, we still have a poor understanding of the underlying physiological and ecological mechanisms driving diversity effects and how they may interact with soil nutrient availability. We collected data in a grassland experiment factorially manipulating fertilization, species richness, functional composition (slow-growing vs. fast-growing species), and functional diversity in resource economic traits. We measured aboveground productivity, nitrogen...

Ant behavioral maturation is mediated by a stochastic transition between two fundamental states

Thomas Richardson, Tomas Kay, Raphael Braunschweig, Opaline A. Journeau, Matthias Ruegg, Sean McGregor, Paolo De Los Rios & Laurent Keller
The remarkable ecological success of social insects is often attributed to their advanced division of labour, which is closely associated with temporal polyethism in which workers transition between different tasks as they age. Young nurses are typically found deep within the nest where they tend to the queen and the brood, whereas older foragers are found near the entrance and outside the nest. However, the individual-level maturation dynamics remain poorly understood because following individuals over...

Physically asymmetric division of the C. elegans zygote ensures invariably successful embryogenesis

Radek Jankele, Pierre Gönczy & Rob Jelier
Asymmetric divisions that yield daughter cells of different sizes are frequent during early embryogenesis, but the importance of such a physical difference for successful development remains poorly understood. Here, we investigated this question using the first division of C. elegans embryos, which yields a large AB cell and a small P1 cell. We equalized AB and P1 sizes using acute genetic inactivation or optogenetic manipulation of the spindle positioning protein LIN-5. We uncovered that only...

Photosynthesis from stolen chloroplasts can support sea slug reproductive fitness

Paulo Cartaxana, Felisa Rey, Charlotte LeKieffre, Diana Lopes, Cedric Hubas, Jorge E. Spangenberg, Stéphane Escrig, Bruno Jesus, Gonçalo Calado, Rosário Domingues, Michael Kühl, Ricardo Calado, Anders Meibom & Sónia Cruz
Some sea slugs are able to steal functional chloroplasts (kleptoplasts) from their algal food sources, but the role and relevance of photosynthesis to the animal host remain controversial. While some researchers claim that kleptoplasts are slowly digestible ‘snacks’, others advocate that they enhance the overall fitness of sea slugs much more profoundly. Our analysis show light-dependent incorporation of 13C and 15N in the albumen gland and gonadal follicles of the sea slug Elysia timida, representing...

Quantification of Bone Marrow Compartments in Histological Sections

Josefine Tratwal & Olaia Naveiras
We report the development of a semi-automated image analysis plug-in, MarrowQuant, which employs the open-source software QuPath, to systematically quantify multiple bone components in H&E sections in an unbiased manner. MarrowQuant discerns and quantifies the areas occupied by bone, adipocyte ghosts, hematopoietic cells and the interstitial/microvascular compartment. A separate feature, AdipoQuant, fragments adipocyte ghosts in H&E-stained sections of extramedullary adipose tissue sections to render adipocyte area and size distribution. Quantification of BM hematopoietic cellularity with...

Phenotypic plasticity versus ecotypic differentiation under recurrent summer drought in two drought-tolerant pine species

Christoph Bachofen, Anouchka Perret-Gentil, Tom Wohlgemuth, Pierre Vollenweider & Barbara Moser
1. Despite worldwide reports of high tree mortality, growing evidence indicates that many tree species are well adapted to survive repeated dry spells. The drought resilience of trees is related to their phenotypic plasticity and ecotypic differentiation. Whether these two mechanisms act at the same organisational level of a tree and involve similar plant traits is still unknown. 2. We assessed phenotypic plasticity and ecotypic differentiation across four populations of Pinus sylvestris and Pinus nigra...

Dataset: A multi-site, year-round turbulence microstructure atlas for the deep perialpine Lake Garda

Sebastiano Piccolroaz, Bieito Fernández Castro, Marco Toffolon & Henk Dijkstra
This repository includes the dataset described in "A multi-site, year-round turbulence microstructure atlas for the deep perialpine Lake Garda", Scientific Reports, 2021, DOI: 10.1038/s41597-021-00965-0 A multi-site, year-round dataset comprising a total of 606 high-resolution turbulence microstructure profiles of shear and temperature gradient in the upper 100 m depth is made available for Lake Garda (Italy). Concurrent meteorological data were measured from the fieldwork boat at the location of the turbulence measurements. During the fieldwork campaign...

Registration Year

  • 2021
    12

Resource Types

  • Dataset
    8
  • Image
    2
  • Text
    2

Affiliations

  • École Polytechnique Fédérale de Lausanne
    12
  • Swiss Federal Institute for Forest, Snow and Landscape Research
    3
  • University of Lausanne
    2
  • KU Leuven
    2
  • Stanford University
    1
  • University of Aveiro
    1
  • Hospital Universitario 12 De Octubre
    1
  • University of Southampton
    1
  • Lawrence Berkeley National Laboratory
    1
  • University College London
    1