The data herein presents a new chironomid record and associated chironomid-based temperature reconstruction covering the mid Eemian to the end of the first Würmian stadial (ca. 125–105 ka), augmented by results for the late Rissian glaciation and the early Brörup interstadial from the Füramoos palaeolake, southern Germany. There is an unconformity in the sediment core analysed between the late Rissian sediments and the mid Eemian sediments. These data also include non-chironomid invertebrate remains, including Ceratopogonidae,...

Supplemental Material for Prescription Trends in Hospice Care: A Longitudinal Retrospective and Descriptive Medication Analysis by Ursina Wernli, Désirée Hischier, Christoph R. Meier, Sibylle Jean-Petit-Matile, Alice Panchaud, Andrea Kobleder, and Carla Meyer-Massetti in American Journal of Hospice and Palliative Medicine®.

Psychotic disorders are frequently associated with decline in functioning and cognitive difficulties are observed in subjects at clinical high risk (CHR) for psychosis. In this work, we applied automatic approaches to neurocognitive and functioning measures, with the aim of investigating the link between global, social and occupational functioning, and cognition. 102 CHR subjects and 110 patients with recent onset depression (ROD) were recruited. Global assessment of functioning (GAF) related to symptoms (GAF-S) and disability (GAF-D)....

Additional file 1.

Additional file 1: Figure S1. Images of neutrophils response to PMA in HC as well as AQP4 + NMOSD patients. Representative fluorescent microscope image of neutrophils from HC (top panel) and AQP4 + NMOSD (lower panel) after exposure to PMA. DNA (Hoechst 33342) in blue, neutrophil elastase (NE) in green and DNA fragments (TUNEL) as well as merged images are shown. Images obtained at 40 × magnification; scale bar 20 µm. HC: n = 3;...

Additional file 3: Figure S3. Evaluation of serum cytokines and chemokines in AQP4 + NMOSD, MOGAD patients and HC. Levels of GM-CSF (A), IL-6 (B), IL-8 (C), IL-15 (D), TNF-alpha (E) and IL-10 (F) were investigated using the Meso Scale Diagnostics MULTISPOT Assay System in serum samples from AQP4 + NMOSD (left panel) and MOGAD (right panel) patients compared with their respective HC. Data are represented as median and IQR in scatter plot with a...

Additional file 2. Key resources for each component of the Basel Approach for coNtextual ANAlysis (BANANA).

Additional file 4. Overview of variables assessed and themes explored in the SMILe project.

Additional file 1: Figure S1. Images of neutrophils response to PMA in HC as well as AQP4 + NMOSD patients. Representative fluorescent microscope image of neutrophils from HC (top panel) and AQP4 + NMOSD (lower panel) after exposure to PMA. DNA (Hoechst 33342) in blue, neutrophil elastase (NE) in green and DNA fragments (TUNEL) as well as merged images are shown. Images obtained at 40 × magnification; scale bar 20 µm. HC: n = 3;...

Abstract Background We aimed to assess the prevalence of Salmonella Typhi through DNA and IgM-antibody detection methods as a prelude to extended surveillance activities at sites in Ghana, Madagascar, and Ethiopia. Methods We performed species-specific real-time polymerase reaction (RT-PCR) to identify bacterial nucleic acid, and enzyme-linked immunosorbent assay (ELISA) for detecting HlyE/STY1498-, CdtB/STY1886-, pilL/STY4539- and Vi-antigens in blood and biopsy specimens of febrile and non-febrile subjects. We generated antigen-specific ELISA proxy cut-offs by change-point analyses,...

Abstract Background We aimed to assess the prevalence of Salmonella Typhi through DNA and IgM-antibody detection methods as a prelude to extended surveillance activities at sites in Ghana, Madagascar, and Ethiopia. Methods We performed species-specific real-time polymerase reaction (RT-PCR) to identify bacterial nucleic acid, and enzyme-linked immunosorbent assay (ELISA) for detecting HlyE/STY1498-, CdtB/STY1886-, pilL/STY4539- and Vi-antigens in blood and biopsy specimens of febrile and non-febrile subjects. We generated antigen-specific ELISA proxy cut-offs by change-point analyses,...

The angiosperm family Primulaceae is morphologically diverse and distributed nearly worldwide. However, phylogenetic uncertainty has limited the ability to identify major morphological and biogeographic transitions. We used target capture sequencing with the Angiosperms353 kit for over 300 species across Ericales, tree-based sequence curation, and multiple phylogenetic approaches to investigate the phylogenetics of the major clades of Primulaceae and their relationship to other Ericales. The study included 150 samples of Primulaceae comprising nearly all recognized genera...

Supplemental material, sj-docx-1-eso-10.1177_23969873231151488 for Apical pulmonary lesions suspected of malignancy visible on neck CT angiography performed for acute stroke: Prevalence, treatment, and clinical implications – the PLEURA study by Tolga D Dittrich, Mara Aujesky, Salome Rudin, Annaelle Zietz, Benjamin Wagner, Alexandros Polymeris, Valerian L Altersberger, Tim Sinnecker, Henrik Gensicke, Stefan T Engelter, Philippe Lyrer, Viviane Hess, Raoul Sutter, Christian H Nickel, Leo H Bonati, Urs Fischer, Marios Psychogios, Mira Katan and Gian Marco De Marchis...

Background:Computed tomography angiography (CTA) of the supraaortic arteries is commonly used for acute stroke workup and may reveal apical pulmonary lesions (APL).Aim:To determine the prevalence, follow-up algorithms, and in-hospital outcomes of stroke patients with APL on CTA.Methods:We retrospectively included consecutive adult patients with ischemic stroke, transient ischemic attack, or intracerebral hemorrhage and available CTA at a tertiary hospital between January 2014 and May 2021. We reviewed all CTA reports for the presence of APL. APL...

Additional file 1: search strategy.

Additional file 2: Main findings extracted from included studies.

Additional file 2: Fig. S2 CSF and serum NfL concentrations in control and naïve animals. No differences in NfL concentrations were observed between the 2 groups in both (A) CSF and (B) serum on two-way ANOVA. ANOVA: analysis of variance; NfL: neurofilament-light chain

Additional file 3: Fig. S3 Correlation between CSF and serum NfL concentrations. (A) In all animals at all time points, (B) stratified by treatment groups at all time points, and (C) within DTH animals stratified by time points. DTH: delayed-type hypersensitivity; NfL: neurofilament-light chain; r: Pearson correlation coefficient

Supplementary Material 1

Additional file 1. Histogram, smooth function and Pearson's correlation coefficients for continuous candidate predictors.

Additional file 3. Calibration plots for the logistic regression models MABE = MABESS (left side) and MMBRP (right side) based on the derivation cohort. The Brier score and scaled Brier score of MABE, MABESS was 0.14 and 17.01%, respectively. In contrast, MMBRP had a Brier score and scaled Brier score of 0.14 and 15.41%, respectively.

Additional file 4. Logistic regression model based on the ABE and ABESS variable selection, calculated on the total cohort.

Additional file 3. Self-reported relationship with colleagues.

Additional file 6. Facility-level comparisons of scores for each domain.