Supplemental material, sj-docx-2-wso-10.1177_17474930221140793 for Mechanical thrombectomy for large vessel occlusion between 6 and 24 h: outcome comparison of DEFUSE-3/DAWN eligible versus non-eligible patients by Tolga D Dittrich, Peter B Sporns, Lilian F Kriemler, Salome Rudin, Anh Nguyen, Annaelle Zietz, Alexandros A Polymeris, Christopher Tränka, Sebastian Thilemann, Benjamin Wagner, Valerian L Altersberger, Ines Piot, Filip Barinka, Martin Hänsel, Henrik Gensicke, Stefan T Engelter, Philippe A Lyrer, Raoul Sutter, Christian H Nickel, Mira Katan, Nils Peters, Lars...

Background:The DEFUSE-3 and DAWN trials showed that mechanical thrombectomy (MT) improves the outcome of selected patients with anterior circulation large vessel occlusions (LVO) up to 24 h after stroke onset. However, it is unknown whether only those patients fulfilling the trial inclusion criteria benefit, or whether benefit is seen in a broader range of patients presenting between 6 and 24 h.Aims:We determined whether fulfilling the DEFUSE-3 and DAWN selection criteria affects outcomes in MT patients...

Anisogamy—the size dimorphism of gametes—is the defining difference between the male and female sexual strategies. Game-theoretic thinking led to the first convincing explanation for the evolutionary origins of anisogamy in the 1970s. Since then, formal game-theoretic models have continued to refine our understanding of when and why anisogamy should evolve. Such models typically presume that the earliest anisogamous organisms had separate sexes. However, in most taxa, there is no empirical evidence to support this assumption....

Proportions of monoecious individuals when there is no advantage to specialising in one gamete type

Purpose: To explore the association between the degree of Chronic illness management and survival rates at 1-, 3-, 5-years post heart transplantation. Methods: Exploratory secondary analysis of a cross-sectional, international study (Building Research Initiative Group study). Latent profile analysis was performed to classify 36 heart transplant centers according to the degree of chronic illness management. Results: The analysis resulted in 2 classes with 29 centers classified as “low-degree chronic illness management” and 7 centers as...

Supplemental material, sj-docx-1-msj-10.1177_13524585221144742 for Plasma neurofilament light chain in children with relapsing MS receiving teriflunomide or placebo: A post hoc analysis of the randomized TERIKIDS trial by Jens Kuhle, Tanuja Chitnis, Brenda Banwell, Marc Tardieu, Douglas L Arnold, Andreea M Rawlings, Svend S Geertsen, Alex L Lublin, Stephane Saubadu, Philippe Truffinet and Ludwig Kappos in Multiple Sclerosis Journal

Supplemental material, sj-docx-1-msj-10.1177_13524585221144742 for Plasma neurofilament light chain in children with relapsing MS receiving teriflunomide or placebo: A post hoc analysis of the randomized TERIKIDS trial by Jens Kuhle, Tanuja Chitnis, Brenda Banwell, Marc Tardieu, Douglas L Arnold, Andreea M Rawlings, Svend S Geertsen, Alex L Lublin, Stephane Saubadu, Philippe Truffinet and Ludwig Kappos in Multiple Sclerosis Journal

Background:Computed tomography angiography (CTA) of the supraaortic arteries is commonly used for acute stroke workup and may reveal apical pulmonary lesions (APL).Aim:To determine the prevalence, follow-up algorithms, and in-hospital outcomes of stroke patients with APL on CTA.Methods:We retrospectively included consecutive adult patients with ischemic stroke, transient ischemic attack, or intracerebral hemorrhage and available CTA at a tertiary hospital between January 2014 and May 2021. We reviewed all CTA reports for the presence of APL. APL...

Supplemental material, sj-doc-2-eso-10.1177_23969873231151488 for Apical pulmonary lesions suspected of malignancy visible on neck CT angiography performed for acute stroke: Prevalence, treatment, and clinical implications – the PLEURA study by Tolga D Dittrich, Mara Aujesky, Salome Rudin, Annaelle Zietz, Benjamin Wagner, Alexandros Polymeris, Valerian L Altersberger, Tim Sinnecker, Henrik Gensicke, Stefan T Engelter, Philippe Lyrer, Viviane Hess, Raoul Sutter, Christian H Nickel, Leo H Bonati, Urs Fischer, Marios Psychogios, Mira Katan and Gian Marco De Marchis...

Supplemental material, sj-docx-1-his-10.1177_11786329231153278 for Healthcare Costs and Health-Related Quality of Life in Older Multimorbid Patients After Hospitalization by Paola Salari, Séverine Henrard, Cian O’Mahony, Paco Welsing, Arjun Bhadhuri, Katharina Tabea Jungo, Thomas Beck, Denis O’Mahony, Stephen Byrne, Anne Spinewine, Wilma Knol, Nicolas Rodondi and Matthias Schwenkglenks in Health Services Insights

Objectives:We identified factors associated with healthcare costs and health-related quality of life (HRQoL) of multimorbid older adults with polypharmacy.Methods:Using data from the OPERAM (OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid older people) trial, we described the magnitude and composition of healthcare costs, and time trends of HRQoL, during 1-year after an acute-care hospitalization. We performed a cluster analysis to identify groups with different cost and HRQoL trends. Using multilevel models, we also...

Supplemental material, sj-pdf-1-tan-10.1177_17562864221150040 for Natalizumab in cerebrospinal fluid and breastmilk of patients with multiple sclerosis by Ilaria Callegari, Mika Schneider, Vera Aebischer, Margarete M. Voortman, Undine Proschmann, Tjalf Ziemssen, Raija Lindberg, Bettina Fischer-Barnicol, Michael Khalil, Ludwig Kappos, Jens Kuhle, Nicholas S.R. Sanderson and Tobias Derfuss in Therapeutic Advances in Neurological Disorders

Abstract Background An increasing number of countries are using or planning to use quality indicators (QIs) in residential long-term care. Knowledge regarding the current state of evidence on usage and methodological soundness of publicly reported clinical indicators of quality in nursing homes is needed. The study aimed to answer the questions: 1) Which health-related QIs for residents in long-term care are currently publicly reported internationally? and 2) What is the methodological quality of these indicators?...

Additional file 2. Measurement of PPH knowledge scores.

Additional file 2. List of consulted websites and organizations.

Additional file 1. Table S1. Individual elements of the Elixhauser index. Table S2. All Admission diagnoses with n > 50.

Additional file 1: Table S1. Study settings. Table S2. Adjusted regression estimates, overall and restricted to pre-COVID-19 period (before April 2020).

Additional file 2: Figure S1. Inclusion flow-charts. Figure S2. Complementary day 28 health outcome indicators, by country. Figure S3. Results of HRP2/pLDH Combo tests at day 28 follow-up, by detected antigen (HRP2 and/or pLDH), in a sub-sample of study patients. Figure S4. Mean haemoglobin (Hb) concentration and percent of children with anaemia (Hb <11 g/dL) among children sick or healthy at follow-up. Figure S5. (A) Time trend in monthly inclusions and case fatality ratio (CFR)...

Abstract Background In a cohort of primary health care users across Kosovo (KOSCO cohort), high rates and poor control of diabetes and hypertension were observed. These conditions can be prevented and better controlled by adapting to a healthy lifestyle. Physical activity is an important target, as inactivity and related obesity were very prevalent in the KOSCO cohort. This qualitative study aims to identify individual and structural barriers to physical activity perceived by patients with diabetes...

Additional file 1. Search strings used in the databases.

Additional file 1. Survey questions extracted from the original INSPIRE Population Survey (translated from German) (Siqeca et al., 2021).

Additional file 3. Example Questions from the Interview Guide used in the INSPIRE parent study (translated from German) (Esser et al., 2022).

Abstract Background Home-dwelling frail older adults are often faced with multimorbidity and complex care needs, requiring health and social care systems that support frail older adults to age in place. The objective of this paper was to investigate the types of formal health and social care as well as informal care and social support used by home-dwelling frail older adults; whether they perceive their support as sufficient; and their experience with and preferences for care...

Additional file 4. List of articles excluded after full-text screening.

Supplementary Material 1