31 Works

The permeability of granite deformed in the brittle regime to large strains: Implications for the permeability of fractured geothermal reservoirs

Michael Heap , Hugo Duwiquet , Luke Griffiths , Laurent Guillou-Frottier , Patrick Baud & Marie Violay
Efficient fluid flow and circulation are important for an economically viable geothermal reservoir. One type of underexplored reservoir for high-temperature geothermal exploitation is a crustal fault zone, where hot fluids from depths corresponding to the brittle-ductile transition are brought to the surface via crustal-scale, permeable fault zones. To better understand the evolving permeability of reservoir rock during deformation in the brittle regime—fault formation and sliding on the fault—we performed triaxial experiments on samples of well-characterised...

Additional file 1 of The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Flavia Hodel, Olivier Naret, Clara Bonnet, Nicole Brenner, Noemi Bender, Tim Waterboer, Pedro Marques-Vidal, Peter Vollenweider & Jacques Fellay
Additional file 1: Fig. S1. Flowchart illustrating the inclusion/exclusion of individuals in the study. Orange boxes indicate the number of included antigens and pathogens.

Additional file 2 of The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Flavia Hodel, Olivier Naret, Clara Bonnet, Nicole Brenner, Noemi Bender, Tim Waterboer, Pedro Marques-Vidal, Peter Vollenweider & Jacques Fellay
Additional file 2: Fig. S2. Scatterplot and regression line (with 95% confidence intervals) to describe the relationship of hs-CRP with characteristics of study participants. Relationship between hs-CRP and A) age, B) sex, C) BMI and D) polygenic risk score (PRS). For linear regressions, linear regression equation, R-squared and P-value are shown.

Additional file 5 of The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Flavia Hodel, Olivier Naret, Clara Bonnet, Nicole Brenner, Noemi Bender, Tim Waterboer, Pedro Marques-Vidal, Peter Vollenweider & Jacques Fellay
Additional file 5: Fig. S5. Polygenic risk score for hs-CRP (CRP-PRS) was significantly associated with hs-CRP levels. Scatter plots with linear regression line of polygenic risk scores predicting hs-CRP levels for individuals in the cohort. 95% confidence interval is showed in grey shade.

Additional file 4 of The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Flavia Hodel, Olivier Naret, Clara Bonnet, Nicole Brenner, Noemi Bender, Tim Waterboer, Pedro Marques-Vidal, Peter Vollenweider & Jacques Fellay
Additional file 4: Fig. S4. Distribution of polygenic risk score (PRS) values. Density distribution of standardized PRS values by subcohort (CoLaus|PsyCoLaus and UKB) and across all participants (combined).

Additional file 5 of The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Flavia Hodel, Olivier Naret, Clara Bonnet, Nicole Brenner, Noemi Bender, Tim Waterboer, Pedro Marques-Vidal, Peter Vollenweider & Jacques Fellay
Additional file 5: Fig. S5. Polygenic risk score for hs-CRP (CRP-PRS) was significantly associated with hs-CRP levels. Scatter plots with linear regression line of polygenic risk scores predicting hs-CRP levels for individuals in the cohort. 95% confidence interval is showed in grey shade.

Self-affine synthetic surface

Tevis D. B. Jacobs, Till Junge & Lars Pastewka
This surface contains virtual measurements taken out of a large self-affine synthetic surface with Hurst exponent 0.8. The original surface had 50,000 x 50,000 data points and was created using a Fourier filtering algorithm. The surface was "measured" in block containing 500 x 500 data points with a variety of scan sizes ranging from almost the full surface with 100 μm width to 10 μm to 1 μm, with pixel sizes scaling accordingly. This surface...

Tetravalent uranium mobilization by complexation or oxidation and associated U isotope fractionation

Yvonne Roebbert , Chris Daniel Rosendahl , Ashley Brown , Axel Schippers , Rizlan Bernier-Latmani & Stefan Weyer
Uranium (U) isotopes are suggested to monitor the success of (bio)remediation relying on the reduction of soluble and mobile U(VI) to less soluble U(IV)1. However, the subsurface stability of U(IV), typically present as solid-phase non-crystalline U, may be affected by complexation or oxidation. Understanding these processes and their impact on U isotope fractionation is important to correctly interpret field U isotope signatures. We investigated U mobilization by complexation and oxidation and measured the associated U...

Positive interactions between corals and damselfish increase coral resistance to temperature stress

Andrew Shantz, Mark Ladd, Leila Ezzat, Russell Schmitt, Sally Holbrook, Rebecca Vega Thurber, Deron Burkepile & Emily Schmeltzer
By the century’s end, many tropical seas will reach temperatures exceeding most coral species’ thermal tolerance on an annual basis. The persistence of corals in these regions will therefore depend on their abilities to tolerate recurrent thermal stress. Although ecologists have long recognized that positive interspecific interactions can ameliorate environmental stress to expand the realized niche of plants and animals, coral bleaching studies have largely overlooked how interactions with community members outside of the coral...

Additional file 1 of Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders

Melek Firat Altay, Alan King Lun Liu, Janice L. Holton, Laura Parkkinen & Hilal A. Lashuel
Additional file 1: Table S1. The primary and secondary antibodies included in this study. AC = autoclave; agg-aSyn = aggregated alpha-synuclein; aSyn = alpha-synuclein; FA = formic acid; GFAP = glial fibrillary acidic protein; Iba1 = ionized calcium binding adaptor protein 1; IF = immunofluorescence; IHC = immunohistochemistry; MBP = myelin basic protein; mc = monoclonal; mus = mouse; na = not applicable; NF = neurofilament; pc = polyclonal; rab = rabbit; SB = slot...

Two simple movement mechanisms for spatial division of labour in social insects

Thomas Richardson, Nathalie Stroeymeyt, Alessandro Crespi & Laurent Keller
Many animal species divide space into a patchwork of home ranges, yet there is little consensus on the mechanisms individuals use to maintain fidelity to particular locations. Theory suggests that animal movement could be based upon simple behavioural rules that use local information such as olfactory deposits, or global strategies, such as long-range biases toward landmarks. However, empirical studies have rarely attempted to distinguish between these mechanisms. Here, we perform individual tracking experiments on four...

Additional file 2 of The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Flavia Hodel, Olivier Naret, Clara Bonnet, Nicole Brenner, Noemi Bender, Tim Waterboer, Pedro Marques-Vidal, Peter Vollenweider & Jacques Fellay
Additional file 2: Fig. S2. Scatterplot and regression line (with 95% confidence intervals) to describe the relationship of hs-CRP with characteristics of study participants. Relationship between hs-CRP and A) age, B) sex, C) BMI and D) polygenic risk score (PRS). For linear regressions, linear regression equation, R-squared and P-value are shown.

Additional file 4 of The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Flavia Hodel, Olivier Naret, Clara Bonnet, Nicole Brenner, Noemi Bender, Tim Waterboer, Pedro Marques-Vidal, Peter Vollenweider & Jacques Fellay
Additional file 4: Fig. S4. Distribution of polygenic risk score (PRS) values. Density distribution of standardized PRS values by subcohort (CoLaus|PsyCoLaus and UKB) and across all participants (combined).

Synthetic self-affine topography scanned with a virtual spherical probe

Tevis D. B. Jacobs, Till Junge & Lars Pastewka
This surface contains a self-affine topography that has been scanned with a spherical virtual probe of radius 40 nm. The probe was lowered normal to the surface on each point of the reference topography (that is also included here) and the center of the probe was taken as the "measured" value of the topography. The reference topography has a Hurst exponent of 0.8 and was generated with a Fourier-filtering algorithm. This surface was used to...

Warming may extend tree growing seasons and compensate for reduced carbon uptake during dry periods

Charlotte Grossiord, Christoph Bachofen, Jonas Gisler, Eugenie Mas, Yann Vitasse & Margaux Didion-Gency
1. Warming and drought alter plant phenology, photosynthesis and growth with important consequences for the global carbon cycle and the earth’s climate. Yet, few studies have attempted to tease apart their effects on tree phenology, particularly leaf senescence, and on source and sink activity. 2. We experimentally assessed the single and combined effects of warming and reduced soil moisture on the phenology (leaf-out and senescence date, growing season length) and aboveground sink (height and diameter...

Additional file 3 of The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Flavia Hodel, Olivier Naret, Clara Bonnet, Nicole Brenner, Noemi Bender, Tim Waterboer, Pedro Marques-Vidal, Peter Vollenweider & Jacques Fellay
Additional file 3: Fig. S3. Principal component analysis (PCA) of combined genotyping data. A) PCA plot of the first ten PCs of the genotyping data. Samples are colored by cohort. B) Histogram explaining the variance of each PC component. In the histogram, the variance explained by each eigenvalue is labeled on top.

Additional file 3 of The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Flavia Hodel, Olivier Naret, Clara Bonnet, Nicole Brenner, Noemi Bender, Tim Waterboer, Pedro Marques-Vidal, Peter Vollenweider & Jacques Fellay
Additional file 3: Fig. S3. Principal component analysis (PCA) of combined genotyping data. A) PCA plot of the first ten PCs of the genotyping data. Samples are colored by cohort. B) Histogram explaining the variance of each PC component. In the histogram, the variance explained by each eigenvalue is labeled on top.

The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Flavia Hodel, Olivier Naret, Clara Bonnet, Nicole Brenner, Noemi Bender, Tim Waterboer, Pedro Marques-Vidal, Peter Vollenweider & Jacques Fellay
Abstract Multiple human pathogens establish chronic, sometimes life-long infections. Even if they are often latent, these infections can trigger some degree of local or systemic immune response, resulting in chronic low-grade inflammation. There remains an incomplete understanding of the potential contribution of both persistent infections and human genetic variation on chronic low-grade inflammation. We searched for potential associations between seropositivity for 13 persistent pathogens and the plasma levels of the inflammatory biomarker C-reactive protein (CRP),...

Additional file 1 of The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Flavia Hodel, Olivier Naret, Clara Bonnet, Nicole Brenner, Noemi Bender, Tim Waterboer, Pedro Marques-Vidal, Peter Vollenweider & Jacques Fellay
Additional file 1: Fig. S1. Flowchart illustrating the inclusion/exclusion of individuals in the study. Orange boxes indicate the number of included antigens and pathogens.

Additional file 6 of The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Flavia Hodel, Olivier Naret, Clara Bonnet, Nicole Brenner, Noemi Bender, Tim Waterboer, Pedro Marques-Vidal, Peter Vollenweider & Jacques Fellay
Additional file 6: Fig. S6. Seroprevalence of tested antigens in the CoLaus|PsyCoLaus. List of the 27 antigens available from the CoLaus|PsyCoLaus study that are shared with the UK Biobank. The percentages indicate the seroprevalence of antibodies against infectious disease antigens tested using Multiplex Serology platform. The grey boxes indicate the pathogen on which the antigen protein is found, and the family to which the pathogen belongs.

Additional file 7 of The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Flavia Hodel, Olivier Naret, Clara Bonnet, Nicole Brenner, Noemi Bender, Tim Waterboer, Pedro Marques-Vidal, Peter Vollenweider & Jacques Fellay
Additional file 7: Fig. S7. Seroprevalence of tested antigens in the UK Biobank. List of the 27 antigens available from the UK Biobank that are shared with the CoLaus|PsyCoLaus study. The percentages indicate the seroprevalence of antibodies against infectious disease antigens tested using Multiplex Serology platform. The grey boxes indicate the pathogen on which the antigen protein is found, and the family to which the pathogen belongs.

Additional file 7 of The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Flavia Hodel, Olivier Naret, Clara Bonnet, Nicole Brenner, Noemi Bender, Tim Waterboer, Pedro Marques-Vidal, Peter Vollenweider & Jacques Fellay
Additional file 7: Fig. S7. Seroprevalence of tested antigens in the UK Biobank. List of the 27 antigens available from the UK Biobank that are shared with the CoLaus|PsyCoLaus study. The percentages indicate the seroprevalence of antibodies against infectious disease antigens tested using Multiplex Serology platform. The grey boxes indicate the pathogen on which the antigen protein is found, and the family to which the pathogen belongs.

The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Flavia Hodel, Olivier Naret, Clara Bonnet, Nicole Brenner, Noemi Bender, Tim Waterboer, Pedro Marques-Vidal, Peter Vollenweider & Jacques Fellay
Abstract Multiple human pathogens establish chronic, sometimes life-long infections. Even if they are often latent, these infections can trigger some degree of local or systemic immune response, resulting in chronic low-grade inflammation. There remains an incomplete understanding of the potential contribution of both persistent infections and human genetic variation on chronic low-grade inflammation. We searched for potential associations between seropositivity for 13 persistent pathogens and the plasma levels of the inflammatory biomarker C-reactive protein (CRP),...

Additional file 2 of Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders

Melek Firat Altay, Alan King Lun Liu, Janice L. Holton, Laura Parkkinen & Hilal A. Lashuel
Additional file 2: Fig. S1. Specificity validation of the aSyn antibodies LASH-BL 34-45, LASH-BL 80-96 and BD SYN-1 by pre-adsorption followed by IHC on DLB1 cingulate cortex (layers V–VI). aSyn = alpha-synuclein; DLB = dementia with Lewy bodies; IHC = immunohistochemistry. Fig. S2. (a) A representative image of a cortical LB positive for NF and LASH-BL 34-45, and negative for GFAP. Image from DLB1 cingulate cortex taken using Zeiss LSM700 confocal microscope. (b) The oligodendrocytes...

Registration Year

  • 2022
    31

Resource Types

  • Text
    20
  • Dataset
    6
  • Collection
    4
  • Journal Article
    1

Affiliations

  • École Polytechnique Fédérale de Lausanne
    29
  • University of Lausanne
    17
  • Swiss Institute of Bioinformatics
    16
  • German Cancer Research Center
    16
  • University Hospital of Lausanne
    16
  • University College London
    6
  • University of Oxford
    6
  • Department of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, PA 15261, USA
    2
  • Cluster of Excellence livMatS, Freiburg Center for Interactive Materials and Bioinspired Technologies, University of Freiburg, Georges-Köhler-Allee 105, 79110 Freiburg, Germany
    2
  • Department of Microsystems Engineering, University of Freiburg, Georges-Köhler-Allee 103, 79110 Freiburg, Germany
    2