439 Works

Health and social care of home-dwelling frail older adults in Switzerland: a mixed methods study

Olivia Yip, Suzanne Dhaini, Jan Esser, Flaka Siqeca, Maria Jose Mendieta, Evelyn Huber, Andreas Zeller, Sabina De Geest, Mieke Deschodt, Franziska Zúñiga, Leah L. Zullig & Heather A. King
Abstract Background Home-dwelling frail older adults are often faced with multimorbidity and complex care needs, requiring health and social care systems that support frail older adults to age in place. The objective of this paper was to investigate the types of formal health and social care as well as informal care and social support used by home-dwelling frail older adults; whether they perceive their support as sufficient; and their experience with and preferences for care...

What the policy and stewardship landscape of a national health research system looks like in a developing country like Iran: a qualitative study

Atousa Poursheikhali, Mohammed Alkhaldi, Reza Dehnavieh, AliAkbar Haghdoost, Ali Masoud, Somayeh Noorihekmat, Mohammad Reza Cheshmyazdan & Mousa Bamir
Abstract Background The health research system (HRS) is an important national priority that requires a systematic and functional approach. Evaluating the HRS of Iran as a developing country and identifying its challenges reveals the stewardship-related role in how the whole system is operating well. This study aims to assess the HRS in terms of stewardship functions and highlight the enhancement points. Methods This study was carried out between March 2020 and April 2021 using a...

Additional file 1 of Evidence for publicly reported quality indicators in residential long-term care: a systematic review

Magdalena Osińska, Lauriane Favez & Franziska Zúñiga
Additional file 1. Search strings used in the databases.

Plasma neurofilament light chain in children with relapsing MS receiving teriflunomide or placebo: A post hoc analysis of the randomized TERIKIDS trial

Jens Kuhle, Tanuja Chitnis, Brenda Banwell, Marc Tardieu, Douglas L Arnold, Andreea M Rawlings, Svend S Geertsen, Alex L Lublin, Stephane Saubadu, Philippe Truffinet & Ludwig Kappos
Background:The phase 3 TERIKIDS study demonstrated efficacy and manageable safety for teriflunomide versus placebo in children with relapsing multiple sclerosis (RMS).Objective:Evaluate plasma neurofilament light chain (pNfL) concentrations in TERIKIDS.Methods:Patients received placebo or teriflunomide (14 mg adult equivalent) for up to 96 weeks in the double-blind (DB) period. In the open-label extension (OLE), all patients received teriflunomide until up to 192 weeks after randomization. pNfL was measured using single-molecule array assay (Simoa® NF-light™).Results:Baseline mean age was...

Plasma neurofilament light chain in children with relapsing MS receiving teriflunomide or placebo: A post hoc analysis of the randomized TERIKIDS trial

Jens Kuhle, Tanuja Chitnis, Brenda Banwell, Marc Tardieu, Douglas L Arnold, Andreea M Rawlings, Svend S Geertsen, Alex L Lublin, Stephane Saubadu, Philippe Truffinet & Ludwig Kappos
Background:The phase 3 TERIKIDS study demonstrated efficacy and manageable safety for teriflunomide versus placebo in children with relapsing multiple sclerosis (RMS).Objective:Evaluate plasma neurofilament light chain (pNfL) concentrations in TERIKIDS.Methods:Patients received placebo or teriflunomide (14 mg adult equivalent) for up to 96 weeks in the double-blind (DB) period. In the open-label extension (OLE), all patients received teriflunomide until up to 192 weeks after randomization. pNfL was measured using single-molecule array assay (Simoa® NF-light™).Results:Baseline mean age was...

Data from: No carbon \"bet hedging\" in pine seedlings under prolonged summer drought and elevated CO2

Christoph Bachofen, Barbara Moser, Günter Hoch, Jaboury Ghazoul, Tom Wohlgemuth & Thomas Wohlgemuth
More frequent drought episodes are expected to cause higher mortality in isohydric tree species such as pines, because individuals close their stomata early during drought in order to maintain constant needle water potentials. It has been suggested that trees delay the ensuing carbon starvation by actively storing carbon at the expense of growth (“bet hedging”). Because such a strategy is only adaptive in drought-prone regions, we hypothesise that the degree of carbon “bet hedging” should...

Data from: Comparative proteomics of stenotopic caddisfly Crunoecia irrorata identifies acclimation strategies to warming

Joshua Niklas Ebner, Danilo Ritz & Stefanie Von Fumetti
Species’ ecological preferences are often deduced from habitat characteristics thought to represent more or less optimal conditions for physiological functioning. Evolution has led to stenotopic and eurytopic species, the former having decreased niche breadths and lower tolerances to environmental variability. Species inhabiting freshwater springs are often described as being stenotopic specialists, adapted to the stable thermal conditions found in these habitats. Whether due to past local adaptation these species have evolved or have lost intra-generational...

Widespread intersex differentiation across the stickleback genome – the signature of sexually antagonistic selection?

Daniel Berner, Mirjam Bissegger, Telma Laurentino & Marius Roesti
Females and males within a species commonly have distinct reproductive roles, and the associated traits may be under perpetual divergent natural selection between the sexes if their sex-specific control has not yet evolved. We here explore whether such sexually antagonistic selection can be detected based on the magnitude of differentiation between the sexes across genome-wide genetic polymorphisms by whole-genome sequencing of large pools of female and male threespine stickleback fish. We find numerous autosomal genome...

Data from: Climatic refugia boosted allopatric diversification in Western Mediterranean vipers

Fernando Martínez-Freiría, Inês Freitas, Marco A. L. Zuffi, Philippe Golay, Sylvain Ursenbacher & Guillermo Velo-Antón
Abstract: Aim: to understand the role of climate in fostering diversification, this study reconstructs the historical biogeography of Western Mediterranean vipers Location: Western Mediterranean Basin Taxon: Vipera aspis and V. latastei-monticola complex Methods: phylogeographic analyses were performed over mitochondrial (three genes) and nuclear sequences (two genes), extensively covering species ranges. A total of 4,056 records were assigned to genetic units, using interpolations of genetic data, to test phylogenetic niche conservatism, under a 3D hypervolume approach,...

Structural manipulations of a shelter resource reveal underlying preference functions in a shell-dwelling cichlid fish

Aneesh Bose, Johannes Windorfer, Alex Böhm, Fabrizia Ronco, Adrian Indermaur, Walter Salzburger & Alex Jordan
Many animals can modify the environments in which they live, thereby changing the selection pressures they experience. A common example of such niche-construction is the use, creation, or modification of environmental resources for use as nests or shelters. Because these resources often have correlated structural elements, it can be difficult to disentangle the relative contribution of these elements to resource choice, and the preference functions underlying niche-construction behaviour remain hidden. Here, we present an experimental...

Data from: Daphnia females adjust sex allocation in response to current sex ratio and density

Isobel Booksmythe, Nina Gerber, Dieter Ebert & Hanna Kokko
Cyclical parthenogenesis presents an interesting challenge for the study of sex allocation, as individuals’ allocation decisions involve both the choice between sexual and asexual reproduction, and the choice between sons and daughters. Male production is therefore expected to depend on ecological and evolutionary drivers of overall investment in sex, and those influencing male reproductive value during sexual periods. We manipulated experimental populations, and made repeated observations of natural populations over their growing season, to disentangle...

Data from: Bayesian divergence-time estimation with genome-wide SNP data of sea catfishes (Ariidae) supports Miocene closure of the Panamanian isthmus

Madlen Stange, Marcelo R. Sánchez-Villagra, Walter Salzburger & Michael Matschiner
The closure of the Isthmus of Panama has long been considered to be one of the best defined biogeographic calibration points for molecular divergence-time estimation. However, geological and biological evidence has recently cast doubt on the presumed timing of the initial isthmus closure around 3 Ma but has instead suggested the existence of temporary land bridges as early as the Middle or Late Miocene. The biological evidence supporting these earlier land bridges was based either...

Data from: Real-time social selection maintains honesty of a dynamic visual signal in cooperative fish

Judith C. Bachmann, Fabio Cortesi, Matthew D. Hall, N. Justin Marshall, Walter Salzburger & Hugo F. Gante
Our understanding of animal communication has been largely driven by advances in theory since empirical evidence has been difficult to obtain. Costly signaling theory became the dominant paradigm explaining the evolution of honest signals, according to which communication reliability relies on differential costs imposed on signalers to distinguish animals of different quality. On the other hand, mathematical models disagree on the source of costs at the communication equilibrium. Here we present an empirical framework to...

Dsuite - fast D-statistics and related admixture evidence from VCF files

Milan Malinsky, Michael Matschiner & Hannes Svardal
Patterson’s D, also known as the ABBA-BABA statistic, and related statistics such as the f4-ratio, are commonly used to assess evidence of gene flow between populations or closely related species. Currently available implementations often require custom file formats, implement only small subsets of the available statistics, and are impractical to evaluate all gene flow hypotheses across datasets with many populations or species due to computational inefficiencies. Here we present a new software package Dsuite, an...

Heavy Metal Bricolage

Lavinia Pflugfelder
Using the term “bricolage”, this article examines the articulation of religious imagery in the visual language of extreme metal. Transgression and bricolage, which describes a specific mode of reusing elements of cultural repertoire to fashion new expressions, have their own history and tradition in heavy metal. Any implementation of its visual language relies accordingly on shared knowledge of scene traditions and patterns to decode, but disembedded religious images and religious patterns are abundant in pop...

Spontaneous point mutations in the capsule synthesis locus leading to structural and functional changes of the capsule in serogroup A meningococcal populations

Emma Ispasanie, Francesca Micoli, Araceli Lamelas, Dominique Keller, Francesco Berti, Riccardo De Ricco, Roberta Di Benedetto, Simona Rondini & Gerd Pluschke
Whole genome sequencing analysis of 100 Neisseria meningitidis serogroup A isolates has revealed that the csaABCD-ctrABCD-ctrEF capsule polysaccharide synthesis locus represents a spontaneous point mutation hotspot. Structural and functional properties of the capsule of 11 carriage and two disease isolates with non-synonymous point mutations or stop codons in capsule synthesis genes were analyzed for their capsular polysaccharide expression, recognition by antibodies and sensitivity to bactericidal killing. Eight of eleven carriage isolates presenting capsule locus mutations...

Raw nucleotide counts for clinal Misty Lake and stream stickleback samples

Daniel Berner & Quiterie Haenel
How ecological divergence causes strong reproductive isolation between populations in close geographic contact remains poorly understood at the genomic level. We here study this question in a stickleback fish population pair adapted to contiguous, ecologically different lake and stream habitats. Clinal whole-genome sequence data reveal numerous genome regions (nearly) fixed for alternative alleles over a distance of just a few hundred meters. This strong polygenic adaptive divergence must constitute a genome-wide barrier to gene flow...

Data from: Molecular evolution of key metabolic genes during transitions to C4 and CAM photosynthesis

Eric W. Goolsby, Abigail J. Moore, Lillian P. Hancock, Jurriaan M. De Vos & Erika J. Edwards
PREMISE OF THE STUDY: Next-generation sequencing facilitates rapid production of well-sampled phylogenies built from very large genetic datasets, which can then be subsequently exploited to examine the molecular evolution of the genes themselves. We present an evolutionary analysis of 83 gene families (19 containing carbon-concentrating mechanism (CCM) genes, 64 containing non-CCM genes) in the portullugo clade (Caryophyllales), a diverse lineage of mostly arid-adapted plants that contains multiple evolutionary origins of all known photosynthesis types in...

Data from: Two-year impact of community-based health screening and parenting groups on child development in Zambia: follow-up to a cluster-randomized controlled trial

Peter C. Rockers, Arianna Zanolini, Bowen Banda, Mwaba Moono Chipili, Robert C. Hughes, Davidson H. Hamer & Günther Fink
Background: Early childhood interventions have potential to offset the negative impact of early adversity. We evaluated the impact of a community-based parenting group intervention on child development in Zambia. Methods and Findings: We conducted a non-masked cluster-randomized controlled trial in Southern Province, Zambia. Thirty clusters of villages were matched based on population density and distance from the nearest health center, and randomly assigned to intervention (15 clusters, 268 caregiver-child dyads) or control (15 clusters, 258...

Data from: Spatial population genetic structure of a bacterial parasite in close coevolution with its host

Jason P. Andras, Peter D. Fields & Dieter Ebert
Knowledge of a species’ population genetic structure can provide insight into fundamental ecological and evolutionary processes including gene flow, genetic drift, and adaptive evolution. Such inference is of particular importance for parasites, as an understanding of their population structure can illuminate epidemiological and coevolutionary dynamics. Here we describe the population genetic structure of the bacterium Pasteuria ramosa, a parasite that infects planktonic crustaceans of the genus Daphnia. This system has become a model for investigations...

Data from: Despite high levels of expression in thymic epithelial cells, miR-181a1 and miR-181b1 are not required for thymic development

Heather E. Stefanski, Yan Xing, Patricia A. Taylor, Stefano Maio, Jorge Henao-Meija, Adam Williams, Richard A. Flavell, Georg A. Hollander & Bruce R. Blazar
MicroRNAs (miRNAs) have been shown to be key modulators of post-transcriptional gene silencing in many cellular processes. In previous studies designed to understand the role of miRNAs in thymic development, we globally deleted miRNA exclusively in thymic epithelial cells (TECs), which are critical in thymic selection. This resulted in the loss of stromal cells that instruct T cell lineage commitment and affect thymocyte positive selection, required for mature T cell development. Since murine miR-181 is...

Data from: Mouth dimorphism in scale-eating cichlid fish from Lake Tanganyika advances individual fitness

Adrian Indermaur, Anya Theis, Bernd Egger & Walter Salzburger
Random asymmetry, that is the co-existence of left- and right-sided (or -handed) individuals within a population, is a particular case of natural variation; what triggers and maintains such dimorphisms remains unknown in most cases. Here, we report a field-based cage experiment in the scale-eating Tanganyikan cichlid Perissodus microlepis (Boulenger, 1898), which occurs in two morphs in nature: left-skewed and right-skewed individuals with respect to mouth orientation. Using underwater cages stocked with scale-eaters and natural prey...

Whole genome re-sequencing of mother and offspring D. magna genotypes

Luca Cornetti
Inbreeding refers to the fusion of related individuals' gametes, with self-fertilization (selfing) being an extreme form of inbreeding—involving gametes produced by the same individual. Selfing is expected to reduce heterozygosity by an average of 50 % in one generation; however, little is known about the empirical variation on a genome level surrounding this figure, and the factors that affect variation. We selfed genotypes of the cyclic parthenogen Daphnia magna and analyzed whole genomes of mothers...

Data from: Disentangling structural genomic and behavioral barriers in a sea of connectivity

Julia M. I. Barth, David Villegas-Ríos, Carla Freitas, Even Moland, Bastiaan Star, Carl André, Halvor Knutsen, Ian Bradbury, Jan Dierking, Christoph Petereit, David Righton, Julian Metcalfe, Kjetill S. Jakobsen, Esben M. Olsen, Sissel Jentoft & Julia M.I. Barth
Genetic divergence among populations arises through natural selection or drift and is counteracted by connectivity and gene flow. In sympatric populations, isolating mechanisms are thus needed to limit the homogenizing effects of gene flow to allow for adaptation and speciation. Chromosomal inversions act as an important mechanism maintaining isolating barriers, yet their role in sympatric populations and divergence with gene flow is not entirely understood. Here, we revisit the question whether inversions play a role...

sj-pdf-3-prf-10.1177_02676591211024817 – Supplemental material for Outcome of right ventricular assist device implantation following left ventricular assist device implantation: Systematic review and meta-analysis

Gregory Reid, Constantin Mork, Brigita Gahl, Christian Appenzeller-Herzog, Ludwig K von Segesser, Friedrich Eckstein & Denis A Berdajs
Supplemental material, sj-pdf-3-prf-10.1177_02676591211024817 for Outcome of right ventricular assist device implantation following left ventricular assist device implantation: Systematic review and meta-analysis by Gregory Reid, Constantin Mork, Brigita Gahl, Christian Appenzeller-Herzog, Ludwig K von Segesser, Friedrich Eckstein and Denis A Berdajs in Perfusion

Registration Year

  • 2023
    24
  • 2022
    224
  • 2021
    25
  • 2020
    20
  • 2019
    12
  • 2018
    28
  • 2017
    23
  • 2016
    20
  • 2015
    22
  • 2014
    14

Resource Types

  • Dataset
    211
  • Text
    135
  • Collection
    64
  • Image
    27
  • Journal Article
    2

Affiliations

  • University of Basel
    439
  • Swiss Tropical and Public Health Institute
    68
  • University Hospital of Basel
    43
  • University of Zurich
    37
  • University of Bern
    35
  • KU Leuven
    34
  • Charité - University Medicine Berlin
    22
  • Duke University
    22
  • University of Oxford
    22
  • National University of Singapore
    20